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Leptogenesis via a varying Weinberg operator:a semi-classical approach

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Chinese Physics C 2019年第3期43卷 22-28页

作者： silvia Pascoli Jessica Turner Ye-Ling Zhou Institute for Particle Physics Phenomenology Department of PhysicsDurham UniversitySouth RoadDurham DH1 3LEUnited Kingdom Theoretical Physics Department Fermi National Accelerator LaboratoryP.O.Box 500BataviaIL 60510USA

In this paper, we introduce leptogenesis via a varying Weinberg operator from a semi-classical *** mechanism is motivated by the breaking of an underlying symmetry which triggers a phase transition that causes the coupling of the Weinberg operator to become dynamical. Consequently, a lepton anti-lepton asymmetry arises from the interference of the Weinberg operator at two different spacetime points. Using the semi-classical approach,we treat the Higgs as a background field and show that a reflection asymmetry between leptons and anti-leptons is generated in the vicinity of the bubble wall. We solve the equations of motion of the lepton and anti-lepton quasiparticles to obtain the final lepton asymmetry.

关键词： leptogenesis Weinberg operator phase transition

Hepatic steatosis,low-grade chronic inflammation and hormone/growth factor/adipokine imbalance

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World Journal of Gastroenterology 2010年第38期16卷 4773-4783页

作者： Giovanni Tarantino silvia Savastano Annamaria Colao Department of Clinical and Experimental Medicine Federico Ⅱ University Medical School of Naples Department of Molecular and Clinical Endocrinology and Oncology Section of EndocrinologyFederico Ⅱ University Medical School of Naples

Non-alcoholic fatty liver disease (NAFLD), a further expression of metabolic syndrome, strictly linked to obesity and diabetes mellitus, is characterized by insulin resistance (IR), elevated serum levels of free fatty acids and fatty infi ltration of the liver, which is known as hepatic steatosis. Hepatocyte apoptosis is a key feature of this disease and correlates with its severity. Free-fatty-acidinduced toxicity represents one of mechanisms for the pathogenesis of NAFLD and hormones, growth factors and adipokines influence also play a key role. This review highlights the various pathways that contribute to the development of hepatic steatosis. Circulating concentrations of inflammatory cytokines are reckoned to be the most important factor in causing and maintaining IR. Low-grade chronic inflammation is fundamental in the progression of NAFLD toward higher risk cirrhotic states.

关键词： Hepatic steatosis Low-grade chronic inflammation Adipokines Hormones Growth factors

Role of myelin sheath energy metabolism in neurodegenerative diseases

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Neural Regeneration Research 2015年第10期10卷 1570-1571页

作者： silvia Ravera Isabella Panfoli Pharmacy Department Biochemistry Laboratory University of Genova

More than any other organs,brain energy demand is entirely dependent on glucose catabolism through the oxidative phosphorylation（OXPHOS）.Glucose is the major cerebral energy substrate in the nervous system（NS）.Ket... 详细信息

关键词： Role of myelin sheath energy metabolism in neurodegenerative diseases RGC

On the Estimation of the Functional Size of Software from Requirements Specifications

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Journal of Computer Science & Technology 2007年第3期22卷 358-370页

作者： Nelly Condori-Fernández silvia Abrahao Oscar Pastor Department of Information Systems and Computation Valencia University of TechnologyCamino de Vera s/n46020 ValenciaSpain

This paper introduces a measurement procedure, called RmFFP, which describes a set of operations for modelling and estimating the size of object-oriented software systems from high-level specifications using the OO-Method Requirement Model. OO-Method is an automatic software production method. The contribution of this work is to systematically define a set of rules that allows estimating the functional size at an early stage of the software production process, in accordance with COSMIC-FFP. To do this, we describe the design, the application, and the analysis of the proposed measurement procedure following the steps of a process model for software measurement. We also report initial results on the evaluation of RmFFP in terms of its reproducibility.

关键词： requirement specification product metrics measurement technique

Is transient elastography a useful tool for screening liver disease?

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World Journal of Gastroenterology 2009年第12期15卷 1409-1414页

作者： Paolo Del Poggio silvia Colombo Hepatology Unit Treviglio HospitalTreviglio(Bg)24047Italy

Transient elastography(TE)is a new non invasive tool for measuring liver stiffness,which is correlated to the histologic stage of liver *** studies in chronic liver disease(CLD)have determined a good accuracy of TE in predicting significant fibrosis and an optimal accuracy in predicting *** liver stiffness ranges between 3.3-7.8 KPa and using a cut off of 7.1 KPa,significant fibrosis and cirrhosis can be excluded with a very high negative predictive value(NPV).Positive predictive value(PPV)for the diagnosis of cirrhosis is lower using just a single scan but increases to 90% if high stiffness values are confirmed by a second independent *** the presence of fatty liver and metabolic syndrome slightly increases the readings and may reduce the accuracy of the *** is uncertain if this increase is related to the presence of steatofibrosis or ifit is caused by steatosis *** can be used in screening patients attending the liver clinics to identify those with signifi cant fi brosis or cirrhosis and may be particularly useful in discriminating HBV inactive carriers from chronic hepatitis B ***,however,is not reliable in predicting the presence of esophageal varices in *** potential indication for TE is the systematic screening of populations at high risk for CLD,such as intravenous drug users and alcoholics,but further studies are needed to determine its diagnostic accuracy in these settings.

