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中国急性冠状动脉综合征患者治疗和预后的地区差异:来自国家胸痛中心的证据

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Science bulletin 2024年第9期69卷 1302-1312页

作者：周书铎张岩董雪洁马郡雄李娜史红 sidney C.Smith Jr 金音子许铭向定成郑志杰霍勇 Department of Global Health Peking University School of Public HealthBeijing 100191China Institute for Global Health and Development Peking UniversityBeijing100871China Department of Cardiology Peking University First HospitalBeijing 100034China Chinese Medical Association Beijing 100052China Division of Cardiovascular Medicine School of MedicineUniversity of North Carolina at Chapel HillNorth Carolina 27599-3140USA Department of Cardiology General Hospital of Southern Theater Command of PLAGuangzhou 510010China

Regional variations in acute coronary syndrome(ACS) management and outcomes have been an enormous public health issue. However, studies have yet to explore how to reduce the variations. The National Chest Pain Center Program(NCPCP) is the first nationwide, hospital-based, comprehensive, continuous quality improvement program for improving the quality of care in patients with ACS in China. We evaluated the association of NCPCP and regional variations in ACS healthcare using generalized linear mixed models and interaction analysis. Patients in the Western region had longer onset-to-first medical contact(FMC) time and time stay in non-percutaneous coronary intervention(PCI) hospitals, lower rates of PCI for ST-elevation myocardial infarction(STEMI) patients, and higher rates of medication *** in Central regions had relatively lower in-hospital mortality and in-hospital heart failure *** in the door-to-balloon time(Dto b) and in-hospital mortality between Western and Eastern regions were less after accreditation(β =-8.82, 95% confidence interval(CI)-14.61 to-3.03;OR = 0.79, 95%CI 0.70 to 0.91). Similar results were found in differences in Dto b time, primary PCI rate for STEMI between Central and Eastern regions. The differences in PCI for higher-risk non-ST-segment elevation acute coronary syndrome(NSTE-ACS) patients among different regions had been ***, the differences in medication use between Eastern and Western regions were higher after accreditation. Regional variations remained high in this large cohort of patients with ACS from hospitals participating in the NCPCP in China. More comprehensive interventions and hospital internal system optimizations are needed to further reduce regional variations in the management and outcomes of patients with ACS.

关键词： Acute coronary syndromes Quality improvement Regional variations Quality metrics

The magnetosheath at high spectral resolution

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Earth and Planetary Physics 2024年第1期8卷 234-246页

作者： K.D.Küntz D.Koutroumpa W.R.Dunn A.Foster F.S.Porter D.G.Sibeck b.Walsh The Henry A.Rowland Department of Physics and Astronomy Johns Hopkins University3701 San Martin DriveBaltimoreMD21218USA NASA Goddard Space Flight Center 8800 Greenbelt RoadGreenbeltMD 20771USA LATMOS-OVSQ CNRSUVSQ Paris-SaclaySorbonne Université11 Boulevard d’Alembert78280GuyancourtFrance Department of Physics and Astronomy University College LondonLondonUK The Centre for Planetary Science at UCL/birkbeck Gower StreetLondon WC1E 6BTUK Center for Astrophysics Harvard University&Smithsonian Institution60 Garden StreetCambridgeMA 02138USA Center for Space Physics Boston University110 Cummington MallBostonMAUSA

While we eagerly anticipate SMILE’s(Solar wind Magnetosphere Ionosphere Link Explorer)unprecedented X-ray observations of the Earth’s magnetosheath and the initiation of a new era of magnetospheric research,it seems appropriate to look ahead to the abilities of the next generation of astrophysics *** these,the Line Emission Mapper(LEM),a large aperture micro-calorimeter based mission,is currently planned to be able to observe the magnetosheath at high spectral resolution(~2 eV).With a field of view of~30′,LEM will allow higher spatial resolution and higher cadence measurement of the motion of a very small portion of the magnetopause over relatively short periods of time(multiple hours),complementing SMILE’s global ***’s strength is its spectral *** will be able to measure the abundance of a broad range of elements and ionization states,many of which are inaccessible to current in situ instruments,and will be able to separate the emission from the magnetosheath from the emission from the cosmic X-ray background using the difference in their relative velocities.

关键词： magnetosheath charge exchange solar wind abundances

Correlative CD4 and CD8 T-cell immunodominance in humans and mice:Implications for preclinical testing

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Cellular & Molecular Immunology 2023年第11期20卷 1328-1338页

作者： Tertuliano Alves Pereira Neto John sidney Alba Grifoni Alessandro Sette Center for Infectious Disease and Vaccine Research La Jolla Institute for Immunology(LJI)La JollaCA92037USA Department of Medicine Division of Infectious Diseases and Global Public HealthUniversity of CaliforniaSan DiegoLa JollaCA92037USA

Antigen-specific T-cell recognition is restricted by Major Histocompatibility Complex(MHC)molecules,and differences between CD4 and CD8 immunogenicity in humans and animal species used in preclinical vaccine testing are yet to be fully *** this study,we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes Database(IEDb)*** first analyzed SARS-CoV-2 spike(S)and nucleoprotein(N),which are two common targets of the immune response and well studied in both human and mouse *** observed a weak but statistically significant correlation between human and H-2^(b)mouse T-cell responses(CD8 S specific(r=0.206,p=1.37×10^(−13));CD4 S specific(r=0.118,p=2.63×10^(−5))and N specific(r=0.179,p=2.55×10^(−4))).Due to intrinsic differences in MHC molecules across species,we also investigated the association between the immunodominance of common Human Leukocyte Antigen(HLA)alleles for which HLA transgenic mice are available,namely,A*02:01,b*07:02,DRb1*01:01,and DRb1*04:01,and found higher significant correlations for both CD8 and CD4(maximum r=0.702,p=1.36×10^(−31)and r=0.594,p=3.04−122,respectively).Our results further indicated that some regions are commonly immunogenic between humans and mice(either H-2^(b)or HLA transgenic)but that others are human ***,we noted a significant correlation between CD8 and CD4 S-(r=0.258,p=7.33×10^(21))and N-specific(r=0.369,p=2.43×10^(14))responses,suggesting that discrete protein subregions can be simultaneously recognized by T *** findings were confirmed in other viral systems,providing general guidance for the use of murine models to test T-cell immunogenicity of viral antigens destined for human use.

关键词： T cells SARS-CoV-2 Vaccine Animal testing HLA

Pancreaticβ-cell dysfunction in type 2 diabetes:Implications of inflammation and oxidative stress

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World Journal of Diabetes 2023年第3期14卷 130-146页

作者： Phiwayinkosi V Dludla Sihle E Mabhida Khanyisani Ziqubu bongani b Nkambule Sithandiwe E Mazibuko-Mbeje sidney Hanser Albert Kotze basson Carmen Pheiffer Andre Pascal Kengne biomedical Research and Innovation Platform South African Medical Research CouncilCape Town 7505South Africa Department of biochemistry and Microbiology University of ZululandKwaDlangezwa 3880South Africa Department of biochemistry North-West UniversityMmabatho 2745South Africa School of Laboratory Medicine and Medical Sciences University of KwaZulu-NatalDurban 4000South Africa Department of Physiology and Environmental Health University of LimpopoSovenga 0727South Africa Department of Medicine University of Cape TownCape Town 7500South Africa Non-Communicable Diseases Research Unit South African Medical Research CouncilTygerberg 7505South Africa

Insulin resistance and pancreaticβ-cell dysfunction are major pathological mechanisms implicated in the development and progression of type 2 diabetes(T2D).beyond the detrimental effects of insulin resistance,inflammation and oxidative stress have emerged as critical features of T2D that defineβ-cell *** markers of inflammation such as C-reactive protein,tumor necrosis factor alpha,and interleukin-1βare consistently associated withβ-cell failure in preclinical models and in people with ***,important markers of oxidative stress,such as increased reactive oxygen species and depleted intracellular antioxidants,are consistent with pancreaticβ-cell damage in conditions of *** effects illustrate a pathological relationship between an abnormal inflammatory response and generation of oxidative stress during the progression of *** current review explores preclinical and clinical research on the pathological implications of inflammation and oxidative stress during the development ofβ-cell dysfunction in ***,important molecular mechanisms and relevant biomarkers involved in this process are discussed to divulge a pathological link between inflammation and oxidative stress duringβ-cell failure in *** the clinical relevance of the review,a systematic analysis of evidence from randomized controlled trials is covered,on the potential therapeutic effects of some commonly used antidiabetic agents in modulating inflammatory makers to improveβ-cell function.

关键词： Type 2 diabetes Insulin resistance β-cell dysfunction Inflammation Oxidative stress

A MAGNUS EXPANSION FOR THE EQUATION Y'= AY - Yb

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Journal of Computational Mathematics 2001年第1期19卷 15-26页

作者： Arieh Iserles (Department of Applied Mathematics and Theoretical Physics, University of cambridge, Silver Street, cambridge Cb3 9EW, England) University of cambridge 英国 CB3 9EW

The subject matter of this paper is the representation of the solution of the linear differential equation Y = AY - Yb, Y(0) = Yo, in the form y(t) = eΩ(t)Y0 and the representation of the function n as a generalization of the classical Magnus expansion. An immediate application is a new recursive algorithm for the deriVation of the baker- Campbell-Hausdorff formula and its symmetric generalization.

关键词： Geometric integration Magnus expansions b aher- Campbell- Hausdorff formula.

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.bai Y.bai O.bakina A.barnyakov V.blinov V.bobrovnikov D.bodrov A.bogomyagkov A.bondar I.boyko Z.H.bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong b.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.b.He S.Q.He X.G.He Y.L.He Z.b.He Z.X.Heng b.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.b.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.b.Jiang J.Jiang S.Z.Jiang J.b.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang b.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.b.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin b.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.b.Liu J.Liu J.J.Liu J.b.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.b.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata b.b.Qi Y.Q.Qi W.b.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China beihang University Beijing 100191China budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the bEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Confirmation of a Sub-Saturn-size Transiting Exoplanet Orbiting a G Dwarf:TOI-1194 b and a Very Low Mass Companion Star: TOI-1251 b from TESS

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Research in Astronomy and Astrophysics 2024年第3期24卷 129-143页

作者： Jia-Qi Wang Xiao-Jun Jiang Jie Zheng Hanna Kellermann Arno Riffeser Liang Wang Karen A.Collins Allyson bieryla Lars A.buchhave Steve b.Howell Elise Furlan Eric Girardin Joao Gregorio Eric Jensen Felipe Murgas Mesut Yilmaz Sam Quinn Xing Gao Ruo-Yu Zhou Frank Grupp Hui-Juan Wang CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy Of SciencesBeijing 10010China University of Chinese Academy of Sciences Beijing 100049China University Observatory Munich Scheinertrsse 1.D-81679 MunichGemany Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1D-85748 GarchingGermany National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China Center for Astrophysics Harvard&Smithsonian60 Garden Street.CambridgeMA 02138USA National Space Institute Technical University of DenmarkElektrovejDK-2800 KgsLyngbyDenmark NASA Ames Research Center Moffett FieldCA 94035USA NASA Exoplanet Science Institute Caltech/IPACMail Code 100-221200 E.California Blvd.PasadenaCA91125USA Grand Pra Observatory Switzerland Department of Physics Washington UniversitySt.LouisMO 63130.USA Department of Physics and Astronomy Swarthmore CollegeSwarthmorePA 19081USA Instituto de Astrofísica de Canarias(IAC) E-38205 La Laguna.TenerifeSpain Departamento de Astrofísica Universidad de La LagunaSpain Dept.of Astronomy and Space Sciences Ankara UniversityTandogan 06100AnkaraTurkey Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Urumqi No.1 Senior High School Urumqi 830002China Lijiang Gemini Observatory Lijiang 674199China

We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(J),and a very low mass companion star with a mass of about 96.5±1.5 MJ,TOI-1251 *** candidates provided by the Transiting Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by ground-based telescopes with small and medium *** analysis is performed based on data from several telescopes worldwide,including telescopes in the Sino-German multiband photometric campaign,which aimed at confirming TESS Objects of Interest(TOIs)using ground-based small-aperture and medium-aperture telescopes,especially for long-period ***-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric *** measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041RJ and the amplitude of the RV curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 b is confirmed based on the multiband photometric and high-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(J) and amplitude of the RV curve is 9849_(-40)^(+42)ms^(-1).

关键词： planets and satellites fundamental parameters-planets and satellites gaseous planets-stars fundamental parameters-stars low-mass-methods data analysis-techniques photometric-techniques spectroscopic

Epigenetic regulation: methylation of histone and non-histone proteins

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Science China(Life Sciences) 2009年第4期52卷 311-322页

作者： LAN Fei1 & SHI Yang 2 1 Department of biology, Constellation Pharmaceuticals, 148 sidney Street, cambridge, MA 02139, USA 2 Department of Pathology, Harvard Medical School, 77 Ave Louise Pasteur, boston MA, 02115, USA Department of biology Constellation Pharmaceuticals Cambridge USA Department of Pathology Harvard Medical School Boston USA

Histone methylation is believed to play important roles in epigenetic memory in various biological processes. However, questions like whether the methylation marks themselves are faithfully transmit- ted into daughter cells and through what mechanisms are currently under active investigation. Previ- ously, methylation was considered to be irreversible, but the recent discovery of histone lysine de- methylases revealed a dynamic nature of histone methylation regulation on four of the main sites of methylation on histone H3 and H4 tails (H3K4, H3K9, H3K27 and H3K36). Even so, it is still unclear whether demethylases specific for the remaining two sites, H3K79 and H4K20, exist. Furthermore, be- sides histone proteins, the lysine methylation and demethylation also occur on non-histone proteins, which are probably subjected to similar regulation as histones. This review discusses recent pro- gresses in protein lysine methylation regulation focusing on the above topics, while referring readers to a number of recent reviews for the biochemistry and biology of these enzymes.

关键词： epigenetics histone histone modification histone lysine methylation histone methylase histone demethylase epigenetic inheritance non-histone methylation

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Author Spotlight

CCS Chemistry 2022年第5期4卷 1461-1464页

作者： Hecht, sidney Wang, Ruibing Huang, Jing Zheng, Haoquan Univ Wisconsin Mol Biol Madison WI 53706 USA MIT Fac Chem Cambridge MA 02139 USA Univ Virginia Chem Charlottesville VA 22903 USA Univ Virginia Biol Charlottesville VA 22903 USA Smith Kline & French Lab Preclin Res & Dev R&D Philadelphia PA USA Smith Kline & French Lab Preclin Chem R&D Philadelphia PA USA Arizona State Univ Ctr Bioenerget Biodesign Inst Tempe AZ 85287 USA Arizona State Univ Chem Tempe AZ 85287 USA Queens Univ Kingston ON Canada Natl Res Council Canada Ottawa ON Canada Univ Macau Taipa Macau Peoples R China NIH Bldg 10 Bethesda MD 20892 USA Hunan Univ Changsha Hunan Peoples R China Shaanxi Normal Univ Sch Chem & Chem Engn Xian Shaanxi Peoples R China Stockholm Univ Prof Xiaodong Zous Grp Stockholm Sweden

sidney Hecht *** obtained his *** chemistry at the University of Illinois,*** studies as a National Institutes of Health(NIH)Postdoctoral Fellow in molecular biology at the University of Wisconsin(USA),he became a member of the Massachusetts Institute of Technology(MIT)Chemistry Faculty from 1971 to 1979,John *** Professor of Chemistry and Professor of biology at the University of Virginia(USA)from 1978 to 2008.

关键词： doctor Fellow Illinois