检索结果-南通市图书馆

Sedimentological and Chemical Processes During Flushing Tests at Iffezheim Barrage(River Rhine)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川大学学报（工程科学版） 2005年第S1期37卷 7-15页

作者： silke WIEPRECHT Inst.of Hydraulic Eng. Univ.Stuttgart70550 StuttgartGermany

This paper analyzes the situation at the Iffezheim barrage along the fiver *** the start of operation in 1977 several million cubic meters of very fine sediment have been deposited in the ***- cause of stability problems and reduced safety in the event of flooding,an extraction of the material is neces- *** assays showed a high concentration of *** flushing without any additional measures is not *** order to leam more about the morphological and chemical in...

关键词： sedimentation in reservoirs flushing suspended material HCB

Treatment sequencing in metastatic castrate-resistant prostate cancer

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2014年第3期16卷 426-431页

作者： Oliver Sartor silke Gillessen Department of Medicine and Urology Tulane University School of Medicine New Orleans Louisiana USA Department of Medical Oncology Kantonsspital St. Gallen St. Gallen Switzerland.

Six different treatments have demonstrated improved survival in phase III trials targeted to patients with metastatic castration-resistant prostate cancer （mCRPC）. Front-line therapeutic options for mCRPC include docetaxel, sipuleuceI-T, abiraterone and radium-223. Post-docetaxel options include cabazitaxel, abiraterone, enzalutamide and radium-223. Despite much progress in recent years, much is yet unknown and debates occur over optimal treatment choices and sequences. None of the new agents have been compared to one another, thus physicians in practice today must make choices based on non-randomized comparisons, toxicity considerations and various assumptions. Abiraterone is now moving into the front line mCRPC space given recent regulatory approvals and enzalutamide will follow soon. Both of the hormonal agents have less toxicity when compared to chemotherapeutic options and both of these hormonal agents are expected to be used in a considerable number of mCRPC patients in the years ahead. Little data are available for the post-abiraterone or post-enzalutamide setting. In this review the currently available sequencing data are summarized and interpreted. It is now clear that cross resistance is a potential issue between various treatments, especially those agents that target the androgen axis. This review highlights the need for additional studies to optimize the current treatments for these patients.

关键词： abiraterone cabazitaxel castrate-resistant docetaxel enzalutamide~ radium-223 sipuleuceI-T

Sex estimation in a Turkish population using Purkait’s triangle:a virtual approach by 3-dimensional computed tomography(3D-CT)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forensic Sciences Research 2022年第2期7卷 97-105页

作者： Julieta G.García-Donas Suna Ors Ercan Inci Elena F.Kranioti Oguzhan Ekizoglu Negahnaz Moghaddam silke Grabherr Centre for anatomy and human identification school of science and engineeringUniversity of DundeescotlandUK Department of radiology Bakirkoy Training and research hospitalistanbulTurkey Department of Forensic science University of cretecreteGreece University center of Legal Medicine Lausanne-Geneva Lausanneswitzerland Unit of Forensic imaging and anthropology University center of Legal Medicine Lausanne-GenevaLausanneswitzerland Swiss human institute of Forensic Taphonomy University center of Legal Medicine Lausanne-GenevaLausanneswitzerland

Sex estimation is considered one of the first steps in the forensic identification *** and morphometrical differences between males and females have been used as means for morphoscopic and metric methods on both cranial and postcranial skeletal *** dry skeletal elements are not available,virtual data can be used as a *** present research explores 3-dimensional(3D)scans from a Turkish population to test a sex estimation method developed by Purkait(2005).Overall,296 individuals were used in this study(158 males and 138 females).Purkait’s triangle parameters were measured on computed tomography(CT)scans obtained from both right and left femora of each patient at the Bakirkoy *** Konuk Training Research Hospital(Istanbul,Turkey).Intra-and inter-observer errors were assessed for all variables through technical error of measurements *** asymmetry and sex differences were evaluated using parametric and non-parametric statistical *** and multivariate discriminant function analyses were then *** errors demonstrated an overall agreement within and between experts,as indicated by technical error of measurement(TEM)*** bilateral asymmetries were reported,and all parameters demonstrated a statistically significant difference between males and *** discriminant models were generated by applying single and combined parameters,producing a total correct sex classification ranging from 78.4%to 92.6%.In addition,over 67%of the total sample was accurately classified,with 95%or greater posterior *** study demonstrates the feasibility of 3D sex estimation using Purkait’s triangle on a Turkish population,with accuracy rates comparable to those reported in other *** is the first attempt to apply this method on virtual data and although further validation and standardisation are recommended for its application on dry bone,this research constitutes a signif

关键词： Forensic sciences forensic anthropology sex estimation computed tomography Purkait’s triangle

Step-up approach in emphysematous hepatitis: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2022年第2期14卷 464-470页

作者： silke Francois Maridi Aerts Hendrik Reynaert Ruth Van Lancker Johan Van Laethem Rastislav Kunda Nouredin Messaoudi Department of Gastroenterology Universitair Ziekenhuis BrusselBrussels 1090Belgium Department of Gastroenterology and Hepatology Vrije Universiteit BrusselUniversitair Ziekenhuis BrusselBrussels 1090Belgium Department of Intensive Care Vrije Universiteit BrusselUniversitair Ziekenhuis BrusselBrussels 1090Belgium Department of Infectious Diseaeses Vrije Universiteit BrusselUniversitair Ziekenhuis BrusselBrussels 1090Belgium Department of Surgery Vrije Universiteit BrusselUniversitair Ziekenhuis BrusselBrussels 1090Belgium Department of Surgery Europe HospitalsBrussels 1180Belgium

BACKGROUND Emphysematous hepatitis(EH)is a rare,rapidly progressive fulminant gasforming infection of the liver *** is often fatal and mostly affects diabetes *** SUMMARY We report a case of EH successfully managed by a step-up approach consisting of aggressive hemodynamic support,intravenous antibiotics,and percutaneous drainage,ultimately followed by laparoscopic *** 11 documented cases worldwide,only 1 of the patients survived,treated by urgent laparotomy and surgical *** EH is a life-threatening *** high mortality rate makes timely diagnosis essential,in order to navigate treatment accordingly.

关键词： Emphysematous hepatitis Septic shock Step-up approach Percutaneous drainage Laparoscopic deroofing Case report

Mechanisms of Optimal Defense Patterns in Nicotiana attenuata: Flowering Attenuates Herbivory-elicited Ethylene and Jasmonate Signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2011年第12期53卷 971-983页

作者： Celia Diezel silke Allmann Ian T.Baldwin Department of Molecular Ecology Max-Planck Institute for Chemical Ecology Jena 07745 Germany Department of Plant Physiology Swammerdam Institute for Life Sciences Amsterdam 1098 XH the Netherlands

To defend themselves against herbivore attack, plants produce secondary metabolites, which are variously inducible and constitutively deployed, presumably to optimize their fitness benefits in light of their fitness costs. Three phytohormones, jasmonates （JA） and their active forms, the JA-isoleucine （JA-Ile） and ethylene （ET）, are known to play central roles in the elicitation of induced defenses, but little is known about how this mediation changes over ontogeny. The Optimal Defense Theory （ODT） predicts changes in the costs and benefits of the different types of defenses and has been usefully extrapolated to their modes of deployment. Here we studied whether the herbivore-induced accumulation of JA, JA-Ile and ET changed over ontogeny in Nicotiana attenuata, a native tobacco in which inducible defenses are particularly well studied. Herbivore-elicited ET production changed dramatically during six developmental stages, from rosette through flowering, decreasing with the elongation of the first corollas during flower development. This decrease was largely recovered within a day after flower removal by decapitation. A similar pattern was found for the herbivore-induced accumulation of JA and JA-Ile. These results are consistent with ODT predictions and suggest that the last steps in floral development control the inducibility of at least three plant hormones, optimizing defense-growth tradeoffs.

关键词： flowering jasmonic acid jasmonic acid-isoleucine ethylene Manduca sexta Nicotiana attenuata ontogeny optimal defense theory plant-herbivore interactions.

The Earliest Acupuncture and Moxibustion Manuscript Was Found in Dunhuang

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2011年第6期17卷 471-472页

作者：赵琪 silke Assmus-Helfen Medical Center of Acupuncture and Moxibustion Beijing Hospital of Integrated Chinese and Western Medicine The University of Bonn

In 1900, around 50 000 books and manuscripts were discovered in the Mogao Grottoes of Dunhuang in Gansu Province, China. Known today as the ＂Dunhuang Heritage＂, this trove had been sealed in a cave for close on 900 years. Among the books, there was a volume entitled ＂New Compendium of Works on Moxibustion for Emergencies （新集备急炙经）＂. It is the earliest original manuscript for the collection of acupuncture papers at present and is particularly precious as not having been found recorded in any ancient books.

关键词： The Earliest Acupuncture and Moxibustion Manuscript Was Found in Dunhuang

Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第2期14卷 115-123页

作者： Sailas BENJAMIN silke FLOTHO Torsten BRCHERS Friedrich SPENER Department of Biochemistry University of Münster48149 MünsterGermany Enzyme Technology Laboratory Biotechnology DivisionDepartment of BotanyUniversity of CalicutKerala 673 635India Department of Molecular Biosciences Lipidomics Research CenterUniversity of GrazHeinrichstrasse 318010 GrazAustria

The purpose of this study was to examine the induction profiles(as judged by quantitative reverse transcription polymerase chain reaction(qRT-PCR)) of peroxisome proliferator-activated receptor(PPAR) α,β,γ subtypes and major PPAR-target genes bearing a functional peroxisome proliferator responsive element(PPRE) in HepG2 cell model upon feeding with cis-9,trans-11-octadecadienoic acid(9-CLA) or trans-10,cis-12-octadecadienoic acid(10-CLA) or their precursor fatty acids(FAs).HepG2 cells were treated with 100 μmol/L 9-CLA or 10-CLA or their precursor FAs,viz.,oleic,linoleic,and trans-11-vaccenic acids against bezafibrate control to evaluate the induction/expression profiles of PPAR α,β,γ subtypes and major PPAR-target genes bearing a functional PPRE,i.e.,fatty acid transporter(FAT),glucose transporter-2(GLUT-2),liver-type FA binding protein(L-FABP),acyl CoA oxidase-1(ACOX-1),and peroxisomal bifunctional enzyme(PBE) with reference to β-actin as house keeping *** the three housekeeping genes(glyceraldehyde 3-phosphate dehydrogenase(GAPDH),β-actin,and ubiquitin),β-actin was found to be *** sulfoxide(DMSO),the common solubilizer of agonists,showed a significantly higher induction of genes ***-PCR profiles of CLAs and their precursor FAs clearly showed upregulation of FAT,GLUT-2,and L-FABP(～0.5-2.0-fold).Compared to 10-CLA,9-CLA decreased the induction of the FA metabolizing gene ACOX-1 less than did PBE,while 10-CLA decreased the induction of PBE less than did *** CLAs and precursor FAs upregulated PPRE-bearing genes,but with comparatively less or marginal activation of PPAR *** indicates that the binding of CLAs and their precursor FAs to PPAR subtypes results in PPAR activation,thereby induction of the target transporter genes coupled with downstream lipid metabolising genes such as ACOX-1 and *** sum up,the expression profiles of these candidate genes showed that CLAs and their precursor FAs are involved in lipid signalling

关键词：晶状体上皮细胞蛋白质组分细胞增殖姜黄素

Integrated colloidal quantum dot photodetectors with color-tunable plasmonic nanofocusing lenses

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2015年第1期4卷 538-544页

作者： silke L Diedenhofen Dominik Kufer Tania Lasanta Gerasimos Konstantatos ICFO-Institut de Ciencies Fotoniques Barcelona 08860Spain

High-sensitivity photodetection is at the heart of many optoelectronic applications,including spectroscopy,imaging,surveillance,remote sensing and medical *** the highest possible sensitivity for a given photodetector technology requires the development of ultra-small-footprint detectors,as the noise sources scale with the area of the *** must be accomplished while sacrificing neither the optically active area of the detector nor its ***,such designs are based on diffraction-limited approaches using optical ***,we employ a plasmonic flat-lens bull’s eye structure(BES)to concentrate and focus light into a nanoscale colloidal quantum dot(CQD)*** plasmonic lenses function as nanofocusing resonant structures that simultaneously offer color selectivity and enhanced ***,we demonstrate the first CQD photodetector with a nanoscale footprint,the optically active area of which is determined by the BES;this detector represents an exciting opportunity for high-sensitivity sensing.

关键词： PbS quantum dots photodetectors plasmonic bull’s eye structures plasmonic lens

Affairs happen---to whom？ A study on extrapair paternity in common nightingales

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2017年第4期63卷 421-431页

作者： Conny LANDGRAF Kerstin WILHELM Jutta WIRTH Michael WEISS silke KIPPER Leibniz Institute for Zoo and Wildlife Research (IZW) Alfred-Kowalke-StraBe 17 10315 Berlin Germany Animal Behavior Group Free University of Berlin TakustraBe 6 14195 Berlin Germany Institute of Evolutionary Ecology and Conservation Genomics University of UIm Albert Einstein Allee 11 89069 UIm Germany Behavioural Ecology Group Department of Animal Sciences Wageningen University De Elst 1 6708 WD Wageningen The Netherlands Department of Exposition Unit Epidemiology Statistics and Mathematical Modelling Federal Institute for Risk Assessment (BfR) Max-Dohrn-Str. 8-10 10589 Berlin Germany Chair of Zoology School of Life Sciences Weihenstephan Technische Universitat Munchen LieseI-Beckmann-StraBe 4 85350 Freising Germany

Most birds engage in extrapair copulations despite great differences across and within species. Besides cost and benefit considerations of the two sex environmental factors have been found to alter mating strategies within or between populations and/or over time. For socially monogamous species, the main advantage that females might gain from mating with multiple males is probably increasing their offspring's genetic fitness. Since male (genetic) quality is mostly not directly measurable for female birds, (extrapair) mate choice is based on male secondary traits. In passerines male song is such a sexual ornament indicating male phenotypic and/or genetic quality and song repertoires seem to affect female mate choice in a number of species. Yet their role in extrapair mating behavior is not well understood. In this study, we investigated the proportion of extrapair paternity (EPP) in a population of common nightingales . We found that EPP rate was rather high (21.5% of all offspring tested) for a species without sexual dimorphism and high levels of paternal care. Furthermore, the occurrence of EPP was strongly related to the spatial distribution of male territories with males settling in densely occupied areas having higher proportions of extrapair young within their own brood. Also, song repertoire size affected EPP: here larger repertoires of social mates were negatively related to the probability of being cuckolded. When directly comparing repertoires sizes of social and extrapair mates, extrapair mates tended to have larger repertoires. We finally discuss our results as a hint for a flexible mating strategy in nightingales where several factors-including ecological as well as male song features-need to be considered when studying reproductive behavior in monogamous species with complex song.

关键词：亲子鉴定夜莺一夫一妻制交配策略 EPP 种内差异环境因素直接测量