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Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第7期13卷 287-295页

作者： Yucinda YY Khor siew-keah lee Dharmani Devi M Wei Chih Ling Department of Pre-clinical Sciences M.Kandiah Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSelangorMalaysia Department of Pharmacology Faculty of MedicineUniversiti MalayaKuala LumpurMalaysia

Objective:To investigate the effect of epigallocatechin-3-gallate(EGCG)on endothelial dysfunction in spontaneously hypertensive rats(SHR).Methods:Wistar-Kyoto(WKY)rats and SHR were divided into four groups;WKY control,SHR control and SHR treated with EGCG(50 mg/kg/day)or losartan(10 mg/kg/day).The treatment was given daily for 4 weeks by oral gavage and the blood pressure was monitored by tail-cuff method every 3 *** endothelium-dependent relaxations were assessed in isolated phenylephrine-precontracted aortic rings at the end of *** vascular levels of reactive oxygen species,nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate were also ***,the expression of angiotensinⅡtype 1(AT_(1))receptor protein was ***:The systolic blood pressure was significantly decreased in SHR treated with *** impaired endothelium-dependent relaxation was significantly improved in aortic ring isolated from the EGCG-treated SHR *** also significantly increased the levels of nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate,while decreasing the level of reactive oxygen species and the protein expression of AT_(1)receptor in ***:EGCG attenuates endothelial dysfunction in SHR by decreasing oxidative stress and increasing vascular nitric oxide bioavailability,which may be modulated partly by inhibition of vascular AT_(1)*** increase in endothelium-dependent relaxation may contribute to a decrease in blood pressure in hypertensive animals.

关键词： Epigallocatechin-3-gallate Vascular protection Antihypertension Tetrahydrobiopterin Cyclic guanosine monophosphate Angiotensin typeⅠreceptor Spontaneously hypertensive rats

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Pulse oximeter as a home assessment tool:Knowledge and user experience among the community in Malaysia during the COVID-19 pandemic

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Asian Pacific Journal of Tropical Medicine 2022年第5期15卷 213-219页

作者： siew-keah lee Jin Wei Ma Khai Ying Chan Yi Song Cheong Wan Ting Hong Regine Chew Yi Ong Wei Cheng Tay Ang-Lim Chua Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia

Objective:To determine the degree of knowledge in the usage of pulse oximeter as a home assessment tool among the community in ***:A cross-sectional survey was conducted in November *** questionnaire assessed the knowledge in using pulse oximeters,user experience and opinions in using pulse oximeter as a home assessment tool during the ***:A total of 504 respondents were included in the study,and the mean score in knowledge related to application of pulse oximetry was 73.00%,while the mean score in knowledge related to factors affecting pulse oximetry readings was only 38.51%.A total of 90.5% of the respondents recognised normal pulse rate and 88.5% knew the blood oxygen saturation levels of a healthy adult,while 69.4% recognised the definition of silent *** addition,the majority of the respondents agreed that factors such as poor blood circulation(71.2%),excessive movements(69.8%),and hand position(60.7%)affected oximetry ***,61.7%,81.7%,77.2% and 76.8% of the respondents could not identify nail polish,skin colour,skin thickness and tattoos as factors that may affect oximetry readings ***:The respondents showed a satisfactory level of knowledge related to application of pulse oximetry,but a poor level of knowledge related to factors affecting pulse oximetry readings among the community in *** efforts in educating the community on the correct use of pulse oximeters are crucial for appropriate home assessment and avoiding unnecessary stress.

