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Journal of Hainan Medical University 2020年第4期26卷 33-39页

作者： Yuan-Ming Zhong Tong Wan Bing-Kun He si-xian wu Xi-Feng Zhong Zhuo-Tan wu Department of Orthopedics(Spinal Surgery) the First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023China Graduate School Guangxi University of Chinese MedicineNanning 530001China

Objective:A meta-analysis was performed to evaluate the difference of curative effect of Huoxue huayu Chinese medicine compound combined with intervertebral pore lens in the treatment of lumbar disc ***:CNKI,VIP,CBM,PubMed and Web of Science were searched by computer and included in the clinical trial data about the treatment of lumbar disc herniation by the Huoxue huayu Chinese medicine compound and intervertebral pore *** were extracted and Cochrane system was used to evaluate the quality of the *** system in ReMan 5.1 was used to evaluate the publication bias and Stata 12.0 was used for meta ***:A total of 1039 patients were included in 16 articles,including 519 patients in the treatment group and 520 patients in the control *** results showed that the total effective rate of the treatment group was higher than that of the control group(RR=1.20,95%CI(1.11,1.30),Psion:Huoxue huayu Chinese medicine compound and intervertebral pore lens can improve the clinical effect and is worth ***,due to the poor quality of the literature,more high-quality double-blind randomized controlled trials with large samples are needed.

关键词： Huoxue huayu Chinese medicine compound Intervertebral pore lens Lumbar disc herniation Meta-analysis

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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自激式电感耦合等离子体光源设计及光谱分析

光谱学与光谱分析 2025年第1期45卷 66-71页

作者：卢思贤龙开红詹陈锐李明北方工业大学电气与控制工程学院北京100144 益阳职业技术学院电子与信息工程学院湖南益阳413055

电感耦合等离子体(ICP)光谱仪是一种应用范围很广的元素分析仪,主要用于元素定性与定量的分析。ICP光源是光谱仪的核心部件,它在光谱仪中扮演着至关重要的角色。目前主流的ICP光源有两种:自激式和他激式,各自具有优缺点。他激式光源电... 详细信息

电感耦合等离子体(ICP)光谱仪是一种应用范围很广的元素分析仪,主要用于元素定性与定量的分析。ICP光源是光谱仪的核心部件,它在光谱仪中扮演着至关重要的角色。目前主流的ICP光源有两种:自激式和他激式,各自具有优缺点。他激式光源电路复杂、体积庞大、阻抗匹配速度较慢、最大输出功率有限。设计了一种基于镀金工艺的高功率MOSFET和变频实现阻抗匹配的自激式ICP光源,该光源采用射频放大和阻抗匹配一体化的设计,把从负载线圈采样的频率信号f_(1)以及功率放大电路放大后的频率相位f_(0)进行相位比较,再根据两者相位差的变化,进而控制频率的变化,实现阻抗匹配;设计上采用了镀金工艺的金属化硅N通道型高功率的MOSFET实现功率放大,具有更大的功率密度、更小的体积,最大输出功率超过2400 W。对研制的ICP光源进行了电学静态测试,给出了鉴相器、压控振荡器以及功率的输出特性,验证了各电路在相应工作状态下的性能表现;同时结合光谱仪进行了包含Ba、Na和Li元素标准溶液的测试,获得了目标元素的光谱信号;另外,对获得的光谱信号进行了处理,使用了基于EEMD特征增强的方法对目标元素光谱信号进行有效增强,信号的线性决定系数(R^(2))从0.97降至0.99,相对标准偏差(RSD)从6.47%降至1.07%,增强了信号的准确性和可用性。本文所研制的自激式ICP光源,通过射频放大和阻抗匹配一体化设计缩小了体积,变频技术使阻抗匹配速度从毫秒级提升到纳秒级,镀金工艺的MOSFET技术使最大输出功率从原来的1800 W增加到2400 W,为ICP光源的进一步优化和应用奠定了基础,具有重要的科学研究和工程实践意义。

关键词：自激式ICP光源阻抗匹配光谱信号 EEMD算法

Functionalized Copolymers of Isobutylene with Vinyl Phenol: Synthesis,Characterization, and Property

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Chinese Journal of Polymer Science 2019年第9期37卷 919-929页

作者： Shi-Xuan Yang Zi-Yu Fan Feng-Yu Zhang si-Hao Li Yi-xian wu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology

The random copolymers of isobutylene (IB) with polar comonomers of 4-acetoxystyrene (ACS) or 4-tert-butoxystyrene (TBO), P(IB-co-ACS) and P(IB-co-TBO), could be successfully synthesized via cationic copolymerization with FeCh-based initiating system. The kinetics of the cationic copolymerization process was in situ investigated by inserting a diamond probe into the reaction system by ATR-FTIR spectroscopy. The chemical structure and incorporation content of polar comonomers in the copolymers were characterized by GPC with RI/UV dual detectors and 1H-NMR spectroscopy. The corresponding functionalized random copolymers of IB with vinyl phenol P(IB-co-POH) carrying phenolic hydroxyl side groups could be further prepared via the complete hydrolysis of acetoxyl side groups in P(IB-co-ACS) or tert-butoxyl side groups in P(IB-co-TBO) copolymers. The functionalized P(IB-co-POH) copolymers became hydrophilic with water contact angle (WCA) of ca. 80° for the self-assembly in hot water, compared to the hydrophobic polyisobutylene with WCA of ca. 110°. The functionalized P(IB-co-POH) copolymers also displayed an excellent self-healing property due to the interaction of intermolecular hydrogen bonding and formation of three dimentional supramolecular networks from phenolic hydroxyl side groups. Furthermore, P(IB-co-POH) copolymers also provided a good matrix for the homogeneous dispersion for silica nanoparticles due to the formation of hydrogen bonding between copolymer chains and silica nanoparticles.

关键词： Cationic polymerization Isobutylene Copolymers Polar monomer Functionalized polyisobutylenes

Safety Control of a Class of Fully Actuated Systems Subject to Uncertain Actuation Dynamics

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Journal of Systems Science & Complexity 2022年第2期35卷 543-558页

作者： wu si LIU Tengfei State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110004China

Safety is an essential requirement for control ***,controlled mobile robots are subject to safety constraints,to which control laws in typical forms may not be directly *** paper employs barrier function to describe safety constraints,analyzes the interaction between the barrier function and the uncertain actuation dynamics by employing the ideas of interconnected systems,and proposes a quadratic-programming-based integration of the control algorithms subject to the safety constraint for a class of fully actuated systems.

关键词： Dynamic uncertainties fully-actuated systems safety control

Fractional Cooling Strategy of the Hot-Stamping Process and Its Influence on Formability and Mechanical Properties of Ultra-High-Strength Steel Parts

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Acta Metallurgica sinica(English Letters) 2019年第3期32卷 343-351页

作者： xian-Hong Han Cheng-Long Wang si-si Chen Jun Chen Department of Plasticity Technology School of Materials Science and Engineering Shanghai Jiao Tong University SAIC General Motors Co. Ltd

The effects of forming temperature on the formability and product properties of hot-stamping boron steel B1500HS were investigated. Based on the fractional cooling strategy, boron steel sheets were heated to achieve full austenitization before they were removed from the furnace and cooled to the forming temperature using different cooling methods. Subsequently,they were simultaneously press-formed and quenched inside the tool until the martensitic transformation was finished. A series of thermal tensile tests were conducted to study the effects of forming temperatures on the stamping performance indices, including elongation, yield ratio, and hardening exponent. Then, the mechanical properties and microstructures of the hot-stamped products were characterized. Finally, an irregular part was formed using different fractional cooling strategies, while its formability and springback phenomena were discussed. The results show that using a fast-cooling method to reach 650 °C as the forming temperature optimizes the formability of the tested B1500HS boron steel. The best mechanical properties and smallest springback values were achieved using this optimal strategy.

关键词： Hot-stamping Fractional cooling Forming temperature Formability

N-soliton solutions for the nonlocal two-wave interaction system via the Riemann–Hilbert method

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Chinese Physics B 2018年第12期27卷 157-163页

作者： si-Qi Xu xian-Guo Geng School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China College of Civil Engineering Xinyang Normal UniversityXinyang 464000China

In this paper, a nonlocal two-wave interaction system from the Manakov hierarchy is investigated via the Riemann–Hilbert approach. Based on the spectral analysis of the Lax pair, a Riemann–Hilbert problem for the nonlocal two-wave interaction system is constructed. By discussing the solutions of this Riemann–Hilbert problem in both the regular and nonregular cases, we explicitly present the N-soliton solution formula of the nonlocal two-wave interaction system. Moreover,the dynamical behaviour of the single-soliton solution is shown graphically.

