检索结果-南通市图书馆

MDCT, MR and interventional radiology in biliary atresia candidates for liver transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Radiology 2011年第9期3卷 215-223页

作者： Roberto Miraglia Settimo Caruso Luigi Maruzzelli Marco Spada silvia riva Marco Sciveres Angelo Luca Department of Diagnostic and Interventional Radiology Mediterranean Institute for Transplantation and Advanced Specialized Therapies University of Pittsburgh Medical Center 90127 Palermo Italy Department of Transplantation Surgery Mediterranean Institute for Transplantation and Advanced Specialized Therapies University of Pittsburgh Medical Center 90127 Palermo Italy Department of Pediatric Hepatology Mediterranean Institute for Transplantation and Advanced Specialized Therapies University of Pittsburgh Medical Center 90127 Palermo Italy

The multi-detector computed tomography (MDCT) scan and magnetic resonance (MR) of the abdomen play a key role in the work-up to liver transplantation (LT) by identifying congenital anomalies or cirrhosis-related modifications, conditions that can require changes in surgical technique. Moreover, the MDCT and MR scans allow identification of cirrhotic liver hepatic masses, extrahepatic porto-systemic shunts, eventual thrombosis of portal system and radiological signs of portal hypertension associated with biliary atresia (BA). The aim of this paper is to review MDCT, MR imaging and interven-tional radiology procedures performed to evaluate morphological changes and degree of portal hypertension in pediatric patients with end-stage liver disease secondary to BA, who are candidates for LT. Advances in the field of MR, MDCT and in percutaneous minimally invasive techniques have increased the importance of radiology in the management of pediatric patients with BA who are candidates for LT.

关键词： Portal hypertension Imaging Children Chol- angiopathy Transplant

Diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon nano-onions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2020年第1期14卷 76-89页

作者： Viviana Maffeis Lisa Moni Daniele Di Stefano silvia Giordani Renata riva Nano Carbon Materials Istituto Italiano di Tecnologia(IIT)10144 TorinoItaly Department of Chemistry and Industrial Chemistry University of Genova16146 GenovaItaly School of Chemical Sciences Dublin City UniversityDublin 9Ireland Department of Pharmacy University of Genova16147 GenovaItaly

The search for new fluorescent molecules for possible applications as functional p-electron systems and their conjugation with different nanomaterials is nowadays of paramount importance to broaden the availability of materials with different *** we present a diversity-oriented approach to heterocyclic luminophores based on a multicomponent Ugi reaction followed by a Pd-mediated cascade *** new molecules are coupled to carbon nano-onions,and hybrid systems represent the first example of blue emitters conjugated with these carbon nanoparticles.

关键词： carbon nano-onions multicomponent reactions blue emitters fluorescence isoquinolines

Revaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第30期14卷 4745-4752页

作者： Alessia riva Paola Trombini Raffaella Mariani Alessandra Salvioni Sabina Coletti silvia Bonfadini Valentina Paolini Matteo Pozzi Rita Facchetti Giorgio Bovo Alberto Piperno Department of Clinical Medicine University of Milano-Bicocca San Gerardo Hospital Department of Clinical and Preventive Medicine University of Milano-Bicocca Department of Clinical Pathology San Gerardo Hospital University of Milano-Bicocca

AIM： To re-evaluate the diagnostic criteria of insulin resistance hepatic iron overload based on clinical, biochemical and histopathological findings. METHODS： We studied 81 patients with hepatic iron overload not explained by known genetic and acquired causes. The metabolic syndrome （MS） was defined according to ATPⅢ criteria. Iron overload was assessed by liver biopsy. Liver histology was evaluated by Ishak＇s score and iron accumulation by Deugnier＇s score; steatosis was diagnosed when present in ≥ 5% of hepatooltes. RESULTS： According to transferrin saturation levels, we observed significant differences in the amount of hepatic iron overload and iron distribution, as well as the number of metabolic abnormalities. Using Receiving Operating Curve analysis, we found that the presence of two components of the MS differentiated two groups with a statistically significant different hepatic iron overload （P 〈 0.0001）. Patients with ≥2 metabolic alterations and steatosis had lower amount of hepatic iron, lower transferrin saturation and higher sinusoidal iron than patients with 〈 2 MS components and absence of steatosis. CONCLUSION： In our patients, the presence of ≥ 2 alterations of the MS and hepatic steatosis was associated with a moderate form of iron overload with a prevalent sinusoidal distribution and a normal transferrin saturation, suggesting the existence of a peculiar pathogenetic mechanism of iron accumulation. These patients may have the typical dysmetabolic iron overload syndrome. By contrast, patients with transferrin saturation ≥ 60% had more severe iron overload, few or no metabolic abnormalities and a hemochromatosis-like pattern of iron overload.

