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World Journal of Gastroenterology 2007年第7期13卷 1141-1143页

作者： Güldeniz Karadeniz Cakmak Ali Ugur Emre Oge Tascilar sibel bekta■ Bulent Hamdi Uan Oktay Irkorucu Kemal Karakaya Yucel Ustundag Mustafa Comert Department of Surgery Zonguldak Karaelmas Uni-versity School of Medicine Kozlu-Zonguldak Turkey Department of Pathology Zonguldak Karaelmas University School of Medicine Kozlu-Zonguldak Turkey Department of Gastroenterology Zonguldak Karaelmas University School of Medicine Kozlu-Zonguldak Turkey

Lipoma within an inverted Meckel's diverticulum presen- ting with hemorrhage and partial intestinal obstruction is an exceptional clinical entity. We report a case of 47-year-old male with a history of recurrent episodes of partial intestinal obstruction and melena due to a subserosal lipoma located in the base of an inverted Meckel's diverticulum. According to our knowledge, this is the first case of a lipoma within a Meckel's diverticulum giving rise to this clinical scenario without the existence of heterotrophic gastric or pancreatic tissues.

关键词： Meckel's diverticulum Lipoma Inversion Intestinal obstruction Hemorrhage

Study on bi-directional pedestrian movement using ant algorithms

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Chinese Physics B 2016年第1期25卷 525-534页

作者： sibel Gokce Ozhan Kayacan Department of Physics Faculty of Arts and Sciences Celal Bayar University

A cellular automata model is proposed to simulate bi-directional pedestrian flow. Pedestrian movement is investigated by using ant algorithms. Ants communicate with each other by dropping a chemical, called a pheromone, on the substrate while crawling forward. Similarly, it is considered that oppositely moving pedestrians drop ＇visual pheromones＇ on their way and the visual pheromones might cause attractive or repulsive interactions. This pheromenon is introduced into mod- elling the pedestrians＇ walking preference. In this way, the decision-making process of pedestrians will be based on ＇the instinct of following＇. At some densities, the relationships of velocity-density and flux-density are analyzed for different evaporation rates of visual pheromones. Lane formation and phase transition are observed for certain evaporation rates of visual pheromones.

关键词： cellular automata computer simulation bi-directional pedestrian flow phase transition

Encapsulation of bioactive compounds in shalgam and investigation of the possibilities of their use in probiotic food production

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Food Bioscience 2022年第6期50卷 1120-1129页

作者： Feyza Tosya sibel Bölek Department of Food Technology Experimental Medicine Research and Application CenterUniversity of Health Sciences TurkeyUskudar34662IstanbulTurkey

Shalgam,a naturally fermented beverage,is a prebiotic supplement and has high antioxidant *** study aimed to encapsulate shalgam to develop a functional probiotic beverage by freeze *** size measurement and surface morphology,wettability,solubility,bulk density,tapped bulk density,moisture,water activity,total polyphenol,total monomeric anthocyanin,antioxidant activity and encapsulation efficiency analyzes were performed for characterization of shalgam *** obtained shalgam capsules were used in kefir production at the rate of 0%,5%,10%,15%(w/v).Color,viscosity,water soluble dry matter determination,total protein,total fat,titration acidity,pH,microbiological and sensory analysis of kefir samples were *** microcapsules increased total phenolic,anthocyanin and antioxidant activity of kefir significantly(p<0.05).Kefir samples containing 5%shalgam microcapsules had the highest microbiological viability and sensory score.

关键词： Encapsulation Kefir Shalgam Anthocyanin Probiotic

Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis

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Hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 271-276页

作者： Basak Gümüs Güler sibel Ozler Department of Health Sciences Istinye UniversityIstanbul 34010Turkey Department of Perinatology Selcuk University Faculty of MedicineKonya 42130Turkey

Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy *** study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA ***:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the *** increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to *** adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA ***:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment.

关键词： Intrahepatic cholestasis of pregnancy Syndecan-1 Glypican-3 Adverse perinatal outcome Response to UDCA

What aspects do we overlook in the rehabilitation of patients with inflammatory bowel disease?

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World Journal of Gastroenterology 2024年第27期30卷 3268-3272页

作者： Benil Nesli Ata sibel Eyigor Department of Physical Medicine and Rehabilitation Izmir City HospitalIzmir 35530Türkiye Department of Physical Medicine and Rehabilitation Faculty of MedicineEge UniversityIzmir 35100Türkiye

In this editorial,we comment on the article by Stafie et *** bowel disease(IBD)constitutes a cluster of chronic and progressive inflammatory disorders affecting the digestive *** can impede an individual’s capacity to perform daily activities,hinder work productivity,limit physical capabilities,and negatively impact medical *** physical activity and structured exercise programs are becoming increasingly important in many chronic inflammatory diseases,they are not being sufficiently implemented in IBD *** prevention of future disability and drug dependence in IBD patients requires timely diagnosis and treatment of musculoskeletal problems,including sarcopenia,as well as decreased muscle strength,aerobic capacity,and bone mineral *** improve treatment outcomes for IBD patients,it is crucial to develop individualized rehabilitation programs tailored to their unique *** critical is the active participation of pertinent departments in this *** is imperative to highlight the significance of creating a personalized rehabilitation program with a multidisciplinary approach in IBD management.

