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Anti-inflammatory efficiency of levobupivacaine in an experimental colitis model

World Journal of Gastroenterology 2010年第20期16卷 2537-2541页

作者： Ugur Duman Aysun Yilmazlar Ersin Ozturk sibel Aker Emre Sarandol Tuncay Yilmazlar Department of General Surgery Uludag University School of Medicine16069 BursaTurkey Department of Anesthesiology and Reanimation Uludag University School of Medicine16069 BursaTurkey Department of Pathology Uludag University School of Medicine16069 BursaTurkey Department of Biochemistry Uludag University School of Medicine16069 BursaTurkey

AIM:To investigate the efficiency of levobupivacaine in treating experimentally induced colitis in ***:Colitis was induced by trinitrobenzene sulfonic acid and ethanol in 30 rats under general anesthesia,and 10 rats were used as a sham *** to induction of colitis,rats were divided into three groups;budesonide group received 0.1 mg/kg budesonide,levobupivacaine group received 10 mg/kg levobupivacaine and saline group received 1 mL saline solution via rectal route for 7 *** the sham group,only routine rectal catheterization was performed without use of any *** the end of 7 d,laparotomy and total colectomy were performed for histopathological ex-amination in all rats and blood samples were drawn for measurement of tumor necrosis factor(TNF)-αand interleukin(IL)-6 following cardiac *** and microscopic evaluations of the specimens were performed by a pathologist blinded to group assignment of the ***:Weight loss(P=0.016)and macroscopic examination scores(P=0.001)were significantly higher in saline group than *** scoring was comparable between all colitis groups(P=0.350).There was no significant difference in TNF-αlevels and IL-6 levels(P=0.150).CONCLUSION:The significant improvement in macroscopic scores suggests that levobupivacaine may have topical anti-inflammatory effects in an experimental colitis model;however,this finding was not supported by microscopic findings.

关键词： Trinitrobenzene sulfonic acid Colitis Levobupivacaine Budesonide

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Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer

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World Journal of Gastroenterology 2007年第33期13卷 4437-4444页

作者： sibel Erdamar Esra Ucaryilmaz Gokhan Demir Tayfun Karahasanoglu Gulen Dogusoy Ahmet Dirican Suha Goksel Department of Pathology Cerrahpasa Medical CollegeIstanbul University Cerrahpasa 34303 Istanbul Turkey Department of Oncology Cerrahpasa Medical College Istanbul University Cerrahpasa 34303 Istanbul Turkey Department of General Surgery Cerrahpasa Medical College Istanbul University Cerrahpas34303 Istanbul Turkey Department of Statistics Cerrahpasa Medical College Istanbul University Cerrahpasa 34303 Istanbul Turkey

AIM： To assess the incidence of MLH1 （the human MutL homologue） and MSH2 （the human MutS homologue） protein expression in Turkish patients with sporadic colorectal cancers and to compare their survival and clinicopathological features. METHODS： We validated the tissue microarray technology in 77 colorectal carcinomas by analyzing the immunohistochemical expression of proteins involved in two main pathways of colorectal carcinogenesis： p53 protein for loss of heterozygosity tumors; MLH1 and MSH2 proteins for microsatellite instability （MSI）. RESULTS： Our analysis showed that 29 （39.2%） had loss of MLH1 expression, 5 （6.8%） had loss of MSH2 expression and 2 cases had loss of expression of both proteins. We found that 60% of MSH2-negative tumors were located in the right side of the colon; all MSH2-negative cases were women. In addition, the loss of MSH2 expression was correlated with low p53 expression. Neither MLH1 nor MSH2 expressions were associated with prognosis, although there seemed a tendency of longer survival （71.7 ± 8.65 mo vs 47.08± 5.26 too） for the patients with MLHl-negative versus MLHl-positive carcinomas. There were not significant differences in overall and recurrence-free survival among MLH1/MSH2-positive and -negative cases.CONCLUSION： Our data supports that Turkish patients with MLH1- and MSH2-defective tumors have some distinct features from each other. Although prognostic importance remains controversial, immunohistochemical analysis of mismatch repair genes may be used as a routine histopathological examination of sporadic colorectal carcinomas.