关键词： nonlocal two-wave interaction system Riemann–Hilbert problem N-soliton solutions

single-cell profiling lights different cell trajectories in plants

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aBIOTECH 2021年第1期2卷 64-78页

作者： Hong-xiang Zheng Feng-hui wu si-min Li xian Sheng Zhang Na Sui Shandong Provincial Key Laboratory of Plant Stress College of Life SciencesShandong Normal UniversityJi’nan 250014ShandongChina State Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai’an 271018ShandongChina

The molecular mechanism of the maintenance and differentiation of plant stem cells is an eternal theme in studies on plant growth and *** advances in single-cell RNA sequencing(scRNAseq)methods have completely changed the understanding of cell heterogeneity and cell function,allowing research precision to identify the differentiation trajectory of stem cells maintained and differentiated at the cellular *** review aimed to mainly discuss the novel insights provided by scRNA-seq for the maintenance and initiation of plant stem cells,cell differentiation,cell response to environmental changes,and improvement strategies for *** addition,it highlighted additional perspectives beyond scRNA-seq,such as spatial transcriptomes,epigenomes,and single-cell multiomics,for a renewed understanding of stem cell maintenance and cell differentiation,thus providing potential targets and theoretical foundations for crop improvement.

关键词： Epigenomes Plant development Plant stem cells single-cell multi-omics single-cell RNA sequencing

Highly Cis-1,4 Selective Polymerization of Conjugated Dienes Catalyzed by ^-heterocyclic Carbene-ligated Neodymium Complexes

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Chinese Journal of Polymer Science 2020年第12期38卷 1305-1312页

作者： Shu Zhang Na wu Yi-xian wu State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Neodymium complexes containing N heterocyclic carbene(NHC)ligands,NdCl5[1,3,R(NCH=)2C]-THF,(Nd1:R=2,6-Pr2C6H3,x=0;Nd2:R=2,6-Et2C6H3,x=1;Nd3:R=2.4,6-Me3C6H2,x=1)were synthesized and employed as precatalysts for the coordination polymerization of conjugated dienes(butadiene and isoprene).In combination with trisobutylaluminium(TIBA),Nd1 promoted butadiene polymerization to produce extremely high cis-1,4(up to 99.0%)polybutadienes with high molecular weight(Mw=250-780 kg·mol 1).The Nd1/TIBA catalytic system also exhibited both high catalytic activity and cis-1,4 selectivity(up to 97.8%)for isoprene *** catalytic activity,molecular weight and molecular weight distribution of resulting polydienes were directly influenced by Al/Nd molar ratio,aging method,and polymerization *** interestingly,the high cis-1,4 selectivity of the catalyst towards butadiene and isoprene kept almost unchanged under different reaction *** cis-1,4 polyisoprenes with high molecular weight(Mw=210-530 kg·mol 1)and narrow molecular weight distribution (Mw/Mn=1.9-2.7)as well as high cis-1.4 selectivity(-~97%)could be synthesized by using the aged Nd1/TIBA catalytic system in the presence of isoprene(100 equivalent to Nd)at low AlNd molar ratios of *** with low molecular weights(Mw=12-76 kg·mol-7)and narrow molecular weight distributions (Mw/Mn=1.7-2.6)were obtained by using Nd2 and Nd3 as precatalysts,indicating that the molecular weight of resulting polyisoprenes can be adjusted by changing the substitutes of ligand in Nd complex.

关键词： Neodymium complex N heterocydic carbene igand Coordination polymerization Cis-14 sletivity Aging method

Uniqueness of the Infinite Open Cluster for High-density Percolation on Lattice sierpinski Carpet

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Acta Mathematica sinica,English Series 2001年第1期17卷 141-146页

作者： xian Than wu Department of Mathematics Capital Normal University

We prove the uniqueness of infinite open cluster for high-density bond percolation on lattice sierpinski Carpet; forthermore, an alternative proof of the existence of phase transition of the model is given. A rescalin... 详细信息

关键词： Lattice sierpinski Carpet Infinite open cluster FKG Inequality Rescaling