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守正与创新:一级学科更名背景下档案学科发展路径

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档案学研究 2024年第1期 4-11页

作者：卢思佳陈晓婷中国人民大学信息资源管理学院北京100872

一级学科更名背景下,档案学科身处变革的风口,探讨档案学科发展应当何去何从具有重要意义。一级学科更名这一事件在为档案学科提供更强有力的支撑、拓展档案学科发展空间、优化档案学科人才培养体系的同时,也使档案学科地位被边缘化、... 详细信息

一级学科更名背景下,档案学科身处变革的风口,探讨档案学科发展应当何去何从具有重要意义。一级学科更名这一事件在为档案学科提供更强有力的支撑、拓展档案学科发展空间、优化档案学科人才培养体系的同时,也使档案学科地位被边缘化、独立性被削弱、课程消隐泛化、生源危机加重。由此,本文提出档案学科守正与创新的发展路径。一则,应守学科之本,不断优化档案学科建设。即担当使命,回应并引领社会需求;正本清源,聚焦档案学科研究根本;立足本土,促进档案学科自主创新。二则,应借更名之机,谋求档案学科新增长点。即融合发展,拓展档案学科研究视野;协同开放,培育更广范围的学科共同体;着力长远,探索学科教育的新布局。

关键词：档案学科学科更名学科发展

Tumor necrosis factor-α signaling in nonalcoholic steatohepatitis and targeted therapies

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Journal of Genetics and Genomics 2022年第4期49卷 269-278页

作者： sijia lu Yibing Wang Junli Liu Shanghai Diabetes Institute Department of Endocrinology and MetabolismShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China School of Kinesiology Shanghai University of SportsShanghai 200438China

Nonalcoholic steatohepatitis(NASH),an inflammatory subtype of nonalcoholic fatty liver disease,is featured by significantly elevated levels of various proinflammatory *** numerous proinflammatory factors that contribute to NASH pathogenesis,the secreted protein,tumor necrosis factoralpha(TNF-α),plays an essential role in multiple facets of NASH progression and is therefore considered as a potential therapeutic *** this review,we will first systematically describe the preclinical studies on the biochemical function of TNF-αand its intracellular downstream signaling mechanisms through its ***,we extensively discuss its functions in regulating inflammation,cell death,and fibrosis of liver cells in the pathogenesis of NASH,and the molecular mechanism that TNF-αexpression is regulated by NF-κB and other upstream master regulators during NASH *** TNF-αis one of the causal factors that remarkably contributes to NASH progression,combination of therapeutic modalities,including TNF-α-based therapies may lead to the resolution of NASH via multiple pathways and thus generate clinical *** translational studies,we summarize recent advances in strategies targeting TNF-αand its signaling pathway,which paves the way for potential therapeutic treatments for NASH in the future.

关键词： TNF-αsignaling NASH Inflammation Cell death Fibrosis

改进高斯两步移动搜索法的公园绿地步行可达性评价

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测绘科学 2024年第4期49卷 177-186页

作者：江黎明张兴辉卢思佳曹传新桑秋中国城市建设研究院有限公司北京100120 中国城市规划设计研究院北京100044 北京建筑大学建筑与城市规划学院北京100044

针对高斯两步移动搜索法不满足城市空间精细化治理的客观需求,该文以北京市西城区为例,综合考虑不同公园绿地属性差异,在高斯两步移动搜索法的基础上分别构建公园绿地综合服务能力评价与吸引力评价模型提出阈值可变化方法,解决其固定阈... 详细信息

针对高斯两步移动搜索法不满足城市空间精细化治理的客观需求,该文以北京市西城区为例,综合考虑不同公园绿地属性差异,在高斯两步移动搜索法的基础上分别构建公园绿地综合服务能力评价与吸引力评价模型提出阈值可变化方法,解决其固定阈值问题。并对高斯两步移动搜索法和可变阈值的高斯两步移动搜索法进行对比分析。结果表明,该文方法使搜索阈值精细化、动态化,更能精准真实地反映居民日常游览公园绿地的出行实际,对未来城市公园绿地空间的合理规划布局与建设具有良好的参考价值。

关键词：高斯两步移动搜索法搜索阈值步行可达性公园绿地

长读长测序技术在胚胎植入前遗传学检测中的应用

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中华生殖与避孕杂志 2024年第2期44卷 188-192页

作者：万成丁韬力马杰良王兴兴杨季陆思嘉序康医疗科技(苏州)有限公司苏州215000

近年来,长读长测序技术发展迅速,在基因组、转录组、表观遗传学等研究方向发挥了重要作用,并显示出在临床检测领域的广阔应用前景。本文介绍了主要的长读长测序平台的基本原理和性能,综述了该技术在胚胎植入前遗传学检测中的研究进展,... 详细信息

近年来,长读长测序技术发展迅速,在基因组、转录组、表观遗传学等研究方向发挥了重要作用,并显示出在临床检测领域的广阔应用前景。本文介绍了主要的长读长测序平台的基本原理和性能,综述了该技术在胚胎植入前遗传学检测中的研究进展,以及当前面临的主要挑战和未来可能的发展方向。

关键词：生殖健康胚胎植入前遗传学检测长读长测序临床应用

Advances in the pathogenesis of Rett syndrome using cell models

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Animal Models and Experimental Medicine 2022年第6期5卷 532-541页

作者： sijia lu Yongchang Chen Zhengbo Wang State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingChina Yunnan Key Laboratory of Primate Biomedical Research KunmingChina

Rett syndrome(RTT)is a progressive neurodevelopmental disorder that occurs mainly in girls with a range of typical symptoms of autism spectrum ***2 protein loss-of-function in neural lineage cells is the main cause of RTT *** it is still hard to understand the mechanism of RTT on the basis of only clinical patients or animal models,cell models cultured in vitro play indispensable *** we reviewed the research progress in the pathogenesis of RTT at the cellular level,summarized the preclinical-research-related applications,and prospected potential future development.

关键词： cell models MeCP2 pathogenesis Rett syndrome

Current overview on the genetic basis of key genes involved in soybean domestication

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aBIOTECH 2022年第2期3卷 126-139页

Modern crops were created through the domestication and genetic introgression of wild relatives and adaptive differentiation in new *** the domestication-related genes and unveiling their molecular diversity provide clues for understanding how the domesticated variants were selected by ancient people,elucidating how and where these crops were *** genetics and genomics have explored some domestication-related genes in soybean(Glycine max).Here,we summarize recent studies about the quantitative trait locus(QTL)and genes involved in the domestication traits,introduce the functions of these genes,clarify which alleles of domesticated genes were selected during domestication.A deeper understanding of soybean domestication could help to break the bottleneck of modern breeding by highlighting unused genetic diversity not selected in the original domestication process,as well as highlighting promising new avenues for the identification and research of important agronomic traits among different crop species.

关键词： Soybean Domestication Diversity Gene

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岩块宏细观参数对垮落带岩体力学特性的影响

矿业研究与开发 2024年第1期44卷 73-81页

作者：林圆唐建新袁芳孔令锐李成王潇鲁思佳重庆大学煤矿灾害动力学与控制国家重点实验室重庆400044 重庆大学资源与安全学院重庆400044

为研究岩块的宏细观参数对垮落带岩体力学特性的影响,采用现场试验方法对采空区岩芯试样进行侧限压缩试验;基于试验结果采用PFC3D数值模拟方法开展了工程尺度下垮落带压缩变形特性的数值模拟,分析了模型尺寸、岩块块度、碎胀系数和细观... 详细信息

