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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Phallales (Agaricomycetes, Fungi) from Southern Brazil

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Studies in Fungi 2019年第1期4卷 162-184页

作者： Trierveiler-Pereira l Meijer AAR silveira RMB Programa de Pós-Graduação em Botânica Departamento de BotânicaIBUniversidade Federal do Rio Grande do Sul(UFRGS)Porto Alegre-RSBrazil Rodovia PR-405 km 36GuaraqueçabaParanáBrazil

An illustrated and annotated checklist with key to 24 species of phalloids known to occur in Southern Brazil(States of Paraná,Santa Catarina and Rio Grande do Sul)are *** species belong to the orders Clathraceae,Claustulaceae,lysuraceae,Phallaceae and *** species are also *** floriforme and Staheliomyces cinctus are the first reports from Southern Brazil and laternea pusilla is new to the State of Santa Catarina.

关键词： Brazilian mycota fungal taxonomy phalloid fungi Phallomycetidae stinkhorns

Spectral Model for Soybean Yield Estimate Using MODIS/EVI Data

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International Journal of Geosciences 2013年第9期4卷 1233-1241页

作者： Anibal Gusso Jorge Ricardo Ducati Mauricio Roberto Veronez Damien Arvor luiz Gonzaga da silveira jr. Environmental Engineering UNISINOSSao LeopoldoBrazil Remote Sensing Center and Astronomy Department UFRGSPorto AlegreBrazil Graduate Program in Geology UNISINOSSao LeopoldoBrazil Institut de Recherche Pour le Developpement(IRD) MontpellierFrance Graduate Program in Applied Computing UNISINOSSao LeopoldoBrazil

Attaining reliable and timely agricultural estimates is very important everywhere, and in Brazil, due to its characteristics, this is especially true. In this study, estimations of crop production were made based on the temporal profiles of the Enhanced Vegetation Index (EVI) obtained from Moderate Resolution Imaging Spectroradiometer (MODIS) images. The objective was to evaluate the coupled model (CM) performance of crop area and crop yield estimates based solely on MODIS/EVI as input data in Rio Grande do Sul State, which is characterized by high variability in seasonal soybean yields, due to different crop development conditions. The resulting production estimates from CM were compared to official agricultural statistics of Brazilian Institute of Geography and Statistics (IBGE) and the National Company of Food Supply (CONAB) at different levels from 2000/2001 to 2010/2011 crop years. Results obtained with CM indicate that its application is able to generate timely production estimates for soybean both at municipality and local levels. Validation estimates with CM at State level obtained R2 = 0.95. Combining all cropping years at municipality level, estimates were highly correlated to official statistics from IBGE, with R2 = 0.91 and RMSD = 10,840 tons. Spatially interpolated comparisons of yield maps obtained from the CM estimates and IBGE data also showed visual similarity in their spatial distribution. local level comparisons were performed and presented R2 = 0.95. Implications of this work point out that time-series analysis of production estimates are able to provide anticipated spatial information prior to the soybean harvest.

关键词： Remote Sensing Coupled Model Soy Yield Forecast Satellite Images

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Advance in the use of gold nanoparticles in the treatment of neurodegenerative diseases:new perspectives

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Neural Regeneration Research 2021年第12期16卷 2425-2426页

作者： Gustavo de Bem silveira Alexandre Pastoris Muller Ricardo Andrez Machado-de-Ávila Paulo Cesar lock silveira laboratory of Experimental Pathophysiology Graduate Program in Health SciencesUniversidade do Extremo Sul CatarinenseCriciúmaSCBrazil Programa de Pós Graduação em Farmacologia UFSCFlorianópolisSCBrazil

Various conditions affecting nerve cells and the nervous system due to the loss of neurons and their connecting networks are described under the superordinate phrase“Neurodegenerative diseases”.Such diseases lead to disability due to gradual neuronal death in both the central nervous system and the peripheral nervous *** many of these diseases have unknown causes,sometimes these are due to medical conditions such as alcoholism,a tumor,or a stroke,or other causes which may include genetic mutations,toxins,chemicals,and viruses.

关键词： diseases degenerative treatment

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Very weak solutions to the two-dimensional Monge-Ampére equation Dedicated to Professor Jean-Yves Chemin on the Occasion of His 60th Birthday

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Science China Mathematics 2019年第6期62卷 1041-1056页

作者： Wentao Cao lászló Székelyhidi jr. Institut für Mathematik Universit?t Leipzig

In this short note we revisit the convex integration approach to constructing very weak solutions to the 2D Monge-Ampére equation with H?lder-continuous ?rst derivatives of exponent β lewicka and Pakzad(2017) with a new diagonalization procedure which avoids the use of conformal coordinates, which was introduced by De lellis et al.(2018) for the isometric immersion problem.

关键词： Monge-Ampére equation convex integration weak solutions