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Enhancing the outcomes of diabetic vitrectomy with pharmacological adjuvants

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World Journal of Methodology 2025年第2期15卷 15-20页

作者： Chun-Yao cheng wen-Rui Hao Tzu-Hurng cheng Department of Ophthalmology Cathay General HospitalTaipei 10633TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404328TaiwanChina

This editorial offers insights from a minireview by Venkatesh et al,who explored pharmacological adjuvants for diabetic ***,they synthesized current knowledge and evaluated the efficacy of various adjunctive therapies in improving the outcomes of diabetic retinopathy and managing associated ***,we highlight the key roles of pharmacological adjuvants in optimizing surgical techniques,minimizing intraoperative challenges,and enhancing postoperative *** further discuss the potential implications of this approach for clinical practice and future research directions in this evolving ***,this editorial underscores the importance of incorporating pharmacological adjuvants into standard diabetic vitrectomy care to improve surgical outcomes and thus patients’quality of life.

关键词： Diabetic vitrectomy Pharmacological adjuvants Surgical outcomes Diabetic retinopathy Clinical implications

Improving postoperative outcomes in patients with pancreatic cancer:Inflammatory and nutritional biomarkers

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World Journal of Clinical Oncology 2025年第1期16卷 59-64页

作者： Chun-Han cheng wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic *** et al evaluated the ability of seven biomarkers to predict postoperative recovery and long-term *** biomarkers were albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,nutritional risk index,and geriatric nutritional risk *** PNI was found to be a strong predictor of both overall and recurrence-free survival,underscoring its clinical relevance in managing patients with pancreatic cancer.

关键词： Pancreatic cancer Prognostic nutritional index Systemic immune-inflammation index Postoperative recovery Prognosis

Unveiling mitochondrial mysteries:Exploring novel tRNA variants in type 2 diabetes mellitus

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World Journal of Diabetes 2025年第1期16卷 1-6页

The recent study of Ding et al provides valuable insights into the functional implications of novel mitochondrial tRNATrp and tRNASer(AGY)variants in type 2 diabetes mellitus(T2DM).This editorial explores their findings,highlighting the role of mitochondrial dysfunction in the pathogenesis of *** examining the molecular mechanisms through which these tRNA variants contribute to disease progression,the study introduces new targets for therapeutic *** discuss the broader implications of these results,emphasizing the importance of understanding mitochondrial genetics in addressing T2DM.

关键词： Mitochondrial tRNA variants Type 2 diabetes mellitus Mitochondrial dysfunction Genetic markers Therapeutic strategies

The circadian clock affects starvation resistance through the pentose phosphate pathway in silkworm,Bombyx mori

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Insect Science 2025年第1期32卷 55-68页

作者： Tai-Ming Dai Jian-Feng Qiu cheng Luo wen-Zhao Cui Kai Liu Jiang-Lan Li Ruji Peng Yang-Hu sima Shi-Qing Xu School of Life Sciences Suzhou Medical College of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Agricultural Biotechnology&Ecology(IABE) Soochow UniversitySuzhouJiangsu ProvinceChina

Disruption of the circadian clock can affect starvation resistance,but the molecular mechanism is still ***,we found that starvation resistance was significantly reduced in the core gene BmPer deficient mutant silkworms(Per−/−),but the mutant's starvation resistance increased with larval *** natural physiological conditions,the weight of mutant 5th instar larvae was significantly increased compared to wild type,and the accumulation ability of triglycerides and glycogen in the fat bodies was ***,under starvation conditions,the weight consumption of mutant larvae was increased and cholesterol utilization was *** analysis showed that beta-oxidation was significantly upregulated under starvation conditions,fatty acid synthesis was inhibited,and the expression levels of genes related to mitochondrial function were significantly *** investigations revealed that the redox balance,which is closely related to mitochondrial metabolism,was altered in the fat bodies,the antioxidant level was increased,and the pentose phosphate pathway,the source of reducing power in cells,was *** findings suggest that one of the reasons for the increased energy burden observed in mutants is the need to maintain a more robust redox balance in metabolic *** necessitates the diversion of more glucose into the pentose phosphate pathway to ensure an adequate supply of reducing power.

关键词： Bombyx mori circadian clock oxidative stress pentose phosphate pathway starvationresistance

China's Yangtze River drought: A cascade of impacts from mountains to sea

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Science China Earth Sciences 2025年第3期68卷 957-962页

作者： Nan JIA Jie cheng Yinshuai LI Lilin ZHENG wen SONG Ruishan CHEN Annah ZHU Center for Systems Integration and Sustainability Part of College of Agriculture and Natural Resources Michigan State University School of Design Shanghai Jiao Tong University School of Geographic Sciences East China Normal University Wageningen University

1. Introduction With record heatwaves and low precipitation, in 2022 the Yangtze River basin experienced its most severe drought since 1961(Lyu et al., 2023). Meanwhile, it also hosted the most severe heatwave recorde...

