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Genes & Diseases 2024年第3期11卷 43-46页

作者： Zhengqi Wen Wenliang Li Chengmin Shi Junrui Ma sihui zhao Ruize Zhou Xihong Liu Rong Yang Zhiping Zhang Hushan Zhang Bo Li Department of Oncology The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China The Third Affliated Hospital of Kunming Medical University(Yunnan Cancer Center) KunmingYunnan 650021China Gastrointestinal and Hernia Surgery The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China School of Nursing Yunnan University of Chinese MedicineKunmingYunnan 650022China Department of General Surgery The First People's Hospital of Yunnan ProvinceKunmingYunnan 650000China Department of General Surgery The Affiliated Hospital of Yunnan UniversityYunnan 650011China Medical Department 3D Medicines Inc.Shanghai 201114China zhaotong Health Vocational College ZhaotongYunnan 657000China

Colorectal cancer(CRC)is one of the most common cancers around the world,and it is one of the leading causes of cancer-related death.1 Although anti-EGFR therapy and immune checkpoint inhibitor(ICl)therapy are becoming more and more important for colorectal therapy,however,clinical outcomes of current treatments for metastatic CRC,especially with ICls,have been shown to be affected by the status of ***,KRAS mutation status detection has become a very important diagnostic factor for managing metastatic CRC patients.

关键词： KRAS colorectal patients

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磁浮子液位计的应用

山东化工 2024年第13期53卷 205-207页

作者：周佳佳赵嗣辉中石化广州工程有限公司广东广州510620

磁浮子液位计又称为磁性液位计或磁翻板液位计,是在石油、化工、电力等工业领域广泛使用的液位测量仪表之一。通过对磁浮子液位计在实际选型、安装、维护使用过程中遇到的问题进行汇总和分析,介绍了磁浮子液位计的测量原理和特点,为磁... 详细信息

磁浮子液位计又称为磁性液位计或磁翻板液位计,是在石油、化工、电力等工业领域广泛使用的液位测量仪表之一。通过对磁浮子液位计在实际选型、安装、维护使用过程中遇到的问题进行汇总和分析,介绍了磁浮子液位计的测量原理和特点,为磁浮子液位计在石油、化工领域中的实际选型和具体使用提供参考。

关键词：磁浮子液位计选型安装维护

A Unifi ed View of Carbon Neutrality:Solar-Driven Selective Upcycling of Waste Plastics

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Transactions of Tianjin University 2024年第1期30卷 1-26页

作者： Zhiyong zhao Shuai Yue Gaohua Yang Pengfei Wang sihui Zhan MOE Key Laboratory of Pollution Processes and Environmental Criteria Tianjin Key Laboratory of Environmental Remediation and Pollution ControlCollege of Environmental Science and EngineeringTianjin 300350China

With the rapid development of plastic production and consumption globally,the amount of post-consumer plastic waste has reached levels that have posed environmental *** the substantial CO_(2)emissions throughout the plastic lifecycle from material production to its disposal,photocatalysis is considered a promising strategy for eff ective plastic recycling and *** can upgrade plastics into value-added products under mild conditions using solar energy,realizing zero carbon *** this paper,we explain the basics of photocatalytic plastic reformation and underscores plastic feedstock reformation pathways into high-value-added products,including both degradation into CO_(2)followed by reformation and direct reformation into high-value-added ***,the current applications of transforming plastic waste into fuels,chemicals,and carbon materials and the outlook on upcycling plastic waste by photocatalysis are presented,facilitating the realization of carbon neutrality and zero plastic waste.

关键词： Photocatalysis Photoreforming Plastics upcycling Carbon neutrality Energy storage and conversion

Tailoring the surface and interface structures of photocatalysts to enhance hydrogen production

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Science China Chemistry 2024年第4期67卷 1161-1174页

作者： Tao Zhang Pengfei Wang Shuai Yue Fei Li Zhiyong zhao sihui Zhan MOE Key Laboratory of Pollution Processes and Environmental Criteria/Tianjin Key Laboratory of Environmental Remediation and Pollution Control College of Environmental Science and EngineeringNankai UniversityTianjin 300350China

Photocatalytic water splitting using semiconductor photocatalysts is a promising approach for the production of carbon-neutral,sustainable and clean hydrogen ***,the separation and transport of photoinduced carriers are generally considered to be rate-limiting steps,and their low efficiency remains a major ***,much effort has been devoted to developing new strategies in surface/interface engineering of photocatalysts to improve the dynamics of charge separation/*** feature article briefly summarizes recent advances in photocatalyst surface/interface engineering by our research group,which have been achieved through the design of various novel photocatalysts,including interfacial modulation,heterostructure construction,heteroatom doping,single atom and diatom *** article is divided into three parts:first,we briefly introduce the three key processes involved in solar water splitting and reveal relationships between the properties of nanostructural photocatalysts and the fundamentals of water splitting;second,we detail methods and strategies for surface and interfacial structures to improve the efficiency of the fundamental processes,especially charge separation;finally,we explore prospects for photocatalytic water splitting *** article provides a valuable resource and strategies for researchers currently working in the field of photocatalytic water splitting.