关键词： Transient elastography Screening Liverdisease Hepatitis B Hepatitis C Non alcoholic steatohepatitis Cirrhosis

Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity

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World Journal of Gastroenterology 2018年第15期24卷 1601-1615页

作者： Carlos J Pirola silvia Sookoian Department of Genetics and Molecular Biology of Complex Diseases. University of Buenos Aires Institute of Medical Research A Lanari Buenos Aires Argentina National Scientific and Technical Research Council-University of Buenos Aires. Institute of Medical Research (IDIM) Clinical and Molecular Hepatology University of Buenos Aires Institute of Medical Research A Lanari Buenos Aires Argentina National Scientific and Technical Research Council-University of Buenos Aires. Institute of Medical Research (IDIM)

This review intends to uncover how information from large-scale genetic profiling(whole genome sequencing, and whole exome sequencing) of nonalcoholic fatty liver disease(NAFLD), as well as information from circulating transcriptomics(cell-free mi RNAs) and metabolomics, contributes to the understanding of NAFLD pathogenesis. A further aim is to address the question of whether OMICs information is ready to be implemented in the clinics. The available evidence suggests that any new knowledge pertaining to molecular signatures associated with NAFLD and nonalcoholic steatohepatitis should be promptly translated into the clinical setting. Nevertheless, rigorous steps that must include validation and replication are mandatory before utilizing OMICs biomarkers in diagnostics to identify patients at risk of advanced disease, including liver cancer.

关键词： nonalcoholic steatohepatitis Fibrosis Liver biopsy Genetics PNPLA3 TM6SF2 Metabolomics Proteomics Transcriptomics nonalcoholic fatty liver disease miR122

Repurposing drugs to target nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2019年第15期25卷 1783-1796页

作者： silvia Sookoian Carlos J Pirola Department of Clinical and Molecular Hepatology National Scientific and Technical Research Council (CONICET) University of Buenos Aires Institute of Medical Research (IDIM) Department of Molecular Genetics and Biology of Complex Diseases National Scientific and Technical Research Council (CONICET) University of Buenos Aires Institute of Medical Research (IDIM)

Nonalcoholic fatty liver disease(NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage. The main obstacle to better disease management pertains to the lack of approved pharmacological interventions for the treatment of nonalcoholic steatohepatitis(NASH) and NASH-fibrosis-the severe histological forms. Over the past decade,tremendous advances have been made in NAFLD research, resulting in the discovery of disease mechanisms and novel therapeutic targets. Hence, a large number of pharmacological agents are currently being tested for safety and efficacy. These drugs are in the initial pharmacological phases(phase 1 and 2),which involve testing tolerability, therapeutic action, and pharmacological *** is thus reasonable to assume that the next generation of NASH drugs will not be available for clinical use for foreseeable future. The expected delay can be mitigated by drug repurposing or repositioning, which essentially relies on identifying and developing new uses for existing drugs. Here, we propose a drug candidate selection method based on the integration of molecular pathways of disease pathogenesis into network analysis tools that use OMICs data as well as multiples sources, including text mining from the medical literature.

关键词： Drug discovery Drug repositioning Fibrosis Genetics Treatment Systems biology

Rising Powers and the Reform of Global Economic Governance:The BRICS and the Normative Challenge Ahead

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Fudan Journal of the Humanities and Social Sciences 2020年第1期13卷 135-150页

作者： silvia Menegazzi LUISS Guido Carli Viale Pola 1200198 RomeItaly

At a time when the liberal international economic order seems under threat,the transformation of global economic governance poses a strong normative challenge to existing international *** recent establishment of new international financial institutions(IFIs)-the Asian Infrastructure Investment Bank(AIIB)and the New Development Bank(NDB)-signified a steady process of transformation of the architecture of contemporary global *** rising powers understand,establish and conduct formal and informal rules within new international financial systems is of fundamental importance for the future of world economic order,although not necessarily signaling a decline for the Western-style economic governance and its normative *** global economic governance has profoundly changed in the last decade,the suggestion here is that rising powers'efforts to reshape the current global economic order have often been overestimated and only partially contextualized within the enormous achievements gained from economic opportunities driven by Western *** on the contestation of these different world views,the paper analyzes the approach of BRICS(Brazil,Russia,India,China and South Africa)New Development Bank countries to global economic governance within the newly established IFIs,questioning how the normative challenge represents either an opportunity or a threat to the current global order.

关键词： Rising powers BRICS NDB Global economic governance Normative challenge

The Management of Mental Health, and Service Networks in Italy

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International Journal of Mental Health Promotion 2023年第8期25卷 927-935页

作者： silvia Carbone Political and Legal Sciences Department University of MessinaMessina98029Italy

Madness has attracted and frightened for centuries,and talking about this means discussing how this diversity was built and managed in different social contexts and historical *** all societies have had,and still have,the same relationship with *** is only with the affirmation of the Modern State,and of Capitalism,that the idea of“normality”indispensable to be able to conceive diversity as something dangerously distant and different from the norm takes *** our post-modern society,people with mental illness in Italy can resort to specialists and social-health *** the heterogeneous answers given after the approval of law 180 appear to be increasingly *** this research,much attention will be paid to how the social and health services,located in different areas of Italy(Messina,Rome,Trento)face the current growing risk of social,housing and economic isolation of these fragile *** aim of the research is to explore the possibility of a new relationship between the social-health service and the local *** the one hand,research investigates what the contribution of the services could *** the other what the spaces of protagonism and participation of the community could be in inclusion process *** order to better understand the differences between these two dimensions,a qualitative research approach was chosen through the conduct of in-depth *** this way it was possible to investigate:(1)the partial representations characteristic of the single individual,family members,operators and stackholders in general;(2)the services around the topic dealt with is *** the first results of the research it emerges that the territory can no longer be considered as an abstract entity,but becomes the social space within which the construction of a new community welfare can and must take place.

关键词： Management of mental health service networks sociology care qualitative research community welfare territory