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Insulin receptor is implicated in triple-negative breast cancer by decreasing cell mobility

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The Journal of Biomedical Research 2021年第3期35卷 189-196页

作者： ying Yang xiang Chen Changyan Ma Department of Medical Genetics School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Department of General Surgery the Affiliated Yixing Hospital of Jiangsu UniversityYixingJiangsu 214200China

Triple-negative breast cancer(TNBC)has a poor prognosis and typically earlier onset of metastasis in comparison with other breast cancer *** has been reported that insulin receptor(INSR)is downregulated in TNBC,however,its clinical significance and functions in TNBC remain to be *** this study,we found that INSR expression was significantly downregulated in TNBC,and overexpression of INSR suppressed cell migration and invasion in *** addition,the survival rate of breast cancer patients with low INSR expression was lower than that of patients with high INSR *** expression was significantly correlated with lymph node metastasis,clinical tumor stages,ER status,PR status,and the proliferation index Ki-67 *** summary,our study suggests that INSR may serve as a biomarker for breast cancer prognosis and it may be a potential target for TNBC treatment.

关键词： insulin receptor triple-negative breast cancer migration invasion prognosis

MRI联合血清SDF-1、NDRG4诊断卵巢癌的应用价值

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中国CT和MRI杂志 2025年第1期23卷 137-139页

作者：王静静李莹相世峰邯郸市中心医院CT室河北邯郸056000

目的分析磁共振成像(MRI)联合血清基质细胞衍生因子-1(SDF-1)、N-myc下游调节因子4(NDRG4)诊断卵巢癌的应用价值。方法选取2021年11月至2023年11月本院收治的96例经病理学确诊的卵巢癌患者即为卵巢癌组,同期收治确诊为卵巢良性肿瘤患... 详细信息

目的分析磁共振成像(MRI)联合血清基质细胞衍生因子-1(SDF-1)、N-myc下游调节因子4(NDRG4)诊断卵巢癌的应用价值。方法选取2021年11月至2023年11月本院收治的96例经病理学确诊的卵巢癌患者即为卵巢癌组,同期收治确诊为卵巢良性肿瘤患者96例为对照组。采用酶联免疫吸附试验(ELISA)法检测血清中SDF-1、NDRG4水平;血清SDF-1、NDRG4对卵巢癌的诊断价值绘制ROC曲线。采用四格表检测MRI联合血清SDF-1、NDRG4对卵巢癌的诊断价值。结果与对照组相比,卵巢癌组患者血清中SDF-1水平显著升高, NDRG4水平显著降低(P<0.05)。卵巢癌患者血清SDF-1、NDRG4水平与TNM分期、琳巴结转移、分化程度、 CA125相关(P<0.05)。血清SDF-1、NDRG4联合诊断卵巢癌发生的AUC显著高于单独诊断的AUC值(Z_(SDF-1~SDF-1+NDRG4)=2.084,P=0.037;Z_(NDRG4~SDF-1+NDRG4)=2.570,P=0.010)。MRI联合血清SDF-1、NDRG4检测诊断卵巢癌的敏感性低于单一指标,特异性高于单一指标。结论卵巢癌患者血清中SDF-1高表达、NDRG4低表达, MRI联合血清SDF-1、NDRG4检测能够提高对卵巢癌的诊断效能。

关键词：磁共振成像基质细胞衍生因子-1 N-myc下游调节因子4 卵巢癌诊断

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Substituent Effects on the Hydrogen Bonding Between Phenolate and HF, H_2O and NH_3

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Chemical Research in Chinese Universities 2002年第3期18卷 348-353页

作者： FANG ying LIU Lei GUO Qing xiang Department of Chemistry University of Science and Technology of ChinaHefei 230026P.R.China

B3LYP/6 31+g( d ) calculations were performed on the hydrogen bonded complexes between substituted phenolates and HF, H 2O as well as NH 3. It was found that some properties of the non covalent complexes, including the interaction energies, donor acceptor (host guest) distances, bond lengths, and vibration frequencies, could show well defined substituent effects. Thus, from the substituent studies we can not only understand the mechanism of a particular non covalent interaction better, but also easily predict the interaction energies and structures of a particular non covalent complex, which might otherwise be very hard or resource consuming to be known. This means that substituent effect is indeed a useful tool to be used in supramolecular chemistry and therefore, many valuable studies remain to be carried out.

