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Ras homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5126-5128页

作者： sijia liu Jiang Ren Long Zhang International Biomed-X Research Center Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouChina Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province HangzhouChina The Eight Affiliated Hospital of Sun Yat-Sen University ShenzhenChina MOE Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhouChina Cancer Center Zhejiang UniversityHangzhouChina

In a recently published study in Nature,a group led by Cédric Blanpain identified Ras homolog family member J(RHOJ)as a key regulator of epithelial-mesenchymal transition(EMT)-associated chemoresistance in skin squamous cell carcinoma(SCC).1 Mechanistically,this study demonstrated that RHOJ promotes DNA repair and replication of EMT tumor cells to assist them in rapidly repairing DNA lesions induced by chemotherapy(Fig.1).

关键词： chemotherapy homolog family

Targeting TGFβ signal transduction for cancer therapy

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Signal Transduction and Targeted Therapy 2021年第2期6卷 277-296页

作者： sijia liu Jiang Ren Peter ten Dijke Oncode Institute and Department of Cell and Chemical Biology Leiden University Medical CenterEinthovenweg 202300 RC LeidenThe Netherlands

Transforming growth factor-β(TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of cell fate during embryonic development and in the maintenance of adult tissue *** of TGFβ family signaling can lead to a plethora of developmental disorders and diseases,including cancer,immune dysfunction,and *** this review,we focus on TGFβ,a well-characterized family member that has a dichotomous role in cancer progression,acting in early stages as a tumor suppressor and in late stages as a tumor *** functions of TGFβ are not limited to the regulation of proliferation,differentiation,apoptosis,epithelial-mesenchymal transition,and metastasis of cancer *** reports have related TGFβ to effects on cells that are present in the tumor microenvironment through the stimulation of extracellular matrix deposition,promotion of angiogenesis,and suppression of the ant-tumor immune *** pro-oncogenic roles of TGFβ have attracted considerable attention because their intervention provides a therapeutic approach for cancer ***,the critical function of TGFβin maintaining tissue homeostasis makes targeting TGFβa ***,we review the pleiotropic functions of TGFβin cancer initiation and progression,summarize the recent clinical advancements regarding TGFβ signaling interventions for cancer treatment,and discuss the remaining challenges and opportunities related to targeting this *** provide a perspective on synergistic therapies that combine anti-TGFβ therapy with cytotoxic chemotherapy,targeted therapy,radiotherapy,or immunotherapy.

关键词： TGFβ homeostasis stimulation

Characterization of Electric Field Distribution Within High Voltage Press-packed IGBT Submodules Under Conditions of Repetitive Turn-on and Turn-off

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CSEE Journal of Power and Energy Systems 2022年第2期8卷 609-620页

作者： Teng Wen Xiang Cui sijia liu Xuebao Li Zhibin Zhao State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China

The high-voltage high-power press-packed IGBT(PPI)devices are the key component of the DC transmission apparatus.A PPI device is composed of several PPI *** general,the PPI submodule works in a state of repetitive turn-on and turn-off,and the corresponding working voltage is the positive periodic square waveform(PPSW)voltage,which is much different from the conventional AC or DC *** addition,insulation capability is one of the most critical challenges in the design and fabrication of PPI *** improve the insulation capability of the device,composite insulation structures with multiple dielectrics are usually *** the PPSW voltage,it is essential to analyze the transient electric field to solve the insulation challenge of the PPI ***,the electric field of the PPI is often calculated under the electrostatic field or DC ***,the transient characteristics of the electric field are ***,this paper focuses on the analysis of the transient characteristics of the electric field of the PPI submodule under the PPSW *** influences of the waveform parameters of the PPSW voltage on the transient characteristics are demonstrated in *** study is significant for the insulation analysis and design of the PPIs.

关键词： Electroquasistatic field FEM IGBT positive periodic square waveform voltage transient electric field

The effects of different light storage conditions on volatile flavor compounds and sensory properties of melon fruit

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Food Bioscience 2022年第4期48卷 701-708页

作者： sijia liu Yao liu Tuoyi Wang Jie Zhang College of Food and Bioengineering Qiqihar UniversityQiqihar161006China College of Food Science and Engineering Jilin UniversityChangchun130062China

Light can be invoked as a signal for improving metabolism and physiological state during plant ***,little is known about the effects of light on volatile flavor compounds and sensory properties during melon fruit storage,especially for different types of visible *** typical volatile flavor compounds,including 28 esters,7 alcohols,7 aldehydes,4 ketones,2 furans,1 ether,and 1 pyrazine,were identified by gas chromatography-ion mobility spectrometry in melon fruit under blue light,black,green light,red light,and white light storage *** total peak values of the flavor compounds were significantly higher in white light storage condition but significantly lower in black storage condition compared with the controls.A 5-day continuous sensory property study involving color,appearance,freshness,odor,and mouthfeel was *** sensory scores were high in white light storage conditions but low in black storage *** results were consistent with the previous detection results,and white light was found to be more conducive to melon *** study provides useful insights into the effects of light on flavor and sensory properties of melon fruit,as well as a possible way to extend melon fruit shelf life by visible light irradiation.

