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Genetic variation of circHIBADH enhances prostate cancer risk through regulating HNRNPA1-related RNA splicing

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Journal of Biomedical Research 2024年第4期38卷 358-368页

作者： Yifei Cheng Rongjie Shi Shuai Ben silu Chen Shuwei Li Junyi Xin Meilin wang Gong Cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Cancer Hospital Jiangsu Institute of Cancer Researchthe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsu 210009China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215002China

The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer(PCa)as well as to elucidate biological mechanisms underlying the *** first compared expression levels of circRNAs between 25 paired PCa and adjacent normal tissues to identify riskassociated circRNAs by using the MiOncoCirc *** then used logistic regression models to evaluate associations between genetic variants in candidate circRNAs and PCa risk among 4662 prostate cancer patients and 3114 healthy controls,and identified circHIBADH rs11973492 T>C as a significant risk-associated variant(odds ratio=1.20,95%confidence interval:1.08-1.34,P=7.06×10^(-4))in a dominant genetic model,which altered the secondary structure of the corresponding RNA *** the in silico analysis,we found that circHIBADH sponged and silenced 21 RNA-binding proteins(RBPs)enriched in the RNA splicing pathway,among which HNRNPA1 was identified and validated as a hub RBP using an external RNA-sequencing data as well as the in-house(four tissue samples)and publicly available single-cell ***,we demonstrated that HNRNPA1 influenced hallmarks including MYC target,DNA repair,and E2F target signaling pathways,thereby promoting *** conclusion,genetic variants in circHIBADH may act as sponges and inhibitors of RNA splicing-associated RBPs including HNRNPA1,playing an oncogenic role in PCa.

关键词： genetic variants prostate cancer circRNA RNA-binding protein RNA splicing sing-cell RNA sequencing

Genetic variation of circHIBADH enhances prostate cancer risk through regulating HNRNPA1-related RNA splicing

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The Journal of Biomedical Research 2024年第04期 358-368页

作者： Yifei Cheng Rongjie Shi Shuai Ben silu Chen Shuwei Li Junyi Xin Meilin wang Gong Cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Department of Urology the First Affiliated Hospital of Nanjing Medical University Department of Bioinformatics School of Biomedical Engineering and Informatics Nanjing Medical University Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research the Affiliated Cancer Hospital of Nanjing Medical University The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital Gusu School Nanjing Medical University

The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer（PCa） as well as to elucidate biological mechanisms underlying the associations. We first compared expression levels of circRNAs between 25 paired PCa and adjacent normal tissues to identify riskassociated circRNAs by using the MiOncoCirc database. We then used logistic regression models to evaluate associations between genetic variants in candidate circRNAs and PCa risk among 4 662 prostate cancer patients and 3 114 healthy controls, and identified circHIBADH rs11973492 T>C as a significant risk-associated variant(odds ratio = 1.20, 95% confidence interval: 1.08–1.34, P = 7.06 × 10-4) in a dominant genetic model, which altered the secondary structure of the corresponding RNA chain. In the in silico analysis, we found that circHIBADH sponged and silenced 21 RNA-binding proteins（RBPs） enriched in the RNA splicing pathway,among which HNRNPA1 was identified and validated as a hub RBP using an external RNA-sequencing data as well as the in-house（four tissue samples） and publicly available single-cell transcriptomes. Additionally, we demonstrated that HNRNPA1 influenced hallmarks including MYC target, DNA repair, and E2F target signaling pathways, thereby promoting carcinogenesis. In conclusion, genetic variants in circHIBADH may act as sponges and inhibitors of RNA splicing-associated RBPs including HNRNPA1, playing an oncogenic role in PCa.

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The efficacy of a novel tomato extracts formulation on skin aging and pigmentation:A randomized,double-blind,parallel-controlled trial

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Journal of dermatologic science and cosmetic technology

Journal of dermatologic science and cosmetic technology 2024年第1期1卷 13-20页

作者： silu Zhang Shan Lu Yun wang Jiayi Ni Guoxun Xiao Wonderlab Innovation Centre for Healthcare Shenzhen Porshealth Bioengineering Co.Ltd.Shenzhen 518116China Department of Dermatology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Sprim(China)Consulting Co.Ltd. Shanghai 201201China

Background:Oxidative stress is a significant factor in skin aging and pigmentation,which can be precipitated by various *** and tyrosinase inhibitors,such as carotenoids,yeast extract(glutathione),sodium hyaluronate,astaxanthin,and niacin,can individually protect the skin against aging through distinct *** mechanisms potentially enhance the skin barrier and improve signs of aging and ***,the synergistic effects of these compounds,as found in a golden tomato extract formulation,have been scarcely ***:To evaluate the effects of an orally administered formulation on the skin aging and *** and Methods:In this study,a randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLAB?Tomato Niacinamide *** of all participants,62 volunteers completed the experiment and were included in the statistical ***:The results indicated that after eight weeks of consuming the research product,there were no significant changes in the skin indicators within the placebo *** contrast,the treatment group receiving the sample formulation exhibited a 35.63%increase in stratum corneum hydration and a 29.39%reduction in transepidermal water loss(TEWL),suggesting enhanced skin *** assessments revealed improvements in skin color and gloss index by 15.03%and 11.41%,respectively,in the treatment ***,the skin gloss and individual typology angle(ITA)value increased by 18.59%and 6.36%,respectively,leading to a lighter skin *** enhancements were also observed in skin pigmentation,color uniformity,and *** eight weeks of intervention with the sample,blood levels of superoxide dismutase(SOD)and glutathione peroxidase(GPx)increased,while malondialdehyde(MDA)levels ***:These findings confirm that continuous intake of the tomato extract formulation over eight weeks effectively improved the volunteers'skin w

关键词： Skin whitening Skin aging Antioxidant Gold tomato extracts Combination effect

Disease and Economic Burden of Kashin-Beck Disease—China,2021

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China CDC weekly 2024年第2期6卷 40-44页

作者： silu Cui Wenjun Que Zhe Jiao Qing Deng Xufeng Zhang Yanhong Cao Ning Liu Ailin Li Alphonse Sowanou Zhe Li Tuo wang Yang Li Jun Yu Junrui Pei NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Key Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Kashin-Beck Disease ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Heilongjiang Provincial Key Laboratory of Trace Elements and Human HealthKey Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Endemic Fluorosis ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Kashin-Beck disease(KBD)is a chronic and degenerative osteoarthropathy characterized by cartilage *** is an endemic disease that is highly prevalent among the Chinese population and poses a significant health *** is added by this report?This is the first national report on the economic burden of KBD in *** to the data from 2021,KBD has caused significant disease and economic *** most substantial reduction in healthy life expectancy was observed among patients with degree II severity and those aged 60 years and older,resulting in a total indirect economic burden of 112.74 million Chinese Yuan(CNY).What are the implications for public health practice?The results of this study will contribute to informing the development of tailored prevention and control strategies by the *** strategies will include targeted policies and recommendations for appropriate healthcare and financial subsidies,which will be based on the demographic characteristics of the endemic areas.

关键词： prevention degeneration burden

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促红细胞生成素治疗早产儿贫血研究进展

中华实用儿科临床杂志 2019年第23期34卷 1831-1833页

作者：王思璐谢晓恬同济大学附属同济医院(上海市同济医院)儿科上海200065

贫血是早产儿的常见并发症之一.虽然有多种因素均可导致早产儿贫血(AOP),但促红细胞生成素(EPO)缺乏是AOP的主要病因之一.早产儿体内EPO水平不足及其发生机制是目前国内外AOP相关研究的热点,合理采用EPO进行AOP的防治意义已成国际共识,... 详细信息

贫血是早产儿的常见并发症之一.虽然有多种因素均可导致早产儿贫血(AOP),但促红细胞生成素(EPO)缺乏是AOP的主要病因之一.早产儿体内EPO水平不足及其发生机制是目前国内外AOP相关研究的热点,合理采用EPO进行AOP的防治意义已成国际共识,临床也已获显著疗效.现就近3~5年国内外关于AOP发病机制、EPO与AOP的相关性以及EPO防治AOP的临床应用及疗效等方面的最新进展进行综述.

关键词：促红细胞生成素贫血婴儿早产红细胞生成刺激剂阿法达贝汀治疗

Anti-skin aging effects and bioavailability of collagen tripeptide and elastin peptide formulations in young and middle-aged women

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Journal of dermatologic science and cosmetic technology

Journal of dermatologic science and cosmetic technology 2024年第2期1卷 26-37页

作者： Shan Lu silu Zhang Yun wang Jiayi Ni Tiantian Zhao Guoxun Xiao Wonderlab Innovation Centre for Healthcare Shenzhen Porshealth Bioengineering CoLtd.Shenzhen 518116China Sericulture&Agri-food Research Institute Guangdong Academy of Agricultural Sciences Key Laboratory of Functional FoodsMinistry of Agriculture and Rural affairsGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhouGuangdong 510610China Department of Dermatology Shanghai Ninth People‘s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Sprim(China)Consulting Co.Ltd. Shanghai 201201China e Department of Food Science Rutgers UniversityNew BrunswickNJ 08901United States

Background:Collagen peptides(CP),including tripeptides and elastin peptides(EP),are known for their in vitro and in vivo anti-skin aging *** positive results in animal models,the combination effects of CP and EP and the bioavailability of CP in human studies,particularly in young and middle-aged women,remain ***:To evaluate the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged *** and Methods:A single-center,randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLABR fish collagen tripeptide *** consumed the drink over an 8-week ***:Compared to the placebo group,the collagen drink group showed significant improvements in skin hydration(39.19%increase),transepidermal water loss(33.45%decrease),skin elasticity(25.37%increase),dermal collagen content(21.64%increase),pore size(7.94%decrease),wrinkle length(18.09%decrease),skin smoothness(2.85%improvement),and skin roughness(15.32%decrease).Overall pore volume decreased by 60%,and visual assessments indicated a decrease in skin luminosity by 15.20%and smoothness index by 22.55%.Mass spectrometry demonstrated a significant increase in collagen efficacy components,including blood pH and GPH levels(P<0.05).Conclusion:The study confirmed the combination nourishing and anti-skin aging effects of EP and CP on the skin of young and middle-aged women,demonstrating significant improvements in various skin parameters and good bioavailability of collagen peptides.

关键词： Collagen tripeptides Elastin peptides Anti-aging Skin protection Peptide absorption

微创等离子消融术治疗小儿扁桃体肥大伴腺样体肥大对通气功能及氧化应激的影响

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中国医学工程 2022年第6期30卷 79-82页

作者：王思露平舆县人民医院耳鼻咽喉科河南驻马店463400

目的探讨微创等离子消融术治疗小儿扁桃体肥大伴腺样体肥大(AH)对通气功能及氧化应激的影响。方法选取平舆县人民医院2020年4月至2021年4月收治的扁桃体肥大伴AH患儿72例,随机分为实验组和对照组各36例。对照组采用常规扁桃体及腺样体... 详细信息

目的探讨微创等离子消融术治疗小儿扁桃体肥大伴腺样体肥大(AH)对通气功能及氧化应激的影响。方法选取平舆县人民医院2020年4月至2021年4月收治的扁桃体肥大伴AH患儿72例,随机分为实验组和对照组各36例。对照组采用常规扁桃体及腺样体切除术,实验组行微创等离子消融术治疗。比较两组患儿围手术期情况、术后通气功能变化、免疫功能、氧化应激水平及并发症发生情况。结果术中实验组出血量、术后视觉模拟评分法评分(VAS)及并发症发生率均低于对照组,且手术时间短于对照组(P0.05);术后两组患儿免疫球蛋白(Ig)-G、Ig-M及Ig-A水平较术前均有降低(P0.05);术后两组超氧化物歧化酶(SOD)较术前均有降低,实验组高于对照组(P<0.05),两组丙二醛(MDA)较术前均有提升,实验组低于对照组(P<0.05)。结论相较于传统切除治疗而言,微创等离子消融术治疗小儿扁桃体肥大伴AH在保证手术效果的基础上,可有效减少对患儿正常组织的损伤,减轻其术后疼痛水平,同时能尽可能降低手术带来的氧化应激反应,降低患儿术后并发症发生风险,安全性较高。

关键词：扁桃体肥大腺样体肥大儿童微创等离子消融术通气功能氧化应激

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来华预科生教学管理策略研究

淮南职业技术学院学报 2023年第3期23卷 77-79页

作者：王斯璐东北师范大学国际汉学院长春130024

来华预科教育属于学历教育的一部分,但又有别于本科留学生教育。来华预科教育在培养目标、培养内容以及教学上都具有一定的特殊性。这种特殊性也决定了预科一线教师不仅承担了教学工作,同时也要承担学生的管理工作。因此,预科一线教师... 详细信息

来华预科教育属于学历教育的一部分,但又有别于本科留学生教育。来华预科教育在培养目标、培养内容以及教学上都具有一定的特殊性。这种特殊性也决定了预科一线教师不仅承担了教学工作,同时也要承担学生的管理工作。因此,预科一线教师有必要了解和掌握一些预科生管理策略,即培养与管理相结合的策略。既要严格遵循全国预科生的管理标准和评价标准进行管理,同时也要关注预科生的个体差异,比如学习动机、学习策略、情绪变化等,从而对学生进行有效地引导和帮助。

关键词：预科教育一线教师管理策略预科生

“互联网+”背景下应用型本科高校异步SPOC混合式教学模式研究——以外语课程为例

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辽宁省交通高等专科学校学报 2020年第6期22卷 46-49页

作者：王斯璐福州外语外贸学院福建福州350005

伴随着信息化时代MOOC教学的深入发展,SPOC作为MOOC衍生的新形式教学模式得到了教育界的广泛推崇。异步SPOC以SPOC为基础,结合混合式教学理念,通过教师自建线上资源来满足课堂教学的多样化需求,异步SPOC混合式教学模式在课堂动力改革中... 详细信息

伴随着信息化时代MOOC教学的深入发展,SPOC作为MOOC衍生的新形式教学模式得到了教育界的广泛推崇。异步SPOC以SPOC为基础,结合混合式教学理念,通过教师自建线上资源来满足课堂教学的多样化需求,异步SPOC混合式教学模式在课堂动力改革中起了关键作用。鉴于此,本文以应用型高校的外语课程为例,对“互联网+”教育背景下的高校课堂异步SPOC教学模式设计展开分析与探讨,以期推进信息化时代下高校混合式教学工作的有效开展。

关键词：互联网+教育异步SPOC 混合式教学