为研究岩块的宏细观参数对垮落带岩体力学特性的影响,采用现场试验方法对采空区岩芯试样进行侧限压缩试验;基于试验结果采用PFC3D数值模拟方法开展了工程尺度下垮落带压缩变形特性的数值模拟,分析了模型尺寸、岩块块度、碎胀系数和细观力学参数对垮落带岩体力学特性的影响;并采用量纲法分析得到了垮落带的线性应力应变本构关系。结果表明,岩芯试样加载曲线近似线性变化,试样应力应变曲线的斜率随岩芯总长度的增加而增大;垮落带的压缩量随模型径高比和碎胀系数的增大而增大,随岩块块度、有效模量的增大而减小,当模型直径与高度的比值大于3∶1后,模型尺寸对垮落带压缩变形特性影响显著减小;当岩块块度大于1.3m后,垮落带的压缩变形曲线由指数增加变为线性增加;碎胀系数低于2.0时,垮落带压缩变形曲线呈线性变化,高于2.0后,应力应变曲线呈指数变化,垮落带的孔隙压密特性逐渐增强。

关键词：垮落带宏细观参数岩块块度力学特性量纲分析

Phase transition of multi-component(TiZrVNb)C ceramics—Part II:From single phase to multiple phases via adjusting V content

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Journal of Advanced Ceramics 2024年第5期13卷 689-698页

作者： Qingyi Kong Lei Chen sijia Huo Kunxuan Li Wenyu lu Yujin Wang Yu Zhou Institute for Advanced Ceramics School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150080China Key Laboratory of Advanced Structure‒Function Integrated Materials and Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001China National Key Laboratory of Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

To address the relatively mediocre mechanical properties of single-phase multi-component carbide ceramics,a phase transition from a single phase to multiple phases was proposed to achieve superior mechanical properties.A series of(TiZrV_(x)Nb)C_(0.8) ceramics with different V contents were fabricated by spark plasma sintering(SPS).The influence of the V content on the phase composition,microstructural evolution,and mechanical properties was investigated in *** transition behavior from a single phase to multiple phases is discovered and *** formation of the Zr-rich phase and Zr-poor phase can be attributed to the increase in lattice distortion and mixed enthalpy caused by the addition of V.A nanometer lamellar structure with a semi-coherent interface obtained via in situ decomposition is reported for the first time in multi-component carbide *** semi-coherent interfaces with high dislocation density and strain concentration effectively improve the mechanical properties,grain refinement,and multi-phase *** optimal comprehensive mechanical properties of the Vickers hardness(26.3 GPa),flexural strength(369 MPa),and fracture toughness(3.1 MPa·m^(1/2))were achieved for the sample with 20 mol%V.

关键词： multi-component ceramics multiple phases microstructure evolution phase decomposition mechanical properties

Phase transition of multi-component(TiZrVNb)C ceramics—Part I:Phase decomposition induced by carbon content

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Journal of Advanced Ceramics 2024年第5期13卷 679-688页

作者： Qingyi Kong Rao Zhang Lei Chen sijia Huo Wenyu lu Yujin Wang Boxin Wei Yu Zhou Institute for Advanced Ceramics School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150080China Key Laboratory of Advanced Structure‒Function Integrated Materials and Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150001China National Key Laboratory of Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

Phase decomposition can effectively enhance the mechanical properties of carbide ceramics and can overcome the difficulty of enhancing the mechanical properties of single-phase multicomponent carbide *** this work,a series of nonstoichiometric(TiZrVNb)Cx ceramics were prepared by spark plasma sintering(SPS)at different *** effects of the carbon content on the phase composition,microstructure evolution,and mechanical properties were investigated in *** decomposition occurred with decreasing carbon *** different solid solutions of(Ti,V)-rich and Zr-rich phases formed from the decomposition of equimolar single-phase solid solutions,namely,the Zr-poor phase and Zr-rich phase,*** distribution of Nb element is relatively *** semicoherent interfaces between the Zr-poor phase and the Zr-rich phase can harden and strengthen effectively under the synergistic effect of grain *** with phase decomposition structures have apparent advantages compared to single-phase high-entropy *** work provides an important train of thought for the microstructure tailoring and properties optimization of multi-component carbide ceramics.

关键词： multicomponent ceramics nontoichiometry microstructure evolution phase decomposition mechanical properties