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Learning to become addicted,one synapse at a time

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Neural Regeneration Research 2024年第2期19卷 401-402页

作者： Alessio Attardo sidney B.Cambridge Leibniz Institute for Neurobiology MagdeburgGermany Institute for Anatomy II Dr.Senckenberg AnatomyGoethe-University Frankfurt am MainFrankfurtGermany

Addiction has been extensively studied on many levels:from the molecular level,with various“omics”approaches(Natividad et al.,2018;Grecco et al.,2021),to the clinical level,with psychotherapy and MRI imaging(Ceceli ... 详细信息

关键词： clinical therapy

Assembly structures of coastal woody species of eastern South America:Patterns and drivers

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Plant Diversity 2024年第5期46卷 611-620页

作者： Eduardo Vinícius da Silva Oliveira Myrna Friederichs Landim sidney F.Gouveia Graduate Program in Ecology and Conservation Federal University of SergipeSão CristovãoSergipeBrazil National Institute of Science and Technology Ecology Evolution and Conservation of Biodiversity(INCT-EECBio)GoiâniaGoiasBrazil Department of Biology Federal University of SergipeSão CristóvãoSergipeBrazil Department of Ecology Federal University of SergipeSão CristóvãoSergipeBrazil

Tropical regions have provided new insights into how ecological communities are *** dry coastal communities,water stress has been hypothesized to determine plant assembly structure by favoring preadapted lineages from neighboring ecosystems,consistent with functional ***,it is unclear whether this hypothesis is sufficient to explain how coastal communities in tropical ecosystems are ***,we test whether water stress or other factors drive community assembly in woody plant communities across the coastal zone of Brazil,a tropical *** characterized functional and phylogenetic structures of these communities and determined the underlying environmental factors(e.g.,water stress,historical climate stability,edaphic constraints,and habitat heterogeneity)that drive their community *** of coastal woody species show geographically varied patterns,including stochastic arrangements,clustering,and overdispersion of species relative to their traits and phylogenetic *** complexity,water vapor pressure,and soil nutrient availability best explained the gradient in the functional *** deficit,water vapor pressure,and soil organic carbon were the best predictors of variation in phylogenetic *** results support the water-stress conservatism hypothesis on functional and phylogenetic structure,as well as the effect of habitat heterogeneity on functional structure and edaphic constraints on functional and phylogenetic *** effects are associated with increased phenotypic and phylogenetic divergence of woody plant assemblages,which is likely mediated by abiotic filtering and niche opportunities,suggesting a complex pattern of ecological assembly.

关键词： Brazil Completeness Clustering Restinga vegetation Water constraints

中国急性冠状动脉综合征患者治疗和预后的地区差异:来自国家胸痛中心的证据

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Science Bulletin 2024年第9期69卷 1302-1312页

作者：周书铎张岩董雪洁马郡雄李娜史红 sidney C.Smith Jr 金音子许铭向定成郑志杰霍勇 Department of Global Health Peking University School of Public HealthBeijing 100191China Institute for Global Health and Development Peking UniversityBeijing100871China Department of Cardiology Peking University First HospitalBeijing 100034China Chinese Medical Association Beijing 100052China Division of Cardiovascular Medicine School of MedicineUniversity of North Carolina at Chapel HillNorth Carolina 27599-3140USA Department of Cardiology General Hospital of Southern Theater Command of PLAGuangzhou 510010China

Regional variations in acute coronary syndrome(ACS) management and outcomes have been an enormous public health issue. However, studies have yet to explore how to reduce the variations. The National Chest Pain Center Program(NCPCP) is the first nationwide, hospital-based, comprehensive, continuous quality improvement program for improving the quality of care in patients with ACS in China. We evaluated the association of NCPCP and regional variations in ACS healthcare using generalized linear mixed models and interaction analysis. Patients in the Western region had longer onset-to-first medical contact(FMC) time and time stay in non-percutaneous coronary intervention(PCI) hospitals, lower rates of PCI for ST-elevation myocardial infarction(STEMI) patients, and higher rates of medication *** in Central regions had relatively lower in-hospital mortality and in-hospital heart failure *** in the door-to-balloon time(Dto B) and in-hospital mortality between Western and Eastern regions were less after accreditation(β =-8.82, 95% confidence interval(CI)-14.61 to-3.03;OR = 0.79, 95%CI 0.70 to 0.91). Similar results were found in differences in Dto B time, primary PCI rate for STEMI between Central and Eastern regions. The differences in PCI for higher-risk non-ST-segment elevation acute coronary syndrome(NSTE-ACS) patients among different regions had been ***, the differences in medication use between Eastern and Western regions were higher after accreditation. Regional variations remained high in this large cohort of patients with ACS from hospitals participating in the NCPCP in China. More comprehensive interventions and hospital internal system optimizations are needed to further reduce regional variations in the management and outcomes of patients with ACS.

关键词： Acute coronary syndromes Quality improvement Regional variations Quality metrics

A cognitive model＇s view of animal cognition

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Current Zoology 2011年第4期57卷 499-513页

作者： sidney D'MELLO Stan FRANKLIN Department of Psychology University of Memphis Memphis TN 38152 USA Institute of Intelligent Systems University of Memphis Memphis TN 38152 USA

Although it is a relatively new field of study, the animal cognition literature is quite extensive and difficult to synthesize. This paper explores the contributions a comprehensive, computational, cognitive model can make toward organizing and assimilating this literature, as well as toward identifying important concepts and their interrelations. Using the LIDA model as an example, a framework is described within which to integrate the diverse research in animal cognition. Such a framework can provide both an ontology of concepts and their relations, and a working model of an animal＇s cognitive processes that can compliment active empirical research. In addition to helping to account for a broad range of cognitive processes, such a model can help to comparatively assess the cognitive capabilities of different animal species. After deriving an ontology for animal cognition from the LIDA model, we apply it to develop the beginnings of a database that maps the cognitive facilities of a variety of animal species. We conclude by discussing future avenues of research, particularly the use of computational models of animal cognition as valuable tools for hypotheses generation and testing [Current Zoology 57 （4）： 499-513, 2011].

关键词： Cognitive models Computational models LIDA Ontology Taxonomy

Interference of iron as a coagulant on MIB removal by powdered activated carbon adsorption for low turbidity waters

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Journal of Environmental Sciences 2013年第8期25卷 1575-1582页

作者： Ferreira Filho sidney SECKLER Marchetto MARGARIDA Alves Laganaro ROSEMEIRE Department of Hydraulic and Environmental Engineering Polytechnic School University of Sao Paulo Department of Sanitary and Environmental Engineering University of Mato Grosso Companhia de Saneamento Basico do Estado de So Paulo(SABESP)

Powered activated carbon （PAC） is widely used in water treatment plants to minimize odors in drinking water. This study investigated the removal of 2-methylisoborneol （MIB） by PAC adsorption, combined with coagulation using iron as a coagulant. The adsorption and coagulation process were studied through different case scenarios of jar tests. The analysis evaluated the effect of PAC dosing in the liquid phase immediately before or after the coagulant addition. Ferric sulphate was used as the coagulant with dosages from 10 to 30 mg/L, and PAC dosages varied from 10 to 40 mg/L. The highest MIB removal efficiency （about 70%） was achieved without the coagulant addition and with the highest PAC dosage （40 mg/L）. Lower MIB removal efficiencies were observed in the presence of coagulant, showing a clear interference of the iron precipitate or coagulant in the adsorption process. The degree of interference of the coagulation process in the MIB removal was proportional to the ratio of ferric hydroxide mass to the PAC mass. For both cases of PAC dosing, upstream and downstream of the coagulant injection point, the MIB removal efficiency was similar. However, MIB removal efficiency was 15% lower when compared with experiments without the coagulant application. This interference in the MIB adsorption occurs potentially because the coagulant coats the surface of the carbon and interferes with the MIB coming in contact with the carbon＇s surface and pores. This constraint requires an increase of the PAC dosage to provide the same efficiency observed without coagulation.

关键词： adsorption 2-methylisoborneol (MIB) coagulation activated carbon

Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 1-12页

作者： Nguyen Hoa Binh Quang Vo Luan Nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba Dong Thuy Thi Thu Phan Yen Thi Hoang Creswell Jacob Dang Thi Minh Ha Nguyen Lan Huu Shedrawy Jad L?nnroth Knut Nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;Ptreatment (aOR=10.86; 95%CI: 2.64–44.60;Ptreated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

Two-parameter characterization of low cycle,hysteretic fatigue data

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第6期11卷 449-454页

作者： Sheng BAO Wei—liang JIN sidney A. GURALNICK Thomas ERBER Institute of Structural Engineering Zhejiang University Hangzhou 310058 China Department of Civil Engineering Illino& Institute of Technology Chicago IL 60616 USA Department of Physics lllino& Institute of Technology Chicago IL 60616 USA Department of Applied Mathematics Illinois Institute of Technology Chicago IL 60616 USA

The aim of this research is to characterize the development of fatigue damage by means of stress-strain *** were conducted on 14 specimens made of cold-finished unannealed AISI 1018 *** demonstrate that the mechanical hysteresis loop areas,when plotted as a function of the number of loading cycles,show significant variations and demonstrate the three principal stages concerning the progress of the fatigue failure—initial accommodation,accretion of damage and terminal *** three stages of fatigue are marked by the transitions at cycles N2 and *** results show that although fatigue life Nf ranges from 2644 cycles to 108 992 cycles,the ratios of N2/Nf and N3/Nf tend to be stable:N2/Nf=10.7%,N3/Nf=91.3%.

关键词： Hysteresis loss Fatigue life Fatigue damage

Compression Deformation Mechanisms at the Nanoscale in Magnesium Single Crystal

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Acta Metallurgica Sinica(English Letters) 2013年第1期26卷 75-84页

作者： Yafang GUO Xiaozhi TANG Yuesheng WANG Zhengdao WANG sidney YIP Institute of Engineering Mechanics Beijing Jiaotong University Department of Nuclear Science and Engineering Massachusetts Institute of Technology

The dominant deformation mode at low temperatures for magnesium and its alloys is generally regarded to be twinning because of the hcp crystal structure. More recently, the phenomenon of a ＂loss＂ of the twins has been reported in microcompression experiments of the magnesium single crystals. Molecular dynamics simulation of compression deformation shows that the pyramidal 〈α ＋ c〉 slip dominates compression behavior at the nanoscale. No compression twins are observed at different temperatures at different loadings and boundary conditions. This is explained by the analyses, that is, the {10^_12} and {10^11} twins can be activated under c-axis tension, while compression twins will not occur when the c/α ratio of the hcp metal is below √3. Our theoretical and simulation results are consistent with recent microcompression experiments of the magnesium （0001） single crystals.

关键词： Magnesium Compression Slip Molecular dynamics simulation

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脑机接口的物理学

世界科学 2024年第1期 13-16页

作者：李威西德尼·珀科维兹美国埃默里大学

西德尼·珀科维兹深入浅出地介绍研究人员为研发更安全、更耐用、惠及更多人群的脑机接口所做的诸多前沿工作。人类大脑是一种复杂到惊人的机器。人类大脑皮层拥有800多亿个神经元，每个神经元又有1000个突触。我们的大脑每秒大约要处理...

西德尼·珀科维兹深入浅出地介绍研究人员为研发更安全、更耐用、惠及更多人群的脑机接口所做的诸多前沿工作。人类大脑是一种复杂到惊人的机器。人类大脑皮层拥有800多亿个神经元，每个神经元又有1000个突触。我们的大脑每秒大约要处理100兆比特的信息。想象一下，要是在我们思考的时候，尝试实时测量、提取并解释我们大脑中的所有信号，会是什么场景？记录大脑曾经只是科幻小说和电影——比如《X战警》（X-Men）和《黑客帝国》（The Matrix）——才有的情节，但现在，我们真的有可能把大脑同计算机连在一起，并且通过这种系统控制机械手臂，或者把你脑海中的想法记录下来。

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