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Gp78 regulates PMP22 and causes ER stress and autophagy in EV71-VP1-overexpressing mouse Schwann cells

BIOCELL 2024年第4期48卷 653-664页

作者： DANPING ZHU GUANGMING LIU KUAN FENG SUYUN LI DANDAN HU sida yang PEIQING LI Pediatric Emergency Department Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina Department of Child Health Care Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina Pediatric Neurology Department Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina

Background:During Enterovirus type 71(EV71)infection,the structural viral protein 1(VP1)activates endoplasmic reticulum(ER)stress associated with peripheral myelin protein 22(PMP22)accumulation and induces ***,the speciﬁc mechanism behind this process remains ***:In this research,we used the VP1-overexpressing mouse Schwann cells(SCs)models co-transfected with a PMP22 silencing or Autocrine motility factor receptor(AMFR/gp78)overexpressing vector to explore the regulation of gp78 on PMP22 and its relationship with autophagy and ***:The activity of gp78 could be inﬂuenced by EV71-VP1,leading to a decrease in the ubiquitination and degradation of PMP22,resulting in PMP22 accumulation in *** VP1-overexpressing mouse SCs,all three ER stress sensors,including pancreatic endoplasmic reticulum kinase(PERK),activating transcription factor 6(ATF6)and inositol-requiring enzyme 1(IRE1)and the related downstream signals(C/EBP-homologous protein(CHOP)and Caspase 12)were activated,as well as the ER-resident chaperone Glucose-regulated protein 78(GRP78).In addition,VP1 upregulated the autophagy marker Microtubule-associated protein 1 light chain 3 beta(LC3B),while PMP22 silencing or gp78 overexpression reversed the ***,PMP22 silencing or gp78 overexpression increased proliferation of EV71-VP1-transfected mouse ***:Gp78 could regulate PMP22 accumulation through ubiquitination degradation and cause ER stress and autophagy in EV71-VP1-overexpressing mouse ***,the gp78/PMP22/ER stress axis might emerge as a promising therapeutic target for myelin and neuronal damage induced by EV71 infection.

关键词： Enterovirus type 71 AMFR/gp78 PMP22 Autophagy Schwann cells

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Risk Factors of Influenza-Associated Necrotizing Encephalopathy in Children

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Journal of Behavioral and Brain Science 2021年第8期11卷 193-203页

作者： Guangming Liu sida yang Suyun Li Qinglian Chen Weiqiang Xiao Peiqing Li Pediatric Emergency Department Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China Pediatric Neurology Department Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China Pediatric Radiology Department Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China

Objective: A case-control study of Influenza-Associated Necrotizing Encephalopathy (IANE) in children was conducted to explore the risk factors for the diagnosis of IANE, and to provide a predictive reference for the diagnosis of IANE. Methods: The children with IANE who received treatment in our hospital from January 2016 to December 2020 were selected as the study group, and the children with Influenza-Associated Encephalopathy (IAE) group who received treatment in the same period were selected as the control group. The blood biochemical, coagulation function and cerebrospinal fluid test results of the two groups were analyzed by univariate analysis. Receiver Operating Characteristic curve (ROC) analysis was used to determine the optimal threshold point of each index for the indicators with statistically significant differences in univariate analysis results, and multivariate Logistic stepwise regression analysis was performed according to the optimal threshold points. Results: In the IANE group, there were 32 children, including 20 males and 12 females, aged 60 (35, 84) months. There were 40 children in IAE group, including 26 males and 14 females, aged 58 (23, 97) months. Univariate results showed that serum Lactate Dehydrogenase (LDH), Cerebrospinal Fluid Lactate Dehydrogenase (CSF LDH) and Cerebrospinal Fluid Protein (CSF PRO) in the IANE group were significantly higher than those in the IAE group, and the difference between the two groups was statistically significant (P 535 U/L (OR = 31.264, 95% CI: 5.892 - 165.878, P 0.49 g/L (OR = 7.695, 95% CI: 1.052 - 56.305, P = 0.044) were independent risk factors for IANE. Conclusion: For children with influenza whose neurological symptoms appear rapi

关键词： Children Influenza-Associated Necrotizing Encephalopathy Risk Factor

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Brain Complications with Influenza Infection in Children

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Journal of Behavioral and Brain Science 2020年第3期10卷 129-152页

作者： Qinglian Chen Peiqing Li Suyun Li Weiqiang Xiao sida yang Hui Lu Guangzhou Medical University Guangzhou China Department of Radiology Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China Department of Pediatric Neurology Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China Institute of Pediatrics Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China

Objectives: To summarize the characteristics and research progress of influenza-associated brain complications in children and provide references for early diagnosis and brain protection treatment. Methods: Studied published articles of influenza-associated neurocomplications in children from PubMed and summarizes them from epidemiology, clinical manifestations, diagnosis and treatment, and basic research progress. Results: Common brain complications in flu-children include febrile seizures, influenza-associated encephalopathy (IAE), acute or post-influenza encephalitis, and the most severe condition is acute necrotizing encephalopathy (ANE). However, the mechanism and relevant factors of influenza-associated brain damage have not been elucidated. Conclusion: Influenza could be accompanied by various brain lesion complications in dif ferent stages of the disease, some of which are life-threatening or leave severe neurological sequelae, such as ANE. Due to different brain injury mechanisms, specific early diagnosis and brain protection treatment for different complications are unclear or unanimous. Therefore, further classification and basic research are needed.

