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MiR-142-3p Regulates ILC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss

Current Medical Science 2024年第1期44卷 195-211页

作者： Xiang-li PANG Jie LI Jing WANG si-si YAN Jing YANG Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan 430060China Reproductive Medical Center Renmin Hospital of Wuhan UniversityWuhan 430060China Clinic Research Center for Assisted Reproductive Technology and Embryonic Development in Hubei Province Wuhan 430060China

Objective Innate lymphoid cells(ILCs)are a class of newly discovered *** 1 ILCs(ILC1s)are identified in the decidua of humans and *** mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related ***,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling *** study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling *** Mouse models of normal pregnancy and abortion were constructed,and the alterations of ILC1s,miR-142-3p,ILC1 transcription factor(T-bet),and pro-inflammatory cytokines of ILC1s(TNF-α,IFN-γand IL-2)were detected in mice from different *** targeting regulation of HMGB1 by miR-142-3p in ILC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were *** addition,the regulatory effects of miR-142-3p and HMGB1 on ILC1s were detected in vitro by CCK-8,Annexin-V/PI,ELISA,and RT-PCR,***,changes of the NF-κB signaling pathway in ILC1s were examined in the different *** the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of ILC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling *** The number of ILC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all Psignaling pathway(Psignificantly downregulated and the activation of the NF-κB signaling pathway was inhibited in the miR-142-3p Agomir group(all Psion

关键词： maternal-fetal interface group 1 innate lymphoid cells(ILCis) high mobility group box 1(HMGB1) miR-142-3p abortion

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Application of a microscopic optical potential of chiral effective field theory in (p, d) transfer reactions

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Nuclear Science and Techniques 2024年第1期35卷 134-144页

作者： Yi-Ping Xu si-Lu Chen Dan-Yang Pang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China School of Physics Beihang UniversityBeijing 100191China

The microscopic global nucleon–nucleus optical model potential(OMP)proposed by Whitehead,Lim,and Holt,the WLH potential(Whitehead et al.,Phys Rev Lett 127:182502,2021),which was constructed in the framework of many-body per-turbation theory with state-of-the-art nuclear interactions from chiral effective field theory(EFT),was tested with(p,d)transfer reactions calculated using adiabatic wave *** target nuclei included both stable and unstable nuclei,and the incident energies reached 200 *** results were compared with experimental data and predictions using the phenomenological global optical potential of Koning and Delaroche,the KD02 ***,we found that the micro-scopic WLH potential described the(p,d)reaction angular distributions similarly to the phenomenological KD02 potential;however,the former was slightly better than the latter for radioactive *** average,the obtained spectroscopic factors(SFs)using both microscopic and phenomenological potentials were similar when the incident energies were below approxi-mately 120 ***,their difference tended to increase at higher incident energies,which was particularly apparent for the doubly magic target nucleus 40Ca.

关键词： Microscopic optical model potential (p,d)transfer Spectroscopic factors

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Fermi Blazars in the Zwicky Transient Facility Survey:Properties of Large Optical Variations

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Research in Astronomy and Astrophysics 2024年第10期24卷 104-115页

作者： si-si Sun Zhong-Xiang Wang Shun-Hao Ji Department of Astronomy School of Physics and AstronomyYunnan UniversityKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

We analyze the optical light curve data,obtained with the Zwicky Transient Facility(ZTF)survey,for 47 γ-ray blazars monitored by the Large Area Telescope onboard the Fermi Gamma-ray Space Telescope(Fermi).These 47sources are selected because they are among the Fermi blazars with the largest optical variations in the ZTF *** color-magnitude variation patterns are seen in them,with one being redder-to-stable-when-brighter(RSWB;in 31 sources)and the other being stable when brighter(in 16 sources).The patterns fit with the results recently reported in several similar studies with different ***,we find that the colors in the stable state of the sources share similar values,for which(after being corrected for the Galactic extinction)most sources are in a range of 0.4–*** feature could be intrinsic and may be applied in,for example,study of the intragalactic *** also determine the turning points for the sources showing the RSWB pattern,after which the color changes saturate and become *** find a correlation between optical fluxes and γ-ray fluxes at the turning *** physical implications of the correlation remain to be investigated,probably better with a sample of high-qualityγ-ray flux measurements.

