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Efficient overall photosynthesis of H_(2)O_(2) by the BTz@Mn_(0.2)Cd_(0.8)S S-scheme heterojunction

Science China Chemistry 2024年第6期67卷 1953-1960页

作者： Zhongyue chen sijie Wan Bei cheng Wang Wang Yao Xiang Jiaguo Yu Shaowen Cao State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China Hubei Technology Innovation Center for Advanced Composites Wuhan University of TechnologyWuhan430070China Hospital of Wuhan University of Technology Wuhan University of TechnologyWuhan430070China Laboratory of Solar Fuel Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan430074China

The photosynthesis of hydrogen peroxide(H_(2)O_(2))through the selective 2e^(-)oxygen reduction reaction(ORR)from O_(2)and H_(2)O stands out as an environmentally sustainable and cost-effective method for generating this essential chemical.Unfortunately,the widespread application of most photocatalysts is impeded by their reliance on sacrificial agents.In this context,we present a noteworthy advancement in the form of a step-scheme(S-scheme)heterojunction involving a donor-acceptor(D-A)-conjugated polymer and manganese cadmium sulfide(BTz@MCS).This innovative configuration enables efficient photocatalytic H_(2)O_(2)production within a non-sacrificial system,showcasing an impressive H_(2)O_(2)yield of 5,368μmol g^(-1)h^(-1)and an apparent quantum yield of 4.5%at 420 nm.Through insights gained from in-situ irradiated X-ray photoelectron spectroscopy(ISIXPS),in-situ diffuse reflectance infrared Fourier transformations spectroscopy(DRIFTS),and density function calculations(DFT),it is revealed that the sp^(2)C between thiazole-thiazole rings at the BTz and the concentrated holes at the MCS function as spatially separated redox centers.These centers catalyze the selective 2e^(-)ORR and 4e^(-)water oxidation reaction(WOR)concurrently.The O_(2)generated from the WOR is subsequently utilized by the ORR cycle,enabling the overall photosynthesis of H_(2)O_(2)with accelerated total reaction kinetics.Furthermore,the high photocatalytic performance of the developed catalyst is attributed to well-designed S-scheme heterojunctions with tuned band structures.The spatially separated redox centers and effective transfer of photogenerated charge carriers facilitated by the internal electric field significantly enhance reaction kinetics.This study introduces a promising avenue for photocatalytic H_(2)O_(2)production without sacrificial agents,providing valuable insights into the underlying mechanisms in S-scheme heterojunctions.

关键词： hydrogen peroxide non-sacrificial redox centers S-scheme heterojunction

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Accurate cell type annotation for single-cell chromatin accessibility data via contrastive learning and reference guidance

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Quantitative Biology 2024年第1期12卷 85-99页

作者： Siyu Li Songming Tang Yunchang Wang sijie Li Yuhang Jia Shengquan chen School of Statistics and Data Science Nankai UniversityTianjinChina School of Mathematical Sciences and LPMC Nankai UniversityTianjinChina

Recent advances in single-cell chromatin accessibility sequencing(scCAS)technologies have resulted in new insights into the characterization of epigenomic heterogeneity and have increased the need for automatic cell type annotation.However,existing automatic annotation methods for scCAS data fail to incorporate the reference data and neglect novel cell types,which only exist in a test set.Here,we propose RAINBOW,a reference-guided automatic annotation method based on the contrastive learning framework,which is capable of effectively identifying novel cell types in a test set.By utilizing contrastive learning and incorporating reference data,RAINBOW can effectively characterize the heterogeneity of cell types,thereby facilitating more accurate annotation.With extensive experiments on multiple scCAS datasets,we show the advantages of RAINBOW over state-of-the-art methods in known and novel cell type annotation.We also verify the effectiveness of incorporating reference data during the training process.In addition,we demonstrate the robustness of RAINBOW to data sparsity and number of cell types.Furthermore,RAINBOW provides superior performance in newly sequenced data and can reveal biological implication in downstream analyses.All the results demonstrate the superior performance of RAINBOW in cell type annotation for scCAS data.We anticipate that RAINBOW will offer essential guidance and great assistance in scCAS data analysis.The source codes are available at the GitHub website(BioX-NKU/RAINBOW).

关键词： cell type annotation chromatin accessibility novel type reference-guided single-cell

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nr0b1(DAX1) loss of function in zebrafish causes hypothalamic defects via abnormal progenitor proliferation and differentiation

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Journal of Genetics and Genomics 2022年第3期49卷 217-229页

作者： Wei Zhang Yan Li sijie chen Cuizhen Zhang Lili chen Gang Peng State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceFudan UniversityShanghai 200032China Department of Endocrinology Huashan HospitalFudan UniversityShanghai 200040China

The nuclear receptor DAX-1, encoded by the NR0B1 gene, is presented in the hypothalamic tissues in humans and other vertebrates. Human patients with NR0B1 mutations often have hypothalamic-pituitary defects, but the involvement of NR0B1 in hypothalamic development and function is not well understood. Here, we report the disruption of the nr0b1 gene in zebrafish causes abnormal expression of gonadotropins, a reduction in fertilization rate, and an increase in postfasting food intake, which are indicators of abnormal hypothalamic functions. We find that loss of nr0b1 increases the number of prodynorphin(pdyn)-expressing neurons but decreases the number of pro-opiomelanocortin(pomcb)-expressing neurons in the zebrafish hypothalamic arcuate region(ARC). Further examination reveals that the proliferation of progenitor cells is reduced in the hypothalamus of nr0b1 mutant embryos accompanying the decreased expression of genes in the Notch signaling pathway. Additionally, the inhibition of Notch signaling in wildtype embryos increases the number of pdyn neurons, mimicking the nr0b1 mutant phenotype. In contrast,ectopic activation of Notch signaling in nr0b1 mutant embryos decreases the number of pdyn neurons.Taken together, our results suggest that nr0b1 regulates neural progenitor proliferation and maintenance to ensure normal hypothalamic neuron development.

关键词： nr0b1 DAX-1 Hypogonadism Feeding Arcuate nucleus Neural progenitor

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Inertia Market:Mechanism Design and Its Impact on Generation Mix

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 744-756页

作者： Jingwei Hu Zheng Yan Xiaoyuan Xu sijie chen Key Laboratory of Control of Power Transmission and Conversion Ministry of Educationand Shanghai Non-Carbon Energy Conversion and Utilization InstituteShanghai Jiao Tong UniversityShanghai 200240China

Increasing penetration of renewable energy generation poses a challenge to power system inertia adequacy.It is vital to provide long-term incentive signals to induce a generation mix with adequate inertia supply.However,existing literature rarely studies inertia incentive mechanisms or considers inertia constraints when making generation investment decisions.Thus,we propose an inertia market to quantify the value of inertia and to remunerate inertia provision.To examine the impacts of the inertia market on generation mix,we then propose a stochastic bilevel generation investment equilibrium model that depicts a multi-leader and multi-follower Stackelberg game.The lower level of the model considers the proposed inertia market,along with the energy,reserve,and capacity markets.The upper level considers multiple profit-maximizing strategic producers,and each producer is able to build gas-fired generators,wind generators,and energy storages.Numerical experiments demonstrate that a generation mix with adequate inertia supply can be induced with the proposed inertia market whereas there can be inertia shortage without the inertia market.Interestingly,considering carbon taxes,it is more cost-competitive to invest in wind resources with virtual inertia facilities than to substitute wind resources by thermal generators.Correspondingly,the introduction of an inertia market does not significantly reduce wind generation shares but boosts virtual inertia facility penetration.Our findings imply a future power system powered by fully decarbonized power resources with adequate inertia.

关键词： Generation mix generation investment equilibrium inertia market Stackelberg game virtual inertia

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A Reinforcement-learning-based Bidding Strategy for Power Suppliers with Limited Information

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 1032-1039页

作者： Qiangang Jia Yiyan Li Zheng Yan chengke Xu sijie chen Shanghai Jiao Tong University Shanghai 200240China Department of Electrical and Computer Science North Carolina State UniversityRaleigh 27695USA

The power market is a typical imperfectly competitive market where power suppliers gain higher profits through strategic bidding behaviors.Most existing studies assume that a power supplier is accessible to the sufficient market information to derive an optimal bidding strategy.However,this assumption may not be true in reality,particularly when a power market is newly launched.To help power suppliers bid with the limited information,a modified continuous action reinforcement learning automata algorithm is proposed.This algorithm introduces the discretization and Dyna structure into continuous action reinforcement learning automata algorithm for easy implementation in a repeated game.Simulation results verify the effectiveness of the proposed learning algorithm.

关键词： Power market bidding strategy limited information repeated game continuous action reinforcement learning automata

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Blockchain in energy systems:values,opportunities,and limitations

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Frontiers in Energy 2022年第1期16卷 9-18页

作者： sijie chen Jian PING Zheng YAN Jinjin LI Zhen HUANG Key Laboratory of Control of Power Transmission and Conversion(Ministry of Education) Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Thin Film and Microfabrication(Ministry of Education) Department of Micro/Nano-electronicsShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Power Machinery and Engineering(Ministry of Education) Shanghai Jiao Tong UniversityShanghai 200240China

The structure of a power energy system is becoming more distributed than before.It becomes challenging to manage such a system in a centralized way,because a central authority may not exist or may not be trusted by all parties.Blockchain is a promising tool to address this challenge,by enabling trusted collaboration in the absence of a trusted central authority.Its use in the energy sector has been pioneered by several pilot projects.However,to date the energy sector has not seen large-scale deployment of blockchain,partly because the founders of those pilot projects,the public,and utilities have not reached consensus on the values and limitations of blockchain in energy.This perspective aims to bridge this gap.First,the philosophy and unique values of blockchain are discussed.Second,some promising blockchain-based applications in energy systems are presented.Third,some common misunderstandings of blockchain in energy are discussed.Last,some frequently-asked questions from utilities are discussed.Hopefully this perspective can help advance large-scale deployment of blockchain in energy systems.

关键词： blockchain immutability energy trading energy management data synchronization

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Suspension of Australian National Electricity Market in 2022 Necessitates Mechanism Evolution Ensuring Power Supply Security

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 674-679页

作者： Zhenfei Tan Hua Geng Xiaoyuan Xu sijie chen Zheng Yan Key Laboratory of Control of Power Transmission and Conversion Ministry of Educationand Shanghai Non-Carbon Energy Conversion and Utilization InstituteShanghai Jiao Tong UniversityShanghai 200240China

The National Electricity Market(NEM)in Australia was suspended during June 15-23,2022,with a primary attribution to the lack of available generation capacity.This incident is noteworthy because it was the first market suspension in NEM’s history and took place in a major energy exporting country.In this letter,we review the outline and impacts of the incident.From the perspectives of market regulation,electricity supply,and electricity demand,we identify three underlying causes of the market suspension and offer four recommendations for the market mechanism evolution to ensure power supply security.

关键词： Electricity market administered pricing power system security energy crisis demand response

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Development of a novel virus-like particle-based vaccine for preventing tick-borne encephalitis virus infection

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Virologica Sinica 2023年第5期38卷 767-777页

作者： Jielin Tang Muqing Fu Chonghui Xu Bao Xue Anqi Zhou sijie chen He Zhao Yuan Zhou Jizheng chen Qi Yang Xinwen chen Guangzhou National Laboratory Guangzhou510005China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou510530China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou511436China State Key Laboratory of Respiratory Disease Guangzhou Medical UniversityGuangzhou511436China

Tick-borne encephalitis virus(TBEV)is an important tick-borne pathogen that poses as a serious public health concern.The coverage and immunogenicity of the currently available vaccines against TBEV are relatively low;therefore,it is crucial to develop novel and effective vaccines against TBEV.The present study describes a novel strategy for the assembly of virus-like particles(VLPs)by co-expressing the structural(core/prM/E)and non-structural(NS2B/NS3Pro)proteins of TBEV.The efficacy of the VLPs was subsequently evaluated in C57BL/6 mice,and the resultant IgG serum could neutralize both Far-Eastern and European subtypes of TBEV.These findings indicated that the VLP-based vaccine elicited the production of cross-subtype reactive antibodies.The VLPs provided protection to mice lacking the type I interferon receptor(IFNAR^(-/-))against lethal TBEV challenge,with undetectable viral load in brain and intestinal tissues.Furthermore,the group that received the VLP vaccine did not exhibit significant pathological changes and the inflammatory factors were significantly suppressed compared to the control group.Immunization with the VLP vaccine induced the production of multiple-cytokine-producing antiviral CD4+T cells in vivo,including TNF-α^(+),IL-2^(+),and IFN-γ^(+)T cells.Altogether,the findings suggest that noninfectious VLPs can serve as a potentially safe and effective vaccine candidate against diverse subtypes of TBEV.

关键词： Tick-borne encephalitis virus(TBEV) Virus-like particle(VLP) Immunogenicity Neutralization Vaccine

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Efficient overall photosynthesis of HOby the BTz@MnCdS S-scheme heterojunction

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Science China Chemistry 2024年

作者： Zhongyue chen sijie Wan Bei cheng Wang Wang Yao Xiang Jiaguo Yu Shaowen Cao Hubei Technology Innovation Center for Advanced Composites Wuhan University of Technology State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Hospital of Wuhan University of Technology Wuhan University of Technology Laboratory of Solar Fuel Faculty of Materials Science and Chemistry China University of Geosciences

The photosynthesis of hydrogen peroxide(H2O2) through the selective 2 e-oxygen reduction reaction(ORR) from O2and H2O stands out as an environmentally sustainable and cost-effective method for generating this essential chemical.Unfortunately,the widespread application of most photocatalysts is impeded by their reliance on sacrificial agents.In this context,we present a noteworthy advancement in the form of a step-scheme(S-scheme) heterojunction involving a donor-acceptor(D-A)-conjugated polymer and manganese cadmium sulfide(BTz@MCS).This innovative configuration enables efficient photocatalytic H2O2production within a non-sacrificial system,showcasing an impressive H2O2yield of 5,368 μmol g-1h-1and an apparent quantum yield of 4.5% at 420 nm.Through insights gained from in-situ irradiated X-ray photoelectron spectroscopy(ISIXPS),in-situ diffuse reflectance infrared Fourier transformations spectroscopy(DRIFTS),and density function calculations(DFT),it is revealed that the sp2C between thiazole-thiazole rings at the BTz and the concentrated holes at the MCS function as spatially separated redox centers.These centers catalyze the selective 2 e-ORR and 4 e-water oxidation reaction(WOR) concurrently.The O2generated from the WOR is subsequently utilized by the ORR cycle,enabling the overall photosynthesis of H2O2with accelerated total reaction kinetics.Furthermore,the high photocatalytic performance of the developed catalyst is attributed to well-designed S-scheme heterojunctions with tuned band structures.The spatially separated redox centers and effective transfer of photogenerated charge carriers facilitated by the internal electric field significantly enhance reaction kinetics.This study introduces a promising avenue for photocatalytic H2O2production without sacrificial agents,providing valuable insights into the underlying mechanisms in S-scheme heterojunctions.

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Toward a unified information framework for cell atlas assembly

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National Science Review 2022年第3期9卷 7-10页

作者： sijie chen Yanting Luo Haoxiang Gao Fanhong Li Jiaqi Li Yixin chen Renke You Hairong Lv Kui Hua Rui Jiang Xuegong Zhang Bioinformatics Division of BNRIST and Department of Automation MOE Key Lab of BioinformaticsTsinghua University Fuzhou Institute of Data Technology School of Medicine Tsinghua University School of Life Sciences Center for Synthetic and Systems Biology Tsinghua University

Cells are the basic structural and functional unit of the human body. Virtually all cells of a human body possess the same genome, but they exhibit colorful heterogeneities in phenotypes and functions.The heterogeneit...

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