检索结果-南通市图书馆

Acta Metallurgica sinica(English Letters) 2019年第3期32卷 343-351页

作者： Xian-Hong Han cheng-Long Wang si-si chen Jun chen Department of Plasticity Technology School of Materials Science and Engineering Shanghai Jiao Tong University SAIC General Motors Co. Ltd

The effects of forming temperature on the formability and product properties of hot-stamping boron steel B1500HS were investigated. Based on the fractional cooling strategy, boron steel sheets were heated to achieve full austenitization before they were removed from the furnace and cooled to the forming temperature using different cooling methods. Subsequently,they were simultaneously press-formed and quenched inside the tool until the martensitic transformation was finished. A series of thermal tensile tests were conducted to study the effects of forming temperatures on the stamping performance indices, including elongation, yield ratio, and hardening exponent. Then, the mechanical properties and microstructures of the hot-stamped products were characterized. Finally, an irregular part was formed using different fractional cooling strategies, while its formability and springback phenomena were discussed. The results show that using a fast-cooling method to reach 650 °C as the forming temperature optimizes the formability of the tested B1500HS boron steel. The best mechanical properties and smallest springback values were achieved using this optimal strategy.

关键词： Hot-stamping Fractional cooling Forming temperature Formability

Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer(BxPC-3) cells

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第40期20卷 14895-14903页

作者： Ru-Yi chen Bin Xu Su-Feng chen si-si chen Ting Zhang Jun Ren Jian Xu The College of Life Science Zhejiang Chