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Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine

International Journal of Oral Science 2011年第3期3卷 107-116页

作者： sibel yildirim Susan Y. Fu Keith Kim Hong Zhou Chang Hun Lee Ang Li Sahng Gyoon Kim Shuang Wang Jeremy J. Mao Tissue Engineering and Regenerative Medicine Laboratory （TERML） Center for Craniofacial Regeneration Columbia University Medical Center New York NY 10032 USA Department of Basic Science Xi＇an Jiaotong University School of Stomatology Xi＇ an 710049 China

A tooth is a complex biological organ and consists of multiple tissues including the enamel, dentin, cementum and pulp. Tooth loss is the most common organ failure. Can a tooth be regenerated？ Can adult stem cells be orchestrated to regenerate tooth structures such as the enamel, dentin, cementum and dental pulp, or even an entire tooth？ If not, what are the therapeutically viable sources of stem cells for tooth regeneration？ Do stem cells necessarily need to be taken out of the body, and manipulated ex vivo before they are transplanted for tooth regeneration？ How can regenerated teeth be economically competitive with dental implants？ Would it be possible to make regenerated teeth affordable by a large segment of the population worldwide？ This review article explores existing and visionary approaches that address some of the above-mentioned questions. Tooth regeneration represents a revolution in stomatology as a shift in the paradigm from repair to regeneration： repair is by metal or artificial materials whereas regeneration is by biological restoration. Tooth regeneration is an extension of the concepts in the broad field of regenerative medicine to restore a tissue defect to its original form and function by biological substitutes.

关键词： stem cells bioactive cues biomaterials cell homing dental pulp tooth regeneration growth factors scaffold dental implants pulp regeneration

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Tachyphylaxis during ranibizumab treatment of exudative age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 846-848页

作者： sibel Doguizi Sengul Ozdek Selcen Yuksel Department of Ophthalmology Dogubeyazit State Hospital Department of Ophthalmology Faculty of Medicine Gazi University Faculty of Medicine Biostatistics Department Yildirim Beyazit University

Dear Editor,We are intestigators from Turkey primarily studying exudative age-related macular degeneration(AMD).Here we present the results of our retrospective clinical study on tachyphylaxis development during the treatment of exudative AMD with ranibizumab,which,we believe,will form a basis for further prospective studies to predict the drug response in anti-vascular endothelial growth factor

关键词： CHOROIDAL NEOVASCULARIZATION BEVACIZUMAB BLINDNESS THERAPY

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Pediatric dysphagia overview:best practice recommendation study by multidisciplinary experts

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World Journal of Pediatrics 2022年第11期18卷 715-724页

作者： Ebru Umay sibel Eyigor Esra Giray Evrim Karadag Saygi Bulent Karadag Nihal Durmus Kocaaslan Deniz Yuksel Arzu Meltem Demir Engin Tutar Canan Tikiz Eda Gurcay Zeliha Unlu Pelin Celik Ece Unlu Akyuz Guven Mengu Serkan Bengisu sibel Alicura Necati Unver Nida Yekteusaklari Cuma Uz Merve Cikili Uytuni Fatih Bagcier Elif Tarihci Mazlum Serdar Akaltun Iclal Ayranci Sucakli Damla Cankurtaran Zeynep Aykin Resa Aydin Fatma Nazli Department of Physical Medicine and Rehabilitation Ankara University of Health Sciences TurkeyAnkara Diskapi Yildirim Beyazit Training and Research HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Ege UniversityIzmirTurkey Department of Physical Medicine and Rehabilitation Fatih Sultan Mehmet Training and Research HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Marmara UniversityIstanbulTurkey Department of Pediatric Pulmonology Marmara UniversityIstanbulTurkey Department of Plastic Reconstructive and Aesthetic SurgeryMarmara UniversityIstanbulTurkey Department of Pediatric Neurology University of Health SciencesAnkara Dr Sami Ulus MaternityChildren's Health and Diseases Training and Research HospitalAnkaraTurkey Department of Pediatric Gastroenterology Ankara City HospitalAnkaraTurkey Department of Pediatric Gastroenterology Marmara UniversityAnkaraTurkey Department of Physical Medicine and Rehabilitation Celal Bayar UniversityManisaTurkey University of Health Sciences Turkey Gaziler Physical Medicine and Rehabilitation Training and Research HospitalAnkaraTurkey Department of Developmental Pediatric Ankara City HospitalAnkaraTurkey Department of Western Languages and Literatures Ankara Haci Bayram Veli UniversityEnglish Language and Literature DivisionAnkaraTurkey Department of Speech and Language Therapy Uskudar UniversityIstanbulTurkey Department of Otolaryngology Head and Neck SurgeryUniversity of Health SciencesAnkara Diskapi Yildirim Beyazit Training and Research HospitalAnkaraTurkey Department of Otolaryngology Head and Neck SurgeryMarmara UniversityIstanbulTurkey Department of Child and Adolescent Psychiatry Ankara UniversityAnkaraTurkey Department of Physical Medicine and Rehabilitation Istanbul Basaksehir Cam and Sakura City HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Istanbul UniversityIstanbulTurkey Department of Physical Medicine and Rehabilitation Gaziantep UniversityGazian

Background Currently,there is no comprehensive and multidisciplinary recommendation study covering all aspects of pediatric dysphagia(PD).This study aimed to generate PD management recommendations with methods that can be used in clinical practice to fill this gap in our country and in the world,from the perspective of experienced multidisciplinary *** This recommendation paper was generated by a multidisciplinary team,using the seven-step process and a three-round modified Delphi survey via ***,ten open-ended questions were created,and then detailed recommendations including management,diagnosis,treatment,and follow-up were created with the answers from these *** recommendation item was voted on by the experts as overall consensus(strong recommendation),approaching consensus(weak recommendation)and divergent consensus(not recommended).Results In the 1st Delphi round,a questionnaire of 414 items was prepared based on the experts’responses to ten open-ended *** the 2nd Delphi round,59.2%of these items were accepted as *** the 3rd Delphi round,62.6%of 246 items were accepted for inclusion in the *** final version recommendations consisted of 154 *** This study includes comprehensive and detailed answers for every problem that could be posed in clinical practice for the management of PD,and recommendations are for all pediatric patients with both oropharyngeal and esophageal dysphagia.

关键词： Diagnosis Dysphagia Pediatric Recommendation Rehabilitation

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The Factors of Musculoskeletal Pain in Geriatric Patients and the Relationship between Pain and Quality of Life

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International Journal of Clinical Medicine 2017年第8期8卷 504-513页

作者： Esra Cicekci Zuhal Ozisler Sumru Ozel sibel Unsal-Delialioglu Cem Ozisler Diyarbakir Gazi Yasargil Education and Research Hospital PMR Clinics Ministry of Health Diyarbakir Turkey Ankara Physical Medicine and Rehabilitation Education and Research Hospital PMR Clinics Ankara Turkey Ankara Diskapi yildirim Beyazit Education and Research Hospital InternalMedicine-Rheumatology Clinics Ankara Turkey

Aim: The purpose of the study was to assess the musculoskeletal pain frequency and intensity, to pinpoint the factors affecting the pain and to research their effect on patients’ quality of life. Methods: 203 patients over 65 who came to our Physical Therapy and Rehabilitation clinic were included in the study. Intensity of comorbid diseases were calculated by using Cumulative Illness Rating Scale (CIRS). Geriatric Pain Measure-24 (GPM) was used to assess the pain intensity, Geriatric Depression Scale-15 (GDS) was used to detect the presence of depression and Short Form-36 (SF-36) was used to determine quality of life. Results: The median age of the patients was 72.9 ± 6.36 (65 - 92) years. 97% of patients complained of pain. GPM total value mean of the patients was 61.9 (0 - 99.9). GPM scores were significantly higher in patients who were female (p Conclusions: Low education, being single, presence of comorbidities and being a housewife all relates to pain intensity, yet the most important factors are being female and presence of depression. Pain intensity is connected to low quality of life. We think this study will show a path to program geriatric population’s healthcare needs.

关键词： Elderly Pain Quality of Life

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