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Determination of void boundary in a packed bed by laser attenuation measurement

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Particuology 2020年第4期18卷 72-79页

作者： Yuanxiang Lu Zeyi Jiang Xinru Zhang sihan liu Jingsong Wang Xinxin Zhang School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Energy Saving and Emission Reduction for Metallurgical Industry Beijing 100083China Beijing Engineering Research Center of Energy Saving and Environmental Protection Beijing 100083China State Key Laboratory of Advanced Metallurgy Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Voids are important regions in some industrial processes,particularly in the iron-making process,because a void is a zone in which gas-solid heat transfer and reactions *** paper presents a 3D experimental study of void formation measurement with 2D projection in a packed bed using an optical *** developing an experimental laser-attenuation scanning method,invisible voids that form in a packed bed can be detected and identified as relatively stable *** effects of various operational parameters on void formation are analyzed in terms of the resulting void sizes and *** results show that the void shape that forms in the packed bed is close to an ellipsoid and is relatively *** void size is positively correlated with the blast volume rate and is negatively correlated with the blowpipe *** blowpipe depth has no significant effect on either the void formation or *** blast angle affects the void location strongly;when this angle is increased,the void moves *** information and methods obtained in this experiment are significant in aiding understanding of the mechanism of void formation in gas-solid reactors.

关键词： Gas-solid reactor Void formation 3D experiment Optical method Laser attenuation

NCAD v1.0: a database for non-coding variant annotation and interpretation

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Journal of Genetics and Genomics 2024年第2期51卷 230-242页

作者： Xiaoshu Feng sihan liu Ke Li Fengxiao Bu Huijun Yuan Institute of Rare Diseases West China HospitalSichuan UniversityChengduSichuan 610044China

The application of whole genome sequencing is expanding in clinical diagnostics across various genetic disorders, and the significance of non-coding variants in penetrant diseases is increasingly being demonstrated. Therefore, it is urgent to improve the diagnostic yield by exploring the pathogenic mechanisms of variants in non-coding regions. However, the interpretation of non-coding variants remains a significant challenge, due to the complex functional regulatory mechanisms of non-coding regions and the current limitations of available databases and tools. Hence, we develop the non-coding variant annotation database (NCAD, http://***/), encompassing comprehensive insights into 665,679,194 variants, regulatory elements, and element interaction details. Integrating data from 96 sources, spanning both GRCh37 and GRCh38 versions, NCAD v1.0 provides vital information to support the genetic diagnosis of non-coding variants, including allele frequencies of 12 diverse populations, with a particular focus on the population frequency information for 230,235,698 variants in 20,964 Chinese individuals. Moreover, it offers prediction scores for variant functionality, five categories of regulatory elements, and four types of non-coding RNAs. With its rich data and comprehensive coverage, NCAD serves as a valuable platform, empowering researchers and clinicians with profound insights into non-coding regulatory mechanisms while facilitating the interpretation of non-coding variants.

关键词： Non-coding variants Annotation Variant interpretation Database

A Bionic Study on the Anti-erosion Mechanism of Laudakia stoliczkana:Experimental and Numerical Aspects

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Journal of Bionic Engineering 2019年第5期16卷 882-893页

作者： Ping Liang Youhong Sun sihan liu Tianwei Liang Yuhang Zhang Youwei Wang Luquan Ren Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130022China Construction Engineering College Jilin UniversityChangchun 130000China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130022China China FAW Group Corporation R&D Center Changchun 130000China

The scales of body surface of Laudakia stoliczkana have the morphology of convex hulls,which are arranged in groove structure in macroscopic *** body surface skin is mainly composed of the"soft"layer of keratin and the"hard"layer of the cuticle covering on the"soft"*** coupling effect of the scale morphology and skin's structure gives Laudakia stoliczkana the excellent ability to resist the sand erosion in desert *** by the convex surface morphology and the composite structure of the"soft"and"hard"layers of the skin of Laudakia stoliczkana^the coupling bionic samples are febricated and the erosion resistance performance is *** test results show that the coupling bionic samples have good erosion resistance perfbimance and the samples with spherical convex hull exhibit the best erosion resistance ***,based on the theory of stress wave propagation in solid the numerical simula tions of particles impacting to the coupling bionic samples and bionic layered structure are done respectively and the anti-erosion me chanism of the bionic layered structure is *** simulation results are consistent with the experimental results,which show that the coupling bionic samples can effectively reduce the amplitude of the incident stress wave,and thus can prevent the failure of samples.

关键词： coupling bionic anti-erosion sand blasting test stress wave bionic layered structure

Constructing lithiophilic sites-rich artificial solid electrolyte interphase to enable dendrite-free and corrosion-free lithium-sulfur batteries

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Green Energy & Environment 2024年第12期9卷 1891-1900页

作者： Wei Lu Anshun Zhao Qiuxu Chen sihan liu Mingxi Yu Zihao Wang Ze Gao Xue Zhao Guiru Sun Ming Feng Key Laboratory of Functional Materials Physics and Chemistry Ministry of Education Jilin Normal UniversityChangchunJilin130103China College of Information Technology Jilin Engineering Research Center of Optoelectronic Materials and DevicesJilin Normal UniversitySipingJilin136000China School of Science Changchun University of Science and TechnologyChangchunJilin130022China

An artificial solid electrolyte interphase(SEI)with lithiophilic sites and chemical bonds anchoring lithium polysulfides(LiPSs)has been developed as a potential solution to protect the lithium(Li)metal anode of Lithium-sulfur(Li-S)*** strategy aims to guide consistent Li deposition and relieve lithium ***,the evolution process of lithiophilic sites based on aluminum fluoride(AlF_(3))in an artificial SEI is disclosed in Li-S batteries with metal-based lithiophilic *** polyester polymer(PMMA and PPC)/AlF_(3) artificial SEI(MPAF-SEI)was homogeneously anchored on Li anode by in-situ *** conversion of AlF_(3) into Li-Al and LiF lithiophilic sites effectively reduce the Li nucleation overpotential and prevents the formation of Li *** the same time,the polymer can anchor LiPSs by chemical bonds and prevents Li *** optimized MPAF-SEI protected Li demonstrates excellent stability for over 3000 h at a capacity of 1 mAh cm^(-2) in Li||Li symmetric *** Li-S battery with low N/P(4)exhibits a capacity of 532.6 mAh g^(-1) over 300 cycles lifespan at 0.5 C.

关键词： Li anode SEI Lithiophilic sites Li-S battery AlF_(3)

A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering

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Cellular & Molecular Immunology 2021年第8期18卷 1883-1895页

作者： sihan liu Yanxia Fu Kunrong Mei Yinan Jiang Xiaojun Sun Yinyin Wang Fangli Ren Congshan Jiang Liesu Meng Shemin Lu Zhihai Qin Chen Dong Xinquan Wang Zhijie Chang Shigao Yang State Key Laboratory of Membrane Biology School of MedicineTsinghua University100084BeijingChina The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area Shantou University Medical CollegeShantou515041GuangdongChina Department of Biochemistry and Molecular Biology Capital Medical University100069BeijingChina Center for Structural Biology School of Life SciencesMinistry of Education Key Laboratory of Protein ScienceTsinghua University100084BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical ScienceXi’an Jiaotong University Health Science CenterKey Laboratory of Environment and Genes Related to Diseases(Xi’an Jiaotong University)Ministry of EducationXi’an710061ShanxiChina Key Laboratory of Protein and Peptide Pharmaceuticals CAS-University of Tokyo Joint Laboratory of Structural Virology and ImmunologyInstitute of BiophysicsChinese Academy of Sciences100101BeijingChina Institute for Immunology and School of Medicine Tsinghua University100084BeijingChina School of Life Sciences Anhui Medical UniversityHefei230032China

