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Phase transition of multi-component(TiZrVNb)C ceramics—Part II:From single phase to multiple phases via adjusting V content

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Journal of Advanced Ceramics 2024年第5期13卷 689-698页

作者： Qingyi Kong Lei Chen sijia Huo Kunxuan Li Wenyu lu Yujin Wang Yu Zhou Institute for Advanced Ceramics School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150080China Key Laboratory of Advanced Structure‒Function Integrated Materials and Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001China National Key Laboratory of Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

To address the relatively mediocre mechanical properties of single-phase multi-component carbide ceramics,a phase transition from a single phase to multiple phases was proposed to achieve superior mechanical properties.A series of(TiZrVxNb)C0.8 ceramics with different V contents were fabricated by spark plasma sintering(SPS).The influence of the V content on the phase composition,microstructural evolution,and mechanical properties was investigated in detail.The transition behavior from a single phase to multiple phases is discovered and discussed.The formation of the Zr-rich phase and Zr-poor phase can be attributed to the increase in lattice distortion and mixed enthalpy caused by the addition of V.A nanometer lamellar structure with a semi-coherent interface obtained via in situ decomposition is reported for the first time in multi-component carbide ceramics.The semi-coherent interfaces with high dislocation density and strain concentration effectively improve the mechanical properties,grain refinement,and multi-phase formation.The optimal comprehensive mechanical properties of the Vickers hardness(26.3 GPa),flexural strength(369 MPa),and fracture toughness(3.1 MPa·m1/2)were achieved for the sample with 20 mol%V.

关键词： multi-component ceramics multiple phases microstructure evolution phase decomposition mechanical properties

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Tumor necrosis factor-α signaling in nonalcoholic steatohepatitis and targeted therapies

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Journal of Genetics and Genomics 2022年第4期49卷 269-278页

作者： sijia lu Yibing Wang Junli Liu Shanghai Diabetes Institute Department of Endocrinology and MetabolismShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China School of Kinesiology Shanghai University of SportsShanghai 200438China

Nonalcoholic steatohepatitis(NASH),an inflammatory subtype of nonalcoholic fatty liver disease,is featured by significantly elevated levels of various proinflammatory cytokines.Among numerous proinflammatory factors that contribute to NASH pathogenesis,the secreted protein,tumor necrosis factoralpha(TNF-α),plays an essential role in multiple facets of NASH progression and is therefore considered as a potential therapeutic target.In this review,we will first systematically describe the preclinical studies on the biochemical function of TNF-αand its intracellular downstream signaling mechanisms through its receptors.Moreover,we extensively discuss its functions in regulating inflammation,cell death,and fibrosis of liver cells in the pathogenesis of NASH,and the molecular mechanism that TNF-αexpression is regulated by NF-κB and other upstream master regulators during NASH progression.As TNF-αis one of the causal factors that remarkably contributes to NASH progression,combination of therapeutic modalities,including TNF-α-based therapies may lead to the resolution of NASH via multiple pathways and thus generate clinical benefits.For translational studies,we summarize recent advances in strategies targeting TNF-αand its signaling pathway,which paves the way for potential therapeutic treatments for NASH in the future.

关键词： TNF-αsignaling NASH Inflammation Cell death Fibrosis

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Phase transition of multi-component(TiZrVNb)C ceramics—Part I:Phase decomposition induced by carbon content

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Journal of Advanced Ceramics 2024年第5期13卷 679-688页

作者： Qingyi Kong Rao Zhang Lei Chen sijia Huo Wenyu lu Yujin Wang Boxin Wei Yu Zhou Institute for Advanced Ceramics School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150080China Key Laboratory of Advanced Structure‒Function Integrated Materials and Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150001China National Key Laboratory of Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