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Advancing treatment strategies:Insights from network meta-analysis of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 252-255页

作者： Chun-Han cheng wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan City 33305TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404328TaiwanChina

This study examines the pivotal findings of the network meta-analysis of Zhou et al,which evaluated the efficacy of hepatic arterial infusion chemotherapy and combination therapies for advanced hepatocellular carcinoma(HCC).This meta-analysis suggests that therapeutic combinations have greater efficacy than do standard *** article highlights the key insights that have the potential to shift current clinical practice and enhance outcomes for patients with advanced ***,this article discusses further research that can be conducted to optimize these treatments and achieve personalized care for patients with HCC.

关键词： Hepatic arterial infusion chemotherapy Advanced hepatocellular carcinoma Combination therapy Network meta-analysis Treatment efficacy

Radiomics and molecular analysis:Bridging the gap for predicting hepatocellular carcinoma prognosis

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World Journal of Clinical Cases 2025年第4期13卷 56-60页

This editorial examines a recent study that used radiomics based on computed tomography(CT)to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2(EZH2)and its correlation with the survival of patients with hepatocellular carcinoma(HCC).By integrating radiomics with molecular analysis,the study presented a strategy for accurately predicting the expression of EZH2 from CT *** findings demonstrated a strong link between the radiomics model,EZH2 expression,and patient *** noninvasive approach provides valuable insights into the therapeutic management of HCC.

关键词： Hepatocellular carcinoma Computed tomography Radiomics Enhancer of zeste homologue 2 expression Non-invasive imaging

Investigations of inelastic cross sections of H_(2)O molecule by He^(2+) and C^(6+) projectiles with energy range around the Bragg peak

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Nuclear Science and Techniques 2025年第2期36卷 141-154页

作者： Guo-Zhuang Li cheng-Ye Sun Rui cheng Yan-Shi Zhang Liang-wen Chen Sheng Zhang Xin-Xia Li Lei Yang School of Nuclear Science and Technology University of South ChinaHengyang 421001China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Interdisciplinary Center for Fundamental and Frontier Sciences Nanjing University of Science and TechnologyJiangyin 214443China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Inelastic collisions are the dominant cause of energy loss in *** the energy range around the Bragg peak,single ionization(si)and single-electron capture(SC)are the primary inelastic collisions that lead to energy *** study employs the classical trajectory Monte Carlo method to study the si and SC processes of H_(2)O molecules using He^(2+) and C^(6+) projectiles in the energy range of 10 keV/u to 10 MeV/*** total cross sections,single differential cross sections,impact parameter dependence of si and SC,and fragmentation cross sections were *** illustrate that the cross section for si is the highest when the projectile energy is close to the Bragg peak *** the projectile energy is below the Bragg peak energy,the ionized electrons in the forward direction dominate,and the removal of electrons can be associated with large impact *** the projectile energy increases,the emission angle of the electrons gradually transitions from small angles(60°~120°)to large angles(60°~120°),and the removal of electrons is associated with small impact *** energy distributions of the ionized electron are similar when the projectile energy is equal to,below or above the Bragg peak *** fragmentation cross sections after si and SC in the energy range around the Bragg peak were also estimated.

关键词： Classical trajectory Monte Carlo Heavy ion-water molecule collision Inelastic cross sections

Positron annihilation study of defect formation and evolution in matrix graphite under He ion irradiation

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Nuclear Science and Techniques 2025年第1期36卷 13-21页

作者： Hong-Xia Xu Jian-Dang Liu Bang-Jiao Ye Zi-wen Pan Jun Lin Jin-Liang Song Jian-Qing Cao Chao Yan Ying-Ping Hao Jin-Xing cheng Qing-Bo Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025China Beijing Institute of High Technology Beijing 100094China

The stability of matrix graphite under neutron irradiation and in corrosive environments is crucial for the safe operation of molten salt reactors(MSRs).Raman spectroscopy and a slow positron beam were employed to investigate the effects of He ion irradiation fluences and subsequent annealing on the microstructure and defects of the matrix *** ions with 500 keV energy and fluences ranging from 1.1×10^(15)ions∕cm^(2)to 3.5×10^(17)ions∕cm^(2)were used to simulate neutron irradiation at 300 *** samples with an irradiation fluence of 3.5×10^(16)ions∕cm^(2)were subjected to isochronal annealing at different temperatures(573 K,873 K and 1173 K)for 3 *** Raman results revealed that the D peak gradually increased,whereas the intrinsic G peak decreased with increasing irradiation *** the same irradiation fluence,the D peak gradually decreased,whereas the intrinsic G peak increased with increasing annealing *** positron beam analysis demonstrated that the density or size of irradiation defects(vacancy type)increased with higher irradiation fluence,but decreased rapidly with increasing annealing *** Raman spectral analysis of sample cross sections subjected to high irradiation fluences revealed the emergence of amorphization precisely at the depth where ion damage was most pronounced,whereas the surface retained its crystalline *** and positron annihilation analyses indicated that the matrix graphite exhibited good irradiation resistance to He ions at 300 ***,vacancy-type defects induced by He ion irradiation exhibit poor thermal stability and can be easily removed during annealing.

关键词： Graphite Positron annihilation Irradiation Raman spectrum