关键词： Noncovalent interaction Hydrogen bonding Substituent effect Density function theory

sintilimab-induced autoimmune diabetes:A case report and review of the literature

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World Journal of Clinical Cases 2022年第4期10卷 1263-1277页

作者： Jing Yang ying Wang xiang-Min Tong Clinical Laboratory Center Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina Clinical Research Institute Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina Department of Hematology Clinical Trial InstituteZhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND With the widespread application of immune checkpoint inhibitor(ICI)therapy,the number of immune-related adverse effects(irAEs)has increased over the *** diabetes mellitus(DM)is a rare irAEs of ICIs and can be troublesome and life *** SUMMARY We report a 78-year-old woman with no history of diabetes who presented with hyperglycemia up to 23.4 mmol/L(random blood glucose level)after 14 courses of *** A1c was 8.2%,fasting insulin was 0.29 mIU/mL,and fasting C-peptide was decreased to a level with negative *** her medical history and laboratory examination,she was diagnosed with programmed cell death(PD)-1-inhibitor-induced,new-onset autoimmune *** controlling her blood glucose,she was treated with daily insulin by subcutaneous *** was allowed to continue anti-PD-1 therapy and she still obtained some therapeutic *** also reviewed some published cases(n=36)of PD-1/PD-ligand 1(PD-L1)inhibitor-induced *** also discuss potential pathogenic mechanisms,clinical features,prognostic markers(βcell antibodies,human leukocyte antigen type,PD-L1 Level)of this rare adverse *** It is important for all clinicians to be aware of DM as an irAEs of ICIs.

关键词： sintilimab Immune related adverse effects Small cell lung cancer Autoimmune diabetes Case report

Structures and Properties of Two Pillared-layer Mn(Ⅱ) MOFs with 5-Ethyl-pyridine-2,3-dicarboxylate

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Chinese Journal of Structural Chemistry 2019年第9期38卷 1600-1608页

作者： TANG Long SHI De-Qian WANG ying-Lu YIN si-Yu WANG Ji-Jiang HOU xiang-Yang Yan’an University Key Laboratory of New Energy & New Functional Materials Yan’an University Department of Chemistry and Chemical EngineeringShaanxi Key Laboratory of Chemical Reaction Engineering

The reaction of Mn(OAc)2·4 H2 O, 5-ethyl-pyridine-2,3-dicarboxylic acid(H2 epda) and 4,4?-bipyridine(4,4?-bipy)/4,4?-bis(imidazolyl)biphenyl)(bibp) under hydrothermal conditions produced two new manganese(Ⅱ) MOFs [Mn(epda)(4,4?-bipy)1/2](1) and [Mn(epda)(bibp)1/2](2), which were characterized by elemental analysis, infrared spectroscopy, thermogravimetric analyses, and single-crystal X-ray diffraction. The structures of complexes 1 and 2 are similar. In 1, the adjacent Mn(Ⅱ) ions are connected by epda dianion to generate a 2 D(4,4) grid layer, and such 2 D layers are further connected via bibp ligand to form another layer, forming a 2 D pillared-layer. Topologically, the Mn atoms as the node are bridged by the edpa anions and bibp ligands to form a uninodal 5-connected network topology. The magnetic properties of 1 and 2 have also been-investigated, and the exchange interctions were –1.39 and –1.05 cm1, respectively. According to the crystal structures, compounds 1 and 2 were carried out by using hybrid DFT methods at the B3 LYP/6-31 G(d) level. The DFT-BS approach was applied to study the magnetic coupling behaviors for 1 and 2. The result reveals that the calculated exchange coupling constants J were in good agreement with the experimental data.

关键词： Mn(Ⅱ)-MOFs 5-ethyl-pyridine-2,3-dicarboxylate magnetic properties DFT studies

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基于荧光光谱和拉曼光谱技术的中药检测研究

光谱学与光谱分析 2025年第1期45卷 139-145页

作者：逯美红张凡暴雅婷王志军雷海英王翔宇高鹏慧长治学院物理系山西长治046011 西安信息职业大学物理实验中心陕西西安710125 长治学院生命科学系山西长治046011

中医药是中华文化的瑰宝和中华文明的结晶,在全民健康中发挥着重要作用。由于中药生长环境受限及市场需求量的增大,市场上出现了许多以次充好、以假乱真的中药,这对中药发展及质量保障都极为不利。因此,对中药的检测和鉴定非常重要。为... 详细信息

