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The duration of the conventional chemoembolization for hepatocellular carcinoma:factors affecting the procedural time

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Hepatoma Research 2022年第1期8卷 313-326页

作者： Matteo Renzulli Mattia Gentilini Giovanni Marasco Nicolo Brandi Alessandro Granito silvia lo monaco Anna Maria Ierardi Antonio De Cinque Francesco Tovoli Laura Bartalena Daniele Spinelli Fabio Piscaglia Rita Golfieri Department of Radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Internal Medicine and Digestive Physiopathology Unit IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Division of Internal Medicine IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Diagnostic and Interventional Radiology Department Fondazione IRCCS CàGranda Ospedale Maggiore PoliclinicoUniversitàdegli Studi di Milano MilanMilan 20122Italy

Aim:The present study evaluated the duration of chemoembolization in patients with hepatocellular carcinoma,analyzing possible factors affecting the procedural ***:In total,175 patients who underwent chemoembolization have been prospectively *** procedural length was considered the time between the insertion and the removal of the angiographic *** features related to the tumor burden and angiographic procedures,which could be related to the procedural time,were ***:The chemoembolization time resulted in a mean of 58.1 *** longer procedural time was associated with a number of nodules treated per patient≥2(Plocation of the tumor in the left lobe(P=0.001),the exclusion from the Milan criteria(Plonger procedural time are the number of nodules treated≥2,the number of segments with nodules≥2,the involvement of the left lobe,the tumor burden outside the Milan criteria,and the number of segments treated≥*** these characteristics,known in the pre-procedural phase,represent useful tools for a correct planning of the angiographic room’s workflow during the pandemic era as well as in the future to reduce downtime and increase productivity.

关键词： Chemoembolization hepatocellular carcinoma procedural time angiographic room management

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Physical exercise in locally advanced pancreatic adenocarcinoma: "If I walk, I live. Although one can die of cancer, now I am living"

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Journal of Cancer Metastasis and Treatment 2019年第12期4卷 41-48页

作者： Giovanni lo Re silvia Magnaldi Paolo Doretto Roberto Innocente Francesco lo Re Medical Oncology and Immune-related tumors CRO IRCCSAviano 33081Italy Radiology AAS5 PordenonesePordenone 33170Italy Clinical pathology AAS5 PordenonesePordenone 33170Italy Radiotherapy Centro di Riferimento Oncologico(CRO)Aviano 33081Italy Chemotherapy and Medical Toxicology Study UniversityMilan 20129Italy

The most widely used chemotherapeutic combinations in locally advanced (LA) or metastatic pancreatic ductal adenocarcinoma(PDAC)areNab-Paclitaxel-Gemcitabine(Nab-PCT-GEM)andFluorouracil,Folinicacid,Oxaliplatin, and irinotecan (FOLFIRINOX). Chemo-resistance, typical of PDAC, appears to be due to the negative influence of stroma population cells, namely regulatory T cells (Treg) and myeloid-derived suppressor cells, macrophages with inhibitory effects on the antitumor activity of the innate and adaptive immune systems, and resistance to cancer treatment. Among other factors that may influence immune surveillance, constant physical activity appears to reduce the risk of cancer-related mortality and cardiovascular risk. However, this does not seem to increase the survival of patients with PDAC. The exception is our young inoperable patient. For LA head PDAC, he was treated with seven cycles of Nab-PCT-GEM and RT 50 Gy/15 fractions combined to biweekly GEM and salvage FOLFIRINOX. The five-year surviving patient travelled 15,000 km on foot and continues inexorably his "walking therapy".

关键词： Pancreatic adenocarcinoma depression physical activity Nab-paclitaxel fluorouracil regulatory T cells myeloid-derived suppressor cells

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The phylogenetic and evolutionary history of Kokobera virus

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 945-950页

作者： Aletheia Blasi Alessandra lo Presti Eleonora Cella silvia Angeletti Massimo Ciccozzi Unit of Clinical Pathology and Microbiology University Campus Bio-Medico of Rome Department of Infectious Parasitic and Immunomediated Diseases Istituto Superiore di Sanità Public Health and Infectious Diseases Sapienza University

Objective: To estimate the genetic diversity of Kokobera virus, the date of origin and the spread among different viruses in the endemic regions of Australia. Methods: Two datasets were built. The first consisting of 29 sequences of the NS5/3' UTR region of Kokobera group downloaded from Gen Bank, the second including only 24 sequences of Kokobera viruses, focus is on this group. Results: Bayesian time analysis revealed two different entries in Australia of Kokobera virus in the 50 s years with the dated ancestor in 1861 year. Clade A and B showed a clear separation of the Kokobera sequences according to the geographic region. Conclusions: Data from the study showed as Kokobera virus, despite of its ancient origin and its circulation before the European colonization, remained limited to the Australian Country and nowadays limited mostly to the regions were Australian marsupials are mostly found.

关键词： Kokobera virus Phylogeny Date of origin Evolution

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Second Generation Nitrogen Doped Titania Nanoparticles:A Comprehensive Electronic and Microstructural Picture

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中国化学:英文版 2014年第12期32卷 1195-1213页

作者： Francesca Spadavecchia Michele Ceotto Leonardo lo Presti Chiara Aieta Iolanda Biraghi Daniela Meroni silvia Ardizzone Giuseppe Cappellettia Dipartimentodi Chimica Universitàdegli Studidi MilanoVia Golgi 1920133 MilanoItaly Consorzio Interuniversitario Nazionaleperla Scienzaela Tecnologiadei Materiali(INSTM) Via Giusti 950121 FirenzeItaly Istitutodi Scienzee Tecnologie Molecolari Italian CNRVia Golgi 1920133 MilanoItaly Center for Materials Crystallography Aarhus UniversityLangelandsgade 1408000 AarhusDenmark

A state-of-the-art overview of N-dopant characterizations in nano-TiO_(2)second-generation photocatalysts is *** related literature is very rich and sometimes offers contrasting *** we critically discuss up-to-date literature results and our own findings,as retrieved by several experimental(BET,HR-TEM,XPS,DRS,HR-XRPD,EXAFS,electrochemical tools)and theoretical(periodic DFT)*** intent is to pull together outcomes from very different and complementary sources to make an as much as possible coherent picture of the morphological,electrochemical and electronic properties of N-TiO_(2)*** is commonly accepted that critical issues to be considered in the design of high-performing N-TiO_(2)photocatalysts are synthetic strategy,defect concentration and chemical nature of the lattice point *** focus on the latter two issues,with emphasis on sol-gel prepared materials,according to the specific area of expertise of our *** problem of the chemical nature of guest N species into the lattice is crucial,as substitutional(N_(s))or interstitial(N_(i))nitrogen place their valence states just above the valence band or deeper into the band ***,we show how synergism among experimental and theoretical techniques is decisive to disentangle structural,electronic and morphological effects in complex N-doped TiO_(2)matrices.

关键词： point defects flatband potential photovoltage photocurrent DFT calculations

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Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 376-380页

作者： Eleonora Cella Ivan Gabrielli Gianguglielmo Zehender Marta Giovanetti Alessandra lo Presti Alessia Lai Giordano Dicuonzo silvia Angeletti Marco Salemi Massimo Ciccozzi Department of Infectious Parasitic and Immunomediated DiseasesNational Institute of Health Department of Public Health and Infectious Diseases.Sapienza University of Rome University of Rome 'La Sapienza' L.Sacco Department of Biomedical and Clinical Sciences University of Milan University of Rome 'Tor Vergata' Clinical Pathology and Microbiology Laboratory University Hospital Campus Bio-Medico of Rome Department of Pathology and Laboratory Medicine.University of Florida University Hospital Campus Bio-Medico

Objective:To study the genetic diversity of Murray Valley encephalitis virus(MVEV) in Australia and Papua New ***:MVEV envelope gene sequences were aligned using Clustal X and manual editing was performed with *** v.3.7 was used to select the simplest evolutionary model that adequately fitted the sequence *** likelihood analysis was performed using *** phylogenetic signal of the dataset wa.s investigated by the likelihood mapping *** Bayesian phylogenetic tree was built using ***:The phylogenetic trees showed two main *** clade Ⅰincluding eight strains isolated from West *** clade Ⅱ was characterized by at least four epidemic entries,three of which localized in Northern West Australia and one in Papua New *** estimated mean evolutionary rate value of the MVEV envelope gene wa.s0.407 × 10^(-3) substitution/site/year(95%HPD:0.623 × 10~4-0.780× 10^(-3)).Population dynamics defines a relative constant population until the year *** a reduction occurred,probably due to a ***:This study has been useful in supporting the probable connection between climate changes and viral evolution also by the vector point of view:multidisciplinary monitoring studies are important to prevent new viral epidemics inside and outside new endemic areas.