Rheumatoid arthritis(RA)is exacerbated by TNF-alpha ***,it remains unclear whether TNF-α-activated TNFR1 and TNFR2 are regulated by extracellular ***,we showed that soluble glycosylated interleukin-17 receptor D(sIL-17RD),which was produced by proteolytic cleavage,enhanced TNF-α-induced *** revealed that IL-17RD shedding was induced by the proteolytic enzyme TACE and enhanced by TNF-αexpression in ***,sIL-17RD was elevated in the sera of arthritic mice and *** sIL-17RD significantly enhanced the TNF-α-induced proinflammatory response by promoting TNF-α-TNFR-sIL-17RD complex formation and receptor clustering,leading to the accelerated development of collagen-induced *** observations revealed that ectodomain shedding of IL-17RD occurred in RA to boost the TNF-α-induced inflammatory *** sIL-17RD may provide a new strategy for the therapy of RA.

关键词： IL-17RD TACE/ADAM17 Ectodomain shedding TNF-αsignaling Arthritis

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国家环境遥感监测体系研究与实现

遥感学报 2016年第5期20卷 1161-1169页

作者：王桥刘思含环境保护部卫星环境应用中心国家环境保护卫星遥感重点实验室北京100094

随着国家空间基础设施的建设和发展,中国遥感监测体系研究与建设取得了重大突破,从无到有形成了国家环境遥感监测能力,并业务化实现了主要环境遥感监测要素产品的生产与服务,为新时期环境管理工作提供了有力支撑。在分析国内外环境遥感... 详细信息

随着国家空间基础设施的建设和发展,中国遥感监测体系研究与建设取得了重大突破,从无到有形成了国家环境遥感监测能力,并业务化实现了主要环境遥感监测要素产品的生产与服务,为新时期环境管理工作提供了有力支撑。在分析国内外环境遥感发展及中国环境遥感监测需求的基础上,阐述了中国环境监测体系建设的必要性,研究了国家环境遥感监测体系的建立与业务化运行,提出了中国环境遥感监测体系发展思路与下一步重点任务。

关键词：环境遥感监测体系研发与业务化应用

Effect of welding pressure on mechanical properties of resistance spot welding joint

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China Welding 2020年第3期29卷 33-38页

作者： Yin Xiaohui He Guoqiang liu sihan Cui Mengshuan Hu Lei Cui Bing Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials Anhui University of TechnologyMa'anshan 243002China School of Materials Science and Engineering Anhui University of TechnologyMa’anshan 243032China

To investigate the factors affecting the quality of solder joints which would be available for the practical production,an axisymmetric finite element model of the resistance spot welding process simulated by Sysweld finite element software was established for a DP980 steel plate with a thickness of 1 *** simulating the formation process of spot welding nuggets,the distribution characteristics of temperature field and stress field in the process of spot welding heating and cooling can be studied to determine the nugget diameter and shear strength *** results showed that the shear force of the spot-welding joint was affected by the structure,and the nugget diameter was non-linear relationship to the shear *** the DP980 spot welding joint,the critical nugget diameter of the IF fracture mode to PF fracture mode was 4.695 mm,and the maximum value of nugget diameter and residual stress decreased to different degrees with the increase of welding pressure.

关键词： DP980 welding pressure nugget diameter pull-out fracture

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略论墨子的仁学

学术研究 2006年第10期 22-26页

作者：刘斯翰广东省社会科学界联合会

墨子仁学,以“兼爱”为标帜,历来被儒学所攻讦。但墨子仍然从孔子的仁学中继承了若干要素,如从政治理想出发,重视践行和以“爱人”为基础。本文更着重探讨墨子对孔子仁学的改革,提出“反对仁的血缘性”、“在仁的理想中引入利”、“把... 详细信息

墨子仁学,以“兼爱”为标帜,历来被儒学所攻讦。但墨子仍然从孔子的仁学中继承了若干要素,如从政治理想出发,重视践行和以“爱人”为基础。本文更着重探讨墨子对孔子仁学的改革,提出“反对仁的血缘性”、“在仁的理想中引入利”、“把仁之本归之天意”是墨子仁学的重要特色,并且对墨子仁学的形成和评价作了历史的探析。

关键词：墨子仁学孔墨墨学

Genetic variants associated with pathological changes in Alzheimer's diseases

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Genetic variants associated with pathological changes in Alz...