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Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury

Neural Regeneration Research 2022年第1期17卷 217-227页

作者： Xiao-Min Zhang Li-Ni zeng Wan-Yong Yang Lu Ding Kang-Zhen Chen Wen-Jin Fu si-quan zeng Yin-Ru Liang Gan-Hai Chen Hong-Fu Wu Key Laboratory of Stem Cell and Regenerative Tissue Engineering Guangdong Medical UniversityDongguanGuangdong ProvinceChina Biology Research Group Guangzheng Experimental SchoolHuizhouGuangdong ProvinceChina Geriatric Medicine Center Dongguan Waterfront Zone Central HospitalDongguanGuangdong ProvinceChina Scientific Research Center the Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Clinical Laboratory Affiliated Houjie HospitalGuangdong Medical UniversityDongguanGuangdong ProvinceChina Department of Intensive Care Unit Affiliated Houjie HospitalGuangdong Medical UniversityDongguanGuangdong ProvinceChina

Our previous RNA sequencing study showed that the long non-coding RNA ischemia-related factor Vof-16(lncRNA Vof-16)was upregulated after spinal cord injury,but its precise role in spinal cord injury remains *** predictions have indicated that lncRNA Vof-16 may participate in the pathophysiological processes of inflammation and ***12 cells were transfected with a pHBLV-U6-MCS-CMV-ZsGreen-PGK-PURO vector to express an lncRNA Vof-16 knockdown lentivirus and a pHLV-CMVIE-ZsGree-Puro vector to express an lncRNA Vof-16 overexpression *** overexpression of lncRNA Vof-16 inhibited PC12 cell survival,proliferation,migration,and neurite extension,whereas lncRNA Vof-16 knockdown lentiviral vector resulted in the opposite effects in PC12 *** blot assay results showed that the overexpression of lncRNA Vof-16 increased the protein expression levels of interleukin 6,tumor necrosis factor-α,and Caspase-3 and decreased Bcl-2 expression levels in PC12 ***,we established rat models of spinal cord injury using the complete transection at *** cord injury model rats were injected with the lncRNA Vof-16 knockdown or overexpression lentiviral vectors immediately after *** 7 days after spinal cord injury,rats treated with lncRNA Vof-16 knockdown displayed increased neuronal survival and enhanced axonal *** 8 weeks after spinal cord injury,rats treated with the lncRNA Vof-16 knockdown lentiviral vector displayed improved neurological function in the hind ***,lncRNA Vof-16 knockdown injection increased Bcl-2 expression and decreased tumor necrosis factor-αand Caspase-3 expression in treated *** treated with the lncRNA Vof-16 overexpression lentiviral vector displayed opposite *** findings suggested that lncRNA Vof-16 is associated with the regulation of inflammation and *** inhibition of lncRNA Vof-16 may be useful for promoting nerve regeneration and functional recovery a

关键词： apoptosis functional recovery inflammation long non-coding RNA ischemia related factor Vof-16 nerve regeneration nerve repair neurite extension neuronal survival proliferation spinal cord injury

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Switching,explosion,and chaos of multi-wavelength soliton states in ultrafast fiber lasers

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 82-90页

作者： Zhi-zeng si Yue-Yue Wang Chao-Qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

Because of the complexity and difficulty of realizing a multi-wavelength soliton state,reports on its internal dynamic characteristics are *** this study,the switching and periodic soliton explosion processes of the multi-wavelength soliton state in a negative dispersion passively mode-locked fiber laser are *** generation of the multi-wavelength soliton state undergoes the process of noise,oscillation,and stable mode-locking,and the splitting and annihilation of solitons with different group velocities directly impact the generation and disappearance of three *** and negative dispersion lead to different group velocities of *** presence and displacement of solitons with different group velocities cause soliton collisions,which lead to soliton explosions.A soliton experiences relative phase oscillation,chaos,and oscillation,as well as convergence and separation before and after an *** an increase in parameters related to pump power,single-soliton oscillation,multi-wavelength solitons,and chaos are found in experiments and simulations,proving the relevance and reliability between simulation and experimental *** work promotes the dynamical study of multi-soliton collisions in nonlinear science and the development of chaos theory in multi-comb lasers.

关键词： multi-wavelength fiber laser soliton explosion chaos state switching real-time dynamics

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A Multi-Strategy-Improved Northern Goshawk Optimization Algorithm for Global Optimization and Engineering Design

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Computers, Materials & Continua 2024年第7期80卷 1677-1709页

作者： Liang zeng Mai Hu Chenning Zhang quan Yuan Shanshan Wang School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan430068China Hubei Key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of TechnologyWuhan430068China

Optimization algorithms play a pivotal role in enhancing the performance and efficiency of systems across various scientific and engineering *** enhance the performance and alleviate the limitations of the Northern Goshawk Optimization(NGO)algorithm,particularly its tendency towards premature convergence and entrapment in local optima during function optimization processes,this study introduces an advanced Improved Northern Goshawk Optimization(INGO)*** algorithm incorporates a multifaceted enhancement strategy to boost operational ***,a tent chaotic map is employed in the initialization phase to generate a diverse initial population,providing high-quality feasible ***,after the first phase of the NGO’s iterative process,a whale fall strategy is introduced to prevent premature convergence into local *** is followed by the integration of T-distributionmutation strategies and the State Transition Algorithm(STA)after the second phase of the NGO,achieving a balanced synergy between the algorithm’s exploitation and *** research evaluates the performance of INGO using 23 benchmark functions alongside the IEEE CEC 2017 benchmark functions,accompanied by a statistical analysis of the *** experimental outcomes demonstrate INGO’s superior achievements in function optimization ***,its applicability in solving engineering design problems was verified through simulations on Unmanned Aerial Vehicle(UAV)trajectory planning issues,establishing INGO’s capability in addressing complex optimization challenges.

关键词： Northern Goshawk Optimization tent chaotic map T-distribution disturbance state transition algorithm UAV path planning

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Degree of shade tolerance shapes seasonality of chlorophyll, nitrogen and phosphorus levels of trees and herbs in a temperate deciduous forest

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Journal of Forestry Research 2024年第4期35卷 60-72页

作者： Jiajia zeng Fan Liu Yuan Zhu Jiayi Li Ying Ruan Xiankui quan Chuankuan Wang Xingchang Wang Aulin College Northeast Forestry UniversityHarbin 150040People’s Republic of China Center for Ecological Research Northeast Forestry UniversityHarbin 150040People’s Republic of China Key Laboratory of Agricultural Water Resources Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021People’s Republic of China Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016People’s Republic of China Key Laboratory of Sustainable Forest Ecosystem Management Ministry of EducationNortheast Forestry UniversityHarbin 150040People’s Republic of China

Forest productivity is closely linked to seasonal variations and vertical differentiation in leaf ***,leaf structural and chemical traits variation among co-existing species,and plant functional types within the canopy are poorly *** this study,the seasonality of leaf chlorophyll,nitrogen(N),and phosphorus(P)were quantified vertically along the canopy of four major tree species and two types of herbs in a temperate deciduous *** role of shade tolerance in shaping the seasonal variation and vertical differentiation was *** the entire season,chlorophyll content showed a distinct asymmetric unimodal pattern for all species,with greater chlorophyll levels in autumn than in spring,and the timing of peak chlorophyll per leaf area gradually decreased as shade tolerance *** a:b ratios gradually decreased with increasing shade *** N and P contents sharply declined during leaf expansion,remained steady in the mature stage and decreased again during leaf *** the seasons,the lower canopy layer had significantly higher chlorophyll per leaf mass but not chlorophyll per leaf area than the upper canopy layer regardless of degree of shade ***,N and P per leaf area of intermediate shade-tolerant and fully shade-tolerant tree species were significantly higher in the upper canopy than in the *** variations in N:P ratios suggest changes in N or P *** findings indicate that shade tolerance is a key feature shaping inter-specific differences in leaf chlorophyll,N,and P contents as well as their seasonality in temperate deciduous forests,which have significant implications for modeling leaf photosynthesis and ecosystem production.

关键词： Leaf traits Leaf nutrients Seasonal variations Chlorophyll Nitrogen Phosphorus Shade tolerance Canopy layers

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Disulfiram:A novel repurposed drug for cancer therapy

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Chinese Medical Journal 2024年第12期137卷 1389-1398页

作者： Min zeng Baibei Wu Wenjie Wei Zihan Jiang Peiqiang Li Yuanting quan Xiaobo Hu Department of Biochemistry and Molecular Biology School of Basic MedicineHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Institute of Biochemistry of Hengyang Medical School University of South ChinaHengyangHunan 421001China

Cancer is a major global health *** therapeutic strategies can prolong patients’survival and reduce the costs of *** repurposing,which identifies new therapeutic uses for approved drugs,is a promising approach with the advantages of reducing research costs,shortening development time,and increasing efficiency and ***(DSF),a Food and Drug Administration(FDA)-approved drug used to treat chronic alcoholism,has a great potential as an anticancer drug by targeting diverse human *** studies show the antitumor effects of DSF,particularly the combination of DSF and copper(DSF/Cu),on a wide range of cancers such as glioblastoma(GBM),breast cancer,liver cancer,pancreatic cancer,and *** this review,we summarize the antitumor mechanisms of DSF/Cu,including induction of intracellular reactive oxygen species(ROS)and various cell death signaling pathways,and inhibition of proteasome activity,as well as inhibition of nuclear factor-kappa B(NF-κB)***,we highlight the ability of DSF/Cu to target cancer stem cells(CSCs),which provides a new approach to prevent tumor recurrence and ***,DSF/Cu inhibits several molecular targets associated with drug resistance,and therefore it is becoming a novel option to increase the sensitivity of chemo-resistant and radio-resistant *** of DSF/Cu may shed light on its improved application to clinical tumor treatment.

关键词： Disulfiram Aldehyde dehydrogenase Reactive oxygen species Proteasome activity Cancer stem cells Drug resistance

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Evolution of High-energy Electron Distribution in Pulsar Wind Nebulae

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Research in Astronomy and Astrophysics 2024年第7期24卷 201-217页

作者： Yi-Ming Liu Hou-Dun zeng Yu-Liang Xin si-Ming Liu Yi Zhang Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences School of Astronomy and Space Science University of Science and Technology of China School of Physical Science and Technology Southwest Jiaotong University

In this paper,we analyze the spectral energy distributions of 17 powerful (with a spin-down luminosity greater than1035erg s-1) young （with an age less than 15,000 yr） pulsar wind nebulae （PWNe） using a simple timein-dependent one-zone emission *** aim is to investigate correlations between model parameters and the ages of the corresponding PWNe,thereby revealing the evolution of high-energy electron distributions within *** findings are as follows:（1） The electron distributions in PWNe can be characterized by a double power-law with a super-exponential cutoff.（2） As PWNe evolve,the high-energy end of the electron distribution spectrum becomes harder with the index decreasing from approximately 3.5 to 2.5,while the low-energy end spectrum index remains constant near 1.5.（3） There is no apparent correlation between the break energy or cutoff energy and the age of PWNe.（4） The average magnetic field within PWNe decreases with age,leading to a positive correlation between the energy loss timescale of electrons at the break energy or the high-energy cutoff and the age of the PWN.（5） The total electron energy within PWNe remains constant near 2×1048erg,while the total magnetic energy decreases with age.

关键词： gamma-rays: general ISM: general ISM: supernova remnants radiation mechanisms: non-thermal

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Predictors of complications after prophylactic ileostomy reversal for rectal cancer:A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1354-1362页

作者： quan Lv Xin-Peng Shu Dong Peng si-Qi Li Zheng Xiang Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Chongqing Key Laboratory of Department of General Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Previous studies have analyzed the risk factors for complications after ileostomy reversal for rectal cancer(RC),but there were significant differences in the reported risk factors for complications after stoma *** studies have analyzed the risk factors for stoma-related complications and overall postoperative com-plications *** To analyze the risk factors for overall complications and stoma-related complications after ileostomy reversal for patients with *** This was a retrospective study of 439 patients who underwent ileostomy reversal at a clinical center and were followed up between September 2012 and September *** variables are expressed as the mean±SD and were analyzed with independent-sample t tests,while frequency variables are expressed as n(%),and theχ2 test or Fisher’s exact test was *** and multivariate logistic regression analyses were used to identify predictors of overall complications and stoma-related *** The overall complication rate after ileostomy reversal was 11.4%.Patients with lower preoperative albumin concentration(Psis of the study showed that a higher body mass index(BMI)(Psion(P=0.049),time from primary surgery to ileostomy reversal(Psion analysis revealed that a lower preoperative albumin level(Psis revealed that BMI(P<0.01,OR=1.176,95%CI:1.041-1.330)and time from primary surgery to ileostomy reversal(P<0.01,OR=1.140,95%CI:1.038-1.252)were independent risk factors for stoma-related compl

关键词： Ileostomy Reversal Risk factors Complications Rectal cancer

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Carbon dots-derived three-dimensional-ordered macroporous host with high penetrability and catalytic activity for LSBs under lean electrolyte

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Rare Metals 2024年第6期43卷 2560-2573页

作者： Jiao-Zi Duan Hua-Yu Pei quan Yang Xue Li Xin Ba Xue Yong Jun-Ling Guo si-Yu Lu Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001China Country State Center for International Cooperation On Designer Low-Carbon&Environmental Materials School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Hubei Institute of Quality Supervision Inspection Wuhan 430061China Department of Chemistry University of SheffieldSheffeld S37HFUK

The practical energy density of lithium-sulfur batteries(LSBs)is seriously limited by the high electrolyte-to-sulfur ratios(E/S).The E/S can be reduced by employing hosts with easy-to-infiltrate structure that ensures the uniform distribution of a lean electrolyte and high catalytic activity that can suppress"shuttle effect"via accelerating the slow conversion of soluble poly sulfides to insoluble *** the easy-to-infiltrate structures,the three-dimensional-ordered macroporous(3DOM)structure is easier to scale preparation and more suitable for the existing industrial ***,it is difficult to obtain the 3DOM with(1)high penetrability due to the high viscosity of frequently-used organic polymer precursors and(2)high catalytic activity due to the low confinement effect,meaning that uniformly dispersed small-sized catalytic materials are difficult to load on ***,using carbon dots(CDs)with both organic and inorganic properties as a precursor and aggregation limiting agent,a 3DOM host with high penetrability and homodispersed Ni particles of small sizes(Ni-CDs-3DOM)was *** this host:(1)CDs precursor with suitable viscosity can improve the penetrability.(2)CDs can effectively inhibit the agglomeration of Ni particles.(3)Uniformly dispersed small-size Ni particles offer high-efficiency catalytic activity toward sulfur ***,the Ni-CDs-3DOM/sulfur cathode exhibits high sulfur utilization and stable cycling performance even under high sulfur loading(5.5 mg·cm^(-2))and low E/S(6.5μl·mg^(-1)).This work indicates the usefulness of CDs in constructing hosts for LSBs with high energy density.

关键词： Lithium-sulfur batteries Carbon dots Catalytic action Easy-to-infiltrate structure Lean electrolyte

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Method for rapid warning and activity concentration estimates in online waterγ-spectrometry systems

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Nuclear Science and Techniques 2024年第3期35卷 1-12页

作者： Meng Wang Yi Gu Mao-Lin Xiong Liang-quan Ge Qing-Xian Zhang Guo-Qiang zeng Heng Lu Sheng-Liang Guo College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of sichuan Province (Chengdu University of Technology)Chengdu 610059China Chengdu New Ray Technology Co.Ltd Chengdu 610052China

Onlineγ-spectrometry systems for inland waters,most of which extract samples in situ and in real time,are able to produce reliable activity concentration measurements for waterborne radionuclides only when they are distributed relatively uniformly and enter into a steady-state diffusion regime in the measurement *** protect residents’health and ensure the safety of the living environment,better timeliness is required for this measurement *** address this issue,this study established a mathematical model of the online waterγ-spectrometry system so that rapid warning and activity estimates can be obtained for water under non-steady-state(NSS)*** addition,the detection efficiency of the detector for radionuclides during the NSS diffusion process was determined by applying the computational fluid dynamics technique in conjunction with Monte Carlo *** this basis,a method was developed that allowed the online waterγ-spectrometry system to provide rapid warning and activity concentration estimates for radionuclides in *** analysis of the NSS-mode measurements of^(40)K radioactive solutions with different activity concentrations determined the optimum warning threshold and measurement time for producing accurate activity concentration estimates for *** experimental results show that the proposed NSS measurement method is able to give warning and yield accurate activity concentration estimates for radionuclides 55.42 and 69.42 min after the entry of a 10 Bq/L^(40)K radioactive solution into the measurement chamber,*** times are much shorter than the 90 min required by the conventional measurement ***,the NSS measurement method allows the measurement system to give rapid(within approximately 15 min)warning when the activity concentrations of some radionuclides reach their respective limits stipulated in the Guidelines for Drinking-water Quality of the WHO,suggesting that this method con

关键词： Water radioactivity monitoring Dynamic detection efficiency Rapid warning Activity estimation

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Solitons and Their Biperiodic Pulsation in Ultrafast Fiber Lasers Based on CB/GO

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Chinese Physics Letters 2024年第8期41卷 28-32页

作者： Zhen-Tao Ju Zhi-zeng si Xin Yan Chao-Qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

The carbon black(CB)is introduced to manufacture CB/graphene oxide(GO)composite material to mitigate limitations of GO as a saturable absorber with the excellent performance in ultrafast fiber *** a central wavelength of 1555.5 nm,the stable mode-locked pulse with width of 656 fs,repetition rate of 20.16 MHz,and high signal-to-noise ratio of 82.07 dB is experimentally ***,experimental observations for pulsation phenomena of vector biperiodic solitons combining period-1 and period-17,period-2 and period-32,period-3 and period-36 are verified via simulations.

关键词： fiber periodic absorber

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