检索结果-南通市图书馆

维普期刊数据库博看期刊

Sedimentological and Chemical Processes During Flushing Tests at Iffezheim Barrage(River Rhine)

在线全文

学校读者我要写书评

暂无评论

四川大学学报（工程科学版） 2005年第S1期37卷 7-15页

作者： silke WIEPRECHT Inst.of Hydraulic Eng. Univ.Stuttgart70550 StuttgartGermany

This paper analyzes the situation at the Iffezheim barrage along the fiver *** the start of operation in 1977 several million cubic meters of very fine sediment have been deposited in the ***- cause of stability problems and reduced safety in the event of flooding,an extraction of the material is neces- *** assays showed a high concentration of *** flushing without any additional measures is not *** order to leam more about the morphological and chemical in...

关键词： sedimentation in reservoirs flushing suspended material HCB

维普期刊数据库

Treatment sequencing in metastatic castrate-resistant prostate cancer

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2014年第3期16卷 426-431页

作者： Oliver Sartor silke Gillessen Department of Medicine and Urology Tulane University School of Medicine New Orleans Louisiana USA Department of Medical Oncology Kantonsspital St. Gallen St. Gallen Switzerland.

Six different treatments have demonstrated improved survival in phase III trials targeted to patients with metastatic castration-resistant prostate cancer （mCRPC）. Front-line therapeutic options for mCRPC include docetaxel, sipuleuceI-T, abiraterone and radium-223. Post-docetaxel options include cabazitaxel, abiraterone, enzalutamide and radium-223. Despite much progress in recent years, much is yet unknown and debates occur over optimal treatment choices and sequences. None of the new agents have been compared to one another, thus physicians in practice today must make choices based on non-randomized comparisons, toxicity considerations and various assumptions. Abiraterone is now moving into the front line mCRPC space given recent regulatory approvals and enzalutamide will follow soon. Both of the hormonal agents have less toxicity when compared to chemotherapeutic options and both of these hormonal agents are expected to be used in a considerable number of mCRPC patients in the years ahead. Little data are available for the post-abiraterone or post-enzalutamide setting. In this review the currently available sequencing data are summarized and interpreted. It is now clear that cross resistance is a potential issue between various treatments, especially those agents that target the androgen axis. This review highlights the need for additional studies to optimize the current treatments for these patients.

关键词： abiraterone cabazitaxel castrate-resistant docetaxel enzalutamide~ radium-223 sipuleuceI-T

Mechanisms of Optimal Defense Patterns in Nicotiana attenuata: Flowering Attenuates Herbivory-elicited Ethylene and Jasmonate Signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2011年第12期53卷 971-983页

作者： Celia Diezel silke Allmann Ian T.Baldwin Department of Molecular Ecology Max-Planck Institute for Chemical Ecology Jena 07745 Germany Department of Plant Physiology Swammerdam Institute for Life Sciences Amsterdam 1098 XH the Netherlands

To defend themselves against herbivore attack, plants produce secondary metabolites, which are variously inducible and constitutively deployed, presumably to optimize their fitness benefits in light of their fitness costs. Three phytohormones, jasmonates （JA） and their active forms, the JA-isoleucine （JA-Ile） and ethylene （ET）, are known to play central roles in the elicitation of induced defenses, but little is known about how this mediation changes over ontogeny. The Optimal Defense Theory （ODT） predicts changes in the costs and benefits of the different types of defenses and has been usefully extrapolated to their modes of deployment. Here we studied whether the herbivore-induced accumulation of JA, JA-Ile and ET changed over ontogeny in Nicotiana attenuata, a native tobacco in which inducible defenses are particularly well studied. Herbivore-elicited ET production changed dramatically during six developmental stages, from rosette through flowering, decreasing with the elongation of the first corollas during flower development. This decrease was largely recovered within a day after flower removal by decapitation. A similar pattern was found for the herbivore-induced accumulation of JA and JA-Ile. These results are consistent with ODT predictions and suggest that the last steps in floral development control the inducibility of at least three plant hormones, optimizing defense-growth tradeoffs.