关键词： Murray Valley encephalitis virus Phylogeny Evolution

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Genetic diversity in Ebola virus:Phylogenetic and in silico structural studies of Ebola viral proteins

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 329-335页

作者： Alba Grifoni Alessandra lo Presti Marta Giovanetti Carla Montesano Massimo Amicosante Vittorio Colizzi Alessia Lai Gianguglielmo Zehender Eleonora Cella silvia Angeletti Massimo Ciccozzi ProxAgen Ltd.Sofia.Bulgaria Department of Infectious Parasitic and Immunomediated Diseases National Institute of Health Department of Biology University of Rome 'Tor Vergata' Department of Biomedicine and Prevention University of Rome Tor Vergata Laboratory of Infectious Diseases and Tropical Medicine University of Milan Department of Public Health and Infectious Diseases.Sapienza University of Rome.Rome Clinical Pathology and Microbiology Laboratory University Hospital Campus Bio-Medico of Rome University Campus Bio-Medico

Objective:To explore the genetic diversity and the modification of antibody response in the recent outbreak of Ebola ***:Sequences retrieved from public databases,the selective pressure analysis and the homology modelling based on the all protein(***35,*** glycoprotein,small soluble ***30,VP24 and polymerase) were ***:Structural proteins ***35 and VP40 showed relative conserved sequences making them suitable target candidates for antiviral *** the contrary,*** and soluble glycoprotein have high mutation ***:Data from this study point out important aspects of Ebola virus sequence variability that for epitope and vaccine design should be considered for appropriate targeting of conserved protein regions.

关键词： Ebola virus Proteins Evolutionary analysis

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Zika virus spreading in South America: evolutionary analysis of emerging neutralizing resistant Phe279Ser strains

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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 432-438页

作者： Marta Giovanetti Teresa Milano Luiz Carlos Alcantara Laura Carcangiu Eleonora Cella Alessia Lai Alessandra lo Presti Stefano Pascarella Gianguglielmo Zehender silvia Angeletti Massimo Ciccozzi Department of Infectious Parasitic and Immunomediated Diseases National Institute of HealthRomeItaly Department of Biology University of Rome ‘Tor Vergata’RomeItaly Laboratory of Hematology Genetic and Computational Biology Goncalo Moniz Research Center Oswaldo Cruz Foundation (LHGB/CPq GM/FIOCRUZ)SalvadorBahiaBrazil Dipartimento di Scienze Biochimiche ‘A. Rossi Fanelli’ Universita La Sapienza00185 RomeItaly Department of Public Health and Infectious Diseases Sapienza University of RomeRomeItaly Laboratory of Infectious Diseases and Tropical Medicine University of Milan Clinical Pathology and Microbiology Laboratory University Hospital Campus Bio-Medico of RomeRomeItaly University Campus Bio-Medico RomeItaly

Objective: To investigate the genetic diversity of Zika virus(ZIKV) and the relationships existing among these circulating viruses worldwide. To evaluate the genetic polymorphisms harboured from ZIKV that can have an influence on the virus circulation. Methods: Three different ZIKV dataset were built. The first dataset included 63 E gene sequences, the second one 22 NS3 sequences and the third dataset was composed of 108 NS5 gene sequences. Phylogenetic and selective pressure analysis was performed. The edited nucleic acid alignment from the Envelope dataset was used to generate a conceptual translation to the corresponding peptide sequences through UGene software. Results: The phylogeographic reconstruction was able to discriminate unambiguously that the Brazilian strains are belonged to the Asian lineage. The structural analysis reveals instead the presence of the Ser residue in the Brazilian sequences(however already observed in other previously reported ZIKV infections) that could suggest the presence of a neutralization-resistant population of viruses. Conclusions: Phylogenetic, evolutionary and selective pressure analysis contributed to improve the knowledge on the circulation of ZIKV.

