检索结果-南通市图书馆

Journal’s responsibility in maintaining scientifc integrity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2022年第1期18卷 1-3页

作者： Li-Li Yang si-yun xu Zhi-Yi Yang Zheng-Yan Zhao Qiang Shu National Clinical Research Center for Child Health National Children’s Regional Medical CenterChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China

Scientifc integrity has been regarded as a priority in scientifc development in China[1].The Chinese governmental agencies have paid unprecedented attentions on promoting scientifc integrity in recent *** May 2018,the Communist Party of China Central Committee and the State Council issued guidelines on promoting scientifc integrity[2].Ever-harsher punishments for researchers who committing scientifc misconduct were introduced by the Chinese government[3].In November,2018,43 penalties for major academic misconduct were endorsed by 41 national government ***,the Ministry of Science and Technology of China(MOST)were established a notifcation system for reporting cases involving in scientifc misconduct and the related penalties publicly.

关键词： integrity scient Communist

Management of children with COVID-19: experiences from China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2020年第3期16卷 217-218页

作者： si-yun xu Li-Li Yang Qi Qi Xian-Jun Wang Yi-Cheng Xie Zheng-Yan Zhao Qiang Shu Children's Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052China

The coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health *** a special population,children have special respiratory tract structure characteristics,immature immune system,and susceptibility to respiratory virus ***,it is highly important for clinicians to treat the infected children cautiously despite most pediatric patients have milder symptoms and better prognosis compared with the adult patients.

关键词： respiratory acute patients

Social responsibilities of a pediatric journal:considerations and future directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2021年第1期17卷 1-2页

作者： Li-Li Yang Xian-Jun Wang Qi Qi si-yun xu Yi-Cheng Xie Zheng-Yan Zhao Qiang Shu National Clinical Research Center for Child Health National Children's Regional Medical CenterChildren's HospitalZhejiang University School of MedicineHangzhou 310052China

***,the former editor of JAMA,elucidated many social responsibilities for medical journal editing as early as 1987[1].During the pandemic,a medical journal should highlight its social responsibilities in publishing high-qual-ity contents,promoting education to the health care pro-viders and providing readers with the timely and accurate information[1].At the time of this editorial published,the global cases of coronavirus disease 2019(COVID-19)had surpassed 85 *** pandemic and its resulting eco-nomic,health,and educational disruptions have affected all aspects of the youth's lives[2].Quarantine and social isola-tion,increased risks of child abuse and neglect,financially and psychologically stressed family members have led to negative mental outcomes in children and adolescents.

关键词： journal editor publishing

Predictive value of D-dimer for portal vein thrombosis after portal hypertension surgery in hepatitis B virus-related cirrhosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第48期13卷 6588-6592页

作者： Mei-Hai Deng Bo Liu He-Ping Fang Wei-Dong Pan Zhao-Feng Tang Peng Deng Yue-si Zhong Rui-yun xu Department of Hepato-biliary Surgery Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 Guangdong Province China

AIM: To evaluate the predictive value of D-dimer as a predictive indicator of portal vein thrombosis (PVT) after portal hypertension surgery in hepatitis B virus-related cirrhosis. METHODS: A prospective study was carried out in 52 patients who had undergone surgery for portal hypertension in hepatitis B virus-related cirrhosis. Changes in perioperative dynamic D-dimer were observed. The sensitivity, specifi city, positive predictive values and negative predictive values of D-dimer were calculated, and ROC curves were analyzed. RESULTS: The D-dimer levels in the group developing postoperative PVT was signifi cantly higher than those in the group not developing PVT (P = 0.001), and the ROC semi-quantitative and qualitative analysis of D-dimer showed a moderate predictive value in PVT (semi- quantitative value Az = 0.794, P = 0.000; qualitative analysis: Az = 0.739, P = 0.001). CONCLUsiON: Dynamic monitoring of D-dimer levels in patients with portal hypertension after surgery can help early diagnosis of PVT, as in cases where the D-dimer levels steadily increase and exceed 16 μg/mL, the possibility of PVT is very high.

关键词： Portal hypertension Portal vein thrombosis Splenectomy D-dimer Diagnosis

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： siyi xu Junqiu Jia Rui Mao Xiang Cao yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

Experimental Study on the Bed Shear Stress Under Breaking Waves

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2017年第3期31卷 308-316页

作者： HAO si-yu XIA yun-feng xu Hua Nanjing Hydraulic Research Institute Nanjing 210029 China College of Harbor Coastal and Offshore Engineering Hohai University Nanjing 210098 China The State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing 210098 China Key Laboratory of Port Waterway and Sedimentation Engineering of Ministry of Transport Nanjing 210024 China

The object of present study is to investigate the bed shear stress on a slope under regular breaking waves by a novel instrument named Micro-Electro-Mechanical System （MEMS） flexible hot-film shear stress sensor. The sensors were calibrated before application, and then a wave flume experiment was conducted to study the bed shear stress for the case of regular waves spilling and plunging on a 1 ： 15 smooth PVC slope. The experiment shows that the sensor is feasible for the measurement of the bed shear stress under breaking waves. For regular incident waves, the bed shear stress is mainly periodic in both outside and inside the breaking point. The fluctuations of the bed shear stress increase significantly after waves breaking due to the turbulence and vortexes generated by breaking waves. For plunging breaker, the extreme value of the mean maximum bed shear stress appears after the plunging point, and the more violent the wave breaks, the more dramatic increase of the maximum bed shear stress will occur. For spilling breaker, the increase of the maximum bed shear stress along the slope is gradual compared with the plunging breaker. At last, an empirical equation about the relationship between the maximum bed shear stress and the surf similarity parameter is given, which can be used to estimate the maximum bed shear stress under breaking waves in practice.

关键词： bed shear stress direct measurement shear stress sensor spilling breaker plunging breaker

Reducing the measurement errors in nonadiabatic holonomic quantum computers

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-Fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors