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Matched pair analysis of the effect of longer hypothermic machine perfusion time on kidney transplant outcomes

World Journal of Transplantation 2024年第3期14卷 95-101页

作者： Carlos Verdiales Luke Baxter Hyun ja Lim Gavin Beck Michael A Moser Department of Surgery University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada College of Medicine University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada Canada and northern Ontario School of Medicine Thunder BayOntario P7B 5E1Canada Department of Community Health and Epidemiology University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada

BACKGROUnD Hypothermic machine perfusion(HMP)has demonstrated benefits in terms of early kidney transplant function compared to static cold *** longer preservation times have shown detrimental effects,a previous paired study indicated that longer pump times(the second kidney in a pair)might lead to improved *** To revisit the prior paired study's somewhat unexpected results by reviewing our program's *** A total of 61 pairs of transplant recipients who received kidneys from the same donor(2012-2021)were *** were divided into two groups depending on whether they were transplanted first(K1)or second(K2).therefore,the patients in each pair had identical donor characteristics,except for time on the *** analyses included Kaplan-Meyer analysis and paired tests,including Mcnemar's test,student's paired t-test,or Wilcoxon's test,as *** the two groups of recipients had similar demographics(age,body mass index,diabetes,time on dialysis,sensit-ization and retransplants).Cold ischemic times for K1 and K2 were 8.9(95%CI:7.9,9.8)and 14.7 hours(13.7,15.8)(Pn acute rejection at 1 year(P=0.015).Delayed graft function was less common in K2,12/61(20%)than in K1,20/61(33%)(P=0.046).Finally,K2 showed a higher graft survival than K1(P=0.023).COnCLUSIOn Our results agree with a previous study that suggested possible advantages to longer pump *** studies should encourage further research into HMP's potential anti-inflammatory effect.

关键词： Hypothermic machine perfusion Paired kidney study Early acute rejection

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Mechanocatalysis of CO to CO_(2)on TiO_(2)surface controlled at atomic scale

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nano Research 2024年第7期17卷 5826-5834页

作者： Yuuki Adachi Robert Turanský Ján Brndiar Kamil Tokár Qiang Zhu Huan Fei Wen Yasuhiro Sugawara IvanŠtich Yan Jun Li Department of Applied Physics Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Institute of Physics Slovak Academy of SciencesBratislava 84511Slovakia Institute of Informatics Slovak Academy of SciencesBratislava 84507Slovakia Faculty of natural Sciences University of Ss.Cyril and MethodiusTrnava 91701Slovakia Key Laboratory of Instrumentation Science and Dynamic Measurement School of Instrument and ElectronicsNorth University of ChinaTaiyuan 030051China

the common ways to activate a chemical reaction are by heat,electric current,or ***,mechanochemistry,where the chemical reaction is activated by applied mechanical force,is less common and only poorly understood at the atomic *** we report a tip-induced activation of chemical reaction of carbon monoxide to dioxide on oxidized rutile TiO_(2)(110)*** activation is studied by atomic force microscopy,Kelvin probe force microscopy under ultrahigh-vacuum and liquid nitrogen temperature conditions,and density functional theory(DFT)*** reaction is inferred from hysteretic behavior of frequency shift signal further supported by vector force mapping of vertical and lateral forces needed to trigger the chemical reaction with torque motion of carbon monoxide towards an oxygen *** reaction is found to proceed stochastically at very small tip-sample ***,the local contact potential difference reveals the atomic-scale charge redistribution in the reactants required to unlock the *** results open up new insights into the mechanochemistry on metal oxide surfaces at the atomic scale.

关键词： atomic resolution mechanochemistry atomic force microscopy Kelvin probe force microscopy density functional theory(DFT)simulation CO oxidation catalysis rutile TiO_(2)surface

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Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer:An update

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World Journal of Gastroenterology 2018年第48期24卷 5454-5461页

作者： Rafael I ja.n Patricia Prieto Marta Casado Paloma Martín-Sanz Lisardo Boscá Department of Metabolism and Physiopathology of Inflammatory Diseases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Department of Biomedicine Instituto de Biomedicina de Valencia (CSIC) Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares y Hepáticas y DigestivasISCⅢ Unidad Asociada IIBMULPGC Universidad de las Palmas de Gran Canaria (ULPGC)

the biosynthesis of prostanoids is involved in both physiological and pathological processes. the expression of prostaglandin-endoperoxide synthase 2(PTGS2; also known as COX-2) has been traditionally associated to the onset of several pathologies, from inflammation to cardiovascular, gastrointestinal and oncologic events. For this reason, the search of selective PTGS2 inhibitors has been a focus for therapeutic interventions. In addition to the classic non-steroidal anti-inflammatory drugs, selective and specific PTGS2 inhibitors, termed coxibs, have been generated and widely used. PTGS2 activity is less restrictive in terms of substrate specificity than the homeostatic counterpart PTGS1, and it accounts for the elevated prostanoid synthesis that accompanies several pathologies. the main regulation of PTGS2 occurs at the transcription level. In addition to this, the stability of the mRnA is finely regulated through the interaction with several cytoplasmic elements, ranging from specificmicroR nAs to proteins that control mR nA degradation. Moreover, the protein has been recognized to be the substrate for several post-translational modifications that affect both the enzyme activity and the targeting for degradation via proteasomal and non-proteasomal mechanisms. Among these modifications, phosphorylation, glycosylation and covalent modifications by reactive lipidic intermediates and by free radicals associated to the proinflammatory condition appear to be the main changes. Identification of these post-translational modifications is relevant to better understand the role of PTGS2 in several pathologies and to establish a correct analysis of the potential function of this protein in diseases progress. Finally, these modifications can be used as biomarkers to establish correlations with other parameters, including the immunomodulation dependent on molecular pathological epidemiology determinants, which may provide a better frame for potential therapeutic interventions.

关键词： Prostaglandins Prostaglandin-endoperoxide synthase 2 Post-translational modifications Glycosylation Colorectal cancer Inflammation

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Association between Tropical Convection and Boreal Wintertime Extratropical Circulation in 1982/83 and 1988/89

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Advances in Atmospheric Sciences 2003年第4期20卷 593-603页

作者： ja-Yeon MOOn Kyung-ja HA Climate Research Laboratory Meteorological Research InstituteSeoul156-720KoreaDepartment of Atmospheric SciencesPusan National UniversityPusan609-735Korea

Boreal wintertime extratropical circulation is studied in relation to the tropical convection during the 1982/83 El niño and 1988/89 La niña. the anomaly structure of 1982/83 and 1988/89 over the extratropics reveals remarkably different features as the longitudinal tropical forcing region changes. the Rossby wave source (Positive) shows the largest maximum over East Asia in both years due to the persistent heating from the western Pacific warm pool area. However, the sink term shows contrasting features over the subtropics and extratropics between the two years. In the El niño year, enhanced tropical convection over the eastern Pacific produces the Rossby wave sink at 10°n and shifted eastward over the north Pacific, while in the La niña year, the sink area is shifted westward over the north Pacific. the contrasting features between the two events in mean-eddy interaction appears especially over the downstream area of the East Asian Jet. the extension (retraction) of the meanflow eastward (westward) to the east (west) of the dateline is related with the effect of the westward (eastward) E-vector and the strengthening (weakening) of the negative anomalies of the barotropic growth of kinetic energy. Hence, almost opposite characteristics between the two events can explain the close relationship of tropical convection and the extratropical internal variability.

关键词： tropical convection extratropical circulation rossby wave source mean-eddy interaction

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On Uniform Decay for Transmission Problem of Kirchhoff Type Viscoelastic Wave Equation

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1197-1206页

作者： Jeong ja BAE Department of Mathematics Dongeui University

In this paper we consider the large time behavior of solutions to an n-dimensional transmission problem for two Kirchhoff type viscoelastic wave equations, that is, the wave propagation over bodies consisting of two physically different types of materials. One component is a simple elastic part while the other is a viscoelastic component endowed with a long range memory. We show that the dissipation produced by the viscoelastic part is strong enough to produce exponential or polynomial decay of the solution

关键词： existence of solution uniform decay wave equation boundary value problem a priori estimates

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不同益生菌对亚东鲑生长性能和生化指标的影响

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西南农业学报 2024年第5期37卷 1116-1123页

作者：何文佳王万良张忭忭西藏自治区农牧科学院水产科学研究所拉萨850000 西藏土著鱼类繁育与利用技术工程研究中心拉萨850000 西藏自治区渔业与种质资源利用重点实验室拉萨850000 中国水产科学研究院东海水产研究所上海200090

【目的】旨在探讨饲料中添加不同益生菌对亚东鲑(Salmo trutta)生长性能、消化酶活性和血清生化指标的影响。【方法】选择初始体质量为(84.57±1.83)g的亚东鲑鱼种630尾,随机分成7组,每组3个平行,每个平行30尾。对照组投喂基础饲料,实... 详细信息

【目的】旨在探讨饲料中添加不同益生菌对亚东鲑(Salmo trutta)生长性能、消化酶活性和血清生化指标的影响。【方法】选择初始体质量为(84.57±1.83)g的亚东鲑鱼种630尾,随机分成7组,每组3个平行,每个平行30尾。对照组投喂基础饲料,实验组分别添加不同益生菌(酵母菌、EM菌、乳酸菌、枯草芽孢杆菌、复合芽孢杆菌、地衣芽孢杆菌)至基础饲料,饲养3个月。【结果】添加不同益生菌对亚东鲑都具有促生长作用,试验组体长增长率、增重率、特定生长率、食物转化率和摄食率等指标均显著高于对照组(P0.05),而其他菌组之间均有不同程度影响。【结论】综合考虑存活率、生长特性、消化酶活性和血清生化指标,添加EM菌对亚东鲑健康养殖效果较好。

关键词：亚东鲑益生菌生长性能生化指标

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Genome-wide markers for seed yield and disease resistance in perennial ryegrass

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the Crop Journal 2022年第2期10卷 508-514页

作者： Kristina jaškune Vilma Kemešyte Andrius Aleliūnas Grazina Statkeviciute Institute of Agriculture Lithuanian Research Centre for Agriculture and Forestry(LAMMC)Instituto av.1Akademija LT-58344Lithuania

the market success of perennial ryegrass(Lolium perenne L.) cultivars depends on sufficient seed production, as they are propagated by seed. However, breeding for high quality forage production reduces seed yield, and breaking the negative correlation would help to overcome the problem. the foliar disease crown rust is another factor affecting reproductive capacity and thereby seed yield. We evaluated seed yield-related traits and resistance to crown rust in a collection of commercial cultivars and ecotypes of perennial ryegrass and identified genome-wide markers associated with the traits. the study revealed high variation between the ecotype and cultivar groups as well as between years. A genome-wide association study identified 17 DnA single-nucleotide polymorphisms(SnPs) of which eight were associated with crown rust and nine with flag-leaf length. the SnP markers were located within or near predicted genes functioning in defense against pathogens. the identified genes are strong candidates for a further in-depth functional study to continue unravel determination of leaf architecture and crown rust resistance in perennial ryegrass.

关键词： Crown rust Puccinia coronata f.sp.lolli Flag-leaf length Genome-wide association study(GWAS) Seed yield Lolium perenne L.

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表面活性剂对CaO_(2)修复石油烃污染土壤的影响研究

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环境科技 2024年第2期37卷 1-6,12页

作者：张祥孙勇向甲甲上海市政工程设计研究总院(集团)有限公司上海200092 上海申环环境工程有限公司上海200092

将合成的纳米级过氧化钙(nCaO_(2))用于石油烃污染土壤修复,研究过氧化钙(CaO_(2))、柠檬酸(CA)螯合二价铁(Fe(Ⅱ))投加量对石油烃去除效果的影响,并将不同表面活性剂对石油烃氧化的影响进行比较。结果表明,随着CaO_(2)或CA螯合Fe(Ⅱ)... 详细信息

将合成的纳米级过氧化钙(nCaO_(2))用于石油烃污染土壤修复,研究过氧化钙(CaO_(2))、柠檬酸(CA)螯合二价铁(Fe(Ⅱ))投加量对石油烃去除效果的影响,并将不同表面活性剂对石油烃氧化的影响进行比较。结果表明,随着CaO_(2)或CA螯合Fe(Ⅱ)的投加量增大,石油烃去除率均呈先增后降趋势。当n(CaO_(2)):n(Fe(Ⅱ)):n(CA)为4:1:1时,石油烃去除效果最佳,达到70.98%。十二烷基硫酸钠和曲拉通X-100对土壤中石油烃均有较好的增溶效果。质量浓度为3g/L的十二烷基硫酸钠对石油烃的降解可起促进作用,而曲拉通X-100则不利于石油烃的降解。

关键词：过氧化钙石油烃表面活性剂化学氧化纳米材料

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Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort

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World Journal of Gastroenterology 2019年第4期25卷 433-446页

作者： Patricia Prieto Rafael I ja.n Daniel Calle María Gómez-Serrano Estefanía nú?ez María Fernández-Velasco Paloma Martín-Sanz Sergio Alonso Jesús Vázquez Sebastián Cerdán Miguel ángel Peinado Lisardo Boscá Department of Metabolism and Physiopathology of Inflammatory Diseases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (Ciber-CV) Instituto de Salud Carlos III (ISCIII) Laboratorio de Imagen Médica Hospital Universitario Gregorio Mara?ón Laboratorio de Proteómica Cardiovascular Centro Nacional de Investigaciones Cardiovasculares (CNIC) Instituto de Investigación Sanitaria del Hospital Universitario la Paz(IdiPaz) Programa de Medicina Predictiva y Personalizada del Cáncer (PMPPC) Fundación Instituto de investigación en ciencias de la salud Germans Trias i PujolCtra Can Ruti

BACKGROUnD Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2(COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in *** To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic *** Biopsies from both healthy and pathological colorectal tissues were taken under informed consent from patients during standard colonoscopy procedure in the University Hospital of Bellvitge(Barcelona, Spain) and Germans Trias i Pujol University Hospital(Campus Can Ruti)(Barcelona, Spain). Western blot analysis was used to determine COX-2 levels. Deglycosylation assays were performed in both cells and tumor samples incubating each sample with peptide n-glycosidase F(PnGase F). Prostaglandin E2(PGE2) levels were determined using a specific ELISA. 1 H high resolution magic angle spinning(HRMAS) analysis was performed using a Bruker AVIII 500 MHz spectrometer and proteomic analysis was performed in a nano-liquid chromatography-tandem mass spectrometer(nano LC-MS/MS) using a QExactive HF orbitrap *** Our data show that COX-2 has a differential expression profile in tumor tissue of CRC patients vs the adjacent non-tumor area, which correspond to a glycosylated and less active state of the protein. this fact was associated to a lesser PGE2 production in tumors. these results were corroborated in vitro performing deglycosylation assays in HT29 cell line where COX-2 protein profile was modified after Pn

关键词： Colon Carcinoma Cyclooxygenase Prostaglandin Proteomics High resolution magic angle spinning

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the Study of the Behaviors of Zinc and Strontium in Caries-Affected Teeth by Laser-Induced Breakdown Spectroscopy(LIBS) Technique

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光谱学与光谱分析 2020年第3期40卷 980-984页

作者： R.nouir S.Hamzaoui H.Ghalila n.ja dane Faculty of Sciences of Tunis University of TunisEl ManarTunisTunisia Institute of Medical Technologies of Tunis University of Tunis El ManarTunisTunisia

We report on the application of Laser Induced Breakdown Spectroscopy(LIBS)technique to the study of Ca,P,Zn and Sr evolutions for adult caries-affected teeth using nanosecond laser *** aim of this work is to better understand the behaviors of Zn and Sr as trace-elements in the caries eruption with respect to the behaviors of one of the main compounds of the hydroxyapatite crystal which is the *** study was focused on the investigation of these elements’evolutions from three parts of the enamel surfaces of twenty two adult caries-affected teeth;the healthy part,the dental plaque part and the caries-affected *** decrease rates of Zn,Sr and P was,also,compared to the Ca *** concerned normalized emission line *** every species,normalization was done relatively to the emission line intensities of the healthy *** showed that abundances of these elements decrease similarly from the healthy parts to the affected-caries *** higher decrease rate was noticed for the *** evolutions of Zn and Sr for the three parts of the teeth surfaces cannot inform about the substitution of the calcium by these trace-elements,however the comparison of their decrease rates to the calcium one can be considered as a valuable index of this substitution.

关键词： Teeth Caries Trace-elements Substitution LIBS

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