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Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1494-1511页

作者： Guangliang Gao Rui Liu silu hu Mengnan He Jiaman Zhang Dengfeng Gao Jing Li Jiwei hu Jiwen Wang Qigui Wang Mingzhou Li Long Jin Livestock and Poultry Multi‑Omics Key Laboratory of Ministry of Agriculture and Rural Affairs College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Chongqing Engineering Research Center of Goose Genetic Improvement Institute of Poultry ScienceChongqing Academy of Animal SciencesRongchang DistrictChongqing 402460China

Background Goose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant energy intake. As a result, goose offers an excellent model for studying obesity, metabolic disorders, and liver diseases in mammals. Although the impact of the three-dimensional arrangement of chromatin within the cell nucleus on gene expression and transcriptional regulation is widely acknowledged, the precise functions of chromatin architecture reorganization during fat deposition in goose liver tissues still need to be fully *** In this study, geese exhibited more pronounced changes in the liver index and triglyceride(TG) content following the consumption of the high-fat diet(HFD) than mice without significant signs of inflammation. Additionally, we performed comprehensive analyses on 10 goose liver tissues(5 HFD, 5 normal), including generating highresolution maps of chromatin architecture, conducting whole-genome gene expression profiling, and identifying H3K27ac peaks in the livers of geese and mice subjected to the HFD. Our results unveiled a multiscale restructuring of chromatin architecture, encompassing Compartment A/B, topologically associated domains, and interactions between promoters and enhancers. The dynamism of the three-dimensional genome architecture, prompted by the HFD, assumed a pivotal role in the transcriptional regulation of crucial genes. Furthermore, we identified genes that regulate chromatin conformation changes, contributing to the metabolic adaptation process of lipid deposition and hepatic fat changes in geese in response to excessive energy intake. Moreover, we conducted a cross-species analysis comparing geese and mice exposed to the HFD, revealing unique characteristics specific to the goose liver compared to a mouse. These chromatin conformation changes help elucidate the observed characteristics of fat

关键词： Compartment A/B Goose fatty liver Promoter-enhancer interactions Regulation of gene expression

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RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3917-3919页

作者： Xiaoju Tang Lichun Zhong Xin Tian Ying Zou silu hu Jia Liu Ping Li Min Zhu Fengming Luo huajing Wan Department of Respiratory and Critical Care Medicine Clinical Research Center for Respiratory DiseasesWest China HospitalSichuan UniversityNo.37 Guo Xue Xiang610041 ChengduChina Laboratory of Pulmonary Immunology and Inflammation Frontiers Science Center for Disease-related Molecular NetworkSichuan UniversityNo.2222 Xin Chuan Road610200 ChengduSichuanChina

Dear Editor,Acute lung injury(ALI)is a significant contributor to the development of acute respiratory distress syndrome(ARDS),which is a severe clinical condition associated with high morbidity and mortality.1 It is increasingly evident that preserving mitochondrial health in alveolar epithelial cells holds great therapeutic potential for ARDS.2 Mitophagy,a cellular process aimed at maintaining mitochondrial health,plays a critical role in this regard.3 Therefore,gaining a comprehensive understanding of the factors that regulate mitophagy in alveolar epithelial cells during ALI could greatly inform the development of future therapeutic approaches for ARDS.

关键词： acute lung inflammation

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基于马赫线切割的楔形乘波前体改进设计研究

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推进技术 2018年第8期39卷 1696-1702页

作者：吕宇超胡姝瑶蒋崇文北京航空航天大学航空科学与工程学院北京100191

为了改善楔形乘波前体两侧大下反角对其横航向静稳定性的不利影响,利用马赫线切割方法对其进行了改进设计。该方法为在不影响进气道入流的条件下,对前体预压缩面的改进提供了基础。通过斜激波关系式求出了后掠斜楔激波脱体的临界参数,... 详细信息

为了改善楔形乘波前体两侧大下反角对其横航向静稳定性的不利影响,利用马赫线切割方法对其进行了改进设计。该方法为在不影响进气道入流的条件下,对前体预压缩面的改进提供了基础。通过斜激波关系式求出了后掠斜楔激波脱体的临界参数,将其应用于楔形乘波前体的改进,使改进后的外形仍具有乘波特性。使用以上方法对典型楔形乘波前体开展了改进设计,采用数值模拟方法对改进外形进行计算分析。结果表明无粘流场中进气道入流区域的流场与原楔形乘波前体完全一致,无粘升阻比有所提高;同时,改进外形的横航向静稳定性与原楔形乘波体相比有明显改善。粘性数值模拟结果显示改进外形在有粘条件下仍具有较好的乘波特性和升阻比。

关键词：乘波前体马赫线切割进气道流动改进设计

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一种基于属性的固定密文长度广播加密方案

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计算机应用研究 2016年第6期33卷 1780-1784页

作者：胡思路陈燕俐南京邮电大学计算机学院南京210023

针对目前基于属性的广播加密方案存在密文较长、加/解密时计算花销较大等问题,提出了一种高效的密文策略的基于属性的广播加密方案。该方案基于椭圆曲线加密算法,采用动态门限访问结构,加密方可根据需要动态调整门限值。该方案仅当用户... 详细信息

针对目前基于属性的广播加密方案存在密文较长、加/解密时计算花销较大等问题,提出了一种高效的密文策略的基于属性的广播加密方案。该方案基于椭圆曲线加密算法,采用动态门限访问结构,加密方可根据需要动态调整门限值。该方案仅当用户的身份信息包含在广播的授权用户集合中且用户的属性包含在访问结构中时,解密方方可通过双线性配对运算进行密文解密。方案的密文长度及加/解密双线性对运算次数固定,计算效率高且通信开销小。仿真结果验证了方案的有效性。方案安全性是建立在q-BDHE假设之上,在标准模型下可证CPA安全。

关键词：属性广播加密椭圆曲线加密访问结构固定密文长度效率安全性

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精液细菌感染对精液参数及细菌耐药性的影响——附74376例男性不育症患者分析

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南方医科大学学报 2018年第1期38卷 89-94页

作者：尹丝璐胡坚李维娜石林刘刚中南大学基础医学院生殖与干细胞工程研究所湖南长沙410013 中信湘雅生殖与遗传专科医院湖南长沙410000

目的男性不育症患者精液细菌感染对精液参数的影响和耐药分析。方法收集2016年4月~2017年4月在本院就诊的74376例男性不育患者的精液标本,按照细菌培养结果分为感染组和非感染组,比较两组不育症类型和精液参数的差异。对检出菌的种类进... 详细信息

目的男性不育症患者精液细菌感染对精液参数的影响和耐药分析。方法收集2016年4月~2017年4月在本院就诊的74376例男性不育患者的精液标本,按照细菌培养结果分为感染组和非感染组,比较两组不育症类型和精液参数的差异。对检出菌的种类进行统计,及药敏结果进行分析。结果精液细菌感染阳性率为1.38%,其中精液正常组阳性率为1.41%,弱精症组感染阳性率为1.55%,少精症感染阳性率为1.18%,少弱精症感染阳性率为1.57%,无精症感染阳性率为0.17%,无精症组阳性率低于其他组;细菌感染主要影响精子活力(P<0.05)、精子密度和前向精子比例(P<0.01);细菌感染主要种类为:大肠埃希菌占63.59%,肺炎克雷伯菌肺炎亚种占19.80%和奇异变形杆菌占13.22%;药敏结果显示大肠埃希菌、肺炎克雷伯菌肺炎亚种、克氏柠檬酸杆菌对阿莫西林明显耐药,铜绿假单胞菌对复方新诺明、氨苄西林/舒巴坦明显耐药,金黄色葡萄球菌对青霉素明显耐药。结论不育患者精液细菌感染率较低,细菌感染对精子参与受精过程影响较大,可引起精子活力降低,密度减少。感染的细菌种类中大肠杆菌所占比例最高;除金黄色葡萄球菌之外,其他菌种对亚胺培南,美洛培南类药物敏感。

