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Efficacy of the WINROP algorithm for retinopathy of prematurity screening in Southern China

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 127-132页

作者： Yi-chen Bai Rong Wu si-zhe chen Shi-Yu Wei Hui-Jie chen Yan-chen chen Song-Fu Feng Xiao-He Lu Department of Ophthalmology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282Guangdong ProvinceChina Department of Ophthalmology Liuzhou People’s HospitalLiuzhou 545006Guangxi Zhuang Autonomous RegionChina Department of Pediatric Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282Guangdong ProvinceChina

AIM:To evaluate the predicting efficacy of severe retinopathy of prematurity(ROP)by the WINROP algorithm(http://***)in Southern ***:All preterm infants with the gestational age(GA)less than 32 wk were *** ROP screening results and serial postnatal body weight were analysed *** body weight was entered into and measured by the WINROP *** outcomes were analysed,and the sensitivity,specificity,positive predictive value and negative predictive value(NPV)were ***:Totally 432 infants with a median GA of 30.0(24.0-31.9)wk,and a median birth weight(BW)of 1360(540-2700)g were *** these 432 infants,50 were diagnosed as type 1 ROP but only 28 were identified by the WINROP *** sensitivity was 56%(28/50)and the NPV was 92%(252/274).However,for infants with BWsitivity was 93.8%(15/16)and 93.3%(14/15),***,with several postnatal complications added as additional risk factors,the sensitivity was increased to 96%(48/50).CONCLUsiON:The sensitivity of the WINROP algorithm from the Southern Chinese cohort is not as high as that reported in developed *** algorithm is effective for detecting severe ROP from extremely small or preterm *** of the algorithm with additional risk factors could improve the predictive value for infants with a GA>28 wk in China.

关键词： retinopathy of prematurity WINROP preterm infants

Beam based alignment using a neural network

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Nuclear Science and Techniques 2024年第4期35卷 108-118页

作者： Guan-Liang Wang Ke-Min chen si-Wei Wang zhe Wang Tao He Masahito Hosaka Guang-Yao Feng Wei Xu National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Diamond Light Source Oxfordshire OX110DEUK

Beams typically do not travel through the magnet centers because of errors in storage *** beam deviating from the quadrupole centers is affected by additional dipole fields due to magnetic field ***-based alignment(BBA)is often performed to determine a golden orbit where the beam circulates around the quadrupole center *** storage rings with many quadrupoles,the conventional BBA procedure is time-consuming,particularly in the commissioning phase,because of the necessary iterative *** addition,the conventional BBA method can be affected by strong coupling and the nonlinearity of the storage ring *** this study,a novel method based on a neural network was proposed to determine the golden orbit in a much shorter time with reasonable *** golden orbit can be used directly for operation or adopted as a starting point for conventional *** method was demonstrated in the HLS-II storage ring for the first time through simulations and online *** results of the experiments showed that the golden orbit obtained using this new method was consistent with that obtained using the conventional *** development of this new method and the corresponding experiments are reported in this paper.

关键词： Golden orbit Beam-based alignment Neural network Storage ring

Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu zhe-chen Gao Huan Wang Shi-Xuan chen Yuan Xiong Guo-Hui Liu si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

Hepatoprotective effects of Xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism

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World Journal of Hepatology 2024年第7期16卷 1051-1066页

作者： Xiao-Li Mei Shu-Yi Wu si-Lan Wu Xiao-Lin Luo si-Xing Huang Rui Liu zhe Qiang Department of Pharmacology and Toxicology Sichuan-Chongqing Joint Key Laboratory of New Chinese Medicine Creation LaboratoryChongqing Academy of Chinese Materia MedicaChongqing 400061China College of Chinese Medicine Chongqing College of Traditional Chinses MedicineChongqing 402760China Department of Oncology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China College of Pharmacy Chongqing Medical UniversityChongqing 400010China

BACKGROUND The modified Xiaoyao San(MXS)formula is an adjuvant drug recommended by the National Health Commission of China for the treatment of liver cancer,which has the effect of preventing postoperative recurrence and metastasis of hepatocellular carcinoma and prolonging patient ***,the molecular mechanisms underlying that remain *** To investigate the role and mechanisms of MXS in ameliorating hepatic injury,steatosis and *** A choline-deficient/high-fat diet-induced rat nonalcoholic steatohepatitis(NASH)model was used to examine the effects of MXS on lipid accumulation in primary *** tissues were collected for western blotting and immunohisto chemistry(IHC)*** accumulation and hepatic fibrosis were detected using oil red staining and sirius red *** serum samples were collected for biochemical assays and NMR-based metabonomics *** inflammation/lipid metabolism-related signaling and regulators in liver tissues were also detected to reveal the molecular mechanisms of MXS against *** MXS showed a significant decrease in lipid accumulation and inflammatory response in hepatocytes under metabolic *** western blotting and IHC results indicated that MXS activated AMPK pathway but inhibited the expression of key regulators related to lipid accumulation,inflammation and hepatic fibrosis in the pathogenesis of *** metabonomics analysis systemically indicated that the arachidonic acid metabolism and steroid hormone synthesis are the two main target metabolic pathways for MXS to ameliorate liver inflammation and hepatic ***,we found that MXS protected against NASH by attenuating the sex hormone-related metabolism,especially the metabolism of male *** MXS ameliorates inflammation and hepatic steatosis of NASH by inhibiting the metabolism of male *** male hormone related metabolic pathways may be the potential therapeutic app

关键词： Hepatic steatosis Inflammation Sex hormone metabolism Male hormone Phosphatase and tensin homolog deleted on chromosome ten

Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases

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Acta Pharmaceutica sinica B 2024年第6期14卷 2773-2785页

作者： Meng Wang Wen-Wei Li zhe Cao Jianong Sun Jiang Xiong si-Qin Tao Tinghong Lv Kun Gao Shangwen Luo Shi-Hui Dong State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China

Although sulfonation plays crucial roles in various biological processes and is frequently utilized in medicinal chemistry to improve water solubility and chemical diversity of drug leads,it is rare and underexplored in ribosomally synthesized and post-translationally modified peptides(RiPPs).Biosynthesis of RiPPs typically entails modification of hydrophilic residues,which substantially increases their chemical stability and bioactivity,albeit at the expense of reducing water *** explore sulfonated RiPPs that may have improved solubility,we conducted co-occurrence analysis of RiPP class-defining enzymes and sulfotransferase(ST),and discovered two distinctive biosynthetic gene clusters(BGCs)encoding both lanthipeptide synthetase(LanM)and *** expressing these BGCs,we characterized the structures of novel sulfonated lanthipeptides and determined the catalytic details of LanM and *** demonstrate that SslST-catalyzed sulfonation is leader-independent but relies on the presence of A ring formed by *** LanM and ST are promiscuous towards residues in the A ring,but ST displays strict regioselectivity toward *** recognition of cyclic peptide by ST was further *** evaluation underscores the significance of the ST-catalyzed *** study sets up the starting point to engineering the novel lanthipeptide STs as biocatalysts for hydrophobic lanthipeptides improvement.

关键词： Lanthipeptides Sulfotransferases Sulfonation Biosynthesis Genome mining

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仿制药评价逻辑研究

中国临床药理学杂志 2024年第18期40卷 2739-2742页

作者：陈思黄哲沈阳药科大学工商管理学院辽宁沈阳110016

目的分析美国食品药品监督管理局(FDA)发布的仿制药具体产品指南(PSGs),对仿制药评价逻辑进行研究,旨在对我国仿制药评价的思路及技术指南体系的建立提供借鉴。方法通过查询FDA官方网站,汇总截至2022-08-31已发布的2032篇仿制药PSGs,识... 详细信息

目的分析美国食品药品监督管理局(FDA)发布的仿制药具体产品指南(PSGs),对仿制药评价逻辑进行研究,旨在对我国仿制药评价的思路及技术指南体系的建立提供借鉴。方法通过查询FDA官方网站,汇总截至2022-08-31已发布的2032篇仿制药PSGs,识别具体产品的活性成分名称、剂型、给药途径、推荐的生物等效性(BE)研究要求及研究方法等信息,分析FDA对不同给药途径、不同剂型、不同复杂程度的仿制产品的不同的评价要求。结果与结论本文提出了仿制药的评价逻辑,即仿制药的评价过程为基于产品特性,通过与参比制剂进行科学的比较试验进行风险控制,降低剩余风险至可接受的风险水平的过程。

关键词：仿制药评价方法仿制药具体产品指南生物等效性评价逻辑

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当前基层治理共同体构建的方向与路径

中南民族大学学报（人文社会科学版） 2024年第7期44卷 108-116,185,186页

作者：陈思张瑞哲湖北省社会科学院政法研究所湖北武汉430062

基层治理是国家治理的基石,是实现国家治理体系和治理能力现代化的基础工程。在相当长时期内,“行政吸纳社会”的基层治理模式很大程度上抑制了社会组织、社区、公民等治理主体积极性的发挥。近年来,我国基层治理主体不断丰富,基层自治... 详细信息

基层治理是国家治理的基石,是实现国家治理体系和治理能力现代化的基础工程。在相当长时期内,“行政吸纳社会”的基层治理模式很大程度上抑制了社会组织、社区、公民等治理主体积极性的发挥。近年来,我国基层治理主体不断丰富,基层自治能力提升,基层治理放权赋能的趋势明显。实践中,社会治理权力在纵向上下沉,权力分配机制不断适应现实运行的需要。为更好适配基层治理方式的转变,放权赋能的治理路向应通过治理资源的再分配、治理责任的明晰、治理结构的调适等方式,激活治理要素,激发和强化基层多元治理主体自我价值,推动基层社会治理共同体构建,提升基层治理效能。

关键词：治理共同体行政吸纳放权赋能基层治理

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富氮多环含能离子盐的合成和性能

含能材料 2024年第6期32卷 623-630页

作者：王喆尹平庞思平北京理工大学材料学院北京100081

以多氨基稠环化合物6,7-二氨基-3亚氨基-[1,2,4]三唑并[1,2,4]三唑连四唑(TATOT-T)为原料,经过高锰酸钾氧化偶联和高氯酸成盐等步骤,合成了一种偶氮桥联的富氮多环含能化合物2,2′-二四唑基-3,6-二氨基-7,7′-偶氮基-[1,2,4]三唑并[1,2... 详细信息

以多氨基稠环化合物6,7-二氨基-3亚氨基-[1,2,4]三唑并[1,2,4]三唑连四唑(TATOT-T)为原料,经过高锰酸钾氧化偶联和高氯酸成盐等步骤,合成了一种偶氮桥联的富氮多环含能化合物2,2′-二四唑基-3,6-二氨基-7,7′-偶氮基-[1,2,4]三唑并[1,2,4]三唑高氯酸盐(2)。采用傅里叶红外光谱、核磁共振、元素分析、X-射线单晶衍射技术,以及差示扫描量热法(DSC)和热重分析(TG)对化合物2进行结构表征和热性能分析,结合高斯软件计算的生成焓,使用EXPLO5软件计算了其爆轰性能。结果表明,所得化合物2晶体属于单斜晶系,晶体密度为1.750 g·cm^(-3),每个晶胞中包含4个分子,起始热分解温度为232.6℃,理论爆速为8373 m∙s-1,爆压为29.05 GPa,撞击感度为40 J,摩擦感度为360 N,对外界机械刺激钝感,具有良好综合性能。

关键词：富氮含能化合物偶氮桥联四唑稠环稳定性

Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： Zhao-Yuan Wu si-Wei Chi Liu-Jian Ouyang Xiao-Qin Xu Jing-Nan chen Bing-Han Jin Rahim Ullah Xue-Lian Zhou Ke Huang Guan-Ping Dong zhe-Ming Li Ying Shen Jie Shao Yan Ni Jun-Fen Fu Qiang Shu Wei Wu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China Department of Data and Information Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large nu... 详细信息

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(sical examinations in the Department of Pediatric *** applied the least mean square algorithm to establish age-and sex-related reference percentiles of serum levels of *** validation,we recruited 4276 children and adolescents with obesity/overweight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(Psitive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(P<0.01).According to the receiver operating characteristic curves,ALT levels at the 92.58th percentile for boys and the 92.07th percentile for girls yielded the highest accuracy and *** This study provides age-and sex-specific reference ranges for ALT,aspartate aminotransferase,andγ-glutamyltransferase in Chinese children and adolescents,making it the largest population study to ***,the study establishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases