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CD44v8-10 is a marker for malignant traits and a potential driver of bone metastasis in a subpopulation of prostate cancer cells

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Cancer Biology & Medicine 2021年第3期18卷 788-807页

作者： Rosaria A.Fontanella silvia Sideri Chiara di Stefano Angiolina Catizone silvia di agostino Daniela F.Angelini Gisella Guerrera Luca Battistini Giulia Battafarano Andrea Del Fattore Antonio Francesco Campese Fabrizio Padula Paola De Cesaris Antonio Filippini Anna Riccioli Department of Anatomy HistologyForensic Medicine and OrthopaedicsUnit of Histology and Medical EmbryologySapienza UniversityRome 00161Italy Department of Health Sciences School of Medicine-"Magna Graecia"University of Catanzaro Catanzaro 88100Italy IRCCS Fondazione Santa Lucia Rome 00143 Bone Physiopathology Research Unit Genetics and Rare Diseases Research DivisionBambino GesùChildren’s HospitalIRCCSRome 00146Italy Department of Molecular Medicine Sapienza UniversityRome 00161Italy Department of Life Health and Environmental SciencesUniversity of L’AquilaL'Aquila 67100Italy

Objective:Bone metastasis is a clinically important outcome of prostate carcinoma(PC).We focused on the phenotypic and functional characterization of a particularly aggressive phenotype within the androgen-independent bone metastasis-derived PC3 cell *** cells,originated from the spontaneous conversion of a CD44-negative subpopulation,stably express the CD44 v8-10 isoform(CD44 v8-10 pos)and display stem cell-like features and a marked invasive phenotype in vitro that is lost upon CD44 v8-10 ***:Flow cytometry,enzyme-linked immunoassay,immunofluorescence,and Western blot were used for phenotypic and immunologic ***-time quantitative polymerase chain reaction and functional assays were used to assess ***:Analysis of epithelial–mesenchymal transition markers showed that CD44 v8-10 pos PC3 cells surprisingly display epithelial phenotype and can undergo osteomimicry,acquiring bone cell phenotypic and behavioral *** of specific si RNA evidenced the ability of CD44 v8-10 variant to confer osteomimetic features,hence the potential to form bone-specific ***,the ability of tumors to activate immunosuppressive mechanisms which counteract effective immune responses is a sign of the aggressiveness of a *** we report that CD44 v8-10 pos cells express programmed death ligand 1,a negative regulator of anticancer immunity,and secrete exceptionally high amounts of interleukin-6,favoring osteoclastogenesis and immunosuppression in bone ***,we identified a novel pathway activated by CD44 v8-10,involving tafazzin(TAZ)and likely the Wnt/TAZ axis,known to play a role in upregulating osteomimetic ***:CD44 v8-10 could represent a marker of a more aggressive bone metastatic PC population exerting a driver role in osteomimicry in bone.A novel link between TAZ and CD44 v8-10 is also shown.

关键词： Metastasis epithelial phenotype EMT MET IL-6 TAZ

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Application of ultrasonography-elastography score to suspect porto-sinusoidal vascular disease in patients with portal vein thrombosis

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Hepatobiliary & Pancreatic diseases International 2024年第1期23卷 20-24页

作者： Stefania Gioia Adriano De Santis Giulia d’Amati silvia Nardelli Alessandra Spagnoli Arianna di Rocco Lorenzo Ridola Oliviero Riggio Department of Translational and Precision Medicine Sapienza University of RomeRomeItaly Department of Radiological Oncologicaland Pathological SciencesSapienza University of RomeRomeItaly Department of Public Health and Infectious diseases Sapienza University of RomeRomeItaly

Background:Porto-sinusoidal vascular disease(PSVD)and portal vein thrombosis(PVT)are causes of portal hypertension characterized respectively by an intrahepatic and a pre-hepatic obstacle to the flow in the portal *** PVT may be a consequence of PSVD,in PVT patients at presentation,a pre-existing PSVD should be *** these patients the identification of an underlying PSVD would have relevant implication regarding follow-up and therapeutic management,but it could be *** this setting ultrasonography may be valuable in differential *** aim of the study was to use ultrasonography to identify parameters to discriminate between PSVD and“pure”PVT and then to suspect PVT secondary to a pre-existing ***:Fifty-three patients with histologically proven PSVD and forty-eight patients affected by chronic PVT were enrolled and submitted to abdominal ultrasonography with elastography by acoustic radiation force impulse(ARFI).Results:ARFI was higher and superior mesenteric vein(SMV)diameter was wider in PSVD patients than in PVT ***,a prognostic score was obtained as linear combinations of the two parameters with a good discrimination capacity between PSVD and PVT(the area under the curve=0.780;95%confidence interval:0.690-0.869).Conclusions:A score based on ARFI and SMV diameter may be useful to suspect an underlying PSVD in patients with PVT and to identify a subgroup of patients to be submitted to liver biopsy.

关键词： Non-cirrhotic portal hypertension Porto-sinusoidal vascular disease Chronic portal vein thrombosis Liver stiffness Portal hypertension Acoustic radiation force impulse

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Artificial intelligence in detection of small bowel lesions and their bleeding risk:A new step forward

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World Journal of Gastroenterology 2024年第18期30卷 2482-2484页

作者： silvia Cocca Giuseppina Pontillo Giuseppe Grande Rita Conigliaro Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Gastroenterology and Endoscopy Unit Presidio Ospedaliero San Giuseppe Moscati(AversaCE)-ASL CasertaCaserta 81100Italy Department of Gastroenterology and digestive Endoscopy Azienda Ospedaliero Universitaria di ModenaModena 41121Italy

The present letter to the editor is related to the study with the title“Automatic detection of small bowel(SB)lesions with different bleeding risk based on deep learning models”.Capsule endoscopy(CE)is the main tool to assess SB diseases but it is a time-consuming procedure with a significant error *** development of artificial intelligence(AI)in CE could simplify physicians’*** novel deep learning model by Zhang et al seems to be able to identify various SB lesions and their bleeding risk,and it could pave the way to next perspective studies to better enhance the diagnostic support of AI in the detection of different types of SB lesions in clinical practice.

关键词： Capsule endoscopy Small bowel Artificial intelligence Bleeding risk Vascular lesions

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Enhanced Solar Water Desalination by CuCo_(2)S_(4)-decorated Carbon Foam Derived from Waste Plastics

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Chemical Research in Chinese Universities 2024年第3期40卷 548-555页

作者： Muzammil HUSSAIN Tofik Ahmed SHIFA Pratik V.SHINDE Pankaj KUMAR Stefano CENTENARO silvia GROSS Elisa MORETTI Alberto VOMIERO Department of Molecular Sciences and Nanosystems Ca'Foscari University of VeniceVia Torino 15530172 VeniceItaly Department of Industrial Engineering University of PadovaVia Venezia 135131 PadovaItaly Department of Chemical Sciences University of PadovaVia Francesco Marzolo135131 PadovaItaly division of Materials Science Department of Engineering Sciences and MathematicsLulea University of Technology97187 LuleaSweden Center for Cultural Heritage Technologies(CCHT) Istituto Italiano di Tecnologia(IT)Via Torino 15530170 Venezia-MestreItaly

Interfacial solar desalination is an emerging technology for freshwater production,but the finding of novel solar evaporators is still *** the present research,graphitic carbon foam(CF)was synthesized from the upcycling of waste plastic polyethylene terephthalate(PET)waste bottles functionalized with carrollite CuCo_(2)S_(4) as a photothermal *** characterization[X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),and scanning electron microscopy-energy dispersive spectroscopy(SEM-EDS)]confirms the functionalization of carrollite CuCo_(2)S_(4) on graphitic carbon *** UV-Vis spectroscopy analysis showed an enhanced optical absorption in the UV-Vis-near IR region(>96%)for functionalized CuCo_(2)S_(4)-CF foam compared to carbon foam(67%).The interfacial solar desalination experiment presented a significantly enhanced evaporation rate of 2.4 kg·m^(−2)·h^(−1) for CuCo_(2)S_(4)-CF compared to that of CF(1.60 kg·m^(−2)·h^(−1))and that of CuCo_(2)S_(4)(1.60 kg·m^(−2)·h^(−1)).The obtained results proved that the newly synthesized CuCo_(2)S_(4)-CF from the upcycled plastic into new material for the photothermal desalination process can enhance the practice of a circular economy to produce fresh water.

