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Diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in sporadic Creutzfeldt-Jakob disease:One-case report

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Neural Regeneration Research 2011年第29期6卷 2295-2297页

作者： Rosa Morabito Annalisa Baglieri Rosella Ciurleo Francesco Corallo Rosaria De Luca Simona De Salvo silvia guerrera Francesca Timpano Maria Adele Marino Placido Bramanti silvia Marino Neurobioimaging Laboratory IRCCS Centro Neurolesi "Bonino Pulejo"MessinaItaly

The diagnosis of sporadic Creutzfeldt-Jakob disease （sCJD） is extremely difficult. Diffusion-weighted imaging has been shown to be the most sensitive technique for the detection of signal alterations in sCJD patients. The present study analyzed the diagnostic value of diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in the early stage of sCJD in one female patient and correlated the clinical symptoms during disease course and magnetic resonance manifestations. Thalamic and basal ganglia hyperintensities were observed on magnetic resonance images in a very early stage, i.e., when the clinical typical manifestations of the disease were not present. With the progression of the disease, cortical and basal ganglia hyperintensities were observed on magnetic resonance images, showing an obvious cerebral atrophy. These findings suggest that diffusion-weighted imaging and fluid-attenuated inversion recovery sequence are helpful in diagnosing sCJD.

关键词： Creutzfeldt-Jacob disease fluid-attenuated inversion recovery diffusion-weighted imaging magnetic resonance imaging

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CD44v8-10 is a marker for malignant traits and a potential driver of bone metastasis in a subpopulation of prostate cancer cells

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Cancer Biology & Medicine 2021年第3期18卷 788-807页

作者： Rosaria A.Fontanella silvia Sideri Chiara Di Stefano Angiolina Catizone silvia Di Agostino Daniela F.Angelini Gisella guerrera Luca Battistini Giulia Battafarano Andrea Del Fattore Antonio Francesco Campese Fabrizio Padula Paola De Cesaris Antonio Filippini Anna Riccioli Department of Anatomy HistologyForensic Medicine and OrthopaedicsUnit of Histology and Medical EmbryologySapienza UniversityRome 00161Italy Department of Health Sciences School of Medicine-"Magna Graecia"University of Catanzaro Catanzaro 88100Italy IRCCS Fondazione Santa Lucia Rome 00143 Bone Physiopathology Research Unit Genetics and Rare Diseases Research DivisionBambino GesùChildren’s HospitalIRCCSRome 00146Italy Department of Molecular Medicine Sapienza UniversityRome 00161Italy Department of Life Health and Environmental SciencesUniversity of L’AquilaL'Aquila 67100Italy

Objective:Bone metastasis is a clinically important outcome of prostate carcinoma(PC).We focused on the phenotypic and functional characterization of a particularly aggressive phenotype within the androgen-independent bone metastasis-derived PC3 cell *** cells,originated from the spontaneous conversion of a CD44-negative subpopulation,stably express the CD44 v8-10 isoform(CD44 v8-10 pos)and display stem cell-like features and a marked invasive phenotype in vitro that is lost upon CD44 v8-10 ***:Flow cytometry,enzyme-linked immunoassay,immunofluorescence,and Western blot were used for phenotypic and immunologic ***-time quantitative polymerase chain reaction and functional assays were used to assess ***:Analysis of epithelial–mesenchymal transition markers showed that CD44 v8-10 pos PC3 cells surprisingly display epithelial phenotype and can undergo osteomimicry,acquiring bone cell phenotypic and behavioral *** of specific si RNA evidenced the ability of CD44 v8-10 variant to confer osteomimetic features,hence the potential to form bone-specific ***,the ability of tumors to activate immunosuppressive mechanisms which counteract effective immune responses is a sign of the aggressiveness of a *** we report that CD44 v8-10 pos cells express programmed death ligand 1,a negative regulator of anticancer immunity,and secrete exceptionally high amounts of interleukin-6,favoring osteoclastogenesis and immunosuppression in bone ***,we identified a novel pathway activated by CD44 v8-10,involving tafazzin(TAZ)and likely the Wnt/TAZ axis,known to play a role in upregulating osteomimetic ***:CD44 v8-10 could represent a marker of a more aggressive bone metastatic PC population exerting a driver role in osteomimicry in bone.A novel link between TAZ and CD44 v8-10 is also shown.

关键词： Metastasis epithelial phenotype EMT MET IL-6 TAZ

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