检索结果-南通市图书馆

2012广东省预防医学会学术年会

作者： sifan chen xincai xiao xiang feng Wenxue Li niman zhou Lin Zheng yanshuang sun zili zhang wei zhu Guangzhou Center for Disease Control and Prevention School of Public health Sun Yat-Sen Univcrsity guangdong provincial key laboratory of food Nutrition and Health Zhongshan School of Medicine Sun Yat-Sen University

Resveratrol is a natural polyphenolic compound with aim-inflammatory,antioxidant and neuroprorective properties,and it serves as a chemopreventive and chemotherapeutic ***,only very limited data have been obtained regarding rhe effects of resveratrol on preadipocytes,and the mechanisms of these effects remain largely *** this study,murine 3T3-L1 preadipocytes were incubated with resveratrol,and cell apoptosis was investigated. Resveratrol caused S-phase arrest to inhibit cell proliferation and significantly increased the lactate dehydrogenase leaking *** 33258 staining and transmission electron microscopy revealed the uitrastructural changes in nuclear chromatins of apoptotic ***,resveratrol activated the mitochondrial signaling with decreases in the mitochondrial membrane potential,cytochrome c release and the activation of caspase 9 and caspase 3. Resveratrol treatment also increased the protein level of *** using small interfering RNAs of ***-monophosphate-activated protein kinase (AMPK) *** and the AMPK agonist(5-aminoimidazole-4-carboxamide 1-β-D-ribofuranoside) and specific inhibitors for protein kinase B(AKT) or *** was demonstrated that activation of Sirtl inhibited AKT activation and further decreased rhe expression of survivin It could also increase AMI’K *** signaling pathways activated mitochondrion-mediated *** findings clarified the apoptotic effects of resveratrol in 3T3-L1 preadipocytes and revealed the involved pathway including *** and survivin,suggesting its potential therapeutic application in the treatment or prevention of obesity and related metabolic symptoms.

关键词： Resveratrol Silent information regulator 1 AMP-activated protein kinaseα Protein kinase B Survivin Apoprosis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Pioglitazone Ameliorate Lipid Metabolic Disorder in KKAy Mice

Pioglitazone Ameliorate Lipid Metabolic Disorder in KKAy Mic...

引用

广东省环境诱变剂学会、广东省预防医学会卫生毒理专业委员会2010年学术会议

作者： sifan chen~(1,2),yanshuang sun~(1,2),xincai xiao~(1,2,3),zili zhang~(1,2),liangru ke~4,niman zhou~4, zhiming shan~4,xiang feng~(1,2*),wei zhu~(3*) 1 guangdong provincial key laboratory of food,nutrition and health 2 School of Public health,sun Yat-Sen University,Guangzhou,guangdong,P.R.China 3 Guangzhou Center for Disease Control and Prevention,Guangzhou,guangdong,P.R.China 4 Zhongshan School of Medicine,sun Yat-Sen University,Guangzhou,guangdong,P.R.China

To explore the effects of pioglitazone on serum and liver lipid level and antioxidant ability of mice with lipid metabolic disorder and the underlying mechanism,KKA mice were treated with pioglitazone based on their body weights for 12 weeks and their lipid and antioxidant indices were compared to those of KKA mice without pioglitazone treatment as well as those of C57BL/6J *** results show that pioglitazone treatment reduces serum and liver TG,elevates serum HDL-C level,increases serum and liver SOD activity,attenuates serum MDA content,ameliorates liver steatosis,induces liver PPARγexpression and enhances AMPKαphosphorylation level. In conclusion,the results indicate that pioglitazone can regulate blood lipid level,reduce liver lipid deposition and enhance antioxidant capacity of mice with lipid metabolic disorder possibly through increasing AMPK phosphorylation.

关键词： Pioglitazone lipid metabolic disorder AMP-activated protein kinase

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Comparative Genomics Reveals Evolutionary Drivers of Sessile Life and Left-right Shell Asymmetry in Bivalves

引用

Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1078-1091页

作者： Yang zhang Fan Mao Shu xiao Haiyan Yu zhiming xiang Fei Xu Jun Li Lili Wang Yuanyan Xiong Mengqiu chen Yongbo Bao Yuewen Deng Quan Huo Lvping zhang Wenguang Liu Xuming Li Haitao Ma Yuehuan zhang Xiyu Mu Min Liu Hongkun Zheng Nai-kei Wong Ziniu Yu CAS key laboratory of Tropical Marine Bio-resources and Ecology and guangdong provincial key laboratory of Applied Marine Biology Innovation Academy of South China Sea Ecology and Environmental EngineeringSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering guangdong laboratory(Guangzhou) Guangzhou 511458China Biomarker Technologies Co. LtdBeijing 101301China CAS key laboratory of Experimental Marine Biology Center for Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdao 266071China State key laboratory of Biocontrol College of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Zhejiang key laboratory of Aquatic Germplasm Resources College of Biological and Environmental SciencesZhejiang Wanli UniversityNingbo 315100China College of Fisheries Guangdong Ocean UniversityZhanjiang 524088China Hebei key laboratory of Applied Chemistry College of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066044China Department of Pharmacology Shantou University Medical CollegeShantou 515041China

Bivalves are species-rich mollusks with prominent protective roles in coastal *** these ancient lineages,colony-founding larvae anchor themselves either by byssus production or by cemented *** latter mode of sessile life is strongly molded by left-right shell asymmetry during larval development of Ostreoida oysters such as Crassostrea ***,we sequenced the genome of *** in high resolution and compared it to reference bivalve genomes to unveil genomic determinants driving cemented attachment and shell ***,loss of the homeobox gene Antennapedia(Antp)and broad expansion of lineagespecific extracellular gene families are implicated in a shift from byssal to cemented attachment in *** transcriptomic analysis shows a conspicuous divergence between leftright asymmetrical *** and symmetrical Pinctada fucata in their expression ***,a couple of orthologous transcription factor genes and lineage-specific shell-related gene families including that encoding tyrosinases are elevated,and may cooperatively govern asymmetrical shell formation in Ostreoida oysters.

关键词： Comparative genomics Ostreoida oyster Attachment Shell asymmetry Bivalve

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于多中心T1WI影像组学列线图治疗前预测骨肉瘤一年内复发的价值

引用

中华放射学杂志 2020年第9期54卷 874-881页

作者：陈海妹刘金程梓轩全显跃王晓红邓宇陆明周全阳维向之明李绍林刘再毅赵英华南方医科大学第三附属医院(广东省骨科研究院)放射科广州510630 广东省人民医院/广东省医学科学院放射科广州510080 南方医科大学珠江医院放射科广州510282 中山大学第三附属医院放射科广州510630 广州医科大学第一附属医院放射科 510120 南方医科大学第三附属医院(广东省骨科研究院)骨肿瘤科广州510630 南方医科大学生物医学工程学院广东省医学图像处理重点实验室广州510515 广州市番禺区中心医院放射科 511400 中山大学第五附属医院放射科珠海519000

目的探讨基于多中心T1WI影像组学列线图治疗前预测骨肉瘤1年内复发的价值。方法回顾性分析2009年1月至2017年10月来自6个中心的107例接受新辅助化疗和手术切除后经组织学证实的骨肉瘤患者临床及影像资料,根据入组顺序,将来自先入组的4... 详细信息

目的探讨基于多中心T1WI影像组学列线图治疗前预测骨肉瘤1年内复发的价值。方法回顾性分析2009年1月至2017年10月来自6个中心的107例接受新辅助化疗和手术切除后经组织学证实的骨肉瘤患者临床及影像资料,根据入组顺序,将来自先入组的4个中心(n=75)的患者作为训练组,另外2个中心(n=32)的患者作为验证组。基于治疗前T1WI提取的影像组学特征,于训练组中使用最小绝对收缩与选择算子算法(LASSO)进行降维后建立预测骨肉瘤手术后1年内复发的影像组学标签。使用单因素logistic回归筛选独立临床危险因素,使用多变量logistic回归纳入影像组学标签构建列线图预测骨肉瘤复发;使用受试者操作特征(ROC)曲线评估列线图和影像组学标签在训练组中的准确性,并通过验证组进行验证。采用校正曲线评估列线图预测和实际观察复发风险的一致性,采用决策曲线评估列线图的临床实用性。结果基于多中心的T1WI,提取了2个与骨肉瘤术后1年内复发相关的影像组学特征构成影像组学标签,包括1个灰度共生矩阵特征(L_G_1.0_GLCM_homogeneity1,权重值3.122)和1个灰度游程矩阵特征(GLRLM_RP,权重值-2.474)。融合影像组学标签和常规影像学特征(关节侵犯和血管周围浸润)构建列线图,在训练组和验证组中预测骨肉瘤术后1年内复发的ROC曲线下面积分别为0.884和0.821,校正曲线显示列线图在预测和实际观察之间具有良好的一致性。决策曲线分析表明,当风险阈值大于21%时,影像组学列线图具有较大的临床应用价值。结论基于T1WI影像组学列线图可作为非侵入性量化工具,于治疗前预测骨肉瘤在1年内的复发情况,为骨肉瘤的临床决策提供支持。

关键词：骨肉瘤复发磁共振成像影像组学列线图

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：