关键词： Colorectal carcinoma MLH1 MSH2 Immunohistochemistry Prognosis

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Syntheses and Structural Characterization of 1-(4-Phenyl-2-thiazolyl)-3-(4-methylphenyl)-5-(2-furyl)-4,5-dihydro-(1H)-pyrazole and 1-(4-(4-Fluoro)phenyl-2-thiazolyl)-3-(4-methyl-phenyl)-5-(2-furyl)-4,5-dihydro-(1H)-pyrazole

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Chinese Journal of Structural Chemistry 2010年第5期29卷 700-705页

作者： SAHN Zarife sibel ISIK Samil SALGIN-GKSEN Umut GKHAN-KELEK Nesrinb Department of Physics Faculty of Arts and SciencesOndokuz Mayιs University Department of Pharmaceutical Chemistry Faculty of PharmacyHacettepe University

The title compounds were synthesized and characterized by IR,1H-NMR,Mass and elementary analysis and single-crystal X-ray *** 1a,intermolecular C-H…π interactions produce a three-dimensional *** 1b,intermolecular C-... 详细信息

关键词： crystal structure methylphenyl pyrazole

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Synthesis and Structural Studies of 6-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridin-2-amine

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Chinese Journal of Structural Chemistry 2010年第5期29卷 720-725页

作者： SAHN Zarife sibel KARABCEK Serdar SENSES Esra KARABCEK Esra ISIK Samil Department of Physics Faculty of Arts and SciencesOndokuz Mayιs University Department of Chemistry Faculty of Arts and SciencesKaradeniz Technical University

6-（2,5-Dimethyl-1H-pyrrol-1-yl）pyridin-2-amine （1） was synthesized and characte-rized by elemental analyses,1H-NMR and 13C-NMR,FTIR,Uv-Vis,mass spectral studies and single-crystal X-ray *** data obtained from spectral studies support the structural properties of *** N-H…N hydrogen bonds produce an R22（8） *** extensive three-dimensional network formed by C-H…π and N-H…π-facial hydrogen bonds is responsible for the crystal *** combination of C-H…π interactions produces R33（12）,R43（19） and R44（20） rings.

关键词： 2,6-diaminopyridine Schiff bases methylpyridine pyrrol

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Morinda citrifolia L. (noni) and memantine attenuate periventricular tissue injury of the fourth ventricle in hydrocephalic rabbits

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Neural Regeneration Research 2013年第9期8卷 773-782页

作者： sibel Kktürk Süreyya Ceylan Volkan Etus Nezih Yasa Savas Ceylan Department of Histology and Embriyology Faculty of MedicineOrdu UniversityOrduTurkey Department of Histology and Embriyology Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Neurosurgery Faculty of MedicineKocaeli UniversityKocaeliTurkey

This study was designed to evaluate the neuroprotective effects of Morinda citrifofia L. （Rubiaceae） commonly known as noni, and memantine （a N-methy-D-aspartate receptor inhibitor） on hydrocephalus-induced neurodegenerative disorders. Kaolin was injected into the cistern magna of male adult New Zealand rabbits to establish a hydrocephalus animal model. Memantine （20 mg/kg, intraperitoneally; memantine-treated group） or noni （5 mL/kg, intragastrically; noni-treated group） was administered daily for 2 weeks. Microtubule-associated protein-2 and caspase-3 immunohistochemistry were performed to detect neuronal degeneration and apoptosis in the periventricular tissue of the fourth ventricle of rabbits. Microtubule-associated protein-2 staining density was significantly decreased in the hydrocephalic group, while the staining density was significantly increased in the memantine- and noni-treated groups, especially in the noni-treated group. Noni treatment decreased the number of caspase-3-positive cells in rabbits with hydrocephalus, while memantine had no effect. These findings suggest that noni exhibits more obvious inhibitory effects on hydrocephalus-induced neurodegenerative disorders than memantine in periventricular tissue of the fourth ventricle.

关键词： neural regeneration neurodegenerative disease traditional Chinese medicine hydrocephalusMorinda citrifolia L. (noni) memantine fourth ventricle periventricular tissue microtubule-associated protein-2 caspase-3 apoptosis grants-supported paper photographs-containing paper neuroregeneration

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Discrepancy among microsatellite instability detection methodologies in non-colorectal cancer:Report of 3 cases

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World Journal of Clinical Cases 2023年第13期11卷 3105-3113页

作者： ElifŞenocak Taşçı İbrahim Yıldız sibel Erdamar LeylaÖzer Department of Medical Oncology Acıbadem MAA UniversityIstanbul 12345Turkey Department of Pathology Acıbadem MAA UniversityIstanbul 12345Turkey

BACKGROUND Microsatellite instability(MSI)is a predictive biomarker for cancer *** tumor-agnostic nature of MSI makes it a denominator for immunotherapy in several solid *** can be assessed using next-generation sequencing(NGS),fluorescent multiplex PCR,and immunohistochemistry(IHC).CASE SUMMARY Here,we report 3 cases with discordant MSI results detected using different methods.A cholangiocellular carcinoma case revealed proficient mismatch repair(MMR)by IHC but high MSI(MSI-H)by liquid NGS.A cervical cancer case revealed deficient MMR by IHC,microsatellite stable by PCR,and MSI-H by ***,an endometrial cancer case revealed proficient MMR by IHC but MSI-H by *** IHC for MMR status is the first choice due to several ***,in cases of indeterminate IHC results,molecular testing by MSI-PCR is ***,NGS-based MSI assays are being widely used to detect MSI-H *** three methods have high accuracy;however,the inconsistencies between them may lead to misdiagnosis.

关键词： Discordance Immunohistochemistry Microsatellite instability Nextgeneration sequencing Case report

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Women Bodies at Trial by Ordeal since Christianity to Trier Movies

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Journalism and Mass Communication 2015年第12期5卷 650-657页

作者： sibel Kibar Kastamonu University Kastamonu Turkey

In his Antichrist and Nymphomaniac, Lars von Trier seems to defy norms on sex and women＇s desires. However he actually reproduces Christianity＇s perspective that women are sinful by their dispositions. According to the classical creation story, Eve falls into temptation and then, convinces Adam to commit the same crime. All Abrahamic religions but especially Christianity identifies women with the body and bodily desires, rather than the mind which comes from nonmaterial and divine substance. Accordingly, women can easily be deceived by Satan since they contain a lesser amount of mental substance compared to men. In Antichrist, Trier reiterates the story of Adam and Eve in a different context. The woman writes her dissertation on women who are burnt with the accusation of being a witch. But she realizes that her body is sinful and deserving of punishment, too. She finds her salvation when she cuts her clitoris. In Nymphomaniac, the main character gets her clitoris whipped. While she resists traditional and bourgeois morality, she defines herself as morally evil because of her unmanageable sexual desires. Thus, reputed as critical of all social structures and morality, Trier in fact simply rehashes the classical sexist and misogynist perspective.

关键词： Lars Von Trier Nymphomaniac Christianity women's bodies witch trials

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Honey prevents hepatic damage induced by obstruction of the common bile duct

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World Journal of Gastroenterology 2008年第23期14卷 3729-3732页

作者： B Imge Erguder sibel S Kilicoglu Mehmet Namuslu Bulent Kilicoglu Erdinc Devrim Kemal Kismet Ilker Durak Department of Biochemistry Ankara University Faculty of MedicineAnkara 06100Turkey Department of Histology and Embriology Ufuk University Faculty of MedicineAnkara 06800Turkey Ankara Research and Training Hospital Clinics of General SurgeryAnkara 06100Turkey

