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Treatment dilemmas of cetuximab combined with chemotherapy for metastatic colorectal cancer

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World Journal of Gastroenterology 2016年第23期22卷 5332-5341页

作者： feng Wen Qiu Li Department of Medical Oncology Cancer CenterState Key Laboratory of BiotherapyWest China HospitalSichuan University

Although monoclonal antibodies(m Abs) against epidermal growth factor receptor(EGFR) have largely enriched the available therapeutic choices for colorectal cancer(CRC), the understanding and management of their associated clinical toxicities are limited. In addition, the combined strategies of administering EGFR m Abs and traditional cytotoxic agents, such as 5-fluorouracil, oxaliplatin and irinotecan, have resulted in a more complicated management of CRC treatment-related side effects compared with EGFR m Ab monotherapy. We believe that a thorough recognition of the toxicities of EGFR m Ab drugs is essential for physicians to increase the therapeutic index in the treatment of CRC. This review aims to summarize the existing information regarding the treatment dilemmas of cetuximab combined with chemotherapy in the management of metastatic CRC.

关键词： Cetuximab Colorectal cancer Metastatic Toxicity Chemotherapy

Water droplets play a role in Internet of Things applications

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Droplet 2024年第3期3卷 27-48页

作者： feng Wen Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore i-Lab Key Laboratory of Multifunctional Nanomaterials and Smart SystemsSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)SuzhouChina NUS Graduate School—Integrative Sciences and Engineering Programme(ISEP) National University of SingaporeSingapore

Water droplets help life in nature survive,thrive,and *** water droplet serv-ing as one of the indispensable elements in the Internet of Things(IoT),many droplet-oriented technologies,such as microfluidics,droplet manipulation,electrowetting,and energy harvesting,make rapid progress driven by material science,computer science,and ***-based wearable devices are endowed with advantages such as flexibility,sensing ability,and automation for various parameter ***,the continuous exploration of droplet manipulation has led to the emergence of a wide variety of manipulation ***,electrowetting that utilizes exter-nal fields modifying liquid–solid surfaces has found its applications in various areas,including droplet transportation,microfabrication,and *** energy gener-ation from water droplets also presents exciting opportunities for the development of novel electricity *** approaches for droplet utilization underscore the immense potentials and versatilities of droplet-based technologies in the IoT ***,this mini review presents the fundamental droplet-based technologies by summarizing their working mechanisms and methods,device structures,and *** the challenges in materials,fabrication,and system integration,this review shows the overall development roadmap in terms of improved functionality and performance and highlights the opportunities toward multifunctional,self-sustainable,and intelligent systems,which is called for IoT construction.

关键词： IoT utilize fabrication

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虚拟货币洗钱风险及其控制研究

金融理论与实践 2021年第8期 79-87页

作者：冯怡中国人民银行济南分行山东济南250021

虚拟货币交易快捷方便、匿名性的特点被犯罪分子利用成为洗钱新手段。虚拟货币洗钱问题引起FATF及各国金融监管部门的高度关注。我国禁止虚拟货币境内发行和交易,但境内主体仍通过互联网参与境外虚拟货币交易,而现行反洗钱运行体系对虚... 详细信息

虚拟货币交易快捷方便、匿名性的特点被犯罪分子利用成为洗钱新手段。虚拟货币洗钱问题引起FATF及各国金融监管部门的高度关注。我国禁止虚拟货币境内发行和交易,但境内主体仍通过互联网参与境外虚拟货币交易,而现行反洗钱运行体系对虚拟货币洗钱风险的有效控制仍有待提升。应借鉴国际经验,加强顶层设计,尽快完善虚拟货币反洗钱制度,将虚拟货币纳入反洗钱监管;明确有关机构的反洗钱职责,督促其认真履行反洗钱义务,有效控制虚拟货币的洗钱风险。

关键词：虚拟货币洗钱风险控制

Itinerant to relocalized transition of felectrons in the Kondo insulator CeRu_(4)Sn_(6)