中医药是中华文化的瑰宝和中华文明的结晶,在全民健康中发挥着重要作用。由于中药生长环境受限及市场需求量的增大,市场上出现了许多以次充好、以假乱真的中药,这对中药发展及质量保障都极为不利。因此,对中药的检测和鉴定非常重要。为了探究中药的荧光光谱和拉曼光谱特性,选取白芷、苏木、山药、地榆四种中药进行分类检测研究。一方面,从化学成分和结构的角度分析中药白芷和苏木产生荧光的可能性,采用F-4600型荧光光谱仪(200~750 nm)分别在不同激发波长和不同浓度下测试了白芷和苏木水浸液的荧光光谱,探究了白芷和苏木水浸液的荧光光谱特性,并对荧光强度与不同浓度、激发波长的关系进行了探讨。另一方面,采用共聚焦显微拉曼光谱仪(100~4000 cm^(-1))对4种不同产地的山药和2种不同产地的地榆中药饮片的拉曼光谱分别进行测试研究。结果表明,白芷水浸液在波长260~350 nm的光激发下,产生较强荧光,最佳激发波长是340 nm,荧光峰值波长为420 nm,其荧光强度随浓度的增大而增强,且样品浓度较低时,荧光强度与浓度成线性关系;苏木水浸液在200~290 nm的光激发下,产生较强荧光,最佳激发波长为220 nm,荧光峰值波长为345 nm,随浓度的增加,荧光强度先增强后减弱,在浓度为0.175 mg·mL^(-1)时荧光强度达到最大。白芷水浸液和苏木水浸液的荧光强度都与激发波长的关系呈现高斯分布,符合荧光规律。分析山药和地榆的拉曼光谱,发现不同产地的拉曼特征基本一致,确认山药的拉曼特征峰主要集中在477、862、939、1080、1258、1337和1457 cm^(-1)处;地榆的拉曼特征峰主要集中在862和1337 cm^(-1)处,主要归属与已有的化学成分研究结果相符。部分特征峰处拉曼活性出现差异,可以作为区分不同产地中药的依据。该研究结果不仅为荧光光谱在中药鉴定及质量分析中的应用提供了实验数据和方法参考,也为利用拉曼光谱技术实现中药的快速准确检测及产地归属奠定了基础。

关键词：白芷苏木山药地榆荧光光谱拉曼光谱

Controlled Growth and Cathodoluminescence Property of ZnS nanobelts with Large Aspect Ratio

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Nano-Micro Letters 2010年第4期2卷 272-276页

作者： xiang Wu ying Lei Yufeng Zheng Fengyu Qu College of Chemistry and Chemical Engineering Harbin Normal University Center for Biomedical Materials and Engineering Harbin Engineering University

ZnS nanobelts with large aspect ratio are successfully synthesized on a large scale through thermally evaporating of ZnS powder with a trace of SnO_2 powder using gold coated si wafer as the substrate at 1100°*** results indicate that the as-obtained ZnS nanobelts are about 10 nm in thickness and hundreds of micrometers in length,and the aspect ratio reaches more than *** dependent experiments are conducted to better study the growth mechanism of the ZnS ***,optical properties of the as-synthesized ZnS nanobelts are also investigated by using a cathodoluminescence(CL) system,which shows the existence of a strong ultraviolet emission at 342 nm and two poor emission peaks at 522 nm and 683 nm at room temperature,respectively.

关键词： Semiconductor ZnS Nanobelts Cathodoluminescence

High performance lithium oxygen batteries based on a phosphorous-doped holey graphene cathode

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Rare Metals 2022年第12期41卷 4027-4033页

作者： ying Meng Jia-Kui Zhang Hai-ying Lu xiang-Hong Chen Jian-Tie Xu National Engineering Laboratory for VOCs Pollution Control Technology and Equipment Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution ControlSchool of Environment and EnergySouth China University of TechnologyGuangzhou 510640China

The sluggish electrochemical kinetics of cathode is one of the critical issues for the development of high performance lithium oxygen batteries(LOBs).Graphene-based materials have attracted great attentions as advance... 详细信息

关键词： lithium performance kinetics

Re-reddening on Strip Surface After Water Cooling

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Journal of Iron and Steel Research International 2007年第3期14卷 26-29,55页

作者： ZHI ying LIU xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

After water cooling, there is a big temperature difference between the center and the surface of strip, which leads to the heat transfer from the center to the surface, and the surface temperature can rise in a short time. The finite element method was used to simulate the phenomena of re-reddening on the surface of strip and to analyze the temperature field of hot roiled strip during laminar cooling, and the periodical variation curve of the cooling rate was obtained during water cooling and subsequent re-reddening. The results show that the critical line of the cooling rate is at 1/3 of the half-thickness from the strip surface. The regression model of the relation of rereddening temperature, time, and distance from the surface was obtained in the re-reddening region. Re-reddening regularity on the surface of strip under the condition of different thickness and cooling rate was also studied.

关键词： temperature field re-reddening laminar cooling cooling rate hot rolled strip finite element method