Phase decomposition can effectively enhance the mechanical properties of carbide ceramics and can overcome the difficulty of enhancing the mechanical properties of single-phase multicomponent carbide ceramics.In this work,a series of nonstoichiometric(TiZrVNb)Cx ceramics were prepared by spark plasma sintering(SPS)at different temperatures.The effects of the carbon content on the phase composition,microstructure evolution,and mechanical properties were investigated in detail.Phase decomposition occurred with decreasing carbon content.Two different solid solutions of(Ti,V)-rich and Zr-rich phases formed from the decomposition of equimolar single-phase solid solutions,namely,the Zr-poor phase and Zr-rich phase,respectively.The distribution of Nb element is relatively uniform.The semicoherent interfaces between the Zr-poor phase and the Zr-rich phase can harden and strengthen effectively under the synergistic effect of grain refinement.Ceramics with phase decomposition structures have apparent advantages compared to single-phase high-entropy carbides.This work provides an important train of thought for the microstructure tailoring and properties optimization of multi-component carbide ceramics.

关键词： multicomponent ceramics nontoichiometry microstructure evolution phase decomposition mechanical properties

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Advances in the pathogenesis of Rett syndrome using cell models

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Animal Models and Experimental Medicine 2022年第6期5卷 532-541页

作者： sijia lu Yongchang Chen Zhengbo Wang State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingChina Yunnan Key Laboratory of Primate Biomedical Research KunmingChina

Rett syndrome(RTT)is a progressive neurodevelopmental disorder that occurs mainly in girls with a range of typical symptoms of autism spectrum disorders.MeCP2 protein loss-of-function in neural lineage cells is the main cause of RTT pathogenicity.As it is still hard to understand the mechanism of RTT on the basis of only clinical patients or animal models,cell models cultured in vitro play indispensable roles.Here we reviewed the research progress in the pathogenesis of RTT at the cellular level,summarized the preclinical-research-related applications,and prospected potential future development.

关键词： cell models MeCP2 pathogenesis Rett syndrome

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Current overview on the genetic basis of key genes involved in soybean domestication

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aBIOTECH 2022年第2期3卷 126-139页

作者： sijia lu Chao Fang Jun Abe Fanjiang Kong Baohui Liu Innovative Center of Molecular Genetics and Evolution School of Life SciencesGuangzhou UniversityGuangzhou 510006China Guangzhou Key Laboratory of Crop Gene Editing Guangzhou UniversityGuangzhou 510006China Research Faculty of Agriculture Hokkaido UniversitySapporoHokkaido 060-0808Japan

Modern crops were created through the domestication and genetic introgression of wild relatives and adaptive differentiation in new environments.Identifying the domestication-related genes and unveiling their molecular diversity provide clues for understanding how the domesticated variants were selected by ancient people,elucidating how and where these crops were domesticated.Molecular genetics and genomics have explored some domestication-related genes in soybean(Glycine max).Here,we summarize recent studies about the quantitative trait locus(QTL)and genes involved in the domestication traits,introduce the functions of these genes,clarify which alleles of domesticated genes were selected during domestication.A deeper understanding of soybean domestication could help to break the bottleneck of modern breeding by highlighting unused genetic diversity not selected in the original domestication process,as well as highlighting promising new avenues for the identification and research of important agronomic traits among different crop species.

关键词： Soybean Domestication Diversity Gene

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Cardiovascular toxicity with CTLA-4 inhibitors in cancer patients:A meta-analysis

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Cancer Innovation 2024年第3期3卷 49-64页

作者： Huiyi Liu lu Fu Shuyu Jin Xingdong Ye Yanlin Chen sijia Pu Yumei Xue Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdongChina School of Medicine South China University of TechnologyGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Clinical Pharmacology Research Center of Medical SciencesGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina

Background:With the emergence of cytotoxic T lymphocyte-associated protein-4(CTLA-4)inhibitors,the outcomes of patients with malignant tumors have improved significantly.However,the incidence of cardiovascular adverse events has also increased,which can affect tumor treatment.In this study,we evaluated the incidence and severity of adverse cardiovascular events caused by CTLA-4 inhibitors by analyzing reported trials that involved CTLA-4 inhibitor therapy.Methods:Randomized clinical trials published in English from January 1,2013,to November 30,2022,were searched using the Cochrane Library and PubMed databases.All included trials examined all grade and grades 3–5 cardiac and vascular adverse events.These involved comparisons of CTLA-4 inhibitors to placebo,CTLA-4 inhibitors plus chemotherapy to chemotherapy alone,CTLA-4 inhibitors combined with PD-1/PD-L1 inhibitors to PD-1/PD-L1 inhibitors alone,and CTLA-4 inhibitors plus target agent to PD-1/PD-L1 inhibitors plus target agent.The odds ratio(OR)and corresponding 95%confidence intervals(CIs)were calculated using the Mantel-Haenszel method.Results:Overall,20 trials were included.CTLA-4 inhibitors significantly increased the incidence of all-grade cardiovascular toxicity(OR=1.33,95%CI:1.00–1.75,p=0.05).The incidence of all-grade cardiovascular toxicity increased in malignant tumor patients who received single-agent CTLA-4 inhibitors(OR=1.73,95%CI:1.13–2.65,p=0.01),as well as the incidence rate of grades 3–5 cardiovascular adverse events(OR=2.00,95%CI:1.08–3.70,p=0.03).Compared with the non-CTLA-4 inhibitor group,CTLA-4 inhibitors plus chemotherapy,PD-1/PD-L1 inhibitors,or target agent did not significantly affect the incidence of cardiac and vascular toxicity.The incidence of grades 3–5 cardiac failure,hypertension,pericardial effusion,myocarditis,and atrial fibrillation were much higher among patients exposed to CTLA-4 inhibitor,but the data were not statistically significant.Conclusion:Our findings suggest that the incidence rate of all cardiovascular toxicity an

关键词： cardiovascular toxicity CTLA-4 inhibitors malignancies

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考虑分布式电源时空相关及电动汽车充电负荷分布特性的有源配电网概率潮流

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电网技术 2024年第6期48卷 2550-2563,I0084,I0085页

作者：徐艳春李思佳汪平 MI lu 梯级水电站运行与控制湖北省重点实验室(三峡大学) 湖北省宜昌市443002 得克萨斯农工大学电气与计算机工程系美国得克萨斯州77840

目前分布式电源(distribution generation,DG)和电动汽车(electric vehicle,EV)充电负荷等随机变量接入电力系统时时空特性考虑不足,会导致概率潮流计算偏离实际。因此该文提出了考虑DG时空相关及EV分布特性的有源配电网概率潮流模型。... 详细信息

目前分布式电源(distribution generation,DG)和电动汽车(electric vehicle,EV)充电负荷等随机变量接入电力系统时时空特性考虑不足,会导致概率潮流计算偏离实际。因此该文提出了考虑DG时空相关及EV分布特性的有源配电网概率潮流模型。首先,利用场景生成建立时空相关的风电、光伏出力概率模型;然后,考虑路网约束和用户心理,建立考虑EV时空分布特性的负荷概率模型;最后,以Nataf变换结合奇异值分解处理相关性输入变量,运用三点估计法对概率潮流进行计算,通过Cornish-Fisher级数拟合得到累积分布函数。以IEEE-33节点系统进行测试,利用所提模型分析了DG时空相关性和EV分布特性对配电网潮流的影响。结果表明DG时空相关性主要影响系统的波动性,EV分布特性主要影响系统的运行特性。该文研究可为新型配电网的安全运行提供理论指导。

关键词：分布式电源电动汽车充电负荷场景生成时空特性有源配电网概率潮流 Nataf变换

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Comments on‘Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1–AMPK–LKB1 complex’

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Journal of Molecular Cell Biology 2023年第4期15卷 68-69页

作者： sijia lu Suzhen Chen Ji Miao Junli Liu Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes MellitusShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China Division of Endocrinology Boston Children's HospitalBostonMA 02215USA Department of Pediatrics Harvard Medical SchoolBostonMA 02115USA

Human health requires macronutrients,such as amino acids,glucose,and lipids,as well as micronutrients,including copper and iron.Copper is required for the assembly of various enzymes,such as copper/zinc superoxide dismutase and cytochrome c oxidase(Kim et al.,2008).It has been well documented that adenosine monophosphate-activated protein kinase(AMPK)senses intracellular glucose concentrations(Li et al.,2019),mTOR is responsible for monitoring intracellular amino acid levels(Liu and Sabatini,2020),and CD36 functions as a sensor for intracellular lipid amounts(Hao et al.,2020).However,it is still unclear how intracellular copper dynamic changes are sensed and whether copper plays a crucial messenger role in the regulation of metabolism of macronutrients.

关键词： CD36 metabolism

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守正与创新:一级学科更名背景下档案学科发展路径

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档案学研究 2024年第1期 4-11页

作者：卢思佳陈晓婷中国人民大学信息资源管理学院北京100872

一级学科更名背景下,档案学科身处变革的风口,探讨档案学科发展应当何去何从具有重要意义。一级学科更名这一事件在为档案学科提供更强有力的支撑、拓展档案学科发展空间、优化档案学科人才培养体系的同时,也使档案学科地位被边缘化、... 详细信息

一级学科更名背景下,档案学科身处变革的风口,探讨档案学科发展应当何去何从具有重要意义。一级学科更名这一事件在为档案学科提供更强有力的支撑、拓展档案学科发展空间、优化档案学科人才培养体系的同时,也使档案学科地位被边缘化、独立性被削弱、课程消隐泛化、生源危机加重。由此,本文提出档案学科守正与创新的发展路径。一则,应守学科之本,不断优化档案学科建设。即担当使命,回应并引领社会需求;正本清源,聚焦档案学科研究根本;立足本土,促进档案学科自主创新。二则,应借更名之机,谋求档案学科新增长点。即融合发展,拓展档案学科研究视野;协同开放,培育更广范围的学科共同体;着力长远,探索学科教育的新布局。

关键词：档案学科学科更名学科发展

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Two soybean homologues of TERMINAL FLOWER 1 control flowering time under long day conditions

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The Crop Journal 2023年第3期11卷 704-712页

作者： Lingshuang Wang Chun Lin Bohui Li Tong Su Shichen Li Haiyang Li Fanglei He Chuanjie Gou Zheng Chen Yanan Wang Jun Qin Baohui Liu Fanjiang Kong Lin Yue sijia lu Chao Fang Guangdong Key Laboratory of Plant Adaptation and Molecular Design Guangzhou Key Laboratory of Crop Gene EditingInnovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006GuangdongChina College of Agriculture and Biotechnology Yunnan Agricultural UniversityKunming 650201YunnanChina National Key Laboratory of Crop Genetics and Germplasm Enhancement National Center for Soybean ImprovementJiangsu Collaborative Innovation Center for Modern Crop ProductionNanjing Agricultural UniversityNanjing 210095JiangsuChina Institute of Cereal&Oil Crop Hebei Academy of Agricultural and Forestry SciencesKey Laboratory of Crop Genetics and Breeding of HebeiShijiazhuang 050035HebeiChina

Flowering time is a key agronomic trait that directly affect the adaptation and yield of soybean.After whole genome duplications,about 75%of genes being represented by multiple copies in soybean.There are four TERMINAL FLOWER 1(TFL1)genes in soybean,and the TFL1b(Dt1)has been characterized as the determinant of stem growth habit.The function of other TFL1 homologs in soybean is still unclear.Here,we generated knockout mutants by CRISPR/Cas9 genome editing technology and found that the tfl1c/tfl1d double mutants flowered significantly earlier than wild-type plants.We investigated that TFL1c and TFL1d could physically interact with the b ZIP transcription factor FDc1 and bind to the promoter of APETALA1a(AP1a).RNA-seq and q RT-PCR analyses indicated that TFL1c and TFL1d repressed the expressions of the four AP1 homologs and delayed the flowering time in soybean.The two genes play important roles in the regulation of flowering time in soybean and mainly act as the flowering inhibitors under long-day conditions.Our results identify novel components in the flowering-time regulation network of soybean and will be invaluable for molecular breeding of improved soybean yield.

关键词： Soybean TFL1c TFL1d Flowering time

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