关键词： Brain Lesions Risk Factor Influenza Children

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难治性痉挛性癫持续状态的治疗对策

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中华实用儿科临床杂志 2015年第18期30卷 1371-1378页

作者：杨思达广州医科大学附属广州市妇女儿童医疗中心神经科 510623

癫发作依据持续的时程和对治疗的反应分为早期癫持续状态（ early status epilepticus）、确认的癫持续状态（ established status epilepticus）、难治性癫持续状态（ refractory status epilepticus）和超级难治性癫持续状态（ super-... 详细信息

癫发作依据持续的时程和对治疗的反应分为早期癫持续状态（ early status epilepticus）、确认的癫持续状态（ established status epilepticus）、难治性癫持续状态（ refractory status epilepticus）和超级难治性癫持续状态（ super-refractory status epilepticus）。本研究主要针对难治性及超级难治性癫的治疗策略进行系统回顾，包括致病相关因素、脑损伤的分析，指出超级难治性癫是一个重要的临床问题，有着较高的病死率和发病率。现就近期世界范围发表的文献提出的治疗方法进行评价，包括麻醉药物，抗癫药物，镁剂，吡哆醇，类固醇和免疫治疗，生酮饮食，低温疗法，神经外科干预，经颅磁刺激，迷走神经刺激，脑深部刺激，电休克疗法，脑脊液引流及其他传统药物等疗法。强调原因的识别与对因治疗的重要性，推荐难治性癫分段治疗方案及超级难治性癫的管理流程。

关键词：癫难治性/超级难治性治疗策略

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Central Brain Herniation Secondary to Influenza-Related Encephalopathy in a Pontocerebellar Hypoplasia Child: A Case Report and Review

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Journal of Behavioral and Brain Science 2020年第6期10卷 257-264页

作者： Weiqiang Xiao Peiqing Li Yuzhi Yao sida yang Suyun Li Shuyao Ning Hongsheng Liu Department of Pediatric Radiology Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China Department of Pediatric Emergency Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China Department of Surgery Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China Department of Pediatric Neurology Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China Department of Neuroelectrophysiology Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China

Influenza-associated encephalopathy (IAE) can perform as varying patterns of neuroimaging. Central brain herniation (CBH) secondary to IAE is rare;it may be a bad prognosis. Here, we presented a 4-year-old girl with influenza who had a pontocerebellar hypoplasia (PCH) history;she performed the second Magnetic Resonance Imaging (MRI) on Day 6 from onset, showed the diffuse edema and the occurrence of central herniation;the medulla was “Z-like” folded and the basal cisterns were obliterated completely. Finally she was declared dead. The imbalance between supratentorial and infratentorial pressure can lead to the occurrence of CBH. Severe edema relates to IAE and unstable structure of the posterior fossa might be the main reason for the herniation. MRI is helpful in early diagnosis. Early treatment of cerebral edema in patients with congenital abnormalities of the posterior fossa is vital for their management.

关键词： Pontocerebellar Hypoplasia Central Brain Herniation Influenza-Related Encephalopathy Magnetic Resonance Imaging

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浅析无人机航拍的媒体应用价值

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中国科技纵横 2023年第22期 83-85页

作者：杨斯达东北农业大学黑龙江哈尔滨 150001

无人机航拍作为一种新兴技术,近年来在媒体领域得到了越来越广泛的应用.随着无人机技术的不断发展,无人机航拍不仅可以为媒体提供更加全面、生动的视角,也可以在新闻报道、广告宣传、影视制作等多个方面发挥作用.基于此,介绍无人机航拍... 详细信息

无人机航拍作为一种新兴技术,近年来在媒体领域得到了越来越广泛的应用.随着无人机技术的不断发展,无人机航拍不仅可以为媒体提供更加全面、生动的视角,也可以在新闻报道、广告宣传、影视制作等多个方面发挥作用.基于此,介绍无人机航拍在媒体领域中的应用价值和实践路径.介绍无人机航拍的概念和优势,重点探讨无人机航拍在电视新闻报道中的媒体应用价值,包括全知视角纵览新闻现场、一镜到底还原新闻事实、无人机带来新闻拍摄的时效性和成本节约等方面.提出无人机航拍在媒体应用中的融合发展和实践路径,包括"无人机+5G+新闻直播""无人机+大数据+全媒体"和"无人机+AR+VR"打造"沉浸式"新闻等方面.无人机航拍的应用价值在于提供更加多样、全面的视角和内容,为新闻报道、广告宣传、影视制作等多个领域提供新的机遇和挑战.