关键词： Photothermal desalination Cobalt Copper Chalcogenide Waste upcycling Circular economy

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Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

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Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza Fabio Piscopo Marco Tarullo Eleonora Cesari Dante Rotili Antonello Mai Alberto diana Michela Londero Luca Del Giacco Riccardo Masetti Alba di Leone Chiara Naro silvia Masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi Alessandro Fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

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Geophysical evidence of large-scale silica-rich fluid flow above the continental subduction interface

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Science China Earth Sciences 2024年第9期67卷 2796-2809页

作者： Yuantong MAO Liang ZHAO Marco G.MALUSA Stefano SOLARINO silvia PONDRELLI Baolu SUN Coralie AUBERT Simone SALIMBENI Elena EVA Stéphane GUILLOT State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Earth and Environmental Sciences University of Milano-BicoccaMilan 20126Italy Istituto Nazionale di Geofisica e Vulcanologia Osservatorio Nazionale TerremotiGenova 16145Italy Istituto Nazionale di Geofisica e Vulcanologia Sezione di BolognaBologna 40127Italy Université Grenoble Alpes Université Savoie Mont BlancCNRSIRDUGEISTerreGrenoble 38000France

Fluids in subduction zones can have major effects on subduction ***,geophysical constraints on the scale and impact of fluid flow during continental subduction are still *** we analyze the VP/VS ratios in the Western Alpine region,hosting one of the best-preserved fossil continental subduction zones worldwide,to investigate the impact of fluid flow during continental *** found a belt of high VP/VS ratios>1.9 on the upper-plate side of the subduction zone,consistent with a partially serpentinized upper-plate mantle,and a belt of unusually low VP/VS ratiosdicating past fluid flow along the continental subduction *** results suggest that past fluid flow may have reduced the effective stress along the subduction interface thus favoring continental subduction.

关键词： Western Alps Crustal structure Receiver function Vp/Vs ratio Silica enrichment

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Device-assisted enteroscopy: Are we ready to dismiss the spiral?

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World Journal of Gastroenterology 2024年第26期30卷 3185-3192页

作者： Alessandro Mussetto Elettra Merola Cesare Casadei Daniele Salvi Fabiola Fornaroli silvia Cocca Margherita Trebbi Armando Gabbrielli Cristiano Spada Andrea Michielan Department of Gastroenterology S Maria della Croci HospRavenna 48121Italy Department of Gastroenterology Unit G.B.Grassi Hospital(ASL Roma 3)Roma 00122Italy Section of digestive Endoscopy and Gastroenterology Fondazione PoliambulanzaBrescia 25124Italy Gastroenterology and Endoscopy Unit Department of Medicine and SurgeryUniversity of ParmaParma 43125Italy Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Center for Medical Sciences(CISMed) University of TrentoTrento 38122Italy Gastroenterology and digestive Endoscopy Unit Santa Chiara HospitalAzienda Provinciale per i Servizi SanitariTrento 38122Italy digestive Endoscopy Unit Fondazione Policlinico Universitario A.Gemelli IRCSSRoma 00168Italy

Motorized spiral enteroscopy(MSE)is the latest advance in device-assisted *** events related to MSE were discussed in a recent large systematic review and meta-analysis and were directly compared with those of balloon enteroscopy in a case-matched study and a randomized controlled *** the real-life application of MSE,an unexpected safety issue emerged regarding esophageal injury and the technique has been withdrawn from the global market,despite encouraging results in terms of diagnostic and therapeutic *** conducted an Italian multicenter real-life prospective study,which was prematurely terminated after the withdrawal of MSE from the *** primary goals were the evaluation of MSE performance(both diagnostic and therapeutic)and its safety in routine endoscopic practice,particularly in the early phase of introduction in the endoscopic unit.A subanalysis,which involved patients who underwent MSE after unsuccessful balloon enteroscopy,demonstrated,for the first time,the promising performance of MSE as a rescue *** its remarkable performance in clinical practice and its potential role as a backup technique following a previously failed enteroscopy,it may be more appropriate to refine and enhance MSE in the future rather than completely abandoning it.

关键词： Motorized spiral enteroscopy Rescue enteroscopy diagnostic yield Adverse events AGREE classification

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Relationships between emissions of toxic airborne molecules and type 1 diabetes incidence in children:An ecologic study

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World Journal of diabetes 2021年第5期12卷 673-684页

作者： agostino di Ciaula Piero Portincasa Clinica Medica"A.Murri" Department of Biomedical Sciences and Human OncologyUniversity of Bari Medical SchoolBari 70124Italy International Society of Doctors for Environment(ISDE) Via XXV Aprile n.34–52100 ArezzoItaly

BACKGROUND Type 1 diabetes originates from gene-environment interactions,with increasing incidence over *** To identify correlates of childhood type 1 diabetes in European countries using an ecological *** environmental variables potentially influencing the onset of type 1 diabetes have been previously ***,the relationships between epidemiologic data and exposure to toxic airborne molecules are scarcely *** We employed an ecological model to explore,in a wide time period(1990-2018),associations between type 1 diabetes incidence in 19 European countries(systematic literature review)and the nationwide production of five widely diffused air pollutants:particulate matterdiabetes in 18 out of 19 explored *** average difference(last vs first report,all countries)was+6.9×100000/year,with values ranging from-1.4(Germany)to+16.6(Sweden)per 100000/*** the overall production of pollutants decreased progressively from 1990 to 2018,type 1 diabetes incidence was positively associated with the nationwide emissions of PM10,VOCs,and NO but not with those of SO2 and *** 1 diabetes incidence was significantly higher in countries with high emissions than in those with low emissions of PM10(27.5±2.4 vs 14.6±2.4×100000 residents,respectively),VOCs(24.5±4.4 vs 13.2±1.7×100000 residents,respectively),and NO(26.6±3 vs 13.4±2.4×100000 residents,respectively),but not of SO2 or *** Evidence justify further studies to explore better links between long-term air quality and type 1 diabetes onset at the individual level,which should include exposures during *** this respect,type 1 diabetes could be,at least in part,a preventable ***,primary prevention policies acting through a marked abatement of pollutant emissions might attenuate fut

关键词： Type 1 diabetes Epidemiology Air pollution Particulate matter Nitrogen oxide Non-methane volatile organic compounds

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diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon nano-onions

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 76-89页

作者： Viviana Maffeis Lisa Moni Daniele di Stefano silvia Giordani Renata Riva Nano Carbon Materials Istituto Italiano di Tecnologia(IIT)10144 TorinoItaly Department of Chemistry and Industrial Chemistry University of Genova16146 GenovaItaly School of Chemical Sciences Dublin City UniversityDublin 9Ireland Department of Pharmacy University of Genova16147 GenovaItaly

The search for new fluorescent molecules for possible applications as functional p-electron systems and their conjugation with different nanomaterials is nowadays of paramount importance to broaden the availability of materials with different *** we present a diversity-oriented approach to heterocyclic luminophores based on a multicomponent Ugi reaction followed by a Pd-mediated cascade *** new molecules are coupled to carbon nano-onions,and hybrid systems represent the first example of blue emitters conjugated with these carbon nanoparticles.

关键词： carbon nano-onions multicomponent reactions blue emitters fluorescence isoquinolines

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Exploring building's envelope thermal behavior of the neo-vernacular residential architecture in a hot and dry climate region of Algeria

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Building Simulation 2021年第5期14卷 1567-1584页

作者： Khaoula Amraoui Leila Sriti silvia di Turi Francesco Ruggiero Ahmed Kaihoul Department of Architecture LACOMOFA LaboratoryMohamed khider University of BiskraAlgeria Energy Efficiency Unit Department(DUEE) Italian National Agency for New TechnologiesEnergy and Sustainable Economic Development(ENEA)RomeItaly Department of Civil Engineering and Architecture Sciences(diCAR) Polytechnic University of BariItaly Department of Architecture Larbi Ben M'hidi University of Oum El-BouaghiAlgeria

It is well known that the passive strategies applying in traditional buildings respond satisfactory to climatic requirements and succeed to provide maximum indoor comfort with minimum energy *** this point of view,it is interesting to quantitatively assess the effectiveness of the vernacular strategies to improve the environmental performance of the building's envelope under desert climate *** research tries to address this issue and was undertaken in southern Algeria where a very hot and arid climate *** effect of some selected passive cooling strategies on enhancing the building's envelope climate performance was *** strategies are inspired from the local vernacular architecture,and they are expected to provide satisfactory indoor thermal comfort for users and to reduce the energy cooling demand from residential *** field and computational investigations,two existing residential buildings were tested:a typical residential unit and a contemporary vernacular(neo-vernacular)*** the latter,climate responsive strategies inspired from vernacular architecture were applied.A comparison based on site measurements was carried out on the two selected buildings which differ from their envelope design properties and components.

关键词： architectural envelope neo-vernacular architecture cooling passive strategies thermal comfort in hot dry climate computer simulation residential sector

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