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Energy & Environmental Materials 2024年第2期7卷 308-319页

作者： Guanghu He Huang Luo Chuanfang Yan Yuting Wan Dang Wu hang Luo Yuan liu Sheng Chen Key Laboratory of Polymeric Materials and Application Technology of Hunan Province College of ChemistryXiangtan UniversityXiangtan 411105China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Guangdong University of Petrochemical Technology Maoming 525000China

How to achieve synergistic improvement of permittivity(ε_(r))and breakdown strength(E_(b))is a huge challenge for polymer ***,for the first time,theπ-conjugated comonomer(MHT)can simultaneously promote theε_(r)and E_(b)of linear poly(methyl methacrylate)(PMMA)*** PMMA-based random copolymer films(P(MMA-co-MHT)),block copolymer films(PMMA-b-PMHT),and PMMA-based blend films were prepared to investigate the effects of sequential structure,phase separation structure,and modification method on dielectric and energy storage properties of PMMA-based dielectric *** a result,the random copolymer P(MMA-coMHT)can achieve a maximumε_(r)of 5.8 at 1 kHz owing to the enhanced orientation polarization and electron *** electron injection and charge transfer are limited by the strong electrostatic attraction ofπ-conjugated benzophenanthrene group analyzed by the density functional theory(DFT),the discharge energy density value of P(MMA-co-PMHT)containing 1 mol%MHT units with the efficiency of 80%reaches15.00 J cm^(-3)at 872 MV m^(-1),which is 165%higher than that of pure *** study provides a simple and effective way to fabricate the high performance of polymer dielectrics via copolymerization with the monomer of P-type semi-conductive polymer.

关键词： dielectric capacitor electrical properties energy density polymer dielectric semiconductor polymer

Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential

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World Journal of Stem Cells 2024年第5期16卷 512-524页

作者： hang Zhang Ling-Zi Wu Zhen-Yu liu Zi-Bing Jin Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Human induced pluripotent stem cell(hiPSC)technology is a valuable tool for generating patient-specific stem cells,facilitating disease modeling,and invest-igating disease ***,iPSCs carrying specific mutations may limit their clinical applications due to certain inherent *** To investigate the impact of MERTK mutations on hiPSCs and determine whether hiPSC-derived extracellular vesicles(EVs)influence anomalous cell junction and differentiation *** We employed a non-integrating reprogramming technique to generate peripheral blood-derived hiPSCs with and hiPSCs without a MERTK ***-somal karyotype analysis,flow cytometry,and immunofluorescent staining were utilized for hiPSC *** and proteomics were employed to elucidate the expression patterns associated with cell junction abnormalities and cellular differentiation ***,EVs were isolated from the supernatant,and their RNA and protein cargos were examined to investigate the involvement of hiPSC-derived EVs in stem cell junction and *** The generated hiPSCs,both with and without a MERTK mutation,exhibited normal karyotype and expressed pluripotency markers;however,hiPSCs with a MERTK mutation demonstrated anomalous adhesion capability and differentiation potential,as confirmed by transcriptomic and proteomic ***,hiPSC-derived EVs were involved in various biological processes,including cell junction and *** HiPSCs with a MERTK mutation displayed altered junction characteristics and aberrant differentiation ***,hiPSC-derived EVs played a regulatory role in various biological processes,including cell junction and differentiation.

关键词： Cell junction Cellular differentiation Extracellular vesicle Human induced pluripotent stem cells Transcriptomics Proteomics

BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/ Stat3 pathway in mesenchymal stem cells

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Genes & Diseases 2024年第3期11卷 468-483页

作者： Jie Zhang Jinhai Jiang hang liu Shiyu Wang Kaixin Ke siyuan liu Yue Jiang Lu liu Xiang Gao Baicheng He Yuxi Su Department of Pharmacology School of PharmacyChongqing Medical UniversityChongqing 400016China Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing Chongqing Medical UniversityChongqing 400016China Department of Orthopedics Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China orthopedics Department Children's Hospital of Chongqing Medical UniversityChongqing 400014China China International Science and Technology Cooperation Base of Child Development and Critical Disorders Jiangxi Hospital Affiliated Children's Hospital of Chongqing Medical UniversityJiangxi 330000China National Clinical Research Center for Child Health and Disorders China

Bone defects and non-union are prevalent in clinical orthopedy,and the outcomes of current treatments are often *** tissue engineering offers a promising approach to treating these conditions *** morphogenetic protein 9(BMP9)can commit mesenchymal stem cells to osteogenic lineage,and a knowledge of the underlying mechanisms may help advance the field of bone tissue ***-rich repeats con-taining G protein-coupled receptor 4(LGR4),a member of G protein-coupled receptors,is essential for modulating bone *** study is aimed at investigating the impact of LGR4 on BMP9-induced osteogenesis in mesenchymal stem cells as well as the underlying *** marrow stromal cells from BMp9-knockout mice exhibited diminished LGR4 expression,and exogenous LGR4 clearly restored the impaired osteogenic potency of the bone marrow stromal ***,LGR4 expression was increased by BMP9 in C3H10T1/2 ***4 augmented the benefits of BMP9-induced osteogenic markers and bone formation,whereas LGR4 inhibition restricted these ***,the BMP9-induced li-pogenic markers were increased by LGR4 *** protein levels of Raptor and p-Stat3 were elevated by *** knockdown or p-Stat3 suppression attenuated the osteoblastic markers and LGR4 expression brought on by ***4 significantly reversed the blocking ef-fect of Raptor knockdown or p-Stat3 suppression on the BMP9-induced osteoblastic *** interacts with p-Stat3,and p-Stat3 activates the LGR4 promoter *** conclusion,LGR4 boosts BMP9 osteoblastic potency in mesenchymal stem cells,and BMP9 may up-regulate LGR4 via the mTORC1/Stat3 signal activation.

关键词： BMP9 LGR4 mTORC1 Osteogenic differentiation Stat3

Evaluating the necessity of autumn irrigation on salinized soil by considering changes in soil physicochemical properties

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Pedosphere 2024年第4期34卷 837-842页

作者： hang ZHAO Jingwei WU Changsen LI Yawen liu Rui Zhang Qiang ZHAO State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan 430072China

Dear Editor,Soil salinization is one of the main forms of global soil degradation,which seriously threatens food security production (liu et al.,2022).Proper irrigation is the main management measure to control soil salinization (Aragüés et al.,2015;Machado and Serralheiro,2017).For example,in Hetao Irrigation District in Inner Mongolia of northwestern China,the effects of irrigation,seasonal freezing-thawing,and evaporation have led to serious soil salinization *** the 1980s,autumn irrigation (AI) has typically been implemented widely in Hetao Irrigation District before soil freezing (Li et al.,2010;Lu et al.,2019),to leach the salts accumulated on the surface and maintain sufficient soil moisture to create a suitable environment for the next spring sowing.

关键词： soil freezing irrigation

Fe/S oxidation-coupled arsenic speciation transformation mediated by AMD enrichment culture under different pH conditions

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Journal of Environmental Sciences 2024年第3期137卷 681-700页

作者： Yu-hang Zhou Wei-xi Huang Zhen-yuan Nie Hong-chang liu Yue liu Can Wang Jin-lan Xia Wen-sheng Shu Key Lab of Biometallurgy of Ministry of Education of China School of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China School of Life Sciences South China Normal UniversityGuangzhou 510631China

Arsenic(As)speciation transformation in acid mine drainage(AMD)is comprehensively affected by biological and abiotic factors,such as microbially mediated Fe/S redox reactions and changes in environmental conditions(pH and oxidation-reduction potential).However,their combined impacts on arsenic speciation transformation remain poorly ***,we explored arsenic transformation and immobilization during pyrite dissolution mediated by AMD enrichment culture under different acidic pH *** results for incubation and mineralogical transformation of solid residues show that in the presence of AMD enrichment culture,pH 2.0,2.5,and 3.0 are more conducive to the formation of jarosites and ferric arsenate,which could immobilize high quantities of dissolved arsenic by adsorption and *** pH conditions significantly affect the initial adsorption of microbial cells to the minerals and the evolution of microbial community structure,further infuencing the biodissolution of pyrite and the release and oxidation process of Fe/*** results of Fe/S/As speciation transformation of the solid residues show that the transformation of Fe,S,and As in solution is mainly regulated by pH and potential values,which imposed significantly different effects on the formation of secondary minerals and thus arsenic oxidation and *** above results indicated that arsenic transformation is closely related to the Fe/S oxidation associated with pyrite bio-oxidation,and this correlation is critically regulated by the pH conditions of the system.

关键词： Acid mine drainage(AMD) pH conditions Fe/S/As speciation transformation Microbial community structure

Facile synthesis of W-Mo bimetallic oxides with high adsorption properties from secondary resources

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Tungsten 2024年第4期6卷 806-820页

作者： Jia-Li Cheng Yang-si liu Xiao-Li Xi Zuo-Ren Nie Collaborative Innovation Center of Capital Resource-Recycling Material Technology College of Materials Science and Engineering Beijing University of Technology National Engineering Laboratory for Industrial Big-Data Application Technology Beijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Beijing University of Technology

A simple solvothermal method was used to obtain W-Mo bimetallic oxides from W-Mo alloy scrap,and pure metal powders were also used as the raw materials to simulate *** products had a sea urchin-like structure with abundant oxygen vacancies and the products prepared at low temperatures forms a sosoloid resembling orthorhombic *** WMo bimetallic oxide prepared at the reaction temperature of 120 ℃ exhibited excellent selective adsorption performance for methylene blue（MB）,which the adsorption rate of MB reached 99% in 12 min and the adsorption rate reached 90% after6 adsorption *** the W-Mo molar ratio is 1:3,the maximum adsorption capacity of sample for MB can reach1148 mg·*** adsorption process followed the Langmuir and pseudo-second-order models,which is surface-controlled monolayer *** experimental results show the feasibility of preparing W-Mo bimetal oxide products from pure materials and *** process is simple and effective,which offered a potential approach for secondary resource recycling and reusing.

关键词： Oxygen vacancy Selective adsorption Solvothermal W–Mo alloy scrap W–Mo bimetallic oxide

Wearable pressure sensors based on antibacterial and porous chitosan hydrogels for full-range human motion detection

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Science China(Technological Sciences) 2024年第8期67卷 2475-2484页

作者： Zhang YingXin liu hanguang JIN ShunYu LI YaJuan Zhang Wan ZHOU hang NIE ZanXiang HUANG Yuan School of Microelectronics Science and Technology Sun Yat-sen UniversityGuangzhou 510275China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230022China Department of Clinical Laboratory the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China School of Electronic and Computer Engineering Peking University Shenzhen Graduate SchoolShenzhen 518055China Zinergy Shenzhen Ltd. Shenzhen 518109China

Wearable pressure sensors made from conductive hydrogels hold significant potential in health ***,limited pressure range(Pa to hundreds of kPa)and inadequate antibacterial properties restrict their practical applications in diagnostic and health ***,a wearable high-performance pressure sensor was assembled using a facilely prepared porous chitosan-based hydrogel,which was constructed from commercial phenolphthalein particles as a sacrificial *** relationship between the porosity of hydrogels and sensing performance of sensors was systematically ***,the wearable pressure sensor,featuring an optimized porosity of hydrogels,exhibits an ultrawide sensing capacity from 4.83 Pa to 250 k Pa(range-to-limit ratio of 51,760)and high sensitivity throughout high pressure ranges(0.7 kPa~(-1),120–250 kPa).The presence of chitosan endows these hydrogels with outstanding antibacterial performance against *** and ***,making them ideal candidates for use in wearable *** features allow for a practical approach to monitor full-range human motion using a single device with a simple structure.

关键词： porous hydrogels antibacterial performances wearable pressure sensors full-range human motion chitosan

Unveiling the rolling texture variations ofα-Mg phases in a dual-phase Mg-Li alloy

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Journal of Magnesium and Alloys 2024年第6期12卷 2557-2568页

作者： Xiaoyan Li Luyao Jiang Fei Guo Yanlong Ma hang Yu Qiuyu Chen Haiding liu Dingfei Zhang College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054China Chongqing Materials Research Institute Co. Ltd.Chongqing 400707China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

LZ91 Mg-Li alloy plates with three types of initial texture were rolled by 70%reduction at both room temperature and 200℃to explore the rolling texture formation ofα-Mg *** results showed that the rolling texture is largely affected by the initial *** the samples exhibited two main texture components as RD-split double peaks texture and TD-split double peaks texture after large strain *** intensity of the two texture components was strongly influenced by the initial orientation and rolling *** twinning altered the large-split non-basal orientation to a near basal one at low rolling *** basal orientation induced by twinning is unstable,which finally transmitted to the RD-split *** strong TD-split texture formed due to slip-induced orientation transition from its initial *** competition between prismatic and basal slip determined the intensity and tilt angle of the TD-split *** increasing the rolling temperature,the TD-split texture component was enhanced in all three *** of extension twinning behavior and the promotion of prismatic slip at elevated temperature are the main reasons for the difference in hot and cold rolling texture.

关键词： Magnesium-lithium alloys Rolling texture Extension twinning Slip competition

High-performance si/VO_(2)-nanorod heterojunction photodetector based on photothermoelectric effect for detecting human radiation

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Rare Metals 2024年第3期43卷 1177-1185页

作者： Fu-Hai Guo Lan-Zhong Hao Wei-Zhuo Yu si-Qi Li Guan-Chu liu Jing-Yi Hao Yun-Jie liu College of Science China University of PetroleumQingdao266580China School of Materials Science and Engineering China University of PetroleumQingdao266580China

As a typical candidate of optoelectronic materials,vanadium dioxide(VO_(2))has wide applications in photodetectors(PDs),but is still challenging in largely enhancing the photodetecting performance for low-power human ***,high-performance si/VO_(2)nanorods(NRs)heterojunction PDs based on the photothermoelectric(PTE)effect are *** uniform VO_(2)-NRs array films were deposited on si by using magnetron sputtering technique,and a si/VO_(2)heterojunctions were *** device exhibits a four-stage photoresponse and broadband photoresponse from ultraviolet to long-wavelength *** from the unique nanorods structure and the strong PTE effect,the fabricated device exhibits a large enhancement of the photodetecting performance,showing an ultrahigh photodetectivity of 1.6×10^(13)Jones and ultrafast response rates with a risingedge time of~65.0μs,three orders of magnitude higher than other VO_(2)-based ***,the device exhibits unique abilities to detect human radiation even when the human fingers are far away from the device surface up to 10.0 ***,the fabricated si/VO_(2)devices can also be applied as breath sensors to distinguish different breathing *** results supply an effective route to design high-performance photodetectors toward detecting human thermal radiation and respiration.

关键词： Vanadium dioxide Heterojunction Photodetector Photothermoelectric Human radiation and respiration sensing

MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer

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Research 2024年第2期2023卷 239-257页

作者： Cui Wang Kuan Yang Xiaoqian liu si Wang Moshi Song Juan Carlos Izpisua Belimonte Jing Qu Guang-Hui liu Weiqi Zhang CAS Key Laboratory of Genomic and Precision Medicine Beijng Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China sino-Danish College University of Chinese Academy of SciencesBeijing 101408China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Bejing 100101China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ ***,we asked whether the mitochondrial antiviral signaling protein(MAVS),which is essential for driving antiviral response,also regulates human stem cell *** answer this question,we used CRISPR/Cas9-mediated gene editing and directed differentiation techniques to generate various MAVS-knockout human stem cell *** found that human mesenchymal stem cells(hMSCs)were sensitive to MAVS deficiency,as manifested by accelerated senescence *** uncovered that the role of MAVS in maintaining mitochondrial structural integrity and functional homeostasis depends on its interaction with the guanosine triphosphatase optic atrophy type 1(OPA1).Depletion of MAVS or OPA1 led to the dysfunction of mitochondria and cellular senescence,whereas replenishment of MAVS or OPA1 in MAVS-knockout hMSCs alleviated mitochondrial defects and premature senescence *** together,our data underscore an uncanonical role of MAVS in safeguarding mitochondrial homeostasis and antagonizing human stem cell senescence.

关键词： CRISPR/Cas9 homeostasis Mitochondrial