关键词： photocatalytic water splitting surface/interface structures dual-functional photocatalysis

Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

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Genes & Diseases 2024年第5期11卷 335-349页

作者： Jinxuan Zheng Rongcheng Yu Yiqi Tang sihui Su Sainan Wang Chenxi Liao Xuecong Li Jiabin Liao Dongsheng Yu Tingting Ai Wei zhao Vicky Yau Chufeng Liu Liping Wu Yang Cao Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong 510055China Guangdong Provincial Key Laboratory of Oral Diseases GuangzhouGuangdong 510055China Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Oral and Maxillofacial Surgery University at BuffaloBuffaloNY 14214USA Department of Orthodontics Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Developmental defects of enamel are common due to genetic and environmental factors before and after ***42,a Rho family small GTPase,regulates prenatal tooth development in ***,its role in postnatal tooth development,especially enamel formation,remains ***,we investigated Cdc42 functions in mouse enamel development and tooth repair after ***42 showed highly dynamic temporospatial patterns in the developing incisors,with robust expression in ameloblast and odontoblast ***,epithelium-specific Cdc42 deletion resulted in enamel defects in *** differentiation was inhibited,and hypomineralization of enamel was observed upon epithelial Cdc42 *** analysis showed that abnormal mitochondrial components,phosphotransferase activity,and ion channel regulator activity occurred in the Cdc42 mutant dental *** oxygen species accumulation was detected in the mutant mice,suggesting that abnormal oxidative stress occurred after Cdc42 ***,Cdc42 mutant mice showed delayed tooth repair and generated less calcified *** dysfunction and abnormal oxygen consumption were evidenced by reduced Apool and Timm8a1 expression,increased Atp5j2 levels,and reactive oxygen species overproduction in the mutant repair ***-specific Cdc42 deletion attenuated ERK1/2 signaling in the labial cervical *** Sox2 expression in the mutant labial cervical loop after clipping might lead to delayed tooth *** findings suggested that mitochondrial dysfunction,up-regulated oxidative stress,and abnormal ion channel activity may be among multiple factors responsible for the observed enamel defects in Cdc42 mutant ***,Cdc42 exerts multidimensional and pivotal roles in enamel development and is particularly required for ameloblast differentiation and enamel matrix formation.

关键词： Cdc42 Enamel defects Mitochondrial dysfunction Rho GTPase Tooth repair

B细胞激活因子在慢性阻塞性肺疾病中的研究进展

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中国医药 2023年第3期18卷 439-442页

作者：赵思慧赵卉山西医科大学太原030000 山西医科大学第二医院呼吸与危重症医学科太原030000

免疫炎症反应在慢性阻塞性肺疾病(COPD)中发挥重要作用。B细胞激活因子(BAFF)已被广泛研究用于自身免疫性疾病,如系统性红斑狼疮和类风湿关节炎等。BAFF与COPD异常免疫炎症反应的关系非常密切。然而,目前COPD中BAFF的产生机制及临床意... 详细信息

免疫炎症反应在慢性阻塞性肺疾病(COPD)中发挥重要作用。B细胞激活因子(BAFF)已被广泛研究用于自身免疫性疾病,如系统性红斑狼疮和类风湿关节炎等。BAFF与COPD异常免疫炎症反应的关系非常密切。然而,目前COPD中BAFF的产生机制及临床意义尚未完全明确。本文综述了近年来关于BAFF诱导COPD炎症反应发生机制方面的研究进展,以期为COPD免疫炎症反应的预防、治疗提供思路。

关键词：慢性阻塞性肺疾病 B细胞激活因子炎症细胞免疫炎症

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多层菊形样胚胎性肿瘤影像学表现

中国医学影像技术 2024年第2期40卷 193-197页

作者：陈灵旭王晓晨王思慧赵雪宁孙胜军北京市神经外科研究所放射科北京100070 首都医科大学附属北京天坛医院放射科北京100070

目的观察多层菊形样胚胎性肿瘤(ETMR)影像学表现。方法回顾性分析8例经病理证实ETMR患儿的MRI(n=8)和CT(n=6)资料,观察其影像学表现。结果MRI中,8例ETMR最大径32~96 mm,边缘清晰,5例位于幕上、3例位于幕下;幕上ETMR均为巨大囊实性肿块,... 详细信息

目的观察多层菊形样胚胎性肿瘤(ETMR)影像学表现。方法回顾性分析8例经病理证实ETMR患儿的MRI(n=8)和CT(n=6)资料,观察其影像学表现。结果MRI中,8例ETMR最大径32~96 mm,边缘清晰,5例位于幕上、3例位于幕下;幕上ETMR均为巨大囊实性肿块,幕下ETMR体积较小,均未见瘤周水肿。6例ETMR为囊实性,囊性部分呈低T1WI、高T2WI信号且均位于肿瘤边缘,增强后5例实性部分轻度局灶性不均匀强化、1例未见明显强化;其中5例见瘤内出血,5例瘤内见流空血管影,3例侵犯邻近硬脑膜。2例ETMR为实性,增强扫描可见局灶性结节状不均匀强化,且强化部分与表观弥散系数(ADC)图上的低信号区对应;其中1例胆碱(Cho)/肌酸(Cr)升高,N-乙酰天冬氨酸(NAA)降低。弥散加权成像(DWI)中,8例ETMR均显示弥散受限。6例接受CT扫描的患儿中,4例见条片状或点状钙化,与MRI低信号区对应。结论ETMR多为幕上较大囊实性肿块,边缘清楚,囊变常位于肿瘤边缘,可见特征性血管流空影,常伴瘤内出血,可见钙化,无瘤周水肿,DWI明显弥散受限;增强后实性部分轻度不均匀强化。

关键词：儿童脑肿瘤癌,胚胎性磁共振成像体层摄影术,X线计算机

基于改进Stacking算法的致密砂岩储层测井流体识别

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地球物理学进展 2024年第1期39卷 280-290页

作者：史鹏宇徐思慧冯加明史鹏达赵培强毛志强中国石油大学(北京)地球物理学院北京102249 油气资源与工程全国重点实验室北京102249 地球探测与信息技术北京市重点实验室北京102249 中国石油塔里木油田分公司勘探开发研究院库尔勒841000 成都信息工程大学成都610225

致密砂岩储层物性差,测井响应对孔隙流体不敏感,应用传统测井解释图版划分流体类型精度较低.机器学习技术通过学习更多维度的特征,可以建立合适的流体识别模型.相较于单一算法,集成学习可以通过联合多个专家模型提升预测精度,但是不同... 详细信息

致密砂岩储层物性差,测井响应对孔隙流体不敏感,应用传统测井解释图版划分流体类型精度较低.机器学习技术通过学习更多维度的特征,可以建立合适的流体识别模型.相较于单一算法,集成学习可以通过联合多个专家模型提升预测精度,但是不同的集成学习策略性能差距较大.本文提出了一种改进的Stacking算法,通过平均影响值法寻找敏感测井曲线作为输入,利用不同的特征集构建多个子模型,并使用不同集成策略将其组合为若干性能更佳的专家模型进行训练,同时引入独立专家避免过拟合,将专家模型的预测结果通过交叉验证的方式进行模拟预测,最后应用元学习器预测最终结果.将该方法用于库车坳陷迪北气藏致密砂岩储层流体识别,测试准确率可达93%,优于CatBoost模型和XGBoost模型,证明了该方法的有效性和适用性.为致密砂岩储层流体识别提供了新的思路.

关键词：机器学习集成学习 Stacking算法致密砂岩储层流体识别

钢纤维混凝土在低温、超低温环境下动静态力学性能的试验研究

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混凝土 2024年第5期 160-165页

作者：张冰刘军孙斯慧谭一鸣赵一民沈阳理工大学材料科学与工程学院辽宁沈阳110159 沈阳城市建设学院管理学院辽宁沈阳110167 沈阳城市学院商学院辽宁沈阳110112 中房集团辽宁置业有限公司辽宁沈阳110043

对不同纤维体积掺量(0.5%、1.0%、1.5%)的钢纤维混凝土进行了常温、低温和超低温环境下静态力学性能试验,采用75 mm的分离式霍普金森压杆装置(SHPB)进行了3种应变率下的动态力学性能试验,分析了纤维含量,温度区间及应变率效应对混凝土... 详细信息

对不同纤维体积掺量(0.5%、1.0%、1.5%)的钢纤维混凝土进行了常温、低温和超低温环境下静态力学性能试验,采用75 mm的分离式霍普金森压杆装置(SHPB)进行了3种应变率下的动态力学性能试验,分析了纤维含量,温度区间及应变率效应对混凝土力学性能的影响。试验结果表明:当钢纤维含量为1%时,混凝土在低温和超低温下的抗折强度分别提高41.1%和65.7%。在动态力学试验中,应变率为147 s^(-1)时超低温环境下钢纤维混凝土具有更高的动态抗压强度,为159.7 MPa。此外,低温和超低温环境会增加钢纤维混凝土的应变率敏感性导致动态增长因子的提高。

关键词：混凝土超低温力学霍普金森压杆

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儿童与成人新型冠状病毒感染特点比较

长治医学院学报 2020年第1期34卷 25-27页

作者：赵思惠尹国燕长治医学院附属和平医院儿科 046000

2019年12月以来,湖北省武汉市陆续发现了多例新型冠状病毒感染的肺炎患者,随着疫情蔓延,我国其他地区及境外也相继发现了此类病例。该病作为急性呼吸道传染病已纳入《中华人民共和国传染病防治法》规定的乙类传染病,按甲类传染病管理[1]... 详细信息

2019年12月以来,湖北省武汉市陆续发现了多例新型冠状病毒感染的肺炎患者,随着疫情蔓延,我国其他地区及境外也相继发现了此类病例。该病作为急性呼吸道传染病已纳入《中华人民共和国传染病防治法》规定的乙类传染病,按甲类传染病管理[1]。2020年2月,世界卫生组织将新型冠状病毒感染的肺炎命名为"COVID-19"(Corona Virus Disease 2019),该病毒属于β属的新型冠状病毒[1-2]。

关键词：新型冠状病毒感染儿童成人