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Integrin Alpha-v Beta-3-Matrix Metalloproteinase-2 (MMP-2), Cross-Talk

Journal of Cancer Therapy 2015年第9期6卷 793-802页

作者： Hrishikesh sil Amitava Chatterjee Department of Receptor Biology & Tumor Metastasis Chittaranjan National Cancer Institute Kolkata India Ramakrishna Mission vivekananda University (IRDM) Narendrapur Kolkata India

The present study aimed to detect comparative expression of integrin αvβ3 and its involvement in expression and activation of matrix metalloproteinase-2 (MMP-2) in 25 malignant human breast tumor and adjacent normal breast tissues from different clinical TNM stages (DCIS to T4) of the disease and possible involvement of known regulating parameters of MMP-2 like TIMP-2, MT1-MMP and EMPRIN. Integrin αvβ3 was highly expressed in tumors than adjacent normal breast tissues. Pro-MMP-2(72-KD) was mainly expressed in adjacent normal tissues compared to tumors. The mature forms of MMP-2 (68 KD and 64 KD) were found only in tumors. Appreciable expression of TIMP-2 and induction of MT1-MMP and EMPRIN in T2-T4 stages suggested their possible role in MMP-2 activation. Over expression Integrin αvβ3 in tumors than adjacent normal breast tissues was an indication of cancer progression with involvement of integrin signaling. We conclude that, the co-precipitation of MMP-2 with αvβ3 by anti-αv antibody is a strong indication that integrin αvβ3 is a surface receptor for MMP-2 and αvβ3-MMP-2 complex on the surface of tumor cells may play a very important role in determining the invasive property and malignant behavior of tumor tissues. The positive expression of endogenous inhibitor of MMP-2, TIMP-2 may have an appreciable role in activation of this protease and risk of malignancy in advanced stage of the disease. The enhanced expression of MT1-MMP and EMPRIN suggested a role for these factors in gelatinase regulation. However the exact mechanism(s) remains to be investigated. Finally, evaluation of integrin αvβ3 associated MMP-2 expression and activity may add valuable information and can possibly be therapeutic target. The clinical exploitation of integrins will provide oncologists with novel therapeutic strategies for the treatment of malignancy in breast cancer.

关键词： Breast Cancer MMP-2 Alpha v Beta3 MT1-MMP TIMP-2 EMPRIN vEGF

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Phenotype and Epidemiological Profile of Children with Sickle Cell Disease Followed-Up at the Mother and Child Hospital of N’Djamena

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Open Journal of Pediatrics 2016年第3期6卷 237-244页

作者： Franck Houndjahoue silé Souam Nguele Mbanga Djimadoum Joséphine Toralta Khadidja Attimer Hagre Youssouf Blaise Ayivi Pediatric Unit Mother and Child Hospital N’Djamena Chad Unit of Hematology National Referral General Hospital N’Djamena Chad Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin

In Africa, sickle cell disease is still a public health issue. In Chad, a high prevalence area, it may represent a silent disease. To study the quality of care provided to children with sickle cell disease within the framework of a hospital initiative launched in 2011 and in the absence of a national program in Chad, we conducted this research in the pediatric sickle cell disease center of the Mother and Child Hospital of N’Djamena. This was a cross-sectional study, involving 364 children with sickle cell disease out of 12,500 children followed up from May 2011 to December 2014 (3.9%). The sex ratio was 1.3. The average age at diagnosis was 17 months, often in the context of vaso-occlusive crisis (34.6%). The follow-up protocol included monthly appointments following diagnosis of disease. We observed 80% non-compliance among cases;characteristics associated with non-compliance included families with several children, inaccessible anti-pneumococcal prophylaxis based on Penicillin v and very low anti-pneumococcal vaccine coverage (4.4%). These results suggest that there is a need to rapidly implement a national sickle cell disease program including preventive and curative care in Chad.

关键词： Sickle Cell Disease Pediatrics National Program Chad

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An approach to operational risk modeling and estimation of safety levels for deep water work class remotely operated vehicle-A case study with reference to ROSUB 6000

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Journal of Ocean Engineering and Science 2016年第2期1卷 109-118页

作者： N.vedachalam R.Ramesh v.B.N.Jyothi G.A.Ramadass M.A.Atmanand National Institute of Ocean Technology ChennaiIndia

This paper presents a quantitative approach to operational risk modeling and estimation of safety integrity levels,required for the deep water electric work class remotely operated vehicle with reference to ROSUB6000 developed by the National Institute of Ocean Technology,***6000 is used for carrying out bathymetric surveys,gas hydrate surveys,poly-metallic nodule exploration,salvage operations,and meeting emergency response *** system is expected to be in operation for a period of 300 h per year,and has to be extremely safe and *** and models for the quantitative assessment of operational safety and estimation of safety integrity levels for ROv are seldom available in the deep water intervention *** safety instrumented functions implemented in the ROv should be able to meet the sil requirements of specific *** study indicates that the required safety factors are implemented into the design of the state-of-the-art ROv ROSUB 6000,considering IEC 61508/61511 recommendations on Health,Safety and Environment and it is found that the system is able to meet the required sil for seven identified *** paper gives the design and safety engineers in the ROv industry,an overview of the numerical operational risk assessment methods and safety-centered ROv engineering.