关键词： Zika virus Phylogeny Evolution

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Anxiety,depression,and quality of life in Parkinson's disease:the implications of multidisciplinary treatment

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Neural Regeneration Research 2021年第3期16卷 587-590页

作者： Viviana lo Buono Rosanna Palmeri Simona De Salvo Matteo Berenati Agata Greco Rosella Ciurleo Chiara Sorbera Vincenzo Cimino Francesco Corallo Placido Bramanti silvia Marino Giuseppe Di lorenzo Lilla Bonanno Department of Neurobioimaging Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Centro Neurolesi Bonino-PulejoMessinaItaly

Anxiety and depression in Parkinson's disease(PD)reduce well-being of the *** alterations influence motor skills and cognitive performance;moreover,they contribute significantly and independently to worsen rehabilitative treatment *** investigated anxiety,depression,and quality of life in PD patients subjected to multidisciplinary rehabilitative *** self-controlled study included 100 PD patients(49 males and 51 females with the mean age of 64.66 years)admitted to 60 days hospitalization rehabilitative program,between January 2017 and December ***,cognitive,linguistic abilities,and functional independence were evaluated at admission(T0 baseline visit)and 60 days after(T1)the multidisciplinary rehabilitation including motor exercises,speech therapies,and cognitive *** multidisciplinary rehabilitation improved functional status in PD patients and exerted its positive effects on mood,motor abilities,autonomy in the activities of daily life,perception of quality of life,cognitive performance and speech ***-motor symptoms may worsen severe disability and reduce quality of *** are often poorly recognized and inadequately ***,multidisciplinary rehabilitative training represents an optimal strategy to improve disease *** study was approved by Istituito di Ricovero e Cura a Carattere Scientifico(IRCCS)Centro Neurolesi"Bonino-Pulejo"Ethical Committee(approval No.6/2016)in June 2016.

关键词： anxiety depression multidisciplinary rehabilitation Parkinson's disease

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Procalcitonin and mid-regional pro-adrenomedullin as promising markers for sepsis diagnosis and prognosis

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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 973-974页

作者： silvia Angeletti Rossella Ottaviani Arcangela Michela Lanotte Lucia Pedicino Marina De Cesaris Alessandra lo Presti Eleonora Cella Marta Fogolari Massimo Ciccozzi Giordano Dicuonzo Unit of Clinical Pathology and Microbiology Campus Bio-Medico University of Rome Department of Infectious Parasitic and Immunomediated Diseases Istituto Superiore di Sanità Public Health and Infectious Diseases Sapienza University

To the Editor,We read with great interest the recent review by Limongi et *** sepsis biomarkers[1].Recently,the combined use of two biomarkers,procalcitonin(PCT)and mid-regional proadrenomedullin(MR-pro ADM)has been reported in sepsis diagnosis and *** is a polypeptide produced as a precursor of calcitonin by thyroid C cells normally

关键词： PCT MR ADM than

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Molecular epidemiology and phylogeny of Nipah virus infection:A mini review

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 610-615页

作者： silvia Angeletti Alessandra lo Presti Eleonora Cella Massimo Ciccozzi Unit of Clinical Pathology and Microbiology University Campus Bio-Medico of Rome Department of Infectious Parasitic and Immunomediated Diseases Istituto Superiore di Sanità Public Health and Infectious Diseases Sapienza University

Nipah virus(Ni V) is a member of the genus Henipavirus of the family Paramyxoviridae,characterized by high pathogenicity and endemic in South *** is classified as a Biosafety Level-4(BSL-4) *** case-fatality varies from 40%-70% depending on the severity of the disease and on the availability of adequate healthcare *** present no antiviral drugs are available for Ni V disease and the treatment is just *** and evolutionary analyses can be used to help in understanding the epidemiology and the temporal origin of this *** review provides an overview of evolutionary studies performed on Nipah viruses circulating in different *** phylogenetic studies have been published from 2000 to 2015 years,searching on pub-med using the key words ‘Nipah virus AND phylogeny' and twenty-eight molecular epidemiological studies from 2006 to 2015 have been performed,typing the key words ‘Nipah virus AND molecular epidemiology'.Overall data from the published study demonstrated as phylogenetic and evolutionary analysis represent promising tools to evidence NiV epidemics,to study their origin and evolution and finally to act with effective preventive measure.

关键词： Nipah virus Phylogenetic analysis Molecular epidemiology NiV reservoir

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