关键词： (galaxies:)BL Lacertae objects:general (galaxies:)quasars:general gamma-rays:galaxies

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The Effect of Key Nodes on theMalware Dynamics in the Industrial Control Network

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Computers, Materials & Continua 2024年第4期79卷 329-349页

作者： Qiang Fu JunWang Changfu si Jiawei Liu College of Computer Science and Technology Shenyang University of Chemical TechnologyShenyang110142China College of Computer Science and Engineering Northeastern UniversityShenyang110169China

As industrialization and informatization becomemore deeply intertwined,industrial control networks have entered an era of *** connection between industrial control networks and the external internet is becoming increasingly close,which leads to frequent security *** paper proposes a model for the industrial control *** includes a malware containment strategy that integrates intrusion detection,quarantine,and ***,the role of keynodes in the spreadofmalware is studied,a comparisonexperiment is conducted to validate the impact of the containment *** addition,the dynamic behavior of the model is analyzed,the basic reproduction number is computed,and the disease-free and endemic equilibrium of the model is also obtained by the basic reproduction ***,through simulation experiments,the effectiveness of the containment strategy is validated,the influence of the relevant parameters is analyzed,and the containment strategy is *** otherwords,selective immunity to key nodes can effectively suppress the spread ofmalware andmaintain the stability of industrial control *** earlier the immunization of key nodes,the *** the time exceeds the threshold,immunizing key nodes is almost *** analysis provides a better way to contain the malware in the industrial control network.

关键词： Key nodes dynamic model industrial control network simulation

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Unraveling the biological link between diabetes mellitus and prostate cancer:Insights and implications

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World Journal of Diabetes 2024年第6期15卷 1367-1373页

作者： Jian Li Zhi-Peng Li si-si Xu Wei Wang Department of Interventional Oncology Municipal Hospital Affiliated to Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina

This article is a comprehensive study based on research on the connection between diabetes mellitus(DM)and prostate cancer(PCa).It investigates the potential role of DM as an independent risk factor for PCa,delving into the biological links,including insulin resistance and hormonal *** paper critically analyzes previous studies that have shown varying results and introduces mendelian randomization as a method for establishing *** emphasizes the importance of early DM screening and lifestyle modifications in preventing PCa,and proposes future research directions for further understanding the DM-PCa relationship.

关键词： Biological mechanisms Diabetes mellitus Mendelian randomization Prevention prostatic cancer Treatment

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Switching,explosion,and chaos of multi-wavelength soliton states in ultrafast fiber lasers

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 82-90页

作者： Zhi-Zeng si Yue-Yue Wang Chao-Qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

Because of the complexity and difficulty of realizing a multi-wavelength soliton state,reports on its internal dynamic characteristics are *** this study,the switching and periodic soliton explosion processes of the multi-wavelength soliton state in a negative dispersion passively mode-locked fiber laser are *** generation of the multi-wavelength soliton state undergoes the process of noise,oscillation,and stable mode-locking,and the splitting and annihilation of solitons with different group velocities directly impact the generation and disappearance of three *** and negative dispersion lead to different group velocities of *** presence and displacement of solitons with different group velocities cause soliton collisions,which lead to soliton explosions.A soliton experiences relative phase oscillation,chaos,and oscillation,as well as convergence and separation before and after an *** an increase in parameters related to pump power,single-soliton oscillation,multi-wavelength solitons,and chaos are found in experiments and simulations,proving the relevance and reliability between simulation and experimental *** work promotes the dynamical study of multi-soliton collisions in nonlinear science and the development of chaos theory in multi-comb lasers.

关键词： multi-wavelength fiber laser soliton explosion chaos state switching real-time dynamics

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Structure and 2p decay mechanism of^(18)Mg

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Nuclear Science and Techniques 2024年第6期35卷 145-154页

作者： Long Zhou De-Qing Fang si-Min Wang Hui Hua Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

The recently discovered,extremely proton-rich nuclide 18 Mg exhibits ground-state decay via two sequential two-proton(2p)emissions through the intermediate nucleus,*** study investigates the structure and the initial 2p decay mechanism of^(18)Mgby examining the density and correlations of the valence protons using a three-body Gamow coupled-channel *** results show that the ground state of^(18)Mgis significantly influenced by the continuum,resulting in a significant s-wave ***,based on the current framework,this does not lead to a significant deviation in mirror symmetry in either the structure or spectroscopy of the 18Mg-18C ***,the time evolution analysis of the^(18)Mgground state suggests a simultaneous 2p emission during the first step of *** observed nucleon-nucleon correlations align with those of the light-mass 2p emitters,indicating a consistent decay behavior within this nuclear region.