关键词： COVID-19 Pulse oximetry SpO2 Home assessment tool Silent hypoxia

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Cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification among middle-aged adults in Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 61-70页

作者： siew-keah lee Ang-Lim Chua Clement Heng Yew Fong Ban Hao Brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew Kai Bin Liew Yang Shao M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia Faculty of Pharmaceutical Sciences UCSI UniversityMalaysia Faculty of Pharmacy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan Medical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(P<0.05,Pearson correlation).Notably,individuals with higher IHRS tended to have lower knowledge related to CVD and CVD risk prevention,risk perception,and behavioural ***,laborers,active/former smokers,individuals with lower household income and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(P<0.05,one-way ANOVA).While educational level,smoking status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(P<0.05,linear regression).Conclusions:These findings underscore the importance of promoting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART Middle-aged Lifestyle Physical activity Psychosocial stress

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Awareness and perceived barriers in practicing healthy living to prevent hypertension among young adults in Malaysia

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Asian Pacific Journal of Tropical Medicine 2022年第12期15卷 542-550页

作者： lee siew-keah Kang Waye Hann Shun Kah Hoe Lai Rui En Lim Boon Chin Master Manfai Sae Chan Tee Zhi Kang Chua Ang-Lim M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia

Objective:To investigate the knowledge,attitude,and practice levels and perceived barriers towards healthy living to prevent hypertension among young adults in ***:Adults aged 18-25 years reside in Malaysia were recruited via convenience *** characteristics,medical knowledge on hypertension(K1),knowledge(K),attitude(A),practice(P)and perceived barriers in practising healthy living to prevent hypertension were *** scores were categorised into good(80%-100%),upper-moderate(70%-79%),lower-moderate(60%-69%)and poor(<60%).Multivariate analysis was performed to test the difference and relationship of *** correlation test was used to test the association of two continuous ***:A total of 1218 respondents participated in this *** mean score of K1 was 54.1%,while the knowledge,attitude,and practice towards healthy living were 82.7%,78.2%and 68.5%*** prevalence of high salt intake,high fat intakes,low fibre intake,sedentary lifestyle and lack of annual health screening was 83.2%,81.4%,70.3%,and 73.2%,*** BMI was associated with low P scores,while lower socio-economic status,unawareness of self-blood pressure reading and those without family history of hypertension were associated with lower scores in K1,K,A,and P.K1,K,A and P are significantly *** main perceived barriers included self-proclaimed good fit status,frequent consumption of out-of-home food,and addiction to high salt/fat ***:The national strategies for health management should be prioritized in reducing salt and fat,promoting annual health screening,physical activities and fibre intake in this age group.

关键词： Healthy living Physical activity Salt restriction Dietary Hypertension Malaysia Young adults

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Mesomorphic behaviour of new azomethine liquid crystals having terminal bromo substituent

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Chinese Chemical Letters 2012年第2期23卷 177-180页

作者： Sie Tiong Ha Teck Leong lee siew Ling lee Guan Yeow Yeap Yip Foo Win siew Teng Ong Department of Chemical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparMalaysia Ibnu Sina Institute for Fundamental Science Studies Universiti Teknologi Malaysia81310 UTM SkudaiMalaysia Liquid Crystal Research Laboratory School of Chemical SciencesUniversiti Sains Malaysia11800 MindenMalaysia Department.of Chemical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparMalaysia

A homologous series of azomethine esters,4-n-alkanoyloxybenzylidene-4＇-bromoanilines possessing even number of carbon atoms at the terminal alkanoyloxy chain（C_（n-1）H_（2n-1）COO- n = 8,10,12,14,16,18） was synthesized and *** n-octanoyloxy to n-dodecanoyloxy derivatives exhibited enantiotropic smectic A and smectic B phases,n-tetradecanoyloxy to n-octadecanoyloxy derivatives possessed enantiotropic smectic A and monotropic smectic B properties.n-Decanoyloxy derivatives demonstrated the optimum exhibition for both smectic A and smectic B *** was found that the length of terminal alkanoyloxy chain has an influence on mesomorphic properties.