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Frontiers of physics 2023年第5期18卷 153-160页

作者： Fan-ying Wu Qi-yi Wu Chen Zhang Yang Luo Xiangqi Liu Yuan-feng Xu Dong-Hui Lu Makoto Hashimoto Hao Liu yin-Zou Zhao Jiao-Jiao Song Ya-Hua Yuan Hai-Yun Liu Jun He Yu-Xia Duan Yan-feng Guo Jian-Qiao Meng School of Physics and Electronics Central South UniversityChangsha 410083China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China Stanford Synchrotron Radiation Lightsource SLAC National Accelerator LaboratoryMenlo ParkCA 94025USA Beijing Academy of Quantum Information Sciences Beijing 100085China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China

The three-dimensional electronic structure and the nature of Ce 4f electrons of the Kondo insulator CeRu_(4)Sn_(6)are investigated by angle-resolved photoemission spectroscopy,utilizing tunable photon *** results reveal(i)the three-dimensional k-space nature of the Fermi surface,(ii)the localized-to-itinerant transition of f electrons occurs at a much high temperature than the hybridization gap opening temperature,and(iii)the“relocalization”of itinerant f-electrons below 25 K,which could be the precursor to the establishment of magnetic order.

关键词： Kondo insulator heavy fermion ARPES electronic structure relocalization

High power diode-pumped passively mode-locked Nd:YVO_4 laser at repetition rate of 3.2 GHz

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Chinese Physics B 2019年第5期28卷 122-125页

作者： Meng-Yao Cheng Zhao-Hua Wang Yan-Fang Cao Xiang-Hao Meng Jiang-feng Zhu Jun-Li Wang Zhi-yi Wei School of Physics and Optoelectronic Engineering Xidian University Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Songshan Lake Materials Laboratory

A compact high power diode-pumped passively mode-locked Nd:YVO_4 laser with high repetition rate is *** an Nd:YVO_4 crystal and a semiconductor saturable absorber mirror(SESAM) in the oscillator, the picosecond pulse output with an average power of 1.38 W, a repetition rate of 3.24 GHz, and a pulse duration of 11.4 ps is achieved. After one stage of amplification, the final output power reaches 11.34 W, corresponding to a total optical-to-optical efficiency of about 32%. The root mean square(RMS) value of power fluctuation is demonstrated to be less than 0.6% in 24 hours,showing a superior stability with the compact configuration.

关键词： all-solid-state laser high repetition rate Nd:YVO4 laser mode-locked laser

Short-Term Traffic Flow Prediction Based on Road Network Topology

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Journal of Beijing Institute of Technology 2019年第3期28卷 383-388页

作者： feng Jin Baicheng Zhao School of Automation Beijing Institute of Technology

Accurate short-term traffic flow prediction plays a crucial role in intelligent transportation system (ITS), because it can assist both traffic authorities and individual travelers make better decisions. Previous researches mostly focus on shallow traffic prediction models, which performances were unsatisfying since short-term traffic flow exhibits the characteristics of high nonlinearity, complexity and chaos. Taking the spatial and temporal correlations into consideration, a new traffic flow prediction method is proposed with the basis on the road network topology and gated recurrent unit (GRU). This method can help researchers without professional traffic knowledge extracting generic traffic flow features effectively and efficiently. Experiments are conducted by using real traffic flow data collected from the Caltrans Performance Measurement System (PEMS) database in San Diego and Oakland from June 15, 2017 to September 27, 2017. The results demonstrate that our method outperforms other traditional approaches in terms of mean absolute percentage error (MAPE), symmetric mean absolute percentage error (SMAPE) and root mean square error (RMSE).