关键词： Melon fruit Shelf life Light storage Sensory properties Volatile flavor compounds

Finite Element Method for Transient Electric Field by Using Indirect Laplace Transform with High Accuracy

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 401-411页

作者： Teng Wen Xiang Cui Xuebao Li sijia liu Zhibin Zhao State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China China Electric Power Planning&Engineering Institute Beijing 100120China

This paper focuses on the finite element method in the complex frequency domain(CFD-FEM)for the transient electric ***,the initial value and boundary value problem of the transient electric field under the electroquasistatic field in the complex frequency domain is *** addition,the finite element equation and the constrained electric field equation on the boundary are ***,the indirect algorithm of the numerical inverse Laplace transform is *** on it,the calculation procedures of the CFD-FEM are illustrated in ***,the step response,zero-state response under the positive periodic square waveform(PPSW)voltage,and the zero-input response by the CFD-FEM with direct algorithm and indirect algorithm are ***,the reason for the numerical oscillations of the zero-state response under the PPSW voltage is analyzed,and the method to reduce oscillations is *** results show that the numerical accuracy of the indirect algorithm of the CFD-FEM is more than an order of magnitude higher than that of the direct algorithm when calculating the step response of the transient electric *** proposed method can significantly reduce the numerical oscillations of the zero-state response under the PPSW *** proposed method is helpful for the calculation of the transient electric field,especially in the case of frequency-dependent parameters.

关键词： Electroquasistatic field transient electric field finite element method complex frequency domain numerical Laplace transform

The 200-hPa Wind Perturbation in the Subtropical Westerly over East Asia Related to Medium-Range Forecast of Summer Rainfall in China

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Journal of Meteorological Research 2018年第3期32卷 491-502页

作者： Ronghua JIN Yan LI Qingrou LONG sijia liu National Meteorological Center China Meteorological AdministrationBeijing 100081 Key Laboratory of Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000 Chengdu University of Information Technology Chengdu 610225

The 200-hPa wind perturbation(WP) in the subtropical westerly over East Asia(SWEA) has seldom been examined in previous studies, especially in connection with forecast of the summer rainfall in China. Based on the daily NCEP/NCAR reanalysis data and precipitation observations in China from 1 June to 31 August of 1960-2015, this study first systematically analyzes the spatiotemporal distribution features of the 200-hPa WP in the SWEA on different scales, especially during the Meiyu season in the Yangtze-Huaihe region and during the rainy period in North China, by using spectral decomposition and period analysis. It is found that in the 56-yr mean fields, the 200-hPa WP in the SWEA is collocated with the East Asian subtropical jet(EASJ), with the centers of the two systems coincidentally overlapped. The WP filed in the subtropical westerly mainly comprises planetary-and synoptic-scale waves. The quasi-stationary planetary-scale wave seems to determine the shape and intensity of the WP in the SWEA, while the synoptic-scale wave is closely related to the local central intensity of the WP. The daily evolution of the 56-yr mean fields shows that, following the northward(southward) movement of SWEA from 1 June to 31 August, the planetaryscale WP in the SWEA becomes gradually weakened(intensified) whereas the synoptic-scale WP is slightly intensified(weakened).The results also reveal that during the Meiyu season in the Yangtze-Huaihe region, the WP in the SWEA moves northward slowly around 37°-39°N, demonstrating a quasi-biweekly oscillation in its geographic location, which is largely attributed to the strong(weak) planetary-scale(synoptic-scale) component. On the contrast, in the summer rainy season over North China, the WP in the SWEA further strives northward beyond 40°N, showing both quasi-biweekly and weekly oscillations in its position; meanwhile, the planetary-scale wave in the SWEA becomes weakened whereas the synoptic-scale wave is enhanced. These salient variatio

关键词： westerly wind perturbation subtropical westerly East Asia spectral decomposition rainy season in eastern China period analysis

Metal organic polymers with dual catalytic sites for oxygen reduction and oxygen evolution reactions

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Carbon Energy 2023年第5期5卷 127-137页

作者： sijia liu Minghao liu Xuewen Li Shuai Yang Qiyang Miao Qing Xu Gaofeng Zeng CAS Key Laboratory of Low-Carbon Conversion Science and Engineering Shanghai Advanced Research Institute(SARI)Chinese Academy of Sciences(CAS)ShanghaiChina School of Physical Science and Technology ShanghaiTech UniversityShanghaiChina School of Chemical Engineering University of Chinese Academy of SciencesBeijingChina

Metal-organic frameworks and covalent organic frameworks have been widely employed in electrochemical catalysis owing to their designable skeletons,controllable porosities,and well-defined catalytic ***,the poor chemical stability and low electron conductivity limited their activity,and single-functional sites in these frameworks hindered them to show multifunctional roles in catalytic ***,we have constructed novel metal organic polymers(Co-HAT-CN and Ni-HAT-CN)with dual catalytic centers(metal-N_(4) and metal-N_(2))to catalyze oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).By using different metal centers,the catalytic activity and selectivity were *** them,Co-HAT-CN catalyzed the ORR in a 4e^(-)pathway,with a half-wave potential of 0.8 V versus RHE,while the Ni-HAT-CN catalyze ORR in a 2e^(-)pathway with H_(2)O_(2) selectivity over 90%.Moreover,the Co-HAT-CN delivered an overpotential of 350 mV at 10 mA cm^(-2) with a corresponding Tafel slope of 24 mV dec^(-1) for OER in a 1.0 M KOH aqueous *** experimental results revealed that the activities toward ORR were due to the M-N_(4) sites in the frameworks,and both M-N_(4) and M-N_(2) sites contributed to the *** work gives us a new platform to construct bifunctional catalysts.

关键词： covalent organic frameworks metal organic polymers oxygen evolution reaction oxygen reduction reaction single atom catalysts

Rapid,Energy-saving Bioinspired Soft Switching Valve Embedded in Snapping Membrane Actuator

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Journal of Bionic Engineering 2023年第1期20卷 225-236页

作者： Fangzhou Zhao Yingjie Wang sijia liu Miao Jin Luquan Ren Lei Ren Chunbao liu School of Mechanical and Aerospace Engineering Jilin UniversityChangchun130022China Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun130022China School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK

In nature,organisms widely use the interaction of muscle contraction and biological pipelines to form an efficient fluid control ***,a pneumatically powered,Bioinspired Soft Switching valve(BSS valve)with short response time and low-energy consumption is *** BSS valve is composed of flexible walls,a flexible tube and symmetrically arranged Snapping Membrane actuator(SM actuator).It functions based on tube deformation throttling caused by instability of SM actuator *** realize rapid preparation of customized BSS valve,the modular manufacturing method suitable for different materials and structures based on 3D printing and mold forming was *** the membrane flip rate as indicators,the displacement transient response characteristics of three structures actuators were studied,The results proved that spherical and spherical cap membrane SM actuator achieved rapid displacement response under the low critical pressure ***,with critical buckling pressure and capacity utilization efficiency as indicators,we analyzed the characteristics of SM actuators with different radius and wall thickness to obtain reasonable structural parameters configuration of SM *** influence of radius and thickness on SM actuator is revealed,and theoretical model formulas were *** different configurations are presented.(1)Customized BSS valve structures can achieve sequential motion of flexible gripper.(2)BSS valve embedded in soft *** performance tests confirmed it has significant advantages in energy consumption,specific pressure,specific flow,high-frequency cycle load life,and valve can be integrated into the soft pump fluid system as a throttling unit,and provides an idea for fluid drive control integration.

关键词： Bioinspired.Soft robot BSS valve SM actuator

Transient electric field of the combined insulation structure under positive periodic square waveform voltage:Analytical analysis and application

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High Voltage 2022年第5期7卷 877-889页

作者： Teng Wen Xiang Cui Xuebao Li sijia liu Zhibin Zhao State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijingChina

The working voltage of the high-voltage high-power electronic devices is the positive periodic square waveform(PPSW)voltage,which is much different from the conventional AC or DC *** the composite insulation structure of devices,it is important to analyse the transient electric field under the PPSW ***,the existing investigations are often conducted under the electrostatic field due to the high frequency of the PPSW ***,the transient characteristics of the electric field are *** obtain some qualitative conclusions,this paper focusses on the theoretical analysis of the transient characteristics of electric field for the composite insulation structure under the PPSW ***,the formula of the electric field intensity and the interfacial charge density are derived ***,the influence of the cycle and the duty cycle on the transient characteristics are ***,the maximum of the electric field intensity and the interfacial charge density in the positive square waveform steady-state are discussed in ***,the engineering calculation methods for obtaining these maximum values are also ***,an actual model is employed to testify the validity of the analytical *** work is significant for the numerical calculation of the transient electric field of composite insulation structure under the PPSW voltage in engineering.

关键词： composite insulation field