关键词： Remotely operated vehicle HSE Safety integrity level Safety instrumented function

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Anticlockwise metamorphic paths at ca.890–790 Ma from the NE Baidrag block,Mongolia,indicate back-arc compression at the Rodinia periphery

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Geoscience Frontiers 2023年第2期14卷 154-181页

作者： PavlaŠtípská vít Peresty Igor Soejono Karel Schulmann RCAndrew Kylander-Clark Carmen Aguilar Stephen Collett Martin Racek Jitka Míková Otgonbaatar Dorjsuren Nikol Novotná Czech Geological Survey 11821 Praha 1Czech Republic Institute of Petrology and Structural Geology Charles University in PragueAlbertov 6Praha 212800Czech Republic Institut Terre et Environnement de Strasbourg UMR 7063 Universitéde Strasbourg-CNRS1 Rue Blessig67084 StrasbourgCedexFrance Department of Earth Science University of CaliforniaSanta BarbaraCA 93106United States Department of Mineralogy Petrology and Applied GeologyFaculty of Earth ScienceUniversity of Barcelona08028 BarcelonaSpain Institute of Geology Mongolian Academy of SciencesLabor Union StreetSonginokhairkhan DistrictUlaanbaatar 18080Mongolia

The processes leading to the assembly of the Rodinia supercontinent through Grenvillian collisional orogeny are relatively well *** contrast,accretionary orogenic processes occurring at the supercontinent periphery following Rodinia assembly are poorly *** fill this gap,we have identified metamorphic rocks in the Mongolia collage of the Central Asian Orogenic Belt,where numerous data testify for Meso-to Neoproterozoic magmatic *** tectono-metamorphic evolution of the periSiberian tract of the Central Asian Orogenic Belt is mainly characterized by the late Proterozoic–early Cambrian(Baikalian)***,we document here a Tonian age metamorphism at the northern part of the Precambrian Baidrag block,previously considered as a typical example of the Baikalian metamorphic *** study incorporates zircon and in-situ monazite geochronology linked to P-T modelling of Grt-sil-Ky migmatite gneiss and Grt-St ***-sil-Ky gneiss records initial burial to the sillimanite stability field at 720℃ and 6.0 kbar followed by further burial to the kyanite stability field at 750℃ and 9 kbar and decompression to 650℃ and 8 *** Grt-St schist records initial burial to the staurolite stability field at 620℃ and 6 kbar,followed by further burial to 590℃ and 8.5 *** monazite data yield a continuum of ^(207)Pb-corrected ^(238)U/^(206)Pb dates of ca.926–768 Ma in the Grt-sil-Ky gneiss,and ca.937–754 Ma in the Grt-St *** on monazite textural positon,internal zoning,and REE patterns,the time of prograde burial to 6.0 kbar under a thermal gradient of 27–32℃/km is estimated at ca.890–853 *** is not clear whether such high-grade conditions prevailed until a phase of further burial under a geothermal gradient of 18–22℃/km dated at ca.835–815 *** late monazite recrystallization at ca.790 Ma is related to ***,monazite with dates of ca.568–515 Ma occur as whole grains or as rims with sharp boundaries on Tonian monaz

关键词： Central Asian Orogenic Belt Grenvillian-age metamorphism Monazite in-situ U-Pb dating Monazite REE composition Zircon U-Pb dating Thermodynamic modelling

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反相高效液相色谱法同时检测片剂中的头孢呋辛酯及奥硝唑(英文)

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色谱 2008年第6期26卷 763-765页

作者： RANJANE Poonam N GANDHI Santosh v KADUKAR Sayali S RANHER Sandeep S Department of Pharmaceutical Analysis A.I.S.S.M.S.College of Pharmacy

A simple,accurate and sensitive reversed-phase high performance liquid chromatographic(RP-HPLC)method for the simultaneous determination of cefuroxime axetil and ornidazole in combined tablet dosage form has been *** method was performed with a HiQ-sil C18 column(250 mm×4.6 mm)and photodiode array(PDA)detector,using 0.01 mol/L potassium dihydrogen orthophosphate-methanol(56∶44,v/v)as the mobile phase and tinidazole as the internal ***'s law obeys in the concentration ranges of 5-25 μg/mL and 10-50 μg/mL for cefuroxime axetil and ornidazole,*** method has been successfully validated statistically and applied for the analysis of the drugs in pharmaceutical formulation.

关键词：测定方法头孢呋辛酯奥硝唑片剂药物分析反相高效液相色谱法

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