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Seasonal change of circulating leptin associated with testicular activities of the wild ground squirrels(Citellus dauricus)

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Integrative Zoology 2023年第1期18卷 76-92页

作者： Wenyang YU sijie fan Xi WANG Jueyu ZHU Zhengrong YUAN Yingying HAN Haolin ZHANG Qiang WENG Laboratory of Animal Physiology College of Biological Sciences and TechnologyBeijing Forestry UniversityBeijingChina

The purpose of this study was to explore the variations in the circulating leptin concentrations of the wild ground squirrels in relation to seasonal changes in testicular activities.Hematoxylin-eosin staining showed all types of elongated spermatids and spermatogenic cells existed in the testis in April,while the primary spermatocytes and spermatogonia were most advanced stages of germ cells in June.In addition,the primary spermatocytes,secondary spermatocytes,and spermatogonia were most advanced stages of germ cells in September.The highest circulating leptin concentration was consistent with the maximum body weight results from accumulation of adipose tissue in September.The mRNA expression level of leptin receptor(Ob-R)and STAT3 was lowest in June,raised in September,and remained increased in April.Ob-R and STAT3 were stronger staining in the Leydig cells in July.Moreover,the concentrations of testosterone(T)showed the maximum values in April,the minimum values in June,and signiﬁcant increases in September.Furthermore,it is worth noting that the levels of T increased with the mRNA levels of Ob-R,STAT3,StAR,and testicular steroidogenic enzymes(3β-HSD,P450c17,and P450scc).Moreover,RNA-seq analyses of testis during the different periods showed that a total of 4209 genes were differ-entially expressed genes(DEGs);further analysis revealed that DEGs related with the Jak/STAT pathways and reproduction were altered.Taken together,the results suggested that the leptin regulated testicular function through the Jak/STAT pathways and testicular steroidogenic factor expressions.

关键词： leptin Ob-R STAT3 steroidogenic enzyme testis wild ground squirrel

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On-chip ultrafast stackable dielectric laser positron accelerator

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Chinese Physics B 2024年第3期33卷 350-354页

作者：孙斌何阳帆潘晨浩樊思劼王度王少义赵宗清 Department of Plasma Physics and Fusion Engineering School of Nuclear Science and TechnologyUniversity of Science and Technology of ChinaHefei 230026China National Key Laboratory of Plasma Physics Research Center of Laser FusionChina Academy of Engineering PhysicsMianyang 621900China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of High Field Laser Physics and Chinese Academy of Sciences Center for Excellence in Ultra-Intense Laser Science Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Department of Engineering Physics Tsinghua UniversityBeijing 100084China The Institute of Technological Sciences Wuhan UniversityWuhan 430072China

We present a first on-chip positron accelerator based on dielectric laser acceleration.This innovative approach significantly reduces the physical dimensions of the positron acceleration apparatus,enhancing its feasibility for diverse applications.By utilizing a stacked acceleration structure and far-infrared laser technology,we are able to achieve a seven-stage acceleration structure that surpasses the distance and energy gain of using the previous dielectric laser acceleration methods.Additionally,we are able to compress the positron beam to an ultrafast sub-femtosecond scale during the acceleration process,compared with the traditional methods,the positron beam is compressed to a greater extent.We also demonstrate the robustness of the stacked acceleration structure through the successful acceleration of the positron beam.

关键词： dielectric laser accelerator positron accelerator high gradient accelerator inverse Cherenkov effect

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铝锂合金无针搅拌摩擦点焊接头组织演变与强化机制研究

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机械工程学报 2024年第2期60卷 150-158页

作者：褚强杨夏炜李文亚范文龙邹阳帆郝思洁西北工业大学材料学院西安710072 西安航天发动机有限公司西安710100

将2198铝锂合金无针搅拌摩擦点焊作为研究对象,围绕点焊接头微观组织与强化机制开展研究。结果表明,组织细化受连续动态再结晶、应变的几何效应和非连续动态再结晶的共同作用。其中,连续动态再结晶是主要的再结晶机制,同时伴随着剪切织... 详细信息

将2198铝锂合金无针搅拌摩擦点焊作为研究对象,围绕点焊接头微观组织与强化机制开展研究。结果表明,组织细化受连续动态再结晶、应变的几何效应和非连续动态再结晶的共同作用。其中,连续动态再结晶是主要的再结晶机制,同时伴随着剪切织构A/A({111}),B/B({112}),A_(1)*/A_(2)*({111})。焊接过程中析出相同样发生了显著变化,与母材晶体结构呈现半共格/非共格特征的T1相受焊接热循环影响发生粗化或固溶,搅拌区析出相几乎完全固溶,仅观察到少量弥散的与母材晶体共格的β'相,其强化效应明显减弱。无针搅拌摩擦点焊(Probeless friction stir spot welding,P-FSSW)接头非均匀组织特征导致其强化机制由析出强化和形变强化逐渐转变为细晶强化和固溶强化。

关键词：铝锂合金搅拌摩擦点焊微观组织强化机制

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阿帕他胺致皮肤不良反应2例

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中国皮肤性病学杂志 2024年第6期38卷 681-684页

作者：唐欣韵范家明周思婕周培媚成都市第二人民医院皮肤科四川成都610017

例1男,90岁,因前列腺癌使用阿帕他胺治疗,1周后出现面部肿胀,停药后好转,恢复治疗1个月后颈部、耳后出现红色斑块、鳞屑伴瘙痒。例2男,78岁,因前列腺癌使用阿帕他胺治疗,3 d后双下肢出现充血性潮红斑、丘疹伴瘙痒,经对症处理后消退,未... 详细信息

例1男,90岁,因前列腺癌使用阿帕他胺治疗,1周后出现面部肿胀,停药后好转,恢复治疗1个月后颈部、耳后出现红色斑块、鳞屑伴瘙痒。例2男,78岁,因前列腺癌使用阿帕他胺治疗,3 d后双下肢出现充血性潮红斑、丘疹伴瘙痒,经对症处理后消退,未停用阿帕他胺。2个月后皮损复发,逐渐加重,累及全身。2例患者均诊断为阿帕他胺所致药疹。停用阿帕他胺,分别给予局部/系统糖皮质激素等对症治疗后病情缓解。

关键词：雄激素受体抑制剂阿帕他胺皮肤不良反应

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Neuromorphic sensory computing

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Science China(Information Sciences) 2022年第4期65卷 114-127页

作者： Tianqing WAN sijie MA Fuyou LIAO Lingwei fan Yang CHAI Department of Applied Physics The Hong Kong Polytechnic University The Hong Kong Polytechnic University Shenzhen Research Institute

The number of sensory nodes in the Internet of everything continues to increase rapidly and generate massive data. The generated information from sensory nodes is much larger than the total collective human sensory throughput. It is quite challenging to send all of the data produced at sensory terminals to the“Cloud” computation center, especially for those time-delay sensitive applications. This situation demands a dramatic increase in the computation near or inside sensory networks. Inspired by biological sensory systems with a high data compression ratio, neuromorphic sensory computing provides a way to efficiently acquire and process a large volume of data from complex environments. Researchers have been investigating emerging materials, devices, circuits, and computing architectures to implement an artificial sensory system with high energy efficiency, speed, and density. Here we summarize the important features of biological systems and their hardware implementations. Electrons and photons are two representative information carriers, in which electron carrier allows high integration density for complex computing and photon carrier has high connectivity, high speed, wide bandwidth, and low power consumption. We overview the electronic and optical neuromorphic sensory computing and hybrid opto-electronic sensory computing, and present advances on multimodal sensory computing and their potential challenges.

关键词： neuromorphic sensory computing multimodal sensory computing electronic sensory computing optical sensory computing

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鄂尔多斯盆地含氦天然气地球化学特征与富集影响因素

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石油与天然气地质 2024年第2期45卷 384-392页

作者：刘成林丁振刚范立勇康锐洪思婕朱玉新陈践发王海东许诺中国石油大学(北京)油气资源与探测国家重点实验室北京102249 中国石油大学(北京)地球科学学院北京102249 中国石油长庆油气田公司勘探开发研究院陕西西安710018 中国石油油气和新能源分公司北京100007 中国石化石油勘探开发研究院北京102206

鄂尔多斯盆地天然气资源丰富,部分地区天然气中的氦气含量较高,亟需深入研究含氦天然气地球化学特征与富集影响因素。通过采集天然气样品并进行组分和同位素等实验分析测试,结合地质条件,研究了鄂尔多斯盆地含氦天然气的分布、地球化学... 详细信息

鄂尔多斯盆地天然气资源丰富,部分地区天然气中的氦气含量较高,亟需深入研究含氦天然气地球化学特征与富集影响因素。通过采集天然气样品并进行组分和同位素等实验分析测试,结合地质条件,研究了鄂尔多斯盆地含氦天然气的分布、地球化学特征和影响因素,研究结果表明:(1)鄂尔多斯盆地天然气主要为烃类气体,氦气含量为0.016%~0.487%,平均值为0.060%;(2)鄂尔多斯盆地含氦天然气甲烷碳同位素值分布在-53.88‰~-29.23‰,甲烷、乙烷、丙烷和丁烷碳同位素表明烃类气为有机成因;(3)鄂尔多斯盆地含氦天然气3He/4He含量比值为20.10×10^(-9)~120.00×10^(-9),平均值为42.00×10^(-9),R/Ra值为0.014~0.085,平均值为0.030,为壳源氦的特征,不受天然气成因类型和成熟度等因素影响;(4)氦气含量较高的天然气主要分布在鄂尔多斯盆地北部东胜气田、西南部庆阳气田和东南部黄龙气田的上古生界石炭系-二叠系,其分布与古今构造位置、基底断裂、生氦强度及生烃强度相对强弱等因素密切相关。根据含氦天然气地球化学特征评价出富氦-中氦区、低氦区及贫氦区。

关键词：地球化学氦源岩氦气天然气鄂尔多斯盆地

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具有单晶到单晶转化的Cu(Ⅰ)配合物的发光性质

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无机化学学报 2024年第1期40卷 99-110页

作者：牟文龙孙振洲范思杰侯川兵李中峰韩洪亮王果杨玉平金琼花首都师范大学化学系北京100048 首都师范大学资源环境与旅游学院北京100048 中央民族大学理学院北京100081 中国科学院福建物质结构研究所结构化学国家重点实验室福州350002

选用2-(N,N-双(二苯基膦基甲基))胺基吡啶(bdppmapy)为膦配体、二吡啶并[3,2-a∶2',3'-c]吩嗪(dppz)为氮配体、[Cu(CH_(3)CN)_(4)]BF_(4)为铜盐,在常温下进行反应,制备了3种新型Cu(Ⅰ)配合物,分别为[Cu(dppz)(bdppmapy)]_(2)(BF_(4))_(2)·H_(2)O (Cu BF_(4)-1)、[Cu(dppz)(bdppmapy)]BF_(4)(Cu BF_(4)-2)和[Cu(dppz)(bdppmapy)]BF_(4)(Cu BF_(4)-3)。获得了Cu BF_(4)-1和Cu BF_(4)-3的单晶,发现了单晶到单晶转化过程的现象,并探究了溶剂分子的存在对配合物结构和光物理性能的影响。通过单晶X射线衍射确定配合物Cu BF_(4)-1和Cu BF_(4)-3的结构,使用粉末X射线衍射(PXRD)、红外光谱(IR)和核磁共振氢谱/磷谱(~1H/^(31)P NMR)对合成的3个配合物进行结构表征。对配合物进行紫外可见吸收光谱(UV-Vis)、荧光光谱、荧光寿命及量子产率等光物理性质的表征和分析,比较了配合物发光性质的差异,探讨了溶剂分子对配合物结构和光物理性质的影响规律。太赫兹时域光谱对配合物的研究提供了帮助。

关键词： Cu(Ⅰ)配合物弱作用力晶体结构发光性质太赫兹时域光谱

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柑橘果实增糖肥料的生产与应用技术规程

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现代农业科技 2024年第7期 82-85页

作者：欧阳歆段松坡李志明宋思捷范先婷沈宏华南农业大学资源环境学院广东广州510642

华南地区是柑橘的重要产区,但是受昼夜温差小、雨水多、光照不充分等因素影响,柑橘果实存在糖分含量低、口感差等品质问题,严重影响了果农的经济效益。本文从增糖肥料的原料选择、产品配方设计、生产工艺探究、产品质量检测及产品应用... 详细信息

