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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António J.Salgado Nuno A.silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena silva Olaya Fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3231-3232页

作者： Andreia Monteiro Susana Monteiro Nuno A.silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimaraesPortugal

Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterations.A pe rsistent and exagge rated inflammato ry response within the spinal cord accompanies these events(Lima et al.,2022).The complexity and interplay of these mechanisms exacerbate the initial injury,leading to a degenerative process at the injury *** the initial trauma is unavoidable,the secondary injury begins within minutes and can last for months,creating an optimal window for therapeutic intervention.

关键词： alterations injury companies

A Model Structured in Classes for the Study of Student Population Evolution

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上海大学学报（自然科学版） 2014年第2期20卷 127-137页

作者： PEREIRA Edgar rosa Cecilia silva Jacques Department of Mathematics Universidade Federal do Rio Grande do Norte Department of Mathematics Instituto Politecnico da Guarda Department of Mathematics Universidade Federal do Rio Grande do Sul

This paper presents an application of a metapopulation model structured in classes for the study of population evolution of a network of *** global dynamics are considered in two parts,the local,where the evolution for each grade in a cycle is accounted,and the metapopulation or the movement of students between *** of the model is presented.

关键词：应用数学数学分析数学理论数学概念

Flow Dynamics around Two Side by Side Circular Cylinders with Alternating Movements

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World Journal of Mechanics 2023年第1期13卷 1-19页

作者： Alice rosa da silva Faculty of Civil Engineering Federal University of Uberlandia Uberlandia-MG Brazil

The flow dynamics is analyzed through two-dimensional numerical simulations around two circular cylinders arranged side by side, with 4 combinations of alternating motions. All simulations are performed for Re = 1000, amplitude of oscillation (A) equal to 3, frequency ratio (fr) of 0.5, specific rotation (α) equal to 0.5 and different values of spacing ratio (L/D). It is verified that the combination of the type of movement, together with the position of one cylinder in relation to the other, exerts significant influence on the flow dynamics, as well as on the pressure distribution around the cylinder surface and on the average values of the fluid dynamics coefficients. The smallest value of the average pressure coefficient (Cp = -3.3), is obtained for the oscillating cylinder when placed side by side with the clockwise rotation cylinder, case 3 and L/D = 1.5. On the other hand, the lowest mean drag coefficient (Cd = 1.0788), is obtained for the cylinder with counterclockwise rotation, located in the lower position in relation to oscillating cylinder in the upper position, with spacing between them of 1.5. Furthermore, it is observed that the rotation movement is more effective in reducing drag than the rotation-oscillation movement, for the studied frequency ratio.

关键词： Rotation Rotation-Oscillation Flow Dynamic Circular Cylinder

Litter removal impacts on soil biodiversity and eucalypt plantation development in the seasonal tropics

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Journal of Forestry Research 2023年第3期34卷 735-748页

作者： Jonas Inkotte Barbara Bomfim Sarah Camelo da silva Marco Bruno Xavier Valadão Márcio Gonçalves da rosa Roberta Batista Viana Alcides Gatto Reginaldo SPereira Department of Forestry Engineering University of BrasiliaBrasíliaDistrito FederalBrazil Climate and Ecosystem Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA SESI/SENAI Social Service Industry Santa Catarina StateChapecóBrazil

The little layer of tree plantations provides primary nutrients for uptake,buff ers changes in soil moisture,and provides habitat and substrate to soil epigeic ***,this layer in eucalypt plantations is often removed to reduce fuel load during the fi re season in the Brazilian savanna(Cerrado).Therefore,it is necessary to quantify the eff ects of changes in litter dynamics on the function of these plantations,on key nutrient cycling processes and on epigeic fauna diversity and *** two adjacent stands(one juvenile and one mature),the consequences of two years of litter removal were quantifi ed as monthly litterfall,leaf and fi ne wood litter decomposition,epigeic fauna abundance and diversity,soil biogeochemical variables,and tree diameter and basal area *** litterfall rates in juvenile and mature stands did not change with litter removal over the study *** litterfall ranged from 4.1 to 4.9 Mg ha^(−1)a^(−1)in litter removal plots and from 3.9 to 4.8 Mg ha^(−1)a^(−1)in control *** wood litter decomposition was slower in litter removal plots compared to controls,while leaf decomposition rates were similar in *** years of litter removal in the juvenile stand did not aff ect topsoil biogeochemical parameters but decreased available phosphorus at 20–40 cm depth relative to *** the mature stand,total cation exchange capacity(0–20 cm)was higher in controls(6.4 cmol c dm^(−3))relative to litter removal plots(6.3 cmol c dm^(−3)),while soil moisture(0–40 cm depth)was lower in litter removal(25.45 m 3 m^(−3))compared to control plots(26 m^(3)m^(−3))in the dry season.A non-metric multidimensional scaling ordination revealed an increased homogeneity in epigeic fauna where litter was ***,decomposition,diameter increment,four soil physical parameters and fourteen chemical parameters at 0–20 and 20–40 cm depth explained the diff erences in soil epigeic fauna composition between litter removal and control p

关键词： Cerrado Nutrient cycling Soil ecology Soil epigeic fauna Plantation management

Adenoma incidence decreases u nder the efect of polypectomy

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World Journal of Gastroenterology 2012年第11期18卷 1243-1248页

作者： Isadora rosa Paulo Fidalgo Jose Soares Susana Vinga Carla Oliveira Joao P silva Susana M Ferro Paula Chaves Antonio G Oliveira Carlos N Leitao Gastroenterology Department Instituto Portu-gues de Oncologia de Lisboa Francisco Gentil EPE 1099-023Lisboa Portugal Faculdade de Ciencias da Safldeda Universidade da Beira Interior 6200-506 Covilha Portugal Jose Soares Gastroenterology Department Hospital de SantoAntonio EPE 4099-001 Porto Portugal Instituto de Engenharia de Sistemas e Com-putadores: Investigacao e Desenvolvimento 1000-029 LisboaPortugal Hospital de Santo Antonio EPE 4099-001Porto Portugal Pathology Department Instituto Portugues deOncologia de Lisboa Francisco Gentil EPE 1099-023 LisboaPortugal Biostatistics Department Faculdade deCiencias M6dicas 1169-056 Lisboa Portugal

MM： To investigate whether, under the influence of pol ypectomy, the incidence of adenoma decreases with age.METHODS： Consecutive patients with colonic adenomas identified at index colonoscopy were retrospectively selected if they had undergone three or more complete colonoscopies, at least 24 mo apart. Patients who had any first-degree relative with colorectal cancer were excluded. Data regarding number of adenomas at each colonoscopy, their location, size and histological classification were recorded. The monthly incidence density of adenomas after the index examination was estimated for the study population, by using the person-years method. Baseline adenomas were excluded from incidence calculations but their characteristics were correlated with recurrence at follow-up, using the X^42 test.RESULTS： One hundred and fifty-six patients were included （109 male, mean age at index colonoscopy 56.8 ± 10.3 years）, with follow-up that ranged from 48 to 232 mo. No significant correlations were observed between the number, the presence of villous component, or the size of adenomas at index colonoscopy and the presence of adenomas at subsequent colonoscopies （P = 0.49, 0.12 and 0.78, respectively）. The incidence of colonic adenomas was observed to decay from 1.4% person-months at the beginning of the study to values close to 0%, at 12 years after index colonoscopy.CONCLUSION： Our results suggest the sporadic formation of adenomas occurs within a discrete period and that, when these adenomas are removed, all neoplasia-prone clones may be extinguished.

关键词： Colorectal cancer Colorectal adenoma In-cidence Age Polypectomy

QUASILINEAR EQUATIONS USING A LINKING STRUCTURE WITH CRITICAL NONLINEARITIES

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Acta Mathematica Scientia 2022年第3期42卷 975-1002页

作者： Edcarlos D.silva Jefferson S.silva Federal University of Goi′as Zip code 74001-970Goi′as-GOBrazil

It is to establish existence of a weak solution for quasilinear elliptic problems assuming that the nonlinear term is *** potential V is bounded from below and above by positive *** we are considering a critical term which interacts with higher eigenvalues for the linear problem,we need to apply a linking *** that the lack of compactness,which comes from critical problems and the fact that we are working in the whole space,are some obstacles for us to ensure existence of solutions for quasilinear elliptic *** main feature in this article is to restore some compact results which are essential in variational *** that compactness conditions such as the Palais-Smale condition for the associated energy functional is not available in our *** difficulty is overcame by taking into account some fine estimates on the critical level for an auxiliary energy functional.

关键词： Quasilinear Schrödinger equations linking theorems superlinear elliptic equations critical nonlinearities Bounded potentials