关键词： traffic flow prediction gated recurrent unit (GRU) intelligent transportation systems road network topology

Covariate-Assisted Matrix Completion with Multiple Structural Breaks

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Journal of Systems Science & Complexity 2024年第2期37卷 692-728页

作者： MENG Jing feng Long ZOU Changliang WANG Zhaojun School of Statistics and Data Science KLMDASRLEBPSand LPMCNankai UniversityTianjin 300071China

In matrix completion,additional covariates often provide valuable information for completing the unobserved entries of a high-dimensional low-rank matrix *** this paper,the authors consider the matrix recovery problem when there are multiple structural breaks in the coefficient matrix β under the column-space-decomposition model A=Xβ+B.A cumulative sum(CUSUM)statistic is constructed based on the penalized estimation of β.Then the CUSUM is incorporated into the Wild Binary Segmentation(WBS)algorithm to consistently estimate the location of ***,a nearly-optimal recovery of A is *** findings are further corroborated via numerical experiments and a real-data application.

关键词： Additional covariates matrix completion multiple structural breaks wild Binary Segmentation

Tradeoff between heating energy demand in winter and indoor overheating risk in summer constrained by building standards

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Building simulation 2021年第4期14卷 987-1003页

作者： Ran Wang Shilei Lu Wei feng Bowen Xu School of Environment Science and Engineering Tianjin University92 Weijin RoadTianjin300072China Tianjin Key Laboratory of Built Environment and Energy Application Tianjin UniversityTianjin300350China Lawrence Berkeley National Laboratory BerkeleyCA94720USA

Evidence indicates that improvement of thermal performance of building envelope has the potential for aggravating the indoor overheating risk in summer. On the other hand, evolving building standards continue to strengthen the requirements for thermal performance to achieve the energy-saving target. Therefore, this study quantifies the interaction effect between building standards-oriented building design, heating energy demand in winter, and indoor overheating risk in summer. Building databases with different energy efficiency levels are generated using a randomly generated method. Uncertain variables include not only 13 design parameters but also the running state of natural ventilation and external shading. The indoor overheating risk is assessed in terms of severity and duration. Finally, a multi-objective optimization model integrating metamodels and the non-dominated sorting genetic algorithm is proposed to balance heating energy demand in winter and indoor overheating risk in summer. Results indicate that building standards tend to aggravate overheating risk in summer: the duration and severity of high-performance buildings increased by 40.6% and 24.2% than that of conventional-performance buildings. However, window ventilation could offset the adverse effect, and mitigation of duration and severity can be up to 85.2% and 62.1% for high-performance buildings. Window ventilation can weaken the conflict between heating energy demand in winter and overheating risk in summer. As heating energy demand increased from 6.1 to 67.3 kWh/m^(2), the overheating risk changes little that the duration of overheating risk decreased from 17.5% to 15.6% and severity decreased from 8.7 ℃ to 8.3 ℃.

关键词： climate change indoor overheating risk energy codes building design natural ventilation

High-order targeted essentially non-oscillatory scheme for two-fluid plasma model

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Applied Mathematics and Mechanics(English Edition) 2023年第6期44卷 941-960页

作者： Yuhang HOU Ke JIN Yongliang feng Xiaojing ZHENG School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Institute of Extreme Mechanics Northwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of Space Extreme Detection Xi’an 710071China Research Center for Applied Mechanics Xidian UniversityXi’an 710071China

The weakly ionized plasma flows in aerospace are commonly simulated by the single-fluid model,which cannot describe certain nonequilibrium phenomena by finite collisions of particles,decreasing the fidelity of the *** on an alternative formulation of the targeted essentially non-oscillatory(TENO)scheme,a novel high-order numerical scheme is proposed to simulate the two-fluid plasmas *** numerical flux is constructed by the TENO interpolation of the solution and its derivatives,instead of being reconstructed from the physical *** present scheme is used to solve the two sets of Euler equations coupled with Maxwell's *** numerical methods are verified by several classical plasma *** results show that compared with the original TENO scheme,the present scheme can suppress the non-physical oscillations and reduce the numerical dissipation.

关键词： plasma high-order scheme targeted essentially non-oscillatory(TENO)scheme two-fluid model