关键词： Inflammatory bowel disease Physical activity Disability Sarcopenia Structured exercise Rehabilitation

Analysis of serum antibody profile against H pylori VacA and CagA antigens in Turkish patients with duodenal ulcer

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World Journal of Gastroenterology 2006年第42期12卷 6869-6873页

作者： Yusuf Erzin sibel Altun Ahmet Dobrucali Mustafa Aslan sibel Erdamar Ahmet Dirican Murat Tuncer Bekir Kocazeybek Department of Gastroenterology Istanbul University Cerrahpasa Medical Fa-culty 34 303 Kocamustafapasa-Istanbul Turkey Department of Microbiology and Clinical Microbiology Istanbul University Cerrahpasa Medical Faculty 34303 Kocamustafapasa-Istanbul Turkey Department of Pathology Istanbul University Cerrahpasa Medical Faculty 34303 Kocamustafapasa-Istanbul Turkey Department of Biostatistics Istanbul University Cerrahpasa Medical Faculty 34303 Kocamustafapasa-Istanbul Turkey

AIM: To investigate the frequency of seropositivity aga- inst CagA, VacA proteins and to determine their indepen- dent effects on the development of duodenal ulcer (DU) in Turkish patients. METHODS: The study was designed as a prospective one from a tertiary referral hospital. Dyspeptic patients who were referred to our endoscopy unit for upper gas- trointestinal endoscopy between June 2003 and March 2004 and diagnosed to have DU or nonulcer dyspepsia (NUD) were included. Biopsies from the antrum and body of the stomach were taken in order to assess the current H pylori status by histology, rapid urease test and culture. Fasting sera were obtained from all patients and H pylori status of all sera was determined by IgG antibo- dies using an enzyme-linked immunosorbent assay (ELI- SA) kit. All seropositive patients were further analysed using Western blot assays detecting IgG antibodies aga- inst CagA and VacA proteins. The χ2 test was used for statistical comparison of the values and age-sex adjusted multiple regression analysis was used to determine the independent effects of CagA and VacA seropositivities on the development of DU. RESULTS: Sixty-three patients with DU and 62 patients with NUD were eligible for the final analysis. Seropositi- vity for anti-CagA was detected in 51 of 62 (82%), andin 55 of 63 (87%) patients with NUD and DU, respec- tively (p = no significance), and seropositivity for anti- VacA was found in 25 of 62 (40% ) and in 16 of 63 (25%) patients, with NUD and DU, respectively. CONCLUSION: These findings suggest that none of the- se virulence factors is associated with the development of DU in the studied Turkish patients with dyspepsia.

关键词： H pylori Western blot CagA VacA Duode- nal ulcer

Association of complementary and integrative therapy use and symptoms among Turkish patients with familial Mediterranean fever

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Journal of Integrative Medicine 2021年第4期19卷 340-346页

作者： sibel Sentürk Dilek Efe Arslan Adil Cetinkaya Department of Nursing Bucak Health SchoolBurdur Mehmet Akif Ersoy UniversityBurdur 15300Turkey Department of Medical Services and Techniques Vocational School of Health ServicesErciyes UniversityKayseri 38000Turkey Children's Emergency Service Istanbul Education and Research HospitalIstanbul 34000Turkey

Objective: This study explored the correlations between the use of complementary and integrative therapies(CITs) and symptoms among Turkish patients with familial Mediterranean fever(FMF).Methods: This is a cross-sectional and descriptive study. The study was conducted with 1119 FMF patients who were registered to the social networking site for Behcet’s and the FMF Patients Association(Befemder) in Turkey, between January 2018 and February 2019. Data were collected using an online survey, for which a three-part questionnaire was created using a Google form. Descriptive statistics, chi-square test and logistic regression analysis were used to analyze the ***: It was determined that 53.2% of the individuals who participated in the research used various forms of CITs and that 32.8% used vitamin and mineral supplements(calcium, iron, and vitamin B12, C and D), 25.0% used nutritional supplements(fish oil and honey), and 24.6% used oral herbs(ginger, turmeric, green tea and rosemary) and mind–body methods(relaxation, respiration exercise and meditation). It was determined that the percentage of participants that used CITs was higher among women(odds ratio [OR] = 1.825;95% confidence interval [CI] 1.421–2.344), those with joint pain(OR = 1.385;95% CI 1.047–1.832), those with difficulty breathing(OR = 1.323;95% CI 1.031–1.697), those with gastrointestinal symptoms(OR = 1.405;95% CI 1.089–1.814) and those who had a family member with FMF(OR = 1.437;95% CI 1.115–1.851).Conclusion: More than half of the individuals used at least one type of CIT for symptom control.

关键词： Familial Mediterranean fever Complementary and integrative medicine Nursing Turkey

New physical structures and patterns to the optical solutions of the nonlinear Schrödinger equation with a higher dimension

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Communications in Theoretical Physics 2023年第8期75卷 25-41页

作者： Karmina K Ali Abdullahi Yusuf Marwan Alquran sibel Tarla Department of Mathematics Faculty of ScienceUniversity of ZakhoZakhoIraq Department of Computer Science College of ScienceKnowledge UniversityErbil 44001Iraq Department of Computer Engineering Biruni UniversityIstanbulTurkey Department of Computer Science and Mathematics Lebanese American UniversityBeirutLebanon Department of Mathematics Near East University TRNCMersin 10Nicosia 99138Turkey Department of Mathematics and Statistics Jordan University of Science&TechnologyIrbid 22110Jordan Department of Mathematics Faculty of ScienceFirat UniversityElazigTurkey

It is commonly recognized that,despite current analytical approaches,many physical aspects of nonlinear models remain *** is critical to build more efficient integration methods to design and construct numerous other unknown solutions and physical attributes for the nonlinear models,as well as for the benefit of the largest audience *** achieve this goal,we propose a new extended unified auxiliary equation technique,a brand-new analytical method for solving nonlinear partial differential *** proposed method is applied to the nonlinear Schrödinger equation with a higher dimension in the anomalous *** interesting solutions have been ***,to shed more light on the features of the obtained solutions,the figures for some obtained solutions are *** propagation characteristics of the generated solutions are *** results show that the proper physical quantities and nonlinear wave qualities are connected to the parameter *** is worth noting that the new method is very effective and efficient,and it may be applied in the realisation of novel solutions.

关键词： exact solutions nonlinear Schrodinger equation new extended unified auxiliary equation method Jacobi elliptic functions

Ultrastructural view of colon anastomosis under propolis effect by transmission electron microscopy

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World Journal of Gastroenterology 2008年第30期14卷 4763-4770页

作者： sibel Serin Kilicoglu Bulent Kilicoglu Esra Erdemli Department of Histology and Embryology Ufuk University School of Medicine 4th General Surgery Department Ankara Training and Research Hospital Department of Histology and Embryology Ankara University School of Medicine

AIM： To evaluate the effect of propolis administration on the healing of colon anastomosis with light and transmission electron microscopes. METHODS： Forty-eight Wistar-AIbino female rats were divided into two groups and had colon resection and anastomosis. In group Ⅰ, rats were fed with standard rat chow pre- and postoperatively. The rats in group Ⅱ were fed with standard rat chow and began receiving oral supplementation of propolis 100 mg/kg per day beginning 7 d before the operation and continued until they were sacrificed. Rats were sacrificed 1, 3, 7 and 14 d after operation, and anastomotic bursting pressures measured. After the resection of anastomotic segments, histopathological examination was performed with light and transmission electron microscopes by two blinded histologists and photographed. RESULTS： The colonic bursting pressures of the propolis group were statistically significantly better than the control group. UItrastructural histopathological analysis of the colon anastomosis revealed that propotis accelerated the phases of the healing process and stimulated mature granulation tissue formation and collagen synthesis of fibroblasts. CONCLUSION： Bursting pressure measurements and ultra structural histopathological evaluation showed that administration of propolis accelerated the healing of colon anastomosis following surgical excision.

关键词： Propolis Wound healing Colon anastomosis Histopathology Transmission electron microscope

Is exercise ignored in palliative cancer patients?

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World Journal of Clinical Oncology 2014年第3期5卷 554-559页

作者： sibel Eyigor Sedef Akdeniz Rehabilitation Department Faculty of Medicine Physical Therapy Ege University 35100 BornovaIzmirTurkey

Exercise and rehabilitation approaches in palliative care programs for cancer patients affect patients' symptoms, physical functioning, muscle strength, emotional wellbeing, psychological symptoms, functional capacities, quality of life, mortality and morbidity positively. Based on scientific data, palliative cancer patients should be recommended to participate in exercise programs. There is no standard approach to recipe an exercise regimen for a palliative cancer survivor. Studies for demonstrating the positive effects of exercising in palliative care patients are increasing in number day by day. At this point, increasing awareness about exercising in the entire team monitoring the patient and our efforts in this matter seems to be very important.

关键词： Palliative care Cancer Exercise Rehabilitation Muscle