关键词： flowering jasmonic acid jasmonic acid-isoleucine ethylene Manduca sexta Nicotiana attenuata ontogeny optimal defense theory plant-herbivore interactions.

维普期刊数据库

Integrated colloidal quantum dot photodetectors with color-tunable plasmonic nanofocusing lenses

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2015年第1期4卷 538-544页

作者： silke L Diedenhofen Dominik Kufer Tania Lasanta Gerasimos Konstantatos ICFO-Institut de Ciencies Fotoniques Barcelona 08860Spain

High-sensitivity photodetection is at the heart of many optoelectronic applications,including spectroscopy,imaging,surveillance,remote sensing and medical *** the highest possible sensitivity for a given photodetector technology requires the development of ultra-small-footprint detectors,as the noise sources scale with the area of the *** must be accomplished while sacrificing neither the optically active area of the detector nor its ***,such designs are based on diffraction-limited approaches using optical ***,we employ a plasmonic flat-lens bull’s eye structure(BES)to concentrate and focus light into a nanoscale colloidal quantum dot(CQD)*** plasmonic lenses function as nanofocusing resonant structures that simultaneously offer color selectivity and enhanced ***,we demonstrate the first CQD photodetector with a nanoscale footprint,the optically active area of which is determined by the BES;this detector represents an exciting opportunity for high-sensitivity sensing.

关键词： PbS quantum dots photodetectors plasmonic bull’s eye structures plasmonic lens

Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第2期14卷 115-123页

作者： Sailas BENJAMIN silke FLOTHO Torsten BRCHERS Friedrich SPENER Department of Biochemistry University of Münster48149 MünsterGermany Enzyme Technology Laboratory Biotechnology DivisionDepartment of BotanyUniversity of CalicutKerala 673 635India Department of Molecular Biosciences Lipidomics Research CenterUniversity of GrazHeinrichstrasse 318010 GrazAustria

The purpose of this study was to examine the induction profiles （as judged by quantitative reverse tran- scription polymerase chain reaction （qRT-PCR）） of peroxisome proliferator-activated receptor （PPAR） α,β, y subtypes and major PPAR-target genes bearing a functional peroxisome proliferator responsive element （PPRE） in HepG2 cell model upon feeding with cis-9,trans-11-octadecadienoic acid （9-CLA） or trans-10,cis-12-octadecadienoic acid （10-CLA） or their precursor fatty acids （FAs）. HepG2 cells were treated with 100 pmol/L 9-CLA or 10-CLA or their precursor FAs, viz., oleic, linoleic, and trans-11-vaccenic acids against bezafibrate control to evaluate the induc- tion/expression profiles of PPAR （α, β, γ subtypes and major PPAR-target genes bearing a functional PPRE, i.e., fatty acid transporter （FAT）, glucose transporter-2 （GLUT-2）, liver-type FA binding protein （L-FABP）, acyl CoA oxidase-1 （ACOX-1）, and peroxisomal bifunctional enzyme （PBE） with reference to β-actin as house keeping gene. Of the three housekeeping genes （glyceraldehyde 3-phosphate dehydrogenase （GAPDH）, β-actin, and ubiquitin）, β-actin was found to be stable. Dimethyl sulfoxide （DMSO）, the common solubilizer of agonists, showed a significantly higher induction of genes analyzed, qRT-PCR profiles of CLAs and their precursor FAs clearly showed upregulation of FAT, GLUT-2, and L-FABP （-0.5-.0-fold）. Compared to 10-CLA, 9-CLA decreased the induction of the FA metabolizing gene ACOX-1 less than did PBE, while 10-CLA decreased the induction of PBE less than did ACOX-I. Both CLAs and precursor FAs upregulated PPRE-beadng genes, but with comparatively less or marginal activation of PPAR subtypes This indicates that the binding of CLAs and their precursor FAs to PPAR subtypes results in PPAR activation, thereby induction of the target transporter genes coupled with downstream lipid metabolising genes such as ACOX-1 and PBE. To sum up, the expression profiles of these candidate genes showed that CLAs and th

关键词： Conjugated linoleic acid HepG2 cell model qRT-PCR Peroxisome proliferator-activated receptor Peroxisome proliferator responsive element-bearing genes Lipid agonists

维普期刊数据库

Affairs happen---to whom？ A study on extrapair paternity in common nightingales

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2017年第4期63卷 421-431页

作者： Conny LANDGRAF Kerstin WILHELM Jutta WIRTH Michael WEISS silke KIPPER Leibniz Institute for Zoo and Wildlife Research (IZW) Alfred-Kowalke-StraBe 17 10315 Berlin Germany Animal Behavior Group Free University of Berlin TakustraBe 6 14195 Berlin Germany Institute of Evolutionary Ecology and Conservation Genomics University of UIm Albert Einstein Allee 11 89069 UIm Germany Behavioural Ecology Group Department of Animal Sciences Wageningen University De Elst 1 6708 WD Wageningen The Netherlands Department of Exposition Unit Epidemiology Statistics and Mathematical Modelling Federal Institute for Risk Assessment (BfR) Max-Dohrn-Str. 8-10 10589 Berlin Germany Chair of Zoology School of Life Sciences Weihenstephan Technische Universitat Munchen LieseI-Beckmann-StraBe 4 85350 Freising Germany

Most birds engage in extrapair copulations despite great differences across and within species. Besides cost and benefit considerations of the two sex environmental factors have been found to alter mating strategies within or between populations and/or over time. For socially monogamous species, the main advantage that females might gain from mating with multiple males is probably increasing their offspring＇s genetic fitness. Since male （genetic） quality is mostly not directly meas- urable for female birds, （extrapair） mate choice is based on male secondary traits. In passerines male song is such a sexual ornament indicating male phenotypic and/or genetic quality and song repertoires seem to affect female mate choice in a number of species. Yet their role in extrapair mating behavior is not well understood. In this study, we investigated the proportion of extrapair paternity （EPP） in a population of common nightingales Luscinia megarhynchos. We found that EPP rate was rather high （21.5% of all offspring tested） for a species without sexual dimorphism and high levels of paternal care. Furthermore, the occurrence of EPP was strongly related to the spatial distribution of male territories with males settling in densely occupied areas having higher proportions of extrapair young within their own brood. Also, song repertoire size affected EPP： here larger repertoires of social mates were negatively related to the probability of being cuck- olded. When directly comparing repertoires sizes of social and extrapair mates, extrapair mates tended to have larger repertoires. We finally discuss our results as a hint for a flexible mating strat- egy in nightingales where several factors--including ecological as well as male song features-- need to be considered when studying reproductive behavior in monogamous species with complex song.

关键词： common nightingale direct fitness extrapair paternity Luscinia megarhynchos repertoire size territorial settlement.

Annular pancreas associated with duodenal carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第25期16卷 3206-3210页

作者： Enrico Bronnimann silke Potthast Tatjana Vlajnic Daniel Oertli Oleg Heizmann Depart-ment of Surgery University of Basel CH-4031 Basel Switzerland Institute of Diagnostic Radiology University Hospital Basel CH-4031 Basel Switzerland Institute of Pathology University of Basel CH-4031 Basel Switzerland

Annular pancreas (AP) is a rare congenital anomaly. Coexisting malignancy has been reported only in a few cases. We report what is, to the best of our knowledge, the first case in the English literature of duodenal adenocarcinoma in a patient with AP. In a 55-year old woman with duodenal outlet stenosis magnetic resonance cholangiopancreatography showed an aberrant pancreatic duct encircling the duodenum. Duodenojejunostomy was performed. Eight weeks later she presented with painless jaundice. Duodenopancreatectomy revealed a duodenal adenocarcinoma, surrounded by an incomplete AP. Thus, co-existent malignancy with AP can be present without obstructive jaundice and without being visible through preoperative diagnostics.

关键词： Duodenal carcinoma Annular pancreas Duodenopancreatectomy Whipples operation

Biased dispersal of Metrioptera bicolor, a wing dimorphic bush-cricket

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2018年第2期25卷 297-308页

作者： Ina Monika Margret Heidinge silke Hein Heike Feldhaar Hans-Joachim Poethke Field Station Fabrikschleichach University of W（Jrzburg Rauhenebrach Germany W~sseri 8 CH-8816 Hirzel Switzerland Department of Animal Ecology I University of Bayreuth Bayreuth Germany Bavarian State Institute for Viticulture and Horti- culture Bee Research Center An der Steige 15 97206 VeitshSchheim Germany

In the highly fragmented landscape of central Europe, dispersal is of particular importance as it determines the long-term survival of animal populations. Dispersal not only secures the recolonization of patches where populations went extinct, it may also rescue small populations and thus prevent local extinction events. As dispersal involves different individual fitness costs, the decision to disperse should not be random but context- dependent and often will be biased toward a certain group of individuals （e.g., sex- and wing morph-biased dispersal）. Although biased dispersal has far-reaching consequences for animal populations, immediate studies of sex- and wing morph-biased dispersal in orthopterans are very rare. Here, we used a combined approach of morphological and genetic analyses to investigate biased dispersal of Metrioptera bicolor, a wing dimorphic bush-cricket. Our results clearly show wing morph-biased dispersal for both sexes of M. bicolor. In addition, we found sex-biased dispersal for macropterous individuals, but not for micropters. Both, morphological and genetic data, favor macropterous males as dispersal unit of this bush-cricket species. To get an idea of the flight ability ofM. bicolor, we compared our morphological data with that of Locusta migratoria and Schistocerca gregaria, which are very good flyers. Based on our morphological data, we suggest a good flight ability for macropters of M. bicolor, although flying individuals of this species are seldom observed.

关键词： aspect ratio dispersal traits flight muscle ratio Metrioptera bicolor sex-biased dispersal wing load wing morph-biased dispersal

Postmortem imaging as a complementary tool for the investigation of cardiac death

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forensic Sciences Research 2019年第3期4卷 211-222页

作者： Katarzyna Michaud Pia Genet Sara Sabatasso silke Grabherr Lausanne University Hospital and University of Lausanne University Center of Legal Medicine Lausanne-GenevaLausanneSwitzerland Geneva University Hospital University Center of Legal Medicine Lausanne-GenevaGenevaSwitzerland

In the past 2 decades,modern radiological methods,such as multiple detector computed tomography (MDCT),MDCT-angiography,and cardiac magnetic resonance imaging (MRI)were introduced into postmortem practice for investigation of sudden death (SD),including cases of sudden cardiac death (SCD).In forensic cases,the underlying cause of SD is most frequently cardiovascular with coronary atherosclerotic disease as the leading *** are many controversies about the role of postmortem imaging in establishing the cause of death and especially the value of minimally invasive autopsy *** paper discusses the state of the art for postmortem radiological evaluation of the heart compared to classical postmortem examination,especially in cases of *** SCD cases,postmortem CT is helpful to estimate the heart size and to visualize haemopericardium and calcified plaques and valves,as well as to identify and locate cardiovascular *** methods are useful to provide a detailed view of the coronary arteries and to analyse them,especially regarding the extent and location of stenosis and *** postsurgical cases,it allows verification and documentation of the patency of stents and bypass grafts before opening the *** MRI is used to investigate soft tissues such as the myocardium,but images are susceptible to postmortem changes and further work is necessary to increase the understanding of these radiological aspects,especially of the ischemic *** postsurgery cases,the value of postmortem imaging of the heart is reportedly for the diagnostic and documentation *** implementation of new imaging methods into routine postmortem practice is challenging,as it requires not only an investment in equipment but,more importantly,investment in the expertise of interpreting the *** those requirements are implemented,however,they bring great advantages in investigating cases of SCD,as they allow documentation of the body,ori

关键词： Forensic sciences forensic pathology sudden cardiac death postmortem imaging postmortem CT-angiography minimally invasive autopsy autopsy