AIM:To examine the possible effects of honey supplementation on hepatic damage due to obstruction of the common bile duct in an experimental rat model. METHODS:The study was performed with 30 male rats divided into three groups:a sham group,an obstructive jaundice group,and an obstructive jaundice plus honey group. At the end of the study period,the animals were sacrificed,and levels of nitric oxide(NO) ,and NO synthase(NOS) activities were measured in liver tissues,and levels of adenosine deaminase(ADA) and alanine transaminase(ALT) activities were measured in serum. RESULTS:Blood ALT and ADA activities were significantly elevated in the jaundice group as compared to those of the sham group. In the obstructive jaundice plus honey group,blood ALT and ADA activities were significantly decreased as compared to those of the jaundice group. In erythrocytes and liver tissues,NO levels were found to be significantly higher in the obstructive jaundice plus honey group compared to those of the sham group. Additionally,NO levels were found to be significantly higher in liver tissues from the animals in the obstructive jaundice plus honey group than those of the jaundice ***:Honey was found to be beneficial in the prevention of hepatic damage due to obstruction of the common bile duct.

关键词： Honey Obstructive jaundice Adenosine deaminase Nitric oxide

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Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution

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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 155-162页

作者： Haslet Eksi-Kocak sibel Ilbasmis Tamer Sebnem Yilmaz Merve Eryilmaz Ismail Hakkl Boyaci Ugur Tamer Department of Biomedical Engineering Faculty of Engineering Istanbul Aydin University Department of Pharmaceutical Technology Faculty of Pharmacy Gazi University Department of Analytical Chemistry Faculty of Pharmacy Gazi University Food Research Center Hacettepe University

In this study, we proposed a rapid and sensitive method for quantification and spatial distribution of salicylic acid in film tablets using FT-Raman spectroscopy with multivariate curve resolution(MCR). For this purpose, the constituents of film tablets were identified by using FT-Raman spectroscopy, and then eight different concentrations of salicylic acid tablets were visualized by Raman mapping. MCR was applied to mapping data to expose the active pharmaceutical ingredients in the presence of other excipients by monitoring distribution maps and combination of FT-Raman mapping with MCR enabled the determination of lower salicylic acid concentrations. In addition, the distribution of major excipient, lactose, was examined in the tablet form. A calibration curve was obtained by plotting the intensity of the Raman signal at 1635 cm^(-1) versus the concentration of salicylic acid and the correlation was found to be linear within the range of 0.5%–3.9% with a correlation coefficient of 0.99. The limit of detection for the technique was determined 0.35%. The ability of the technique to quantify salicylic acid in tablet test samples was also investigated.

关键词： Raman mapping Multivariate curve resolution FT-Raman spectroscopy Salicylic acid

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Organic Dairy Cattle Breeding in Turkey： A Review

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Journal of Agricultural Science and Technology(A) 2015年第7期5卷 571-576页

作者： sibel Alapala Demirhan Department of Animal Sciences Faculty of Agriculture and Natural Science Usak University Usak 64300 Turkey

Organic animal breeding means the production of certified animal products by considering the well-being of animals without damaging the environment and without using any pesticide in a controlled manner. All aquaculture activities other than organic farming can be defined as conventional farming. Organic animal production has increased significantly annually over the past decade in the world. Dairy cattle production is examined with particular focus on the possibilities of improving the sustainability of ruminant systems and on the possible role of organic production to meet the demand of sustainability. Organic dairy cattle production can improve animal welfare, protect the environment and sustain rewarding rural life styles. Future of organic dairy cattle production will have to rely on continuous search for alternatives in nutrition, disease prevention and control that are environmentally friendly. Understanding organic dairy cattle farming from economic, ecological and animal welfare perspectives will increase the likelihood of success. In the current study, besides the basic principles of organic dairy cattle breeding that is a quite popular branch of business in recent years, the current state, weaknesses and strengths of organic dairy cattle breeding both in Turkey and the world and how organic dairy cattle breeding can be developed are discussed.

关键词： Organic animal raising organic milk animal health and well-being sustainability.

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