检索结果-南通市图书馆

Optimal design of hot rolling process for C-Mn steel by combining industrial data-driven model and multi-objective optimization algorithm

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2018年第7期25卷 700-705页

作者： si-wei wu Xiao-guang Zhou Jia-kuang Ren Guang-ming Cao Zhen-yu Liu Nai-an Shi State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110819 Liaoning China Continuous Rolling Plant of No. 3 Steelmaking of Angang Co. Ltd. Anshan 114021 Liaoning China

A successful mechanical property data-driven prediction model is the core of the optimal design of hot rolling process for hot-rolled strips. However, the original industrial data, usually unbalanced, are inevitably mixed with fluctuant and abnormal values. Models established on the basis of the data without data processing can cause misleading results, which cannot be used for the optimal design of hot rolling process. Thus, a method of industrial data processing of C-Mn steel was proposed based on the data analysis. The Bayesian neural network was employed to establish the reliable mechanical property prediction models for the optimal design of hot rolling process. By using the multi-objective optimization algorithm and considering the individual requirements of costumers and the constraints of the equipment, the optimal design of hot rolling process was successfully applied to the rolling process design for Q345B steel with 0.017% Nb and 0.046% Ti content removed. The optimal process design results were in good agreement with the industrial trials results, which verify the effectiveness of the optimal design of hot rolling process.

关键词： Industrial data Data processing - Mechanical property Optimal design Hot rolling process C-Mn steel

Environmentally friendly expanded graphite-doped ZnO superhydrophobic coating with good corrosion resistance in marine environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2023年第9期42卷 3075-3087页

作者： si-wei wu Quan-Tong Jiang Shuai Yuan Qing-Kun Zhao Chang Liu Heng Tang Qiang Sun Ji-Zhou Duan Bao-Rong Hou Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou510301China CAS Key Laboratory of Marine Environmental Corrosion and Bio-Fouling Institute of OceanologyChinese Academy of SciencesQingdao266071China Sanya Institute of Ocean Eco-Environmental Engineering Sanya572000China University of Chinese Academy of Sciences Beijing100049China Open Studio for Marine Corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266071China

Designing and fabricating the marine anti-corrosion materials without fluorine by superhydrophobic method is a huge challenge. In this study, an environmentally friendly composite coating was prepared by combing modified expanded graphite(EAG) with nano zinc oxide(ZnO). This coating showed superhydrophobic surface and good corrosion resistance. Fourier transform infrared spectroscopy(FITR), X-ray diffraction(XRD),and scanning electron microscopy(SEM) were used to characterize the materials in fabricating process of the coating. The properties of three composite coatings(ZnO,EAG, and EAG@ZnO) were analyzed, including surface roughness, water contact angle, corrosion resistance, selfcleaning and anti-fouling. The combination of ZnO and EAG caused a big water contact angle, leading superhydrophobic surface of the composite coatings. The electrochemical results showed that the superhydrophobic EAG@ZnO coating had a larger capacitive arc diameter and charge transfer resistance, indicating the enhanced anti-corrosion resistance. Meanwhile, the EAG@ZnO coating also showed good self-cleaning and anti-fouling performance according to solid and liquid pollutants *** addition, the mechanical properties and stability of the superhydrophobic EAG@ZnO coatings were evaluated by knife peeling and finger scratch tests. In summary, these superhydrophobic and anti-fouling EAG@ZnO composite coatings provide a potential application in marine corrosion and protection field.

关键词： Coating Superhydrophobic Anti-corrosion Anti-fouling Environmentally friendly

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen Zhen wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da wu Hai-Feng Zhou wei Yang Di Zhu Bi-Fei wu Hai-Bin Shi Sheng Liu wei-Zhong Zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

Cauda equina syndrome with urinary retention as a postoperative complication of lumbar spine surgery:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第10期13卷 40-45页

作者： Kai-wu Yang wei-Hong Lai Da-wei Huang Department of Urology Chiayi Christian HospitalChiayi 600566Taiwan Department of Neurosurgery Chiayi Christian HospitalChiayi 600566Taiwan

BACKGROUND Cauda equina syndrome(CES)is characterized by a group of symptoms that may be caused by inflammation,spinal cord compression,venous congestion,or *** syndrome is commonly an indication for surgical intervention but has not been determined as a postoperative complication following surgery for lumbar spine *** SUMMARY To report the case of a 54-year-old male patient who had CES following spinal surgery,with no obvious compression lesions found during re-exploration,suggesting that vascular insufficiency may have contributed to the ***,a series of urodynamic studies on bladder recovery patterns in such complications have also been *** Postoperative CES requires urgent imaging and exploration to rule out compression;noncompressive cases,including vascular insufficiency may performed conservative management.