关键词： Iron overload Hepatic iron distribution Transferrin saturation Metabolic syndrome Hepatic steatosis

Analysis of peripheral blood dendritic cells as a non-invasivetool in the follow-up of patients with chronic hepatitis C

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第4期22卷 1393-1404页

作者： Andrea Crosignani Antonio riva silvia Della Bella Department of Internal Medicine A.O.San PaoloUniversity of Milan20142 MilanItaly Institute of Hepatology Foundation for Liver ResearchLondon WC1E 6HXUnited Kingdom Department of Medical Biotechnologies and Translational Medicine University of Milan20089 Rozzano(Milan)Italy Lab of Clinical and Experimental Immunology Humanitas Clinical and Research Center20089 Rozzano(Milan)Italy

Hepatitis C virus(HCV) has a high propensity to establish chronic infections. Failure of HCV-infected individuals to activate effective antiviral immune responses is at least in part related to HCV-induced impairment of dendritic cells(DCs) that play a central role in activating T cell responses. Although the impact of HCV on DC phenotype and function is likely to be more prominent in the liver, major HCV-induced alterations are detectable in peripheral blood DCs(pb DCs) that represent the most accessible source of DCs. These alterations include numerical reduction, impaired production of inflammatory cytokines and increased production of immunosuppressive IL10. These changes in DCs are relevant to our understanding the immune mechanisms underlying the propensity of HCV to establish persistent infection. Importantly, the noninvasive accessibility of pb DCs renders the analysis of these cells a convenient procedure that can be serially repeated in patient follow-up. Accordingly, the study of pb DCs in HCV-infected patients during conventional treatment with pegylated interferon and ribavirin indicated that restoration of normal plasmacytoid DC count may represent an additional mechanism contributing to the efficacy of the dual therapy. It also identified the pre-treatment levels of plasmacytoid DCs and IL10 as putative predictors of response to therapy. Treatment of chronic HCV infection is changing, as new generation direct-acting antiviral agents will soon be available for use in interferon-free therapeutic strategies. The phenotypic and functional analysis of pb DCs in this novel therapeutic setting will provide a valuable tool for investigating mechanisms underlying treatment efficacy and for identifying predictors of treatment response.

关键词： Hepatitis C virus Peripheral blood dendriticcells cytokines peg-interferon ribavirin

Use of a lyophilized bovine pericardium graft to repair tunical defect in patients with Peyronie＇s disease： experience in a clinical setting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2017年第3期19卷 316-320页

作者： Javier Romero Otero Borja Garcia Gomez Jose Medina Polo Carlos Pascual Mateoe silvia Garcia Barreras Eduard Garcia Cruz Javier de la riva de la Vifia Alfredo Rodriguez Antolin 12 de Octubre University Hospital Department of Urology Madrid Spain Monteprincipe University Hospital Department of Urology Madrid Spain Clinic Hospital Department of Urology Barcelona Spain

Many different materials are available for grafting during surgery for Peyronie＇s disease （PD）. To study the outcomes associated with the use of a lyophilized bovine pericardium graft （Peri-Guard） to repair tunical defects in patients with PD, descriptive study of 43 patients with disabling penile curvature was performed. Curvature was measured before and after the intervention using a standardized procedure. Surgical technique was plaque excision and grafting of the tunical defect carried out by a single surgeon. A lyophilized bovine pericardium patch was used for grafting. We measured the change in penile curvature and length, the ability to perform successful sexual intercourse without further pharmacological or surgical treatment, and the satisfaction with treatment. Follow-up data were available for a total of 41 patients. Median age was 50 years （IQR 48-52）; mean follow-up time was 14 ± 6 months. Complete penile straightening was achieved in 33 patients （80.5%） and five patients （12.2%） had curvature under 20. Three months after surgery and stretching therapy, mean （s.d.） flaccid penile length increased from 11.2 ± 2.8 cm to 12.1 ± 2.9 cm （P = 0.062）. Seventy-five percentage of patients reported being able to achieve successful intercourse without further treatment. Eighty-five percentage of patients reported to be satisfied with the treatment. There was no evidence of tissue rejection or infection, and only four patients suffered an adverse event. Plaque excision and grafting of the tunical defect with lyophilized bovine pericardium seems to be a safe and effective treatment for patients with PD.

关键词： penile curvature pericardium patch Peyronie's disease surgical treatment