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Chinese Chemical Letters 2021年第2期32卷 918-922页

作者： Guangrui si Xiangjing kong Tao He wei Wu Linhua Xie Jianrong Li Beijing Key Laboratory for Green Catalysis and Separation and Department of Environmental Chemical Engineering Beijing University of TechnologyBeijing 100124China

By taking the functional adva ntages of both pyrazolate and carboxylate ligands,a unique dual-functional pyrazolate-carboxylate ligand acid,4-(3,6-di(pyrazol-4-yl)-9-carbazol-9-yl)benzoic acid(H3PCBA) was designed and *** it,a new Co(Ⅱ)-based metal-organic framework(MOF),Co_(3)(PCBA)_(2)(H_(2)O)_(2)(BUT-75) has been *** revealed a(3,6)-connected net based on the 6-connected linear trinuclear metal node,and showed good chemical stability in a wide pH range from 3 to 12 at room temperature,as well as in boiling *** to the presence of rich exposed Co(Ⅱ) sites in pores,BUT-75 presented high selective CO_(2) adsorption capacity over N2 at 298 ***,it demonstrated fine catalytic performance for the cycloaddition of CO_(2) with epoxides into cyclic carbonates under ambient *** work has not only enriched the MOF community through integrating diverse functio nalities into one ligand but also contributed a versatile platform for CO_(2) fixation,thereby pushing MOF chemistry forward by stability enhancement and application expansion.

关键词： Metal-organic framework(MOF) Pyrazolate-carboxylate ligand Construction CO_(2)selective adsorption CO_(2)fixation

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan weicheng kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

Etoposide Induces Mitochondria-Associated Apoptotic Cell Death in Human Gastric Carcinoma Cells

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Chemical Research in Chinese Universities 2008年第5期24卷 597-602页

作者： LI Jing-hua CHEN Yue WANG Jia-si kong wei JIN Ying-hua Key Laboratory for Molecular Enzymology and Engineering Ministry of Education College of Life Science School of Public Health Jilin University Changchun 130012 P R. China

Recent observations indicate that the resistance of apoptosis is an important process of tumor metastasis and metastases are the cause of 90% of human cancer death. Etoposide, a semisynthetic derivative of the podophyllotoxins, is a clinically used anti-cancer reagent, but the effects of it on metastatic gastric carcinoma cells are totally unknown. In this study, etoposide induced apoptotic cell death in human gastric adenocarcinoma cell line SGC-7901, derived from metastatic lymph nodes, as evidenced by the analysis of DNA fragmentation, apoptotic body formation, caspase activation, and apoptosis specific changes in cell morphology is demonstrated. The depolarization of mitochondrial membrane and the release of cytochrome c were most early events in etoposide treated SGC-7901 cells, and were followed by caspase-3 activation and PARP cleavage. Caspase-8 activation was not detected under the same condition. Thus, it was proposed that etoposide induces caspase-associated apoptotic cell death in human metastatic gastric carcinoma, which is initiated by mitochondrial cytochrome c release.

关键词： Apoptosis Caspase Cytochrome c Etoposide SGC-7901 cells

Global instability of Stokes layer for whole wave numbers

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Applied Mathematics and Mechanics(English Edition) 2016年第8期37卷 999-1012页

作者： wei kong Jisheng LUO Department of Mechanics Tianjin University

The study on the global instability of a Stokes layer, which is a typical unsteady flow, is usually a paradigm for understanding the instability and transition of unsteady flows. Previous studies suggest that the neutral curve of the global instability obtained by the Floquet theory is only mapped out in a limited range of wave numbers （0.2 ≤ a ≤ 0.5）. In this paper, the global instability is investigated with numerical simulations for all wave numbers. It is revealed that the peak of the disturbances displays irregularity rather than the periodic evolution while the wave number is beyond the above range. A ＂neutral point＂ is redefined, and a neutral curve of the global instability is presented for the whole wave numbers with this new definition. This work provides a deeper understanding of the global instability of unsteady flows.

关键词： Stokes layer instantaneous instability Floquet theory neutral curve

GPS: graph contrastive learning via multi-scale augmented views from adversarial pooling

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Science China(Information Sciences) 2025年第1期68卷 145-158页

作者： wei JU Yiyang GU Zhengyang MAO Ziyue QIAO Yifang QIN Xiao LUO Hui XIONG Ming ZHANG School of Computer Science National Key Laboratory for Multimedia Information ProcessingPeking University Artificial Intelligence Thrust The Hong Kong University of Science and Technology Department of Computer Science University of California

Self-supervised graph representation learning has recently shown considerable promise in a range of fields, including bioinformatics and social networks. A large number of graph contrastive learning approaches have shown promising performance for representation learning on graphs, which train models by maximizing agreement between original graphs and their augmented views(i.e., positive views). Unfortunately, these methods usually involve pre-defined augmentation strategies based on the knowledge of human experts. Moreover, these strategies may fail to generate challenging positive views to provide sufficient supervision signals. In this paper, we present a novel approach named graph pooling contrast(GPS) to address these *** by the fact that graph pooling can adaptively coarsen the graph with the removal of redundancy, we rethink graph pooling and leverage it to automatically generate multi-scale positive views with varying emphasis on providing challenging positives and preserving semantics, i.e., strongly-augmented view and weakly-augmented view. Then, we incorporate both views into a joint contrastive learning framework with similarity learning and consistency learning, where our pooling module is adversarially trained with respect to the encoder for adversarial robustness. Experiments on twelve datasets on both graph classification and transfer learning tasks verify the superiority of the proposed method over its counterparts.

