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Rational design, synthesis and prospect of biodegradable magnesium alloy vascular stents

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Journal of Magnesium and Alloys 2023年第9期11卷 3012-3037页

作者： Senwei Wang Chengao Du Xin Shen Xiong wu sihui Ouyang Jun Tan Jia She Aitao Tang Xianhua Chen Fusheng Pan College of Materials Science and Engineering Chongqing UniversityChongqingChina National Engineering Research Center for Mg Alloys Chongqing UniversityChongqingChina Beijing Amsinomed Medical Co LtdBeijingChina

Biodegradable magnesium(Mg) alloys are expected to be promising materials for cardiovascular stents(CVS), which can avoid the longterm clinical problems of current CVS, such as in-stent restenosis, late stent thrombosis, etc. Mg alloy stents exhibit superior biocompatibility and tunable biodegradability, compared with conventional permanent metallic stents. However, the poor formability and non-uniform corrosion of Mg alloy stents hinder their clinical application of CVS. This review focuses on the development of Mg alloys for CVS in recent *** to the results of bibliometric analysis, we analyzed different biodegradable Mg alloy systems. Moreover, the structural design strategies for Mg alloy stents that can reduce the stress concentration, as well as the surface modification methods to control the corrosion behavior and biological performance of Mg alloy stents are also highlighted. At last, this review systematically discussed the potential directions and challenges of biodegradable magnesium stents(BMgS) in cardiovascular fields.

关键词： Mg alloy micro-tube Biodegradable Mg stent Alloying design Structural design Functional properties

调胃承气汤对脓毒症胃肠损伤患者胃肠功能及免疫状态的影响

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中国医药导报 2020年第25期17卷 119-124页

作者：张先进刘敏林新锋温敏勇吴思慧赵馥赵锋利广州中医药大学第一附属医院重症医学科广东广州510405

目的观察调胃承气汤对脓毒症胃肠损伤患者胃肠功能及免疫状态的影响。方法选取2017年10月-2019年5月于广州中医药大学第一附属医院重症医学科收治的脓毒症胃肠损伤患者56例,按就诊顺序进行编号,采用奇偶数法将其随机分为对照组和治疗组,... 详细信息

目的观察调胃承气汤对脓毒症胃肠损伤患者胃肠功能及免疫状态的影响。方法选取2017年10月-2019年5月于广州中医药大学第一附属医院重症医学科收治的脓毒症胃肠损伤患者56例,按就诊顺序进行编号,采用奇偶数法将其随机分为对照组和治疗组,各28例。对照组予西医常规治疗,治疗组在对照组的基础上加用调胃承气汤,1剂/次,2次/d,口服或鼻饲,7 d为1个疗程。观察两组的中医证候疗效、肠鸣音、腹围、腹内压、病情危重程度评分、白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)、人白细胞DR抗原(HLA-DR)、淋巴细胞总数、CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、自然杀伤(NK)细胞及并发症发生情况。结果治疗组的总有效率高于对照组(P<0.05)。治疗后,两组的肠鸣音多于治疗前,腹围短于治疗前,腹内压低于治疗前,且治疗组的肠鸣音多于对照组,腹围短于对照组,腹内压低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的序贯器官衰竭估计评分及急性生理与慢性健康状况Ⅱ评分均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05)。两组治疗后的WBC、CRP及PCT水平均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组HLA-DR、淋巴细胞总数、CD3^+、CD4^+、CD8^+、CD4^+/CD8^+及NK细胞均高于治疗前,且治疗组高于对照组,差异有统计学意义(P<0.05)。两组均未见明显毒副作用。结论调胃承气汤结合西医治疗能有效改善脓毒症胃肠损伤患者的胃肠功能,良性调节患者的免疫状态,疗效优于单纯西医治疗,且安全无毒副作用。

关键词：调胃承气汤脓毒症急性胃肠损伤细胞免疫

cGAS guards against chromosome endto-end fusions during mitosis and facilitates replicative senescence

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Protein & Cell 2022年第1期13卷 47-64页

作者： Xiaocui Li Xiaojuan Li Chen Xie sihui Cai Mengqiu Li Heping Jin Shu wu Jun Cui Haiying Liu Yong Zhao MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yatsen UniversityGuangzhou 510006China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510006China Department of Biochemistry School of Life SciencesSun Yat-sen UniversityGuangzhou 510006China

As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, we identify cGAS as an essential regulator in inhibiting mitotic DNA double-strand break (DSB) repair and protecting short telomeres from end-to-end fusion independent of the canonical cGAS-STING pathway. cGAS associates with telomeric/subtelomeric DNA during mitosis when TRF1/TRF2/POT1 are deficient on telomeres. Depletion of cGAS leads to mitotic chromosome end-to-end fusions predominantly occurring between short telomeres. Mechanistically, cGAS interacts with CDK1 and positions them to chromosome ends. Thus, CDK1 inhibits mitotic non-homologous end joining (NHEJ) by blocking the recruitment of RNF8. cGAS-deficient human primary cells are defective in entering replicative senescence and display chromosome end-to-end fusions, genome instability and prolonged growth arrest. Altogether, cGAS safeguards genome stability by controlling mitotic DSB repair to inhibit mitotic chromosome end-to-end fusions, thus facilitating replicative senescence.

关键词： cGAS telomeres chromosome end-toend fusion DNA damage response non-homologous end joining mitosis genome stability

小脑靶点rTMS治疗PPPD的临床随机对照研究

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大连医科大学学报 2023年第4期45卷 309-312页

作者：刘晓阳吴思慧孙晓明李佳威包圆圆杨星昱孙玲大连市第三人民医院神经功能检测与调控治疗中心辽宁大连116033 大连市第三人民医院病案信息统计科辽宁大连116033

目的分析小脑靶点重复经颅磁刺激(r TMS)治疗持续性姿势-感知性头晕(PPPD)的临床疗效。方法选择2021年7月至2022年12月就诊于大连市第三人民医院眩晕专科门诊并符合PPPD诊断标准的患者68例,以1∶1比例随机分为rTMS组和假刺激组,每组各3... 详细信息

目的分析小脑靶点重复经颅磁刺激(r TMS)治疗持续性姿势-感知性头晕(PPPD)的临床疗效。方法选择2021年7月至2022年12月就诊于大连市第三人民医院眩晕专科门诊并符合PPPD诊断标准的患者68例,以1∶1比例随机分为rTMS组和假刺激组,每组各34例。以头晕残障量表(DHI)评分为主要评价指标,汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)为次要指标。分别比较两组受试者在治疗前、治疗后即刻、治疗后2周、治疗后4周上述量表得分。结果重复测量方差分析结果显示,DHI、HAMA、HAMD、PSQI 4个量表的分组因素、时间因素,以及二者的交互作用均有统计学意义(P0.05),治疗后即刻、治疗后2周、治疗后4周r TMS组各量表分数均明显低于假刺激组,差异有统计学意义(P<0.05)。结论rTMS治疗PPPD安全、有效,值得临床推广应用。

关键词：重复经颅磁刺激持续性姿势-感知性头晕头晕焦虑抑郁

RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-kB hyper-activation and inflammation

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1601-1613页

作者： Yaoxing wu Ling Ma sihui Cai Zhen Zhuang Zhiyao Zhaou Shouheng Jin Weihong Xie Lingli Zhou Lei Zhang Jincun Zhao Jun Cui MOE Key Laboratory of Gene Funrtion and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdongChina State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina

The ongoing 2019 novel coronavirus disease(COVID-19)caused by SARS-CoV-2 has posed a worldwide pandemic and a major global public health *** severity and mortality of COVID-19 are associated with virus-induced dysfunctional inflammatory responses and cytokine ***,the interplay between host inflammatory responses and SARS-CoV-2 infection remains largely ***,we demonstrate that SARS-CoV-2 nucleocapsid(N)protein,the major structural protein of the virion,promotes the virus-triggered activation of NF-kB *** binding to viral RNA,N protein robustly undergoes liquid-liquid phase separation(LLPS),which recruits TAK1 and IKK complex,the key kinases of NF-kB signaling,to enhance NF-kB ***,1,6-hexanediol,the inhibitor of LLPS,can attenuate the phase separation of N protein and restrict its regulatory functions in NF-kB *** results suggest that LLPS of N protein provides a platform to Induce NF-kB hyper-activation,which could be a potential therapeutic target against COVID-19 severe pneumonia.

关键词： inflammation separation activation

Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2392-2407页

作者： sihui Cai Chenqiu Zhang Zhen Zhuang Shengnan Zhang Ling Ma Shuai Yang Tao Zhou Zheyu Wang Weihong Xie Shouheng Jin Jincun Zhao Xiangdong Guan Jianfeng wu Jun Cui Yaoxing wu Guangdong Province Key Laboratory of Pharmaceutical Functional Genes The First Affiliated Hospital of Sun Yat-sen UniversitySchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdongChina MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdongChina State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Critical Care Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Currently,the incidence and fatality rate of SARS-CoV-2 remain continually high ***-19 patients infected with SARS-CoV-2 exhibited decreased type I interferon(IFN-I)signal,along with limited activation of antiviral immune responses as well as enhanced viral *** progresses have been made in revealing the multiple strategies employed by SARS-CoV-2 in impairing canonical RNA sensing ***,it remains to be determined about the SARS-CoV-2 antagonism of cGAS-mediated activation of IFN responses during *** the current study,we figure out that SARS-CoV-2 infection leads to the accumulation of released mitochondria DNA(mtDNA),which in turn triggers cGAS to activate IFN-I *** countermeasures,SARS-CoV-2 nucleocapsid(N)protein restricts the DNA recognition capacity of cGAS to impair cGAS-induced IFN-I ***,N protein disrupts the assembly of cGAS with its co-factor G3BP1 by undergoing DNA-induced liquid-liquid phase separation(LLPS),subsequently impairs the double-strand DNA(dsDNA)detection ability of *** together,our findings unravel a novel antagonistic strategy by which SARS-CoV-2 reduces DNA-triggered IFN-I pathway through interfering with cGAS-DNA phase separation.

