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辽宁教育研究 2007年第9期 39-43页

作者：郭思乐华南师范大学广东广州510631

今天,国家正在实施素质教育战略、教育创新战略和教育均衡发展战略,而实现上述战略的突破口应该大力开展生本教育。生本教育处在教育环境的核心,既能改变教育环境,又能对教育环境提出要求。生本教育提高了学生的素质和创新意识,保证了... 详细信息

今天,国家正在实施素质教育战略、教育创新战略和教育均衡发展战略,而实现上述战略的突破口应该大力开展生本教育。生本教育处在教育环境的核心,既能改变教育环境,又能对教育环境提出要求。生本教育提高了学生的素质和创新意识,保证了教育的均衡发展。

关键词：微观教育研究战略决策生本教育

Smooth muscle AKG/OXGR1 signaling regulates epididymal fluid acid–base balance and sperm maturation

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Life Metabolism 2022年第1期1卷 67-80页

作者： Chang Xu Yexian Yuan Cha Zhang Yuchuan Zhou Jinping Yang Huadong Yi Ishwari Gyawali Jingyi Lu sile guo Yunru Ji Chengquan Tan Songbo Wang Yongliang Zhang Qingyan Jiang Gang Shu Guangdong Laboratory for Lingnan Modern Agriculture National Engineering Research Center for Breeding Swine Industry and Guangdong Province Key Laboratory of Animal Nutritional RegulationCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouGuangdongChina International Peace Maternity and Child Health Hospital Shanghai Key Laboratory of Embryo Original DiseasesSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory for Aquatic Economic AnimalsSchool of Life SciencesSun Yat-Sen UniversityGuangzhouChina

Infertility is a global concern attributed to genetic defects,lifestyle,nutrition,and any other factors that affect the local metabolism and niche microenvironment of the reproductive system.2-Oxoglutarate receptor 1(OXGR1)is abundantly expressed in the testis;however,its cellular distribution and biological function of OXGR1 in the male reproductive system remain *** the current study,we demonstrated that OXGR1 is primarily expressed in epididymal smooth muscle cells(SMCs).Aging and heat stress significantly reduced OXGR1 expression in the *** OXGR1 global knockout and epididymal-specific OXGR1 knockdown models,we revealed that OXGR1 is essential for epididymal sperm maturation and fluid acid–base *** ofα-ketoglutaric acid(AKG),the endogenous ligand of OXGR1,effectively reversed epididymal sperm maturation disorders caused by aging and heat ***,in vitro studies showed that AKG markedly stimulated the release of instantaneous intracellular calcium from epididymal SMCs and substantially reduced the pH_(i) value in the epididymal SMCs via ***,we discovered that AKG/OXGR1 considerably increased the expression of Na^(+)/HCO_(3)^(−)cotransporter(NBCe1)mRNA in the epididymal SMCs,mediated by intracellular calcium *** local AKG/OXGR1 system changed the epididymal fluid pH value and HCO_(3)^(−)concentration,thereby regulating sperm maturation via intracellular calcium signaling and NBCe1 mRNA *** study for the first time reveals the crucial role of OXGR1 in male fertility and sheds light on the applicability of metabolic intermediates in the nutritional intervention of reproduction.

关键词： AKG OXGR1 epididymis acid-base balance sperm maturation

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为什么在教育中要说起生命

现代教育论丛 2007年第1期 13-15页

作者：郭思乐华南师范大学

成长之享受是儿童生命提升的动力。教育的目的是最大限度地开发人的生命潜能。在教育中强调对生命的深刻而全面的认识,是教育得以根本变革的关键所在。

关键词：生命潜能教育的生命机制

Smooth muscle AKG/OXGR1 signaling regulates epididymal fuid acid-base balance and sperm maturation

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Life Metabolism 2022年第01期 67-80页

作者： Chang Xu Yexian Yuan Cha Zhang Yuchuan Zhou Jinping Yang Huadong Yi Ishwari Gyawali Jingyi Lu sile guo Yunru Ji Chengquan Tan Songbo Wang Yongliang Zhang Qingyan Jiang Gang Shu Guangdong Laboratory for Lingnan Modern Agriculture National Engineering Research Center for Breeding Swine Industry and Guangdong Province Key Laboratory of Animal Nutritional Regulation College of Animal Science South China Agricultural University International Peace Maternity and Child Health Hospital Shanghai Key Laboratory of Embryo Original Diseases School of Medicine Shanghai Jiao Tong University State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory for Aquatic Economic Animals School of Life Sciences Sun Yat-Sen University

Infertility is a global concern attributed to genetic defects, lifestyle, nutrition, and any other factors that affect the local metabolism and niche microenvironment of the reproductive system. 2-Oxoglutarate receptor 1（OXGR1） is abundantly expressed in the testis; however, its cellular distribution and biological function of OXGR1 in the male reproductive system remain unclear. In the current study, we demonstrated that OXGR1 is primarily expressed in epididymal smooth muscle cells（SMCs）. Aging and heat stress signifcantly reduced OXGR1 expression in the epididymis. Using OXGR1 global knockout and epididymal-specifc OXGR1 knockdown models, we revealed that OXGR1 is essential for epididymal sperm maturation and fuid acid-base balance. Supplementation of α-ketoglutaric acid（AKG）, the endogenous ligand of OXGR1, effectively reversed epididymal sperm maturation disorders caused by aging and heat stress. Furthermore, in vitro studies showed that AKG markedly stimulated the release of instantaneous intracellular calcium from epididymal SMCs and substantially reduced the p Hi value in the epididymal SMCs via OXGR1. Mechanistically, we discovered that AKG/OXGR1 considerably increased the expression of Na+/HCO3-cotransporter（NBCe1） m RNA in the epididymal SMCs, mediated by intracellular calcium signaling. The local AKG/OXGR1 system changed the epididymal fuid p H value and HCO3-concentration, thereby regulating sperm maturation via intracellular calcium signaling and NBCe1 m RNA expression. This study for the frst time reveals the crucial role of OXGR1 in male fertility and sheds light on the applicability of metabolic intermediates in the nutritional intervention of reproduction.

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华南地区规模化羊场建设存在的问题与建议

黑龙江畜牧兽医 2021年第21期 69-73页

作者：郭思乐邱金戈柳广斌刘德武邓铭华南农业大学动物科学学院广州510642

华南地区得益于地理气候、市场需求和政府政策等优势,肉羊养殖产业具有很大的发展潜力,但在客观上存在着制约因素和发展短板,如可利用耕地紧缺、大面积牧场不足、饲料成本高等。为了给华南地区养殖户规范建造规模化羊场提供参考,以适应... 详细信息

华南地区得益于地理气候、市场需求和政府政策等优势,肉羊养殖产业具有很大的发展潜力,但在客观上存在着制约因素和发展短板,如可利用耕地紧缺、大面积牧场不足、饲料成本高等。为了给华南地区养殖户规范建造规模化羊场提供参考,以适应热带或亚热带季风气候特点和山羊产业发展现状,促进华南地区养羊业安全、健康、可持续发展,经在广东省多地羊场进行调研,分析羊场建设存在的问题,发现羊舍建造设计不合理以及场内机械化水平不高是导致羊场生产效益低下的重要原因。针对上述问题,提出了选址要符合畜牧业发展规划和养殖场建设标准,栏舍要科学统筹布局、选择适宜建设类型、规范生产设施设备、保持良好饲养环境等建议。

关键词：华南地区规模化羊场羊舍建设规划布局存在问题

基于S7-200 PLC的满箱检验机控制系统的开发

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可编程控制器与工厂自动化 2007年第11期 95-96页

作者：梁敏敏马思乐国新毅山东大学控制科学与工程学院

针对我国满箱检测设备大部分依赖进口、自主设备较少的弊端,设计开发了一套满箱检测系统,本文阐述了该满箱检测设备控制系统的设计思想和原则,系统结构、软硬件设计方法及其功能。

关键词： PLC 传感器监控

基于响应面法Pt-Li_(2)O-Al_(2)O_(3)催化甘油水蒸气重整制氢工艺优化

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化工科技 2024年第1期32卷 36-41页

作者：万鑫雅刘思乐赵诗曼郭思源沈阳科技学院化学与化工系辽宁沈阳110167

采用等体积分步浸渍法制备Pt-Li_(2)O-Al_(2)O_(3)催化剂,以甘油为原料,氢产率为评价指标,运用响应面法的Box-Behnken设计对甘油水蒸气重整制氢工艺进行优化。采用SEM、BET等手段对Pt-Li_(2)O-Al_(2)O_(3)催化剂物相、比表面积进行表征... 详细信息

采用等体积分步浸渍法制备Pt-Li_(2)O-Al_(2)O_(3)催化剂,以甘油为原料,氢产率为评价指标,运用响应面法的Box-Behnken设计对甘油水蒸气重整制氢工艺进行优化。采用SEM、BET等手段对Pt-Li_(2)O-Al_(2)O_(3)催化剂物相、比表面积进行表征,同时采用相机对催化剂使用前后的积碳情况进行观察、分析。结果表明,t=632℃、n(水)∶n(甘油)=26、甘油液空速为0.17 h^(-1),氢产率为5.445、5.428,与模型预测的氢产率5.390比较接近。Pt-Li_(2)O/Al_(2)O_(3)催化剂表面比较粗糙,呈疏松、多孔状的结构,有较大的平均孔半径和总孔容积,具有良好的抗积碳性能。

关键词：响应面法甘油制氢

Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction

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Journal of Genetics and Genomics 2018年第8期45卷 419-432页

作者： Lu Qiao Yajun Yang Pengcheng Fu sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology (PICB) Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences CAS Shanghai 200031 China State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai 200433 China Fudan-Taizhou Institute of Health Sciences Taizhou 225300 China Department of Neurology The First People's Hospital of Chenzhou Hunan 423000 China Collaborative Innovation Center of Genetics and Development Shanghai 200438 China Department of Biochemistry and Molecular Biology Preclinical Medicine College Xinjiang Medical University Urumqi 830011 China Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming 650223 China School of Life Science and Technology ShanghaiTech University Shanghai 201210 China

It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics, Genome-wide associ- ation studies （GWAS） were conducted on a discovery panel of Uyghurs, Six significant loci were iden- tified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios.

关键词： Genome-wide association study Dense 3D facial image Ancestry-divergent phenotypes Face prediction Forensic scenario

高速铁路牵引供电系统短路故障变压器异常声响分析

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铁道机车车辆 2022年第1期42卷 121-126页

作者：郭旭刚杨斯泐中国铁道科学研究院集团有限公司机车车辆研究所

通过对故障牵引变电所电气参数进行实时采样记录，对牵引供电系统短路故障后变电所异常声响实时监测数据进行详细分析，通过对问题及数据深度挖掘，找出了异常声响的真实原因，重现了故障发生的全过程。

关键词：短路故障牵引供电综合接地牵引变压器

基于DDRTS的高速铁路全并联AT牵引供电系统研究

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北京交通大学学报 2017年第2期41卷 123-130页

作者：郭旭刚郭晨曦李强杨斯泐王坤中国铁道科学研究院机车车辆研究所北京100081

牵引供电系统是高速铁路的重要子系统之一,其安全和高效地运行是高速铁路可靠性运行的重要保障.本文详细讨论其数学等值模型,基于DDRTS(数字动态实时仿真)搭建了全并联AT高速铁路牵引供电仿真系统,进行不同类型的短路故障模拟仿真并与... 详细信息

牵引供电系统是高速铁路的重要子系统之一,其安全和高效地运行是高速铁路可靠性运行的重要保障.本文详细讨论其数学等值模型,基于DDRTS(数字动态实时仿真)搭建了全并联AT高速铁路牵引供电仿真系统,进行不同类型的短路故障模拟仿真并与现场实测试验数据对比.试验和仿真结果表明:基于DDRTS建立的全并联AT牵引供电仿真系统,能够准确模拟实际供电线路不同故障情况下的电流分布情况.此系统的建立为牵引供电系统工程设计和应用提供重要的理论依据.

关键词： AT供电系统数字动态实时仿真电流分布