关键词：精液质量细菌感染药敏分析

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Monte-Carlo simulation of pinhole collimator of a small field of view gamma camera for small animal imaging

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Nuclear Science and Techniques 2009年第1期20卷 37-41页

作者： Zhu Jie MA Wenyan Zhu Yufeng MA Hongguang WU Yuelei hu huasi ZHANG Boping huO Yonggang LIU silu JIAN Bin WANG Zhaomin The Second Artillery Engineering College Xi＇an 710025 China Nuclear Engineering Department School of Energy ＆ Engineering Xi＇an Jiaotong University Xi＇an 710049 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China Department of Electric Information Engineering Wuhan Polytechnic University Wuhan 430023 China

Needs in scintimammography applications,especially for small animal cardiac imaging,lead to develop a small field of view,high spatial resolution gamma camera with a pinhole *** the ideal pinhole collimator must keep a compromise between spatial resolution and *** order to design a pinhole collimator with an optimized sensitivity and spatial resolution,the spatial resolution and the geometric sensitivity response as a function of the source to collimator distance has been obtained by means of Monte-Carlo simulation for a small field of view gamma camera with a pinhole collimator of various-hole *** results show that the camera with pinhole of 1 mm,1.5 mm and 2 mm diameter has respectively spatial resolution of 1.5 mm,2.25 mm and 3 mm and geometric sensitivity of 0.016%,0.022%and 0.036%,while the source to collimator distance is 3 *** chose the pinhole collimator with hole diameter size of 1.2 mm for our the gamma camera designed based on the trade-off between sensitivity and resolution.

关键词：氢硼聚变衰变原子核模拟能谱

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Recent advances in nonlinear optics for bio‐imaging applications

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Opto-Electronic Advances 2020年第10期3卷 13-30页

作者： silu Zhang Liwei Liu Sheng Ren Zilin Li Yihua Zhao Zhigang Yang Rui hu Junle Qu Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of Education College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518000China

Nonlinear optics,which is a subject for studying the interaction between intense light and materials,has great impact on various research *** many structures in biological tissues exhibit strong nonlinear optical effects,nonlinear optics has been widely applied in biomedical *** in the aspect of bio-imaging,nonlinear optical techniques can provide rapid,label-free and chemically specific imaging of biological samples,which enable the investigation of biological processes and analysis of samples beyond other microscopy *** this review,we focus on the introduction of nonlinear optical processes and their applications in bio-imaging as well as the recent advances in this *** perspective of this field is also presented.

关键词： nonliner optics microscopic imaging bio-imaging label-free chemical specific

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Bird Species Diversity and Spatio-temporal Variation in the Sihong Hongze Lake Wetland National Nature Reserve in Eastern China

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Journal of Resources and Ecology 2024年第4期15卷 826-837页

作者： hu huali XIAO Lihui ZHANG Manyu WANG silu CHEN Taiyu LU Changhu College of Life Science Nanjing Forestry UniversityNanjing 210037China Eastern Hongze Lake Wetland Natural Reserve HuaianJiangsu 223100China Institute of Wildlife Conservation Jiangxi Academy of ForestryNanchang 330037China