关键词： Liquid crystals Schiff base ester Enantiotropic Smectic A Smectic B

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Synthesis and mesomorphic properties of Schiff base esters possessing terminal chloro substituent

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Chinese Chemical Letters 2010年第6期21卷 637-640页

作者： Sie Tiong Ha Lay Khoon Ong siew Ling lee Hong Cheu Lin Yip Foo Win siew Teng Ong Department of Chemical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparPerakMalaysia Department of Science Faculty of Engineering & ScienceUniversiti Tunku Abdul RahmanJln Genting KlangSetapak53300 Kuala LumpurMalaysia Ibnu Sina Institute for Fundamental Science Studies Universiti Teknologi Malaysia81310 UTM SkudaiJohorMalaysia Department of Materials Science & Engineering National Chiao Tung UniversityHsinchu 300TaiwanChina

A homologous series of Schiff base esters,4-chlorobenzylidene-4'-n-alkanoyloxyanilines,containing even number of carbons at the end groups of the molecules(C_(n-1)H_(2n-1)COO-,n=4,6,8,10,12,14,16) were *** mesomorphic properties were investigated by differential scanning calorimetry(DSC) and polarizing optical microscopy(POM).It was found that the end groups of the molecules had an effect on the mesomorphic properties.n-Butanoyloxy was found non-mesogenic,whilst n-hexanoyloxy exhibited monotropic smectic *** higher members in this homologous series were enantiotropic smectogens.

关键词： Schiff base esters Smectic A Smectic B Liquid crystal

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Anisotropic transport of microalgae Chlorella vulgaris in microfluidic channel

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Chinese Physics B 2017年第8期26卷 511-520页

作者： Nur Izzati Ishak S V Muniandy Vengadesh Periasamy Fong-lee Ng siew-Moi Phang Plasma Technology Research Center Department of PhysicsUniversity of MalayaKuala Lumpur 50603Malaysia Center for Theoretical Physics Department of PhysicsUniversity of MalayaKuala Lumpur 50603Malaysia Low Dimensional Materials Research Center Department of PhysicsUniversity of MalayaKuala Lumpur 50603Malaysia Institute of Ocean and Earth Sciences University of MalayaKuala Lumpur 50603Malaysia

In this work, we study the regional dependence of transport behavior of microalgae Chlorella vulgaris inside microflu- idic channel on applied fluid flow rate. The microalgae are treated as spherical naturally buoyant particles. Deviation from the normal diffusion or Brownian transport is characterized based on the scaling behavior of the mean square displacement （MSD） of the particle trajectories by resolving the displacements in the streamwise （flow） and perpendicular directions. The channel is divided into three different flow regions, namely center region of the channel and two near-wall boundaries and the particle motions are analyzed at different flow rates. We use the scaled Brownian motion to model the transitional characteristics in the scaling behavior of the MSDs. We find that there exist anisotropic anomalous transports in all the three flow regions with mixed sub-diffusive, normal and super-diffusive behavior in both longitudinal and transverse directions.

关键词： Brownian motion anomalous transport scaled Brownian motion microfluidic Chlorella vulgaris

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Phenol photocatalytic degradation over mesoporous TUD-1-supported chromium oxide-doped titania photocatalyst

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Chinese Journal of Catalysis 2016年第11期37卷 1871-1881页

作者： Yee Khai Ooi Leny Yuliati siew Ling lee 马来西亚工艺大学理学院化学系马来西亚新山81310 马来西亚工艺大学科学与工业研究所可持续纳米材料中心马来西亚新山81310

Mesoporous Technische Universiteit Delft（TUD-1）-supported chromium oxide-doped titania（Cr-TiO2） was developed as a promising photocatalyst for phenol photodegradation under visible light ***-angle X-ray diffraction and Fourier transform infrared spectroscopy results confirmed the amorphous and mesoporous silicate framework of TUD-1 in TUD-1-supported *** mesostructure of TUD-1 was further verified via N2 adsorption-desorption analysis,which showed a type-IV isotherm with a narrow average pore size distribution of 3.9 nm and high surface area of 490 m^2/*** electron microscopy analysis results indicated that TUD-1-supported Cr-TiO2 contained nanoparticles and porous *** increase in band gap energy was observed after loading Cr-TiO2 into *** with that of unsupported Cr-TiO2,TUD-1-supported Cr-TiO2 showed higher photocatalytic activity for phenol degradation under visible light *** TUD-1 supported Cr-TiO2 photocatalyst with a Si/Ti molar ratio of 30 exhibited the highest photodegradation of phenol（82%） of the prepared *** photodegradation of phenol by the supported catalyst followed the Langmuir adsorption isotherm with first-order kinetics.

关键词： Phenol TUD-1 Titania Photocatalyst Mesoporous

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Microbial reduction of graphene oxide and its application in microbial fuel cells and biophotovoltaics

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Frontiers of Materials Science 2023年第2期17卷 45-63页

作者： Jing-Ye Tee Fong-lee Ng Fiona Seh-Lin Keng G.Gnana kumar siew-Moi Phang Institute of Ocean and Earth Sciences(IOES) Universiti Malaya50603 Kuala LumpurMalaysia Institute for Advanced Studies Universiti Malaya50603 Kuala LumpurMalaysia Department of Physical Chemistry School of ChemistryMadurai Kamaraj UniversityMadurai 625021Tamil NaduIndia Faculty of Applied Sciences UCSI University56000 Kuala LumpurMalaysia

Despite more than a decade of study,there are still significant obstacles to overcome before graphene can be successfully produced on a large scale for commercial *** oxidation of graphite to produce graphene oxide(GO),followed by a subsequent reduction process to synthesize reduced graphene oxide(rGO),is considered the most practical method for mass ***,which are abundant in nature and inexpensive,are one of the potential green reductants for rGO ***,there is no recent review discussing the reported microbial reduction of GO in *** address this,we present a comprehensive review on the reduction of GO by a range of microorganisms and compared their efficacies and reaction ***,presented were the mechanisms by which microorganisms reduce *** also reviewed the recent advancements in using microbially reduced GO as the anode and cathode material in the microbial fuel cell(MFC)and algal biophotovoltaics(BPV),as well as the challenges and future directions in microbial fuel cell research.

关键词： reduced graphene oxide microbial reduction microbial fuel cell algal biophotovoltaics green chemistry

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A novel CARD containing splice-isoform of CIITA regulates nitric oxide synthesis in dendritic cells

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Protein & Cell 2010年第3期1卷 291-306页

作者： Dachuan Huang Sylvia Lim Rong Yuan Ray Chua Hong Shi Mah lee Ng siew Heng Wong Laboratory of Membrane Trafficking and Immunoregulation Department of MicrobiologyImmunology ProgrammeYong Loo Lin School of MedicineNational University of SingaporeBlock MD45 Science Drive 2Singapore 117597Republic of Singapore Laboratory of Flavivirology Department of MicrobiologyImmunology ProgrammeYong Loo Lin School of MedicineNational University of SingaporeBlock MD45 Science Drive 2Singapore 117597Republic of Singapore

MHC class II expression is controlled mainly at transcriptional level by class II transactivator(CIITA),which is a non-DNA binding coactivator and serves as a master control factor for MHC class II genes ***,we describe the function of a novel splice-isoform of CIITA,DC-expressed caspase inhibitory isoform of CIITA(or DC-CASPIC),and we show that the expression of DCCASPIC in DC is upregulated upon lipopolysaccharides(LPS)***-CASPIC localizes to mitochondria,and protein-protein interaction study demonstrates that DC-CASPIC interacts with caspases and inhibits its activity in ***,DC-CASPIC suppresses caspases-induced degradation of nitric oxide synthase-2(NOS2)and subsequently promotes the synthesis of nitric oxide(NO).NO is an essential regulatory molecule that modulates the capability of DC in stimulating T cell proliferation/activation in vitro;hence,overexpression of DC-CASPIC in DC enhances this ***,our findings reveal that DC-CASPIC is a key molecule that regulates caspases activity and NO synthesis in DC.

关键词： dendritic cells caspase CIITA nitric oxide synthase

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