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Physical energies to the rescue of damaged tissues

World Journal of Stem Cells 2019年第6期11卷 297-321页

作者： Federica Facchin silvia canaider Riccardo Tassinari Chiara Zannini Eva Bianconi Valentina Taglioli Elena Olivi Claudia Cavallini Marco Tausel Carlo Ventura Department of Experimental Diagnostic and Specialty Medicine (DIMES)School of MedicineUniversity of BolognaBologna 40100Italy National Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and BiosystemsCNRBologna 40100Italy iB3 SA Lugano 6900Switzerland

Rhythmic oscillatory patterns sustain cellular dynamics, driving the concerted action of regulatory molecules, microtubules, and molecular motors. We describe cellular microtubules as oscillators capable of synchronization and swarming, generating mechanical and electric patterns that impact biomolecular recognition. We consider the biological relevance of seeing the inside of cells populated by a network of molecules that behave as bioelectronic circuits and chromophores. We discuss the novel perspectives disclosed by mechanobiology, bioelectromagnetism, and photobiomodulation, both in term of fundamental basic science and in light of the biomedical implication of using physical energies to govern (stem) cell fate. We focus on the feasibility of exploiting atomic force microscopy and hyperspectral imaging to detect signatures of nanomotions and electromagnetic radiation (light), respectively, generated by the stem cells across the specification of their multilineage repertoire. The chance is reported of using these signatures and the diffusive features of physical waves to direct specifically the differentiation program of stem cells in situ, where they already are resident in all the tissues of the human body. We discuss how this strategy may pave the way to a regenerative and precision medicine without the needs for (stem) cell or tissue transplantation. We describe a novel paradigm based upon boosting our inherent ability for self-healing.

关键词： Stem cells Physical energies Mechanical forces Electric fields Electromagnetic fields Electromagnetic radiation Photobiomodulation Damaged tissues

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