检索结果-南通市图书馆

Curcumin for gastric cancer:Mechanism prediction via network pharmacology,docking,and in vitro experiments

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3635-3650页

作者： Peng-Hui Yang Ya-Nan Wei Bi-Juan Xiao si-yi li Xin-Long li liang-Jun Yang Hua-Feng Pan Geng-Xin Chen The Second School of Clinical Medicine Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Traditional Chinese Medicine The People's Hospital of LonghuaShenzhen 518109Guangdong ProvinceChina Department of Gastroenterology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Centre for Translational Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Curcumin originates from the natural herb turmeric,and its antitumor effects have been known about for a long ***,the mechanism by which curcumin affects gastric cancer(GC)has not been *** To elucidate the potential mechanisms of curcumin in the treatment of *** Network pharmacological approaches were used to perform network analysis of *** first analyzed lipinski’s Rule of Five for the use of *** latent targets were predicted using the PharmMapper,SwissTargetPrediction and DrugBank network *** disease targets were mined through the GeneCard,OMIM,DrugBank and TTD network ***,GO enrichment,KEGG enrichment,protein-protein interaction(PPI),and overall survival analyses were *** results were further verified through molecular docking,differential expression analysis and cell *** We identified a total of 48 curcumin-related genes with 31 overlapping GC-related *** intersection targets between curcumin and GC have been enriched in 81 GO biological processes and 22 significant *** PPI analysis,6 hub targets were identified,namely,estrogen receptor 1(ESR1),epidermal growth factor receptor(EGFR),cytochrome P450 family 3 subfamily A member 4(CYP3A4),mitogen-activated protein kinase 14(MAPK-14),cytochrome P450 family 1 subfamily A member 2(CYP1A2),and cytochrome p450 family 2 subfamily B member 6(CYP2B6).These factors are correlated with decreased survival rates among patients diagnosed with *** docking analysis further substantiated the strong binding interactions between Curcumin and the hub target *** experimental findings demonstrated that curcumin not only effectively inhibits the growth of BGC-823 cells but also suppresses their *** levels of hub targets CYP3A4,MAPK14,CYP1A2,and CYP2B6 in BGC-823 cells were significantly increased in each dose *** Curcumin can play an anti-GC role through a variety of

关键词： Curcumin Gastric cancer Network pharmacology Molecular docking Survival analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aggressive variant prostate cancer:A case report and literature review

引用

世界临床病例杂志 2023年第26期11卷 6213-6222页

作者： Xiang-Tao Weng Wen-li lin Qi-Man Pan Tao-Fen Chen si-yi li Chi-Ming Gu Department of Urology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of Urology The Second Clinical Medical College of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Aggressive variant prostate cancer(AVPC)is a rare disease that progresses *** first-line treatment for AVPC is currently *** examined a rare case of AVPC with rare brain and bladder metastases.A summary review of the mechanism of development,clinicopathological manifestations,associated treatments and prognosis of this disease is *** SUMMARY The patient was diagnosed with prostate cancer(PCA),and was actively treated with endocrine therapy,radiotherapy,chemotherapy,and traditional Chinese ***,he was insensitive to treatment,and the disease progressed *** died five years after being diagnosed with *** We should reach consensus definitions of the AVPC and other androgen receptorindependent subtypes of PCA and develop new biomarkers to identify groups of high-risk *** is crucial to complete a puncture biopsy of the tumor or metastatic lesion as soon as possible in patients with advanced PCA who exhibit clinical features such as low Prostate-specific antigen levels,high carcinoembryonic antigen levels,and insensitivity to hormones to determine the pathological histological type and to create a more aggressive monitoring and treatment regimens.