关键词： Cauda equina syndrome Lumbar spine surgery Urinary retention Urodynamic study Postoperative complication Case report

Risk factors for developing osteoporosis in diabetic kidney disease and its correlation with calcium-phosphorus metabolism,FGF23,and Klotho

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2025年第1期16卷 49-57页

作者： Fan Yang Yan wu wei Zhang Department of Endocrinology Wuhu Second People's HospitalWuhu 241000Anhui ProvinceChina Department of Nephrology Wuhu Second People's HospitalWuhu 241000Anhui ProvinceChina

BACKGROUND The progression of diabetic kidney disease(DKD)affects the patient’s kidney glomeruli and tubules,whose normal functioning is essential for maintaining normal calcium(Ca)and phosphorus(P)metabolism in the *** risk of developing osteoporosis(OP)in patients with DKD increases with the aggravation of the disease,including a higher risk of fractures,which not only affects the quality of life of patients but also increases the risk of *** To analyze the risk factors for the development of OP in patients with DKD and their correlation with Ca-P metabolic indices,fibroblast growth factor 23(FGF23),and *** One hundred and fifty-eight patients with DKD who were admitted into the wuhu Second People’s Hospital from September 2019 to May 2021 were selected and divided into an OP group(n=103)and a normal bone mass group(n=55)according to their X-ray bone densitometry *** data and differences in Ca-P biochemical indices,FGF23,and Klotho were *** correlation of Ca-P metabolic indices with FGF23 and Klotho was discussed,and the related factors affecting OP in patients with DKD were examined by multivariate logistic regression *** The OP group had a higher proportion of females,an older age,and a longer diabetes mellitus duration than the normal group(all Psignificantly higher levels of intact parathyroid hormone(iPTH),blood P,Ca-P product(Ca×P),fractional excretion of phosphate(FeP),and FGF23,as well as lower estimated glomerular filtration rate,blood Ca,24-hour urinary phosphate excretion(24-hour UPE),and Klotho levels(all Psitively correlated with *** contrast,iPTH,blood Ca,Ca×P,and FeP exhibited a positive correlation with FGF23 and an inverse association with Klotho(all P<0.05).Moreover,25-(OH)-D3,iPTH,blood Ca,FePO4,FGF23,Klotho,age,and female gender were key fa

关键词： Diabetic kidney disease Osteoporosis Calcium-phosphorus metabolism FGF23 Klotho

Clinical effects of phospholipase D2 in attenuating acute pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-wei Niu Guo-Chao Zhang wu Ning Hai-Bin Liu Hua Yang Chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(Psion level of PLD2 in the moderate group was also lower than that in the mild group(Psion(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(Psion levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

混杂纤维混凝土弯曲韧性评价体系

土木工程与管理学报 2017年第2期34卷 19-24页

作者：夏冬桃熊思慧吴伟波余阳湖北工业大学土木建筑与环境学院湖北武汉430072

根据纤维总体积掺量为1%的混杂纤维混凝土四点弯曲试验和切口梁弯曲试验的荷载–挠度曲线、韧性指数I_n和纤维混凝土能量吸收值D_n等计算指标,结合试验力学模型以及弯曲韧性评价指标的含义,对两种试验方法下荷载–挠度曲线的精密度进行... 详细信息

根据纤维总体积掺量为1%的混杂纤维混凝土四点弯曲试验和切口梁弯曲试验的荷载–挠度曲线、韧性指数I_n和纤维混凝土能量吸收值D_n等计算指标,结合试验力学模型以及弯曲韧性评价指标的含义,对两种试验方法下荷载–挠度曲线的精密度进行方差分析;对混杂纤维混凝土的韧性指数I_n、纤维混凝土能量吸收值D_n的离散程度进行统计分析。研究表明:对于低掺量混杂纤维混凝土而言,四点弯曲试验与切口梁弯曲试验的荷载–挠度曲线的精密度一致;采用纤维混凝土能量吸收值D_n作为弯曲韧性评价指标,其离散程度较小,所需要的试件数量较少,通过等效抗弯拉强度f_(eq1)、f_(eq2)可以建立弯曲韧性指标与强度指标之间的联系;选用切口梁法的试验方式和纤维混凝土能量吸收值D_n更适宜于低掺量混杂纤维混凝土弯曲韧性研究,有利于以韧性为基础的结构设计方法的发展。

关键词：混杂纤维混凝土韧性指数能量吸收值方差分析离散系数

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang Jian wu Hui Hong wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon