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In-situ construction of abundant active centers on hierarchically porous carbon electrode toward high-performance phosphate electrosorption: Synergistic effect of electric field and capture sites

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Green Energy & Environment 2024年第1期9卷 126-137页

作者： Peng Zhang Fukuan Li Mingming He silu huo Xueli Zhang Benqiang Cen Dezhi Fang Kexun Li Hao Wang College of Environmental Science and Engineering Nankai UniversityTianjin300350China MOE Key Laboratory of Pollution Processes and Environmental Criteria Tianjin Key Laboratory of Environmental Remediation and Pollution ControlTianjin Key Laboratory of Environmental Technology for Complex Trans-Media PollutionNankai UniversityTianjin300350China State Key Laboratory of Simulation and Regulation of Water Cycles in River Basins China Institute of Water Resources and Hydropower ResearchBeijing100038China

Phosphate removal is crucial for eutrophication control and water quality improvement.Electro-assisted adsorption,an eco-friendly elec-trosorption process,exhibited a promising potential for wastewater treatment.However,there are few works focused on phosphate electro-sorption,and reported electrodes cannot attach satisfactory removal capacities and rates.Herein,electro-assisted adsorption of phosphate via in-situ construction of La active centers on hierarchically porous carbon(LaPC)has been originally demonstrated.The resulted LaPC composite not only possessed a hierarchically porous structure with uniformly dispersed La active sites,but also provided good conductivity for interfacial electron transfer.The LaPC electrode achieved an ultrahigh phosphate electrosorption capability of 462.01 mg g^(-1) at 1 V,outperforming most existing electrodes.The superior phosphate removal performance originates from abundant active centers formed by the coupling of electricﬁeld and capture sites.Besides,the stability and selectivity toward phosphate capture were maintained well even under comprehensive conditions.Moreover,a series of kinetics and isotherms models were employed to validate the electrosorption process.This work demonstrates a deep understanding and promotes a new level of phosphate electrosorption.

关键词： Electro-assisted adsorption Electrosorption Phosphate removal Active centers MOF-derived carbon

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Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS

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The Journal of Biomedical Research 2024年第1期38卷 37-50页

作者： Sumeng Wang silu Chen Huiqin Li Shuai Ben Tingyu Zhao Rui Zheng Meilin Wang Dongying Gu Lingxiang Liu Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Oncology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China.

The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis,but a comprehensive understanding of their association with and relevant biomarkers involved in colorectal tumorigenesis is lacking.To address this gap,we conducted a study aiming to investigate this association and identify relevant biomarkers.We analyzed transcriptomic and proteomic profiles of 904 colorectal tumor tissues and 342 normal tissues to examine pathway enrichment,biological activity,and the immune microenvironment.Additionally,we evaluated genetic effects of single variants and genes on colorectal cancer susceptibility using data from genome-wide association studies(GWASs)involving both East Asian(7062 cases and 195745 controls)and European(24476 cases and 23073 controls)populations.We employed mediation analysis to infer the causal pathway,and applied multiplex immunofluorescence to visualize colocalized biomarkers in colorectal tumors and immune cells.Our findings revealed that both DNA replication activity and the flap structure-specific endonuclease 1(FEN1)gene were significantly enriched in colorectal tumor tissues,compared with normal tissues.Moreover,a genetic variant rs4246215 G>T in FEN1 was associated with a decreased risk of colorectal cancer(odds ratio=0.94,95%confidence interval:0.90–0.97,P_(meta)=4.70×10^(-9)).Importantly,we identified basophils and eosinophils that both exhibited a significantly decreased infiltration in colorectal tumors,and were regulated by rs4246215 through causal pathways involving both FEN1 and DNA replication.In conclusion,this trans-omics incorporating GWAS data provides insights into a plausible pathway connecting DNA replication and immunity,expanding biological knowledge of colorectal tumorigenesis and therapeutic targets.

关键词： trans-omics DNA replication tumor immune microenvironment causal mediation colorectal tumorigenesis

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Characterization of the spoilage strength of Aeromonas app. to collagen-rich chilled meat: comparative analysis

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Food Science and Human Wellness 2024年

作者： Junming Gong Liangting Shao silu Liu Xinglian Xu Huhu Wang State Key Laboratory of Meat Quality Control and Cultured Meat Development College of Food Science and Technology Nanjing Agricultural University College of Food Science and Pharmacy Xinjiang Agricultural University

Aeromonas spp. are commonly found in spoilage of chilled meat. Aeromonas salmonicida NCM 29 and Aeromonas salmonicida NCM 57 have been discovered the spoilage heterogeneity in degrading myofibrillar protein. In this study， the two strains were tested to uncover the discrepancy of meat spoilage in collagen-rich chilled meat and extracted collagen. The results revealed that chicken claws， riched in collagen， inoculated with NCM 29 showed higher values of total viable counts (TVC)， total volatile basic nitrogen (TVB-N)， pH， adhered cells， TCA-soluble peptides， and protease activity compared to those inoculated with NCM 57. Furthermore， NCM 29 generated higher quantity of volatile organic compounds related to meat spoilage. The collagenase (hemagglutinin protease， Hap) secreted by NCM 29 has been identified as the key factor responsible for the observed discrepancies in spoilage， which gradually degraded collagen into peptides and hydroxyproline. The capacity of Hap to degrade type I collagen in vitro indicated that it has apparent proteolytic activity， which could reduce the average particle size and alter secondary structure of collagen. SDS-PAGE further confirmed the degradation of the β chain in collagen. These findings not only provide a theoretical basis for in-depth investigation of the meat spoilage mechanisms of Aeromonas spp.， but also encourage us to take measures to avoid the spoilage of related bacteria such as Aeromonas spp. during the preservation process.

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Disease and Economic Burden of Kashin-Beck Disease—China,2021

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China CDC weekly 2024年第2期6卷 40-44页

作者： silu Cui Wenjun Que Zhe Jiao Qing Deng Xufeng Zhang Yanhong Cao Ning Liu Ailin Li Alphonse Sowanou Zhe Li Tuo Wang Yang Li Jun Yu Junrui Pei NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Key Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Kashin-Beck Disease ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Heilongjiang Provincial Key Laboratory of Trace Elements and Human HealthKey Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Endemic Fluorosis ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Kashin-Beck disease(KBD)is a chronic and degenerative osteoarthropathy characterized by cartilage degeneration.It is an endemic disease that is highly prevalent among the Chinese population and poses a significant health risk.What is added by this report?This is the first national report on the economic burden of KBD in China.According to the data from 2021,KBD has caused significant disease and economic burdens.The most substantial reduction in healthy life expectancy was observed among patients with degree II severity and those aged 60 years and older,resulting in a total indirect economic burden of 112.74 million Chinese Yuan(CNY).What are the implications for public health practice?The results of this study will contribute to informing the development of tailored prevention and control strategies by the government.These strategies will include targeted policies and recommendations for appropriate healthcare and financial subsidies,which will be based on the demographic characteristics of the endemic areas.

关键词： prevention degeneration burden

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Genetic variant in a BaP-activated super-enhancer increases prostate cancer risk by promoting AhR-mediated FAM227A expression

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Journal of Biomedical Research 2024年第2期38卷 149-162,I0001-I0010页

作者： Lulu Fan Hao Wang Shuai Ben Yifei Cheng silu Chen Zhutao Ding Lingyan Zhao Shuwei Li Meilin Wang Gong Cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving mechanism.Previous studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor risk.Currently,it is unclear whether BaP is involved in the effect of genetic variants in SEs on prostate cancer risk,nor the associated intrinsic molecular mechanisms.In the current study,by using logistic regression analysis,we found that rs5750581T>C in 22q-SE was significantly associated with prostate cancer risk(odds ratio=1.26,P=7.61×10^(-5)).We also have found that the rs6001092T>G,in a high linkage disequilibrium with rs5750581T>C(r^(2)=0.98),is located in a regulatory aryl hydrocarbon receptor(AhR)motif and may interact with the FAM227A promoter in further bioinformatics analysis.We then performed a series of functional and BaP acute exposure experiments to assess biological function of the genetic variant and the target gene.Biologically,the rs6001092-G allele strengthened the transcription factor binding affinity to AhR,thereby upregulating FAM227A,especially upon exposure to BaP,which induced the malignant phenotypes of prostate cancer.The current study highlights that AhR acts as an environmental sensor of BaP and is involved in the SE-mediated prostate cancer risk,which may provide new insights into the etiology of prostate cancer associated with the inherited SE variants under environmental carcinogen stressors.

关键词： super-enhancer prostate cancer genetic variants AhR BaP FAM227A

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乡村教育发展逻辑与变革路向

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教育研究与实验 2024年第2期 46-55页

作者：陈思露南京大学哲学系南京210023

乡村教育是教育现代化的重要内容,也是乡村振兴和乡村发展的重要组成部分,因而是当代教育理论研究的重要议题。迄今关于乡村教育发展的理论研究、统计数据以及政策建议等,都在不同的程度上束缚于乡土中国视域,并形成关于乡村教育的乡土... 详细信息

乡村教育是教育现代化的重要内容,也是乡村振兴和乡村发展的重要组成部分,因而是当代教育理论研究的重要议题。迄今关于乡村教育发展的理论研究、统计数据以及政策建议等,都在不同的程度上束缚于乡土中国视域,并形成关于乡村教育的乡土发展逻辑。社会基本结构转型中的我国乡村教育,从形态、生态到日常教育生活及交往,都有别于传统的乡村教育,表现出较为典型的“城乡化”发展逻辑,而其发展所面临的问题也有别于“乡土中国”中的乡村教育发展问题。一种新乡村教育的形态和生态正在形成,需要树立大乡村教育观,通过社会的多方努力,真正发展成为现代化的新乡村教育。

关键词：乡村教育乡土中国城乡中国

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三温能量方程离散线性系统的两层迭代算法收敛因子估计及特征分析

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计算物理 2024年第1期41卷 122-130页

作者：郝悦黄思路徐小文计算物理全国重点实验室北京100088 北京应用物理与计算数学研究所北京100094

基于代数多重网格(AMG)方法的理论框架,详细分析基于物理量粗化的两层迭代方法(PCTL)算法的具体收敛性质,刻画算法收敛因子的合理上界,为PCTL算法提供理论保证。进一步深入分析影响PCTL算法收敛速度的代数特征,如对角占优性和耦合强度,... 详细信息

基于代数多重网格(AMG)方法的理论框架,详细分析基于物理量粗化的两层迭代方法(PCTL)算法的具体收敛性质,刻画算法收敛因子的合理上界,为PCTL算法提供理论保证。进一步深入分析影响PCTL算法收敛速度的代数特征,如对角占优性和耦合强度,为PCTL算法的应用和算法调优提供了理论指导。

关键词：三温能量方程组基于物理量粗化的两层迭代方法代数多重网格方法收敛性质影响因子

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面向智能车间的动态过道布置问题建模与优化

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华中科技大学学报(自然科学版) 2024年第6期52卷 17-23+101页

作者：张则强赵敏捷刘思璐计丹西南交通大学机械工程学院轨道交通运维技术与装备四川省重点实验室西南交通大学唐山研究院西南交通大学创新创业学院西南交通大学经济管理学院

针对传统过道布置鲜少考虑快速响应生产需求变化及加工产品组合的灵活性的不足，构建了一种双目标动态过道布置问题数学模型．通过调整不同阶段的设施位置，以达到总物料搬运成本及设施重组成本之和与布局面积最小化的目的．由于双目标... 详细信息

针对传统过道布置鲜少考虑快速响应生产需求变化及加工产品组合的灵活性的不足，构建了一种双目标动态过道布置问题数学模型．通过调整不同阶段的设施位置，以达到总物料搬运成本及设施重组成本之和与布局面积最小化的目的．由于双目标动态过道布置问题具有多项式复杂程度的非确定性问题(NP-hard)的特征，因此又提出了一种基于帕累托(Pareto)占优的多目标改进猫群算法．首先将基本猫群算法离散化；然后引入帕累托占优思想和拥挤距离机制处理双目标结果，并嵌入变邻域搜索结构加快算法寻优；最后采用所提算法测试大量不同规模算例，并与其他算法结果进行对比，验证了该算法的有效性和优越性．