关键词： Structure of^(18)Mg Two-proton decay Proton-proton correlation

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The noise spectral characteristics and noise reduction schemes of screw air-source heat pump:A case study

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Building simulation 2024年第1期17卷 53-70页

作者： Dongsheng Liu Yaohan Feng Jikang Jia Pengfei si Ya Feng China Southwest Architecture Design and Research Institute Co.Ltd. Chengdu 610041China CSCEC Green Construction Engineering Research Center Chengdu 610041China

The screw air-source heat pump can cause incessant high noise levels during operation,which might hinder adoption of this energy-efficient heat ***,acoustic measurements and comparison testing were performed in this *** measurements revealed that the compressor is the main noise source of the heat pump,and it shows a multipeak frequency distribution and a wide frequency spectrum under different work conditions,with multiple peaks at 63,250,and 1000 ***,a compressor sound insulation cover with broadband absorption was proposed,and it was experimentally proven that the insulation cover can reduce the maximum sound pressure level of one unit from 89.8 dBA to 79.1 ***,we proposed several noise reduction strategies and compared their noise reduction effects using computer *** results showed that the noise problem can be effectively improved through the rational design of the sound barrier and the layout and opening options of heat *** distance between the sound barrier and heat pump and the sound attenuation due to diffraction ALa exhibit a U-shaped *** buildings of different heights,the optimal heights of noise barrier are *** 5.5-meter is the optimal height of the sound barrier for single-story *** conclusions can be applied to other building projects for heat pump noise reduction.

关键词： acoustic simulation broadband noise noise reduction air-source heat pump sound barrier

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Emergence of SARS and COVID-19 and preparedness for the next emerging disease X

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Frontiers of Medicine 2024年第1期18卷 1-18页

作者： Ben Hu Hua Guo Haorui si Zhengli Shi CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Severe acute respiratory syndrome(SARS)and Coronavirus disease 2019(COVID-19)are two human Coronavirus diseases emerging in this century,posing tremendous threats to public health and causing great loss to lives and *** this review,we retrospect the studies tracing the molecular evolution of SARS-CoV,and we sort out current research findings about the potential ancestor of *** knowledge about SARS-CoV-2-like viruses found in wildlife,the animal susceptibility to SARS-CoV-2,as well as the interspecies transmission risk of SARS-related coronaviruses(SARSr-CoVs)are gathered ***,we discuss the strategies of how to be prepared against future outbreaks of emerging or re-emerging coronaviruses.

关键词： SARS COVID-19 coronavirus

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Hydrophobic tag tethering degrader as a promising paradigm of protein degradation:Past,present and future perspectives

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Chinese Chemical Letters 2024年第8期35卷 187-200页

作者： si Ha Jiacheng Zhu Hua Xiang Guoshun Luo State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 211198China

Small molecule inhibitors have dominated the pharmaceutical landscape for a long time as the primary therapeutic paradigm targeting pathogenic ***,their efficacy heavily relies on the amino acid composition and spatial constitution of proteins,rendering them susceptible to drug resistance and failing to target undruggable *** recent years,the advent of targeted protein degradation(TPD)technology has captured substantial attention from both industry and *** an event-driven mode,TPD offers a novel approach to eliminate pathogenic proteins by promoting their degrada-tion,thus circumventing the limitations associated with traditional small molecule ***-bic tag tethering degrader(HyTTD)technology represents one such TPD approach that is currently in the burgeoning *** employ endogenous protein degradation systems to induce the degrada-tion of target proteins through the proteasome pathway,which displays significant potential for medical *** this review,we provide a comprehensive overview of the development history and the reported mechanism of action of ***,we delve into the physiological roles,structure-activity re-lationships,and medical implications of HyTTDs targeting various disease-associated ***,we propose insights into the challenges that necessitate resolution for the successful development of HyTTDs,with the ultimate goal of initiating a new age of clinical treatment leveraging the immense po-tential of HyTTDs.

关键词： Targeted protein degradation(TPD) Hydrophobic tag Degrader Hydrophobic tag tethering degrader(HyTTD) Targeted therapy

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