华南地区是柑橘的重要产区,但是受昼夜温差小、雨水多、光照不充分等因素影响,柑橘果实存在糖分含量低、口感差等品质问题,严重影响了果农的经济效益。本文从增糖肥料的原料选择、产品配方设计、生产工艺探究、产品质量检测及产品应用与效果等方面总结了柑橘果实增糖肥料产品的生产与应用技术规程,以期为该地区柑橘果实增糖提供优质的绿色肥料产品和技术支持。

关键词：柑橘果实增糖肥料原料选择配方设计生产工艺质量检测应用效果

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Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3111-3122页

作者： Yang Zheng Cenglin Xu Jinyi Sun Wenjie Ming sijie Dai Yuying Shao Xiaoyun Qiu Menghan Li Chunhong Shen Jinghong Xu fan Fei Jiajia fang Xuhong Jiang Guoqing Zheng Weiwei Hu Yi Wang Shuang Wang Meiping Ding Zhong Chen Department of Neurology Zhejiang Provincial Hospital of Chinese MedicineThe First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310060China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou310053China Institute of Pharmacology and Toxicology College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Epilepsy Center Department of NeurologySecond Affiliated Hospital Zhejiang University School of MedicineHangzhou310009China Department of Neurology Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu322000China

Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery,likely due to the widespread seizure network.Previous studies have primarily focused on the disruption of dysplastic lesions,rather than remote regions such as the hippocampus.Here,we first quantified the epileptogenicity of the hippocampus in patients with late-stage cortical dysplasia.We further investigated the cellular substrates leading to the epileptic hippocampus,using multiscale tools including calcium imaging,optogenetics,immunohistochemistry and electrophysiology.For the first time,we revealed the role of hippocampal somatostatin-positive interneurons in cortical dysplasia-related seizures.Somatostatin-positive were recruited during cortical dysplasia-related seizures.Interestingly,optogenetic studies suggested that somatostatin-positive interneurons paradoxically facilitated seizure generalization.By contrast,parvalbumin-positive interneurons retained an inhibitory role as in controls.Electrophysiological recordings and immunohistochemical studies revealed glutamate-mediated excitatory transmission from somatostatin-positive interneurons in the dentate gyrus.Taken together,our study reveals a novel role of excitatory somatostatin-positive neurons in the seizure network and brings new insights into the cellular basis of cortical dysplasia.

关键词： somatostatin dysplasia seizure

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Automated segmentation of intraretinal cystoid macular edema based on Gaussian mixture model

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Journal of Innovative Optical Health Sciences 2020年第1期3卷 35-47页

作者： Jinghong Wu sijie Niu Qiang Chen Wen fan Songtao Yuan Dengwang Li Shandong Key Laboratory of Medical Physics and Image Processing&Shandong Provincial Engineering and Technical Center of Light Manipulations School of Physics and Electronics Shandong Normal University Jinan 250358P.R.China School of Information Science and Engineering University of Jinan Jinan 250022P.R.China School of Computer Science and Engineering Nanjing University of Science and Technology Nanjing 210094 P.R.China Department of Ophthalmology the First Affiliated Hospital with Nanjing Medical University Nanjing 210094P.R.China

We introduce a method based on Gaussian mixture model(GMM)clustering and level-set to automatically detect intraretina fluid on diabetic retinopathy(DR)from spectral domain optical coherence tomography(SD-OCT)images in this paper.First,each B-scan is segmented using GMM clustering.The original chustering results are refined using location and thickness infor-mation.Then,the spatial information among every consecutive five B-scans is used to search potential fluid.Finally,the improved level-set method is used to obtain the accurate boundaries.The high sensitivity and accuracy demonstrated here show its potential for detection of fluid.

关键词： Gaussian mixture model level-set spectral domain optical coherence tomography(SD-OCT) segmentation

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