As an important hub on the East Asian-Australian Flyway(EAAF),Hongze Lake is an important migratory stopover and wintering site for hundreds of thousands of ***,research on bird community diversity in this area is still *** conducted a bird survey from July 2020 to June 2021 using the line transect method on the terrestrial habitat,as well as the fixed-point method in the lake wetland at the Sihong Hongze Lake Wetland National Nature Reserve located in northwestern Hongze Lake,and analyzed the temporal-spatial variation in the bird *** results showed that a total of 170432 detections of 215 bird species belonging to 18 orders and 55 families were *** terms of species composition,the proportion of terrestrial birds was relatively high,followed by waterfowl richness,with high numbers of Anatidae species and *** bird species abundance,waterfowl had the highest abundance of common coot(Fulica atra),belonging to the Rallidae family,followed by Anatidae and Ardeidae *** abundance of shorebirds was extremely low,and that of non-waterfowl was also *** terms of temporal patterns,the number of bird species and richness index were higher in spring and autumn but lower in winter and *** bird abundance was the highest in winter,and the remaining three seasons were similar in terms of bird *** diversity index and evenness index were higher in spring,summer and autumn,and lowest in *** the spatial pattern,the open water in the western part of the reserve included the most densely distributed areas for birds,and the number of bird species and their abundance were both the highest in that *** were significant differences in the bird community structures among the four *** species number and richness index of birds in the reed habitat were the highest,and the bird abundance was also high,but the diversity index and evenness index were *** the bird abundance in the lake habitat wa

关键词： bird diversity seasonal variation spatial distribution Sihong Hongze Lake Wetland National Nature Reserve

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人力资源实践的双重关注模型与员工绩效:领导-成员交换的差异作用

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华南师范大学学报（社会科学版） 2021年第6期 89-104,206,207页

作者：张光磊胡婷陈丝璐武汉理工大学管理学院武汉430070 华中师范大学经济与工商管理学院武汉430079

人力资源实践的双重关注模型将人力资源实践划分为绩效导向和维持导向两个维度,但既有研究对人力资源实践的兼容现象关注不够。基于社会交换理论,利用331个企业员工调研样本数据,对基于社会性领导-成员交换和经济性领导-成员交换视角的... 详细信息

人力资源实践的双重关注模型将人力资源实践划分为绩效导向和维持导向两个维度,但既有研究对人力资源实践的兼容现象关注不够。基于社会交换理论,利用331个企业员工调研样本数据,对基于社会性领导-成员交换和经济性领导-成员交换视角的人力资源实践的双重关注模型(即绩效导向人力资源实践和维持导向人力资源实践)对员工绩效的影响以及人力资源管理强度的调节作用进行探讨,结果表明:社会性领导-成员交换(SLMX)在绩效导向人力资源实践与员工角色内绩效、角色外绩效之间的关系中起中介作用,经济性领导-成员交换(ELMX)在维持导向人力资源实践与员工角色内绩效、角色外绩效之间的关系中起中介作用;人力资源管理强度不仅正向调节绩效导向人力资源实践与社会性领导-成员交换之间的关系,还正向调节“绩效导向人力资源实践—SLMX—角色外绩效”这一中介机制。

关键词：绩效导向人力资源实践维持导向人力资源实践社会性领导-成员交换经济性领导-成员交换人力资源管理强度

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基于监测业务数据的海域使用强度空间表征方法

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天津师范大学学报（自然科学版） 2018年第6期38卷 42-48页

作者：陈思露刘百桥胡蓓蓓天津师范大学地理与环境科学学院天津300387

为了及时、有效地评估海域开发现状,科学反映海洋资源环境承载力与开发负载之间的协调程度,利用地理信息空间数据分析的核密度原理,在研究海域使用强度概念的基础上,设计了一套以海域使用监测业务数据为数据源,根据海域使用范围、类型... 详细信息

为了及时、有效地评估海域开发现状,科学反映海洋资源环境承载力与开发负载之间的协调程度,利用地理信息空间数据分析的核密度原理,在研究海域使用强度概念的基础上,设计了一套以海域使用监测业务数据为数据源,根据海域使用范围、类型和方式评估海域使用负载,以海域使用负载的空间密度表征海域使用强度的思路和方法,并以渤海区为例进行了实证研究.结果表明:渤海区海域使用强度空间分异明显,有多个集聚区域,呈现"高值核心式"聚集和"较高值平摊式"聚集2种分布态势,海域使用强度空间分布特征与已有认知和研究成果基本一致,表明评估方法总体有效;该方法所需资料易得,操作易行,可以满足大尺度范围内海域使用强度的快速评估要求.

关键词：海域使用强度空间表征方法核密度渤海

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