关键词： graph representation learning graph neural networks graph contrastive learning graph augmentations graph pooling

Theoretical uncertainties of(d,^(3)He)and(^(3)He,d)reactions owing to the uncertainties of optical model potentials

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Nuclear Science and Techniques 2023年第6期34卷 147-153页

作者： wei-Jia kong Dan-Yang Pang School of Physics Beihang UniversityBeijing100191China School of Physics and Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing100191China

The theoretical uncertainties of single proton transfer cross sections of the(^(3)He,d)and(d,^(3)He)reactions,owing to the uncertainties of the entrance-and exit-channel optical model potentials,are examined with the^(30)si(^(3)He,d)^(31)P,^(13)B(d,^(3)He)^(12)Be,and^(34)S(^(3)He,d)^(35)Cl reactions at incident energies of 25,46,and 25 MeV,respectively,within the framework of the distorted wave Born *** differential cross sections at the first peaks in the angular distributions of these reactions are found to have uncertainties of approximately 5%,owing to the uncertainties in the optical model potentials from 20,000 calculations of randomly sampled *** amount of uncertainty is found to be nearly independent of the angular momentum transfer and the target masses within the studied range of incident *** in the single proton spectroscopic factors obtained by matching the theoretical and experimental cross sections at different scattering angles are also discussed.

关键词： Proton transfer reactions Optical model potentials Spectroscopic factors

83例子宫内膜腺癌单纯放射治疗疗效及其影响因素分析

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肿瘤学杂志 2018年第2期24卷 119-124页

作者：焦思萌孔为民宋丹陈娇商若天赵轩宇韩超李凤霜刘婷婷首都医科大学附属北京妇产医院

[目的]分析单独放疗在子宫内膜腺癌治疗中的应用价值及影响疗效的因素;探讨以A点、F点为参照点进行子宫内膜癌单独放射治疗的可行性。[方法 ]回顾性分析83例单纯放射治疗的子宫内膜腺癌患者的临床资料。腔内治疗均应用铱-192腔内治疗机... 详细信息

[目的]分析单独放疗在子宫内膜腺癌治疗中的应用价值及影响疗效的因素;探讨以A点、F点为参照点进行子宫内膜癌单独放射治疗的可行性。[方法 ]回顾性分析83例单纯放射治疗的子宫内膜腺癌患者的临床资料。腔内治疗均应用铱-192腔内治疗机,体外照射应用钴-60体外照射治疗机,其中腔内治疗选取A点及F点为剂量参照点。对年龄、家族史、孕产次、体质指数、临床分期、组织学分级、宫腔深度等预后影响因素进行单因素分析及多因素分析。应用Kaplan-Meier方法计算5年生存率。[结果]83例应用单纯放射治疗患者的5年生存率为51.8%,其中Ⅰ期为70.8%,Ⅱ期为60.6%,Ⅲ期为23.1%。临床分期、组织学分级、宫腔深度（以8cm为界）对子宫内膜癌单独放疗预后影响有统计学意义（P〈0.05）。[结论]单纯放疗是子宫内膜癌可供选择的安全有效的治疗方法,尤其是临床分期为Ⅰ~Ⅲ期不能接受手术治疗的患者。但对于晚期、低分化以及宫腔深度〉8cm的子宫内膜癌患者,单纯放疗疗效欠佳,治疗方案尚需进一步改进。以A点及F点为参照点进行子宫内膜癌二维腔内治疗,方法简单、易于操作。

关键词：子宫内膜癌单纯放疗 A点 F点治疗效果

Analysis of relative error in detection caused by signal-induced noise in Na lidar system

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Science China Earth Sciences 2018年第1期61卷 109-118页

作者： ZHANG YunPeng YI Fan kong wei School of Electronic Information Wuhan University

signal-induced noise(siN) in a photomultiplier tube(PMT) introduces bias into the Na density results that are retrieved from the backscattered signals of Na resonance fluorescence lidar systems. The response characteristics of a PMT when stimulated by a series of light pulses with a fixed width of 1 μs are therefore used to develop a precise siN model to estimate the relative error caused by siN. Unless the strong signals that are returned from the lower atmosphere are excluded, the measured density results are always smaller than the actual values, and the resulting relative error may be 50% or more. Three potential solutions to reduce the siN were quantified for comparison, including use of a chopper system, use of a gated circuit, and separation of the laser beam and the telescope receiver. When optimized parameters are used for these technologies, the relative error can then be reduced to less than 2%.

关键词： Lidar signal-induced noise Photomultiplier tube

Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

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Science China Chemistry 2025年

作者： Jing-Wen Xie Meng-Ting Wang Yan Jin si Li Jian-Hua Qin Shuang-Quan Zang Tomas C.W.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

关键词：

Blind source separation of ship-radiated noise based on generalized Gaussian model

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Journal of Systems Engineering and Electronics 2006年第2期17卷 321-325页

作者： kong wei Yang Bin Information Engineering Coll. of Shanghai Maritime Univ. Shanghai 200135 China

When the distribution of the sources cannot be estimated accurately, the ICA algorithms failed to separate the mixtures blindly. The generalized Gaussian model （GGM） is presented in ICA algorithm since it can model non- Ganssian statistical structure of different source signals easily. By inferring only one parameter, a wide class of statistical distributions can be characterized. By using maximum likelihood （ML） approach and natural gradient descent, the learning rules of blind source separation （BSS） based on GGM are presented. The experiment of the ship-radiated noise demonstrates that the GGM can model the distributions of the ship-radiated noise and sea noise efficiently, and the learning rules based on GGM gives more successful separation results after comparing it with several conventional methods such as high order cumnlants and Gaussian mixture density function.

关键词： blind source separation (BSS) independent component analysis (ICA) generalized Gaussian model(GGM) maximum likelihood (ML).