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Numerical study of short-circuiting flow and particles in a gas cyclone

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Particuology 2023年第1期72卷 81-93页

作者： sijie dong Chenwen Wang Zihui Zhang Qinyu Cai Kejun dong Teng Cheng Bo Wang Key Laboratory of Western China’s Environmental Systems of Ministry of Education Engineering Research Center of Fine Particle Pollution Control Technology and Equipment of Gansu ProvinceCollege of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Key Laboratory of Resource Environment and Sustainable Development of Oasis of Gansu Province College of Geography and Environmental ScienceNorthwest Normal UniversityLanzhou 730000China Center for Infrastructure Engineering Western Sydney UniversityPenrithNSW 2751Australia

Short-circuiting flow is an important secondary flow in gas cyclones, which has a negative impact on the separation performance. To improve the understanding of the short-circuiting flow and guide the optimization of gas cyclones, this paper presents a numerical study of a cyclone using computational fluid dynamics. Based on the steady flow field, three methods were adopted to investigate the formation mechanism and characteristics of the short-circuiting flow and particles. The temporal variation of the tracer species concentration distribution reveals that the formation mechanism of the short-circuiting flow is the squeeze between the airflows entering the annular space of the gas cyclone at different times. The short-circuiting flow region, distinguished through the spatial distribution of the moments of age, is characterized by a small mean age and a large coefficient of variation. The proportion of the short-circuiting particles increases with the increase of the inlet velocity only for small particles. But with the increase of particle size, the proportion of the short-circuiting particles decreases faster at higher inlet velocities, resulting in significant differences in collection efficiency curves.

关键词： Gas cyclone Short-circuiting flow Computational fluid dynamics Species transport Moment of age Particle tracking

不同挤压载荷下方形锂离子电池的力学响应特性研究

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应用力学学报 2024年第4期41卷 797-803页

作者：刘南南张新春董思捷汪玉林尹啸笛张涛华北电力大学机械工程系保定071003 河北省电力机械装备健康维护与失效预防重点实验室保定071003

为实现动力电池在机械载荷下安全防护设计的要求,对不同挤压载荷下方形锂离子电池的力学响应特性进行了研究。首先,对方形锂离子电池进行平面压缩和局部压痕试验,给出了电池的挤压力学响应和内部结构的失效机制;其次,建立方形锂离子电... 详细信息

为实现动力电池在机械载荷下安全防护设计的要求,对不同挤压载荷下方形锂离子电池的力学响应特性进行了研究。首先,对方形锂离子电池进行平面压缩和局部压痕试验,给出了电池的挤压力学响应和内部结构的失效机制;其次,建立方形锂离子电池的有限元模型,研究了不同挤压载荷下电池的力-位移曲线,讨论了不同挤压形式对锂离子电池力学响应的影响。研究结果表明:有限元分析结果与试验结果基本吻合,平面压缩将导致电池内部出现拉伸引起的面内断裂模式,而局部压痕将导致剪切引起的层间断裂模式;锂离子电池在不同挤压载荷下的力学响应受压头尺寸的影响,随着压头尺寸的减小,电池承受的载荷和失效位移会有不同程度减小。

关键词：方形锂离子电池挤压载荷力学响应失效机理

Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2970-2983页

作者： Qi Yang Bao Xue Fengjiang Liu Yongzhi Lu Jielin Tang Mengrong Yan Qiong Wu Ruyi Chen Anqi Zhou Lijie Liu Junjun Liu Changbin Qu Qingxin Wu Muqing Fu Jiayi Zhong Jianwei dong sijie Chen Fan Wang Yuan Zhou Jie Zheng Wei Peng Jinsai Shang Xinwen Chen Guangzhou National Laboratory Guangzhou 510005China State Key Laboratory of Respiratory Disease Guangzhou Medical UniversityGuangzhou 511436China Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436China GMUGIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 511436China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China School of Pharmaceutical Science and Technology Hangzhou lnstitute for Advanced StudyUCASHangzhou 310024China

Respiratory syncytial virus(RSV)is the major cause of bronchiolitis and pneumonia in young children and the *** are currently no approved RSV-specific therapeutic small molecules *** high-throughput antiviral screening,we identified an oral drug,the prenylation inhibitor lonafarnib,which showed potent inhibition of the RSV fusion *** exhibited antiviral activity against both the RSV A and B genotypes and showed low cytotoxicity in HEp-2 and human primary bronchial epithelial cells(HBEC).Time-of-addition and pseudovirus assays demonstrated that lonafarnib inhibits RSV entry,but has farnesyltransferase-independent antiviral ***-electron microscopy revealed that lonafarnib binds to a triple-symmetric pocket within the central cavity of the RSV F metastable pre-fusion *** at the RSV F sites interacting with lonafarnib showed resistance to lonafarnib but remained fully sensitive to the neutralizing monoclonal antibody ***,lonafarnib dose-dependently reduced the replication of RSV in BALB/c ***,lonafarnib could be a potential fusion inhibitor for RSV infection.

关键词： neutral metastable approved

不同挤压载荷下圆柱形锂离子电池的失效机理试验研究

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中国机械工程 2022年第8期33卷 915-920,951页

作者：董思捷张新春汪玉林刘南南陈学晋华北电力大学机械工程系保定071003 河北省电力机械装备健康维护与失效预防重点实验室保定071003

为满足电动汽车动力电池组耐撞性设计的要求,对不同机械滥用工况下锂离子电池单体的失效机理进行了试验研究。通过对三种不同容量的NCR18650圆柱形锂离子电池进行局部压痕和平面压缩加载试验,研究了锂离子电池样本的力-电-热响应,给出... 详细信息

为满足电动汽车动力电池组耐撞性设计的要求,对不同机械滥用工况下锂离子电池单体的失效机理进行了试验研究。通过对三种不同容量的NCR18650圆柱形锂离子电池进行局部压痕和平面压缩加载试验,研究了锂离子电池样本的力-电-热响应,给出了失效电池样本的横截面破坏形式,具体讨论了加载形式和电池容量对锂离子电池失效的影响。研究结果表明,局部压痕和平面压缩将导致电池分别出现内短路和外短路两种触发失效模式。随着额定容量的提高,电池的承载能力降低,从而导致失效位移减小。机械加载形式和额定容量亦对电池表面温度变化有重要影响,局部压痕失效后电池达到的最高表面温度较高,中等容量电池的表面温度变化相对平稳。

关键词：锂离子电池电池容量挤压载荷力-电-热响应失效机理

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入口位置对多入口旋风分离器性能的影响

环境工程学报 2021年第2期15卷 618-625页

作者：董思捷杨柳张子慧王博姜云超兰州大学资源环境学院甘肃省细颗粒物污染控制技术与装备工程研究中心兰州730000 中国石化催化剂有限公司长岭分公司岳阳414012

对称多入口结构有助于提高旋风分离器的性能,但入口位置的选择尚无明确的规范。在Lapple型旋风分离器的基础上,设计了4种不同入口位置的四入口旋风分离器,并采用数值模拟方法研究了入口位置对于其流场和分离性能的影响。结果表明:当入... 详细信息

对称多入口结构有助于提高旋风分离器的性能,但入口位置的选择尚无明确的规范。在Lapple型旋风分离器的基础上,设计了4种不同入口位置的四入口旋风分离器,并采用数值模拟方法研究了入口位置对于其流场和分离性能的影响。结果表明:当入口在径向外侧时,切向速度能够保持稳定,短路流量占比较低,此时压降较低,分离效率较高;而当入口在径向内侧时,切向速度会降低,短路流量占比增大,此时压降降低,分离效率也大幅下降。入口在轴向方向的位置对于流场和性能的影响并不明显,而径向外侧、轴向上方的入口设计为最优方案。

关键词：旋风分离器除尘多入口入口位置数值模拟流场

A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3112-3129页

作者： Yuzheng Zhou Zongpeng Chen sijie Liu Sixu Liu Yujie Liao Ashuai Du Zijun dong Yongxing Zhang Xuan Chen Siyi Tao Xin Wu Aroona Razzaq Gang Xu De-an Tan Shanni Li Youwen Deng Jian Peng Shuyan Dai Xu Deng Xianwen Zhang Taijiao Jiang Zheng Zhang Gong Cheng Jincun Zhao Zanxian Xia Department of Cell Biology School of Life SciencesCentral South University410013 ChangshaChina Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and Technology518112 ShenzhenChina Department of Basic Medicine School of MedicineHunan Normal University410081 ChangshaChina Department of spine surgery The Third Xiangya HospitalCentral South University410013 ChangshaChina School of Basic Medical Sciences Anhui Medical University230032 HefeiChina Hunan Key Laboratory of Neurorestoratology 921 Hospital of Joint Logistics Support Force People’s Liberation Army of China(The Second Affiliated Hospital of Hunan Normal University)410003 ChangshaHunanChina Department of Geriatric Surgery Xiangya HospitalCentral South University410008 ChangshaChina Xiangya School of Pharmaceutical Sciences Central South University410013 ChangshaChina Institute of Infectious Diseases Shenzhen Bay Laboratory518132 ShenzhenChina Guangzhou Laboratory 510005 GuangzhouChina Tsinghua University-Peking University Joint Center for Life Sciences School of MedicineTsinghua University100084 BeijingChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouChina Hunan Key Laboratory of Animal Models for Human Diseases Hunan Key Laboratory of Medical Genetics&Center for Medical GeneticsSchool of Life SciencesCentral South University410008 ChangshaChina

The ORF9b protein,derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2,serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune *** its significance,the precise regulatory mechanisms underlying its function remain *** the present study,we unveil that the ORF9b protein of SARS-CoV-2,including emerging mutant strains like Delta and Omicron,can undergo ubiquitination at the K67 site and subsequent degradation via the proteasome pathway,despite certain mutations present among these ***,our investigation further uncovers the pivotal role of the translocase of the outer mitochondrial membrane 70(TOM70)as a substrate receptor,bridging ORF9b with heat shock protein 90 alpha(HSP90α)and Cullin 5(CUL5)to form a *** this complex,CUL5 triggers the ubiquitination and degradation of ORF9b,acting as a host antiviral factor,while HSP90αfunctions to stabilize ***,treatment with HSP90 inhibitors such as GA or 17-AAG accelerates the degradation of ORF9b,leading to a pronounced inhibition of SARS-CoV-2 ***-cell sequencing data revealed an up-regulation of HSP90αin lung epithelial cells from COVID-19 patients,suggesting a potential mechanism by which SARS-CoV-2 may exploit HSP90αto evade the host *** study identifies the CUL5-TOM70-HSP90αcomplex as a critical regulator of ORF9b protein stability,shedding light on the intricate host–virus immune response dynamics and offering promising avenues for drug development against SARS-CoV-2 in clinical settings.

关键词： stability modulator offering

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喉管直径对旋风分离器性能影响的仿真研究

流体机械 2021年第1期49卷 59-66页

作者：张子慧董思捷姜云超王博兰州大学资源环境学院兰州730000

采用数值模拟方法研究了在普通Lapple型(d/D=0.5)旋风分离器气流出口处外加不同直径的喉管结构对于其流场及性能的影响。采用雷诺应力模型(RSM)模拟旋风分离器内的各向异性湍流,同时采用拉格朗日颗粒追踪(LPT)模型计算颗粒运动。结果表... 详细信息

采用数值模拟方法研究了在普通Lapple型(d/D=0.5)旋风分离器气流出口处外加不同直径的喉管结构对于其流场及性能的影响。采用雷诺应力模型(RSM)模拟旋风分离器内的各向异性湍流,同时采用拉格朗日颗粒追踪(LPT)模型计算颗粒运动。结果表明,喉管直径能有效控制内旋涡的大小,从而影响旋风分离器的性能。随着喉管直径减小,涡核直径先逐渐减小;当喉管直径与筒体直径比值减小至0.3后,涡核直径趋于稳定,颗粒收集效率相对较高;存在一个较优的喉管直径与筒体直径比值范围0.2~0.3,使得效率较高的同时具有较低的压降。

关键词：旋风分离器喉管涡核流场数值模拟

苄基咪唑氯镍酸盐的合成、结构及催化醛醇酯化反应活性研究

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化学通报 2016年第7期79卷 645-649页

作者：董思杰黄亮亮左萌萌周明东辽宁石油化工大学化学与材料科学学院抚顺113001

合成了三种苄基咪唑氯镍酸盐,通过红外光谱、元素分析、1H NMR以及X-射线单晶衍射对其进行结构表征,并研究了其在醛醇酯化反应中的催化活性。结果表明,在优化条件下,苄基咪唑氯镍酸盐对醛醇酯化反应有着较好的催化活性,以1,3-二(4-甲基... 详细信息

合成了三种苄基咪唑氯镍酸盐,通过红外光谱、元素分析、1H NMR以及X-射线单晶衍射对其进行结构表征,并研究了其在醛醇酯化反应中的催化活性。结果表明,在优化条件下,苄基咪唑氯镍酸盐对醛醇酯化反应有着较好的催化活性,以1,3-二(4-甲基苄基)咪唑鎓氯镍酸盐为催化剂,通过一步氧化酯化路线可以有效地催化氧化苯甲醛进行酯化反应,产率为80%。

关键词：苄基咪唑氯镍酸盐结构催化醛醇酯化

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砂土中钢管螺旋桩安装扭矩的研究

中国工程机械学报 2019年第5期17卷 391-396页

作者：张新春何泽群董思捷朱昂华北电力大学机械工程系

为了能够准确预测钢管螺旋桩的承载能力,以满足工程机械高效施工作业的需求,对钢管螺旋桩的安装扭矩进行了研究.给出了砂土中钢管螺旋桩安装扭矩的理论计算模型,考虑到安装过程中土体扰动,引入螺旋进给率这一衡量土体扰动的指标,同时进... 详细信息

为了能够准确预测钢管螺旋桩的承载能力,以满足工程机械高效施工作业的需求,对钢管螺旋桩的安装扭矩进行了研究.给出了砂土中钢管螺旋桩安装扭矩的理论计算模型,考虑到安装过程中土体扰动,引入螺旋进给率这一衡量土体扰动的指标,同时进行现场实验以验证模型可靠性.研究发现:叶片螺距与直径的比值p/D对安装扭矩有重要影响,为了让叶片运动轨迹一致,叶片间距S取螺距p的整数倍,结果表明p/D在0.2~0.3之间较为合理.此外,安装扭矩与抗拔承载力存在一定的关联,可对钢管螺旋桩进行抗拔承载力预测.

关键词：输电线路工程钢管螺旋桩安装扭矩土体扰动承载能力