关键词：过道布置问题动态布局猫群优化算法多目标优化混合整数规划模型

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复杂的肠病:如何运用^(18)F-FDG PET/CT鉴别

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中华核医学与分子影像杂志 2024年第7期44卷 426-428页

作者：刘思璐罗亚平中国医学科学院、北京协和医学院北京协和医院核医学科、核医学分子靶向诊疗北京市重点实验室北京100730

患者男,60岁,主诉间断腹痛、腹泻2年余。患者2020年2月起无明显诱因开始出现腹痛、排稀糊便3~4次/d,便后腹痛可缓解,无脓血、里急后重。2021年7月外院查大便隐血试验(+),艰难梭菌毒素(+),胃镜提示慢性非萎缩性胃炎,结肠镜提示全结肠亚... 详细信息

患者男,60岁,主诉间断腹痛、腹泻2年余。患者2020年2月起无明显诱因开始出现腹痛、排稀糊便3~4次/d,便后腹痛可缓解,无脓血、里急后重。2021年7月外院查大便隐血试验(+),艰难梭菌毒素(+),胃镜提示慢性非萎缩性胃炎,结肠镜提示全结肠亚蒂息肉样隆起,表面粗糙糜烂,直肠黏膜充血水肿,散在大小不等息肉样隆起,表面发红伴糜烂,病理活组织检查(简称活检)提示直肠低级别绒毛状管状腺瘤。之后患者病情加重,表现为腹痛、水样便10+次/d,便中带血,偶有里急后重及肛门坠胀感,2022年2月患者外院再次查病原学、胃肠镜及病理检查结果均大致同前,予甲硝唑、万古霉素和利福昔明治疗后艰难梭菌检查转阴,但患者腹泻仍无改善。2022年5月入本院,查血常规、肝肾功大致正常,血清蛋白电泳M蛋白0.55(正常参考值为0) g/L,免疫固定电泳免疫球蛋白G κ(+),血清游离轻链(serum free light chain, sFLC)-κ 17.0(正常参考值范围3.3~19.6) mg/L, sFLC-λ 20.5(正常参考值范围5.7~26.3) mg/L,sFLC-κ/λ 0.83(正常参考值范围0.26~1.65),骨髓涂片、活检、刚果红染色(-),胃、小肠、结肠、齿龈黏膜活检刚果红染色(-)。

关键词：血清蛋白电泳免疫固定电泳大便隐血试验利福昔明骨髓涂片水样便胃肠镜免疫球蛋白G

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早发性结直肠癌的多组学研究进展

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中华胃肠外科杂志 2024年第5期27卷 447-451页

作者：陈思璐辛俊逸杜牧龙王美林南京医科大学公共卫生学院南京211166

全球范围内,50岁以下的早发性结直肠癌(EOCRC)的发病率不断上升。与晚发性结直肠癌相比,EOCRC具有不同的临床、病理和分子特征,且多发于左半结肠和直肠。然而,EOCRC的发生、发展是一个多因素、多阶段的演变过程,是环境、遗传和生物等因... 详细信息

全球范围内,50岁以下的早发性结直肠癌(EOCRC)的发病率不断上升。与晚发性结直肠癌相比,EOCRC具有不同的临床、病理和分子特征,且多发于左半结肠和直肠。然而,EOCRC的发生、发展是一个多因素、多阶段的演变过程,是环境、遗传和生物等因素共同作用的结果,涉及生命体多层次的调控机制。近年来,随着高通量测序技术的快速发展和完善,利用多层次多组学技术的整合分析已经成为解析复杂疾病发病机制和个体化治疗方案的重要发展方向。本文将对EOCRC在多组学层面的研究进行综述,以期为结直肠癌的早期诊断和精准治疗提供重要科学依据。

关键词：结直肠肿瘤,早发性多组学研究整合分析

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