关键词：无人机航拍媒体应用价值

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基于权值对三角关系中结构平衡的预测研究

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情报杂志 2024年第7期43卷 131-137页

作者：杨思达胡志洋赵一涵杨良斌国际关系学院网络空间安全学院北京100091 新疆大学计算机科学与技术学院乌鲁木齐830046

[研究目的]随着信息化社会的不断发展变化,开源情报的重要性日益突出。通过社交网络中的公开信息对实体间的关系演化进行预测,为使用者提供决策支持。[研究方法]利用微博文本数据挖掘技术,对一年内的官博文本进行收集和清洗,再运用共现... 详细信息

[研究目的]随着信息化社会的不断发展变化,开源情报的重要性日益突出。通过社交网络中的公开信息对实体间的关系演化进行预测,为使用者提供决策支持。[研究方法]利用微博文本数据挖掘技术,对一年内的官博文本进行收集和清洗,再运用共现次数及链路赋予数值等方法,构建社会关系网络,以预测结构不平衡的社交网络。[研究结论]研究结果表明,该方法在一定参数约束下能够生成符合预期的社会关系网络,并有效预测在社会关系网络中结构不平衡状态下可能出现的变化。

关键词：结构平衡三角关系社交网络开源情报新浪微博链路预测

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儿童癫痫持续状态的脑电图表现

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中华实用儿科临床杂志 2017年第12期32卷 888-892页

作者：王秀英宁书尧杨思达广州市妇女儿童医疗中心神经内科 510120

脑电图（EEG）是诊断癫痫持续状态（SE）必不可少的检查，特别在非惊厥性SE中，由于其临床症状轻微或不典型，EEG是诊断的必需条件。SE是一个动忿变化过程，随着发作的持续，EEG也出现变化并出现非痫性的节律改变。发作期EEG无任何特定... 详细信息

脑电图（EEG）是诊断癫痫持续状态（SE）必不可少的检查，特别在非惊厥性SE中，由于其临床症状轻微或不典型，EEG是诊断的必需条件。SE是一个动忿变化过程，随着发作的持续，EEG也出现变化并出现非痫性的节律改变。发作期EEG无任何特定的模式，不同类型SE具有不同的EEG特征，现综述不同类型SE的EEG表现。

关键词：癫痫持续状态脑电图儿童

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昆明市某医院2013～2014年住院婴幼儿感染星状病毒的分子流行病学研究

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病毒学报 2016年第6期32卷 752-757页

作者：杨思达任禹衡邓丽丽杨景晖熊永英井申荣李利昆明理工大学医学院病原生物学实验室昆明650500 昆明理工大学附属医院儿科昆明650034

探讨昆明市某医院2013-2014年住院婴幼儿星状病毒（human astrovirus,HAstV）腹泻的感染情况,分析其分子流行病学特征。通过逆转录RT-PCR法,对63份婴幼儿腹泻样品和42份非腹泻样品进行星状病毒分型鉴定;并扩增1株HAstV全基因组序列。结... 详细信息

探讨昆明市某医院2013-2014年住院婴幼儿星状病毒（human astrovirus,HAstV）腹泻的感染情况,分析其分子流行病学特征。通过逆转录RT-PCR法,对63份婴幼儿腹泻样品和42份非腹泻样品进行星状病毒分型鉴定;并扩增1株HAstV全基因组序列。结果在63份样品中,HAstV检出率为41.27%（26/63）,以HAstV1型为主要流行株;42份对照组中,HAstV感染率为2.38%（1/42）;扩增获得1株HAstV全基因组序列,进化树分析为HAstV1型。本研究获得了昆明地区婴幼儿星状病毒腹泻流行病学数据,为昆明地区星状病毒腹泻的感染、控制提供了重要的理论依据。

关键词：婴幼儿腹泻星状病毒分子流行病学

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A Comprehensive,Prospective and Clinical Investigation of the Neurological Involvement in Children Infected with Enterovirus 71

A Comprehensive,Prospective and Clinical Investigation of th...

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中华医学会急诊医学分会第17次全国急诊医学学术年会

作者： peiqing Li sida yang wei Li Wenying Lai Wencheng Ma Jia-ming Lu Yan Hong Yu-ting Liang Dan-dan Hu Yuan-yuan Gao Yi Zhou Jun Shen Hongsheng Liu Yan-ling Chen Guangzhou women and children's medical center Dongguan Taiping People's Hospital Zhongshan People's Hospital

EV71 has been found the most significant neurotropic enterovirus after *** study is prospective,and of the clinical observation of totally 288 confirmed EV71-infected cases with neurologic complications from January to October 2012 in 3 *** observation index consists of more than 80 terms of neurological symptoms and ***

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