关键词： Aggressive variant prostate cancer Prostate-specific antigen Carcinoembryonic antigen Prostate cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A review of surface roughness measurements based on laser speckle method

引用

Journal of Iron and Steel Research(International) 2023年第10期30卷 1897-1915页

作者： Mei-qi Shao Dong Xu si-yi li Xiao-gang Zuo Chang-ke Chen Gong-zhuang Peng Jia-min Zhang Xiao-chen Wang Quan Yang Institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China Xinjiang Joinworld Co. Ltd.Urumqi 830000XinjiangChina

Surface roughness is commonly used to characterize material microstructure during processing,and accurate measurement of surface roughness is the premise and foundation of ***,online non-destructive measurement of surface roughness based on the laser speckle method has become a hot issue in recent *** improvements in surface roughness measurements based on the laser speckle method are systematically *** of speckle formation is *** statistical properties of the speckle patterns including first-order statistical properties and second-order statistical properties are directly related to surface *** roughness measurements based on the laser speckle method are roughly divided into the speckle contrast method,speckle correlation method,and fractal *** three methods are described in detail,and an extensive comparison among all the methods is *** recent progresses and application of surface roughness measurements are ***,surface roughness measurements based on the laser speckle method are prospected and summarized.

关键词： Surface roughness Non-destructive measurement Laser speckle method Speckle pattern Statistical property

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Well-dispersed Sb particles embedded on N-doped carbon nanofibers toward high-performance li-ion battery

引用

Rare Metals 2024年第7期43卷 2994-3006页

作者： ying li yi-Han Zhao Lu-Lu Zhao Peng-Fei Wang ying Xie Ting-Feng yi School of Materials Science and Engineering Northeastern University Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at Qinhuangdao Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang University

The alloy-type material Sb is widely used in the anode materials of lithium-ion batteries（liBs） due to its high theoretical specific ***,its serious volume expansion problem during alloying/dealloying of li+limits its practical *** this work,C-Sb composite was constructed as anode material of liBs by electrospinning route for the first time,Sb was introduced into the polyacrylonitrile-based hard carbon and coal tar pitch-based soft carbon composite amorphous carbon fiber with a diameter of 300-600 nm,which realized high cycling *** C-Sb-2（the mass ratio of polyacrylonitrile to Sb source is 1:2） electrode displayed charge capacities of 1098.5,930.3,841.7,753.5,643.9 and 545.8 mAh·g-1at 0.1,0.2,0.3,0.5,1 and 2 A·g-1,*** when the current density returned to 0.1 A·g-1,the charge capacity was 939.3 mAh·g-1,revealing good stability and *** introduction of Sb into the amorphous carbon improved its conductivity and addressed the volume expansion issue of high specific capacity Sb during charge/***-situ XRD analysis confirmed the high reversibility of the C-Sb-2 during charging and *** functional theory（DFT） calculations revealed the gradual enhancement of the interface interaction between Sbxliyand amorphous carbon（AMC） with increasing lithium content,contributing to the anchoring of alloy nanoparticles on the AMC surface and buffering the volume change of the ***,the gradual lithiation of Sb facilitated the electron transfer from Sbxliyto *** findings hold promise for designing lithium storage materials with exceptional performance,highlighting the potential of C-Sb composites as anode materials for efficient next-generation lithium storage.

关键词： li-ion battery Metallic Sb Carbon Electrospinning Cycling stability

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nature-inspired design of droplet-synthesized polymeric nanoelectrode for photoelectrochemical microRNA sensing within single cells

引用

Science Bulletin 2024年第2期69卷 159-162页

作者： si-Yuan Yu yi-li liu Zheng li Dechen Jiang Jing-Juan Xu Hong-Yuan Chen Wei-Wei Zhao State Key Laboratory of Analytical Chemistry for life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Nanoelectrodes have been shown to be powerful tools for nanoscopic research on single entities,deepening the understanding of heterogeneity and stochastics for single molecules,nanoparticles and cells[1–3].However,despite their importance,current nanoelectrode preparations are highly restrained to flame/electrochemical etching,metal sputtering,electrochemical deposition,etc.[3],resulting in a limited range of materials(mainly gold,platinum and carbon)for potential-resolved detection of redox-active species(Table S1 online).The enrichment of preparation methods to introduce novel materials and mechanisms should prove significant for the development of nanoelectrodes.

关键词： electrode deepening restrained

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of complete revascularization in acute coronary syndrome after 75 years old:insights from the BleeMACS registry

引用

Journal of Geriatric Cardiology 2023年第10期20卷 728-736页

作者： Ge WANG Xiu-Huan CHEN si-yi li Ze-Kun ZHANG Wei GONG Yan YAN Shao-Ping NIE JoséP.Henriques on behalf of the BleeMACS registry investigators Center for Coronary Artery Disease Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Cardiology Amsterdam University Medical CenterAmsterdamthe Netherlands 不详

BACKGROUND The prognostic benefit of complete revascularization in elderly patients(aged over 75 years)with multi-vessel disease and acute coronary syndrome(ACS)is currently *** study aimed to determine the long-term prognostic impact of complete revascularization in this *** We conducted this study using data obtained from the BleeMACS(Bleeding complications in a Multicenter registry of patients discharged after an Acute Coronary Syndrome)registry,which was carried out from 2003 to *** objective was to categorize older patients diagnosed with ACS into two groups:those who underwent complete revascularization and those who did *** score matching and the Kaplan-Meier analysis were employed to examine differences in one-year clinical *** primary endpoint was major adverse cardiovascular event(MACE),which encompassed a combination of all-cause mortality and myocardial *** Out of 1263 patients evaluated,445 patients(35.2%)received complete *** who underwent complete revascularization had a higher prevalence of hypertension and prior percutaneous coronary intervention compared to those who did *** the one-year follow-up period,complete revascularization was associated with a significantly decreased risk of MACE[13.7%vs.20.5%,hazard ratio(HR)=0.63,95%CI:0.45–0.88,P=0.007]and a lower risk of myocardial infarction(5.9%vs.9.9%,HR=0.55,95%CI:0.33–0.92,P=0.02).However,it was not linked to a lower risk of all-cause death(9.5%vs.13.5%,HR=0.68,95%CI:0.45–1.02,P=0.06).similar results were observed in the subgroup *** Long-term clinical improvements were observed in ACS patients aged over 75 years with multi-vessel disease who achieved complete ***,adhering to guidelines for complete revascularization should be recommended for elderly patients.

关键词： coronary revascularization acute

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predict the evolution of mechanical property of Al-li alloys in a marine environment

引用

Defence Technology（防务技术） 2024年第1期31卷 557-566页

作者： Wei li lin Xiang Guang Wu Hongli si Jinyan Chen yiming Jin Yan Su Jianquan Tao Chunyang Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100036China Chongqing Innovation Center Beijing Institute of TechnologyChongqing400044China First Research Institute of the Ministry of Public Security for PR China Beijing100036China Southwest Technology and Engineering Research Institute Chongqing400039China

The ocean is one of the essential fields of national defense in the future,and more and more attention is paid to the lightweight research of Marine equipment and *** study it is to develop a Machine learning(ML)-based prediction method to study the evolution of the mechanical properties of Al-li alloys in the marine *** obtained the mechanical properties of Al-li alloy samples under uniaxial tensile deformation at different exposure times through Marine exposure *** obtained the strain evolution by digital image correlation(DIC).The strain field images are voxelized using 2D-Convolutional Neural Networks(CNN)autoencoders as input data for Long Short-Term Memory(LSTM)neural ***,the output data of LSTM neural networks combined with corrosion features were input into the Back Propagation(BP)neural network to predict the mechanical properties of Al-li *** main conclusions are as follows:*** variation law of mechanical properties of2297-T8 in the Marine atmosphere is *** the increase in outdoor exposure test time,the tensile elastic model of 2297-T8 changes slowly,within 10%,and the tensile yield stress changes significantly,with a maximum attenuation of 23.6%.*** prediction model can predict the strain evolution and mechanical response simultaneously with an error of less than 5%.*** study shows that a CNN/LSTM system based on machine learning can be built to capture the corrosion characteristics of Marine exposure *** results show that the relationship between corrosion characteristics and mechanical response can be predicted without considering the microstructure evolution of metal materials.

关键词： Marine environment Al-li alloy Machine learning Corrosion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced electrochemical performance of li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3) solid electrolyte by anion doping

引用

Nano Research 2024年第3期17卷 1465-1472页

作者： Jingrui Kang Xu Guo Rui Gu Honglei Hao yi Tang Jiahui Wang li Jin Hongfei li Xiaoyong Wei Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Energy and Materials Shanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai 201209China

Nowadays,the majority of the studies on the substitution are focused on cations(such as Y^(3+),Ti^(4+),P^(5+),etc.)in li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)(LATP),while there are few studies on the substitution of anion O^(2-).In this work,the modified LATP with a series of liCl(LATPClx,x=0.1,0.2,0.3,0.4)additives is prepared to enhance ionic *** successful introduction of Cl-makes the length of the c axis decrease from 20.822(2)to 20.792(1)Å,and the bulk conductivity of 2.13×10^(-3) S·cm^(-1) is achieved in LATPCl_(0.3).Moreover,the Al/Ti-O1/Cl1 and Al/Ti-O_(2)/Cl_(2) distance decrease,while the li1-O_(2)/Cl_(2) distance *** ions migrate more easily in the nanochannel of *** addition,the liCl additive increases the relative density and the grain boundary conductivity of LATPClx ***,a higher ionic conductivity of 2.12×10^(–4) S·cm^(-1) and a low activation energy of 0.30 eV are obtained in LATPCl_(0.3).Correspondingly,the symmetric cell exhibits a low overpotential of±50 mV for over 200 h in LATPCl_(0.3).The solid-state li|LATPCl_(0.3)|NCM811(NCM811=liNi0.8Co0.1Mn0.1O_(2))battery exhibits high initial capacity 185.1 mAh·g^(-1) with a capacity retention rate of 95.4%after 100 cycles at 0.5 *** result suggests that liCl additive is an effective strategy to promote electrochemical properties of LATP solid electrolyte and can be considered for reference to other inorganic solid electrolytes systems.

关键词： li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)(LATP)solid electrolyte anion doping ionic conductivity cyclic performance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SENsiTIVE NUMERICAL siMULATION AND ANALYsiS OF RAINSTORM UsiNG NESTED WRF MODEL

引用

Journal of Hydrodynamics 2006年第5期18卷 578-586页

作者： WANG Shu-chang HUANG si-xun li yi Institute of Meteorology PLA University of Science and Technology Nanjing 211101 China

Nowadays, the nested grid model is widely used to increase the resolution of numerical model. An attempt to investigate the influence of the newly developed nesting technique of WRF model on the mesoscale numerical simulation of severe storm is described in this article. The results of sensitivity tests infer that the WRF model give more accurate and vivid prediction of severe storm with nesting scheme. As is shown in the tests, simulating value of the precipitation centers using nesting scheme are larger than those without using nesting scheme, which indicates that the simulating precipitation of nested storm is closer to the real rainfall. And there is obvious improvement of distribution of rain area and position of precipitation centers. According to the high resolution output data of the WRF model, deep and detailed analysis of characters of the mesoscale system that triggers the rainstorm is reported in this article, and the thermal and dynamical characters of this Meiyu front severe storm are also discussed.

关键词： WRF nesting numerical simulation mesoscale analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Self-assembly of perovskite nanocrystals:From driving forces to applications

引用

Journal of Energy Chemistry 2024年第1期88卷 561-578,I0013页

作者： yi li Fei Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Self-assembly of metal halide perovskite nanocrystals(NCs)into superlattices can exhibit unique collective properties,which have significant application values in the display,detector,and solar cell *** review discusses the driving forces behind the self-assembly process of perovskite NCs,and the commonly used self-assembly methods and different self-assembly structures are ***,we summarize the collective optoelectronic properties and application areas of perovskite superlattice ***,we conclude with an outlook on the potential issues and future challenges in developing perovskite NCs.

关键词： Self-assembly Metal halide perovskite Nanocrystals Driving forces

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：