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Angiogenesis and immune checkpoint dual blockade:Opportunities and challenges for hepatocellular carcinoma therapy

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World Journal of Gastroenterology 2022年第42期28卷 6034-6044页

作者： si-qi li Yang Yang lin-Sen Ye Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

The disease burden related to hepatocellular carcinoma(HCC) is increasing. Most HCC patients are diagnosed at the advanced stage and multikinase inhibitors have been the only treatment choice for them. Recently, the approval of immune checkpoint inhibitors(ICIs) has provided a new therapeutic strategy for HCC. It is noteworthy that the positive outcomes of the phase Ⅲ clinical trial IMBrave150 [atezolizumab(anti-programmed cell death ligand 1 antibody) combined with bevacizumab(anti-vascular endothelial growth factor monoclonal antibody)],showed that overall survival and progression-free survival were significantly better with sorafenib. This combination therapy has become the new standard therapy for advanced HCC and has also attracted more attention in the treatment of HCC with anti-angiogenesis-immune combination therapy. Currently, the synergistic antitumor efficacy of this combination has been shown in many preclinical and clinical studies. In this review, we discuss the mechanism and clinical application of anti-angiogenics and immunotherapy in HCC, outline the relevant mechanism and rationality of the combined application of antiangiogenics and ICIs, and point out the existing challenges of the combination therapy.

关键词： Anti-angiogenesis Immunotherapy Combination therapy Vascular endothelial growth factor Immune checkpoint blockade Hepatocellular carcinoma

Predictors of complications after prophylactic ileostomy reversal for rectal cancer:A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1354-1362页

作者： Quan Lv Xin-Peng Shu Dong Peng si-qi li Zheng Xiang Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Chongqing Key Laboratory of Department of General Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Previous studies have analyzed the risk factors for complications after ileostomy reversal for rectal cancer(RC),but there were significant differences in the reported risk factors for complications after stoma *** studies have analyzed the risk factors for stoma-related complications and overall postoperative com-plications *** To analyze the risk factors for overall complications and stoma-related complications after ileostomy reversal for patients with *** This was a retrospective study of 439 patients who underwent ileostomy reversal at a clinical center and were followed up between September 2012 and September *** variables are expressed as the mean±SD and were analyzed with independent-sample t tests,while frequency variables are expressed as n(%),and theχ2 test or Fisher’s exact test was *** and multivariate logistic regression analyses were used to identify predictors of overall complications and stoma-related *** The overall complication rate after ileostomy reversal was 11.4%.Patients with lower preoperative albumin concentration(Plikely to experience postoperative *** incidence of stoma-related complications was 6.4%.Analysis of the study showed that a higher body mass index(BMI)(Psion(P=0.049),time from primary surgery to ileostomy reversal(Plikely to result in stomarelated complications *** logistic regression analysis revealed that a lower preoperative albumin level(Psis revealed that BMI(P<0.01,OR=1.176,95%CI:1.041-1.330)and time from primary surgery to ileostomy reversal(P<0.01,OR=1.140,95%CI:1.038-1.252)were independent risk factors for stoma-related compl

关键词： Ileostomy Reversal Risk factors Complications Rectal cancer

High-performance si/VO_(2)-nanorod heterojunction photodetector based on photothermoelectric effect for detecting human radiation

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Rare Metals 2024年第3期43卷 1177-1185页

作者： Fu-Hai Guo Lan-Zhong Hao Wei-Zhuo Yu si-qi li Guan-Chu liu Jing-Yi Hao Yun-Jie liu College of Science China University of PetroleumQingdao266580China School of Materials Science and Engineering China University of PetroleumQingdao266580China

As a typical candidate of optoelectronic materials,vanadium dioxide(VO_(2))has wide applications in photodetectors(PDs),but is still challenging in largely enhancing the photodetecting performance for low-power human ***,high-performance si/VO_(2)nanorods(NRs)heterojunction PDs based on the photothermoelectric(PTE)effect are *** uniform VO_(2)-NRs array films were deposited on si by using magnetron sputtering technique,and a si/VO_(2)heterojunctions were *** device exhibits a four-stage photoresponse and broadband photoresponse from ultraviolet to long-wavelength *** from the unique nanorods structure and the strong PTE effect,the fabricated device exhibits a large enhancement of the photodetecting performance,showing an ultrahigh photodetectivity of 1.6×10^(13)Jones and ultrafast response rates with a risingedge time of~65.0μs,three orders of magnitude higher than other VO_(2)-based ***,the device exhibits unique abilities to detect human radiation even when the human fingers are far away from the device surface up to 10.0 ***,the fabricated si/VO_(2)devices can also be applied as breath sensors to distinguish different breathing *** results supply an effective route to design high-performance photodetectors toward detecting human thermal radiation and respiration.

关键词： Vanadium dioxide Heterojunction Photodetector Photothermoelectric Human radiation and respiration sensing

Forward-wave enhanced radiation in the terahertz electron cyclotron maser

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Chinese Physics B 2022年第12期31卷 643-649页

作者： Zi-Chao Gao Chao-Hai Du Fan-Hong li Zi-Wen Zhang si-qi li Pu-Kun liu School of Electronics Peking UniversityBeijing 100871China

Based on the principle of electron cyclotron maser(ECM),gyrotrons are among the most promising devices to generate powerful coherent terahertz(THz)radiation and play a vital role in numerous advanced THz ***,THz ECM systems using a conventional high-Q cavity were theoretically and experimentally demonstrated to suffer from strong ohmic losses,and,accordingly,the wave output efficiency was significantly reduced.A scheme to alleviate such a challenging problem is systematically investigated in this *** traveling-wave operation concept is employed in a 1-THz third harmonic gyrotron oscillator,which strengthens electron-wave interaction efficiency and reduces the ohmic dissipation,simultaneously.A lossy belt is added in the interaction circuit to stably constitute the traveling-wave interaction,and a down-tapered magnetic field is employed to further amplify the forward-wave(FW)*** results demonstrate that the proportion of ohmic losses is nearly halved,and output efficiency is nearly doubled,which is promising for further advancement of high-power continuous-wave operation of the ECM-based devices.

关键词： electron cyclotron maser ohmic loss harmonic operation traveling wave interaction

Bifunctional electrolyte addition for longer life and higher capacity of aqueous zinc-ion hybrid supercapacitors

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Rare Metals 2024年第10期43卷 5060-5069页

作者： Fan Zhang si-qi li li-Nan Xia Chao Yang Lei li Kai-Ming Wang Chen-liang Xu Yuan-Yuan Feng Bin Zhao Fei Shen Xiao-Gang Han ling-Yun Zhu School of Electric Power Civil Engineering and ArchitectureShanxi UniversityTaiyuan 030006China State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi'an Jiaotong UniversityXi'an 710049China Department of Science Materials and Engineering National University of SingaporeSingapore 117576Singapore School of Materials Science and Engineering Anhui UniversityHefei230601China

Owing to uncontrolled and uneven electrodeposition and side reactions,Zn metal anodes inevitably suffer from issues such as dendrite growth,hydrogen evolution reactions,and surface *** paper proposes an efficient strategy to address these critical issues for realizing long-life and high-capacity aqueous zinc-ion hybrid supercapacitors(ZHSCs)by incorporating low-concentration(0.05 mol·L^(-1))redox RbI electrolyte ***,rubidium cations have the ability to influence the negative Zn electrode surface via an electrostatic shielding mechanism,effectively protecting the electrode and minimizing undesired side *** an aqueous solution,iodide anions actively solvate Zn^(2+)ions by stabilizing and modulating the solvation shell surrounding Zn^(2+).Moreover,the presence of iodide ions promotes the uniform deposition of Zn^(2+)species by selective adsorption onto the electrode *** synergistic effect of the electrostatic shielding and halogen ions enables the realization of aqueous symmetric Zn||Zn cells with a substantial cycle life of more than 2000 h Additionally,when applied to commercial activated carbon(AC),the proposed strategy facilitates the development of aqueous ZHSCs,exhibiting high specific capacitances(148.8 F·g^(-1)at 4 A·g^(-1))and ultra-long cycling stability.

关键词： Zn metal anode Zn dendrite Aqueous zincion hybrid supercapacitor Rubidium iodide Synergistic effects of anions and cations

Development of a Handheld Nano-centrifugal Device for Visual Virus Detection

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Journal of Analysis and Testing 2022年第4期6卷 353-364页

作者： Zi-Rong Bi Meng-Lu Hu Yong-Zhong Jiang Er-Hu Xiong Bo-Wen Shu si-qi li Han-Wei Chen Xiao-Hua Chen Xiao-Ming Zhou South China Normal University-Panyu Central Hospital Joint Laboratory of Basic and Translational Medical Research Guangzhou Panyu Central HospitalGuangzhou511400China School of life Sciences South China Normal UniversityGuangzhou510631China Hubei Provincial Center for Disease Control and Prevention Wuhan430079China Dermatology Hospital Southern Medical UniversityGuangzhou510091China Medical Imaging Institute of Panyu Guangzhou511400China Department of Ultrasound Panyu Central HospitalGuangzhou511400China Cancer Center Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou510315China

Gold nanoparticles(AuNPs)colorimetric assays based on distance-dependent optical characteristics have been widely employed for ***,this assay is not effective for visually detecting low-concentration targets due to the faint color ***,we developed a handheld nano-centrifugal device which could separate the crosslinked and non-crosslinked *** showed that the handheld nano-centrifugal device could easily reach more than 6000 r/min within 10 s simply by stretching and tightening the coiled rope in an appropriate ***,combined with the CRISPR/Cas12a nucleic acids recognition system,a field-deployable colorimetric platform termed handheld nano-centrifugal device assisted CRISPR/Cas12a(Hand-CRISPR)has been ***,clinical diagnostics applications for Epstein-Barr virus(EBV)and severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)detection with high sensitivity and accuracy(100%consistency with reverse transcription quantitative real-time polymerase chain reaction(RT-qPCR)test results)have been ***,the Hand-CRISPR platform showed great promise in point-of-care-test(POCT)application,expected to become a powerful supplement to the standard nucleic acid testing method in remote or poverty-stricken areas.

关键词： Nucleic acids assay CRISPR/Cas12a Gold nanoparticles Centrifugal device Clinical diagnostics

Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen qi deficiency syndrome

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World Journal of Cardiology 2024年第7期16卷 422-435页

作者： si-qi li Dong-Yu Min Jun-Wen Jiang Xiao-Ying li Xu-Na Yang Wen-Bo Gu Jia-Hui Jiang li-Hao Chen Han Nan Ze-Yu Chen Second Department of Cardiology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina

BACKGROUND Chronic heart failure is a complex clinical *** Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism is still not *** To identify the effective active ingredients of Jianpi Huatan Quyu recipe and explore its molecular mechanism in the treatment of chronic heart *** The effective active ingredients of eight herbs composing Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis *** target genes of chronic heart failure were searched in the Genecards *** target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drugdisease targets,which were then used to construct a key chemical componenttarget network using Cytoscape 3.7.2 *** protein-protein interaction network was constructed using the String *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape ***,our previously published relevant articles were searched to verify the results obtained via network *** A total of 227 effective active ingredients for Jianpi Huatan Quyu recipe were identified,of which quercetin,kaempferol,7-methoxy-2-methyl isoflavone,formononetin,and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3,MAPK3,AKT1,JUN,MAPK1,TP53,TNF,HSP90AA1,p65,MAPK8,MAPK14,IL6,EGFR,EDN1,FOS,and other *** pathways identified by KEGG enrichment analysis include pathways in cancer,IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,calcium signaling pathway,cAMP signaling pathway,NF-kappaB signaling pathway,AMPK signaling pathway,*** studies on Jianpi Huatan Quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α,IL-6,MAPK

关键词： Jianpi Huatan Quyu recipe Traditional Chinese medicine Chronic heart failure Data mining Network pharmacology Bioinformatics Spleen qi deficiency syndrome

Plasma assisted molecular beam epitaxial growth of GaN with low growth rates and their properties

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Chinese Physics B 2022年第1期31卷 618-625页

作者： Zhen-Hua li Peng-Fei Shao Gen-Jun Shi Yao-Zheng Wu Zheng-Peng Wang si-qi li Dong-qi Zhang Tao Tao qing-Jun Xu Zi-li Xie Jian-Dong Ye Dun-Jun Chen Bin liu Ke Wang You-Dou Zheng Rong Zhang Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and EngineeringNanjing UniversityNanjingChina College of Optoelectronics Engineering Zaozhuang UniversityZaozhuang 277160China Institute of Novel Semiconductors State Key Laboratory of Crystal MaterialShandong UniversityJinan 250100China Xiamen University Xiamen 361005China

A systematic investigation on PA-MBE grown GaN with low growth rates(less than 0.2μm/h)has been conducted in a wide growth temperature range,in order to guide future growth of sophisticated fine structures for quantum device *** to usual growths with higher growth rates,three growth regions have been revealed,namely,Ga droplets,slightly Ga-rich and N-rich 3D growth *** slightly Ga-rich region is preferred,in which GaN epilayers demonstrate optimal crystalline quality,which has been demonstrated by streaky RHEED patterns,atomic smooth surface morphology,and very low defect related yellow and blue luminescence *** growth temperature is a critical parameter to obtain high quality materials and the optimal growth temperature window(~700-760℃)has been *** growth rate shows a strong dependence on growth temperatures in the optimal temperature window,and attention must be paid when growing fine structures at a low growth *** and si doped GaN were also studied,and both p-and n-type materials were obtained.

关键词： GaN molecular beam epitaxy(MBE) low growth rate growth diagram

Coronavirus disease 2019 outbreak in Beijing's Xinfadi Market, China: a modeling study to inform future resurgence response

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Infectious Diseases of Poverty 2021年第3期10卷 122-123页

作者： Xiao-li Wang Xin lin Peng Yang Zun-You Wu Gang li Jennifer M.McGoogan Zeng-Tao Jiao Xin-Jun He si-qi li Hong-Hao Shi Jing-Yuan Wang Sheng-Jie Lai Chun Huang Quan-Yi Wang Beijing Research Center for Preventive Medicine Beijing Center for Disease Prevention and ControlBeijingChina School of Computer Science and Engineering Beihang UniversityBeijingChina WorldPop School of Geography and Environmental ScienceUniversity of SouthamptonSouthamptonUK 不详

Background:A local coronavirus disease 2019(COVID-19)case confirmed on June 11,2020 triggered an outbreak in Beijing,China after 56 consecutive days without a newly confirmed ***-pharmaceutical interventions(NPIs)were used to contain the source in Xinfadi(XFD)*** rapidly control the outbreak,both traditional and newly introduced NPIs in eluding large-scale management of high-risk populations and expanded severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)PCR-based screening in the general population were conducted in *** aimed to assess the effectiveness of the response to the COVID-19 outbreak in Beijing's XFD market and inform future response efforts of resurgence across regions.

关键词： Public health Nonpharmaceutical intervention COVID-19 SARS-CoV-2 Beijing