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Discrepancy among microsatellite instability detection methodologies in non-colorectal cancer:Report of 3 cases

World Journal of Clinical Cases 2023年第13期11卷 3105-3113页

作者： ElifŞenocak Taşçı İbrahim yıldız sibel Erdamar LeylaÖzer Department of Medical Oncology Acıbadem MAA UniversityIstanbul 12345Turkey Department of Pathology Acıbadem MAA UniversityIstanbul 12345Turkey

BACKGROUND Microsatellite instability(MSI)is a predictive biomarker for cancer *** tumor-agnostic nature of MSI makes it a denominator for immunotherapy in several solid *** can be assessed using next-generation sequencing(NGS),fluorescent multiplex PCR,and immunohistochemistry(IHC).CASE SUMMARy Here,we report 3 cases with discordant MSI results detected using different methods.A cholangiocellular carcinoma case revealed proficient mismatch repair(MMR)by IHC but high MSI(MSI-H)by liquid NGS.A cervical cancer case revealed deficient MMR by IHC,microsatellite stable by PCR,and MSI-H by ***,an endometrial cancer case revealed proficient MMR by IHC but MSI-H by *** IHC for MMR status is the first choice due to several ***,in cases of indeterminate IHC results,molecular testing by MSI-PCR is ***,NGS-based MSI assays are being widely used to detect MSI-H *** three methods have high accuracy;however,the inconsistencies between them may lead to misdiagnosis.

关键词： Discordance Immunohistochemistry Microsatellite instability Nextgeneration sequencing Case report

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Assessment of the long-term visual and anatomical outcomes of ranibizumab to treat neovascular age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2018年第4期11卷 645-649页

作者： Bekir Kücük sibel Kadayifcilar Bora Eldem Department of Ophthalmology Hacettepe UniversityAnkara 06100Turkey

AIM： To investigate the long-term visual and anatomical outcomes of patients who underwent intravitreal ranibizumab monotherapy to treat neovascular age-related macular degeneration（AMD） and followed-up for at least 2 ***： A total of 74 eyes of 74 patients who underwent ranibizumab monotherapy for neovascular AMD were included in this retrospective ***： The average patient age was 72.1±6.5（range, 57-85）y, the average follow-up time 46.2±13.1（range, 24-75）mo, and the average number of visits 24.1±9.5（range, 8-48）. The mean number of injections in year 1 was 4.5, 1.6 in year 2, 0.9 in year 3, 0.4 on year 4, and 0.1 in the following years. Within the entire follow-up period, the mean number of injections was 7.6±4.4（range, 2-21）. The mean visual acuity was 48.1±15（range, 15-76） letters at baseline and 45.7±19（range, 7-75） at year 5. The mean central macular thickness was 303±78（range, 178-552） μm at baseline and 251±51（range, 138-359） μm at year 5. Scars developed in 47（63.5%） eyes at the end of the follow-up period, and atrophy was evident in 6（8.1%） ***： Ranibizumab monotherapy can stabilize visual acuity for a mean period of 4 y in patients with neovascular AMD.

关键词： intravitreal injection neovascular age-related macular degeneration ranibizumab

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Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine

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International Journal of Oral Science 2011年第3期3卷 107-116页

作者： sibel y.ldirim Susan y. Fu Keith Kim Hong Zhou Chang Hun Lee Ang Li Sahng Gyoon Kim Shuang Wang Jeremy J. Mao Tissue Engineering and Regenerative Medicine Laboratory （TERML） Center for Craniofacial Regeneration Columbia University Medical Center New York NY 10032 USA Department of Basic Science Xi＇an Jiaotong University School of Stomatology Xi＇ an 710049 China

A tooth is a complex biological organ and consists of multiple tissues including the enamel, dentin, cementum and pulp. Tooth loss is the most common organ failure. Can a tooth be regenerated？ Can adult stem cells be orchestrated to regenerate tooth structures such as the enamel, dentin, cementum and dental pulp, or even an entire tooth？ If not, what are the therapeutically viable sources of stem cells for tooth regeneration？ Do stem cells necessarily need to be taken out of the body, and manipulated ex vivo before they are transplanted for tooth regeneration？ How can regenerated teeth be economically competitive with dental implants？ Would it be possible to make regenerated teeth affordable by a large segment of the population worldwide？ This review article explores existing and visionary approaches that address some of the above-mentioned questions. Tooth regeneration represents a revolution in stomatology as a shift in the paradigm from repair to regeneration： repair is by metal or artificial materials whereas regeneration is by biological restoration. Tooth regeneration is an extension of the concepts in the broad field of regenerative medicine to restore a tissue defect to its original form and function by biological substitutes.

关键词： stem cells bioactive cues biomaterials cell homing dental pulp tooth regeneration growth factors scaffold dental implants pulp regeneration

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年龄相关性黄斑变性的脉络膜厚度评价（英文）

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国际眼科杂志 2014年第9期14卷 1561-1566页

作者： Erkan Unsal Kadir Eltutar Ozen Ayranci Osmanbasoglu sibel Zιrtιloglu Osman Kιzιlay Hulya Gungel 伊斯坦布尔教育研究医院眼科土耳其伊斯坦布尔34098

目的:通过光学相干断层扫描(optical coherence tomography,OCT;RTVue 100-2;V 5.1,Optovue,Fremont,CA,USA)测量比较非新生血管性与新生血管性年龄相关性黄斑变性(age-related macular degeneration,AMD)黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT),并分析脉络膜厚度(choroidal thickness,CT)对AMD新血管形成的影响。方法:本研究为回顾性、横断面研究。以单侧眼患有新生血管性AMD且对侧眼患有非新生血管性AMD的24例患者(48眼)作为研究组,选取年龄与眼轴长度相匹配的40例健康眼作为对照组。非新生血管性AMD亚组研究对象是黄斑区有玻璃疣和/或色素变化眼,而新生血管性AMD亚组研究对象是由于脉络膜新生血管而致视网膜下或视网膜内有渗出液和/或脂性渗出眼。运用OCT垂直测量外侧高反射线(视网膜色素上皮层)到脉络膜巩膜交界面间的距离。选取7个不同点进行脉络膜厚度测量,测量区域为距黄斑中心凹颞侧和鼻侧1500μm范围,测量间距为500μm。测量结果在亚组间进行统计学对比研究。结果:研究组患者平均年龄为72.4±8.97(60～82)岁,对照组受试者平均年龄为71.2±8.8(58～81)岁。新生血管性AMD组中平均SFCT明显大于非新生血管性AMD组的厚度(P0.05);而新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异有统计学意义(P<0.05)。结论:运用OCT对脉络膜厚度进行测量,有助于理解AMD的病理生理机制。然而,仍需要大型前瞻性研究来探求新生血管性AMD中SFCT增厚的原因。

关键词：脉络膜厚度年龄相关性黄斑变性光学相干断层扫描

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