关键词： interferon separated cGAS

Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling

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Signal Transduction and Targeted Therapy 2020年第1期5卷 646-648页

作者： Yaoxing wu Ling Ma Zhen Zhuang sihui Cai Zhiyao Zhao Lingli Zhou Jing Zhang Pei-Hui Wang Jincun Zhao Jun Cui MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen University510275 GuangzhouGuangdongChina State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical University510182 GuangzhouGuangdongChina Advanced Medical Research Institute Cheeloo College of MedicineShandong University250012 JinanShandongChina

Dear Editor,At present,the world is suffering from an ongoing pandemic of 2019 novel coronavirus(COVID-19)which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2/2019-nCoV).To date,>20 million cases were confirmed with a death toll at>700,*** there are no clinically specific and effective antiviral treatments toward SARS-CoV-2 infection so far,the pathological study of SARS-CoV-2 infection and the development of SARS-CoV-2-specific vaccines are progressing rapidly within these several months.1 However,few reports mentioned the mechanism employed by SARS-CoV-2 for evading from surveillance of immune system.

关键词： acute respiratory death

The zinc finger transcription factor,KLF2,protects against COVID-19 associated endothelial dysfunction

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2502-2510页

作者： Suowen Xu Yujie Liu Yu Ding sihui Luo Xueying Zheng Xiumei wu Zhenghong Liu Iqra Ilyas Suyu Chen Shuxin Han Peter J.Little Mukesh K.Jain Jianping Weng Institute of Endocrine and Metabolic Diseases The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Department of Obstetrics and Gynecology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiP.R.China Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Sunshine Coast Health Institute University of the Sunshine CoastBirtinyaQLDAustralia School of Pharmacy Pharmacy Australia Centre of Excellencethe University of QueenslandWoolloongabbaQLDAustralia Department of Medicine Case Cardiovascular Research InstituteCase Western Reserve UniversityClevelandOHUSA Department of Medicine Harrington Heart and Vascular InstituteUniversity Hospitals Cleveland Medical CenterClevelandOHUSA The First Affiliated Hospital Bengbu Medical CollegeBengbuChina

Coronavirus disease 2019(COVID-19)is regarded as an endothelial disease(endothelialitis)with its patho-mechanism being incompletely *** evidence has demonstrated that endothelial dysfunction precipitates COVID-19 and its accompanying multi-organ ***,pharmacotherapies targeting endothelial dysfunction have potential to ameliorate COVID-19 and its cardiovascular *** objective of the present study is to evaluate whether kruppel-like factor 2(KLF2),a master regulator of vascular homeostasis,represents a therapeutic target for C0VID-19-induced endothelial ***,we demonstrate that the expression of KLF2 was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules,ICAM1 and ***-1β and TNF-α;two cytokines elevated in cytokine release syndrome in COVID-19 patients,decreased KLF2 gene ***(atorvastatin and tannic acid)and genetic(adenoviral overexpression)approaches to augment KLF2 levels attenuated COVID-19-serum-induced increase in endothelial inflammation and monocyte ***-generation RNA-sequencing data showed that atorvastatin treatment leads to a cardiovascular protective transcriptome associated with improved endothelial function(vasodilation,antiinflammation,antioxidant status,anti-thrombosis/-coagulation,anti-fibrosis,and reduced angiogenesis).Finally,knockdown of KLF2 partially reversed the ameliorative effect of atorvastatin on COVID-19-serum-induced endothelial inflammation and monocyte ***,the present study implicates loss of KLF2 as an important molecular event in the development of COVID-19-induced vascular disease and suggests that efforts to augment KLF2 levels may be therapeutically beneficial.

关键词： KLF2 inflammation elevated

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生物质热解气力进料光敏在线监测技术研究

北京化工大学学报（自然科学版） 2017年第5期44卷 13-20页

作者：吴煜司慧北京林业大学工学院北京100083

为实现对热解用气力输送进料情况实时监测,以落叶松锯末颗粒为原料,采用遮光管内红外激光头与光敏传感器联用的方法,在自主研发的在线监测实验台上,考察了气体流量对进料率、固气比等的影响,分析了电平均值与进料率、固气比、颗粒速率... 详细信息

为实现对热解用气力输送进料情况实时监测,以落叶松锯末颗粒为原料,采用遮光管内红外激光头与光敏传感器联用的方法,在自主研发的在线监测实验台上,考察了气体流量对进料率、固气比等的影响,分析了电平均值与进料率、固气比、颗粒速率的关系,并对管路各层的颗粒浓度进行了灰度图像重建。结果表明:该方法能有效实现在线监测;电平均值与进料率的变化关系和幂函数在第一象限的规律相似;电平均值与颗粒速率负相关;流体颗粒速率由管路下层到上层依次递增;距离喷嘴越远,电平均值越大,流体颗粒速率越小,颗粒分布更加分散,管路各层浓度更加均匀;圆管(DN 20 mm)流体颗粒平均速率约为0.2~0.6 m/s。

关键词：气力输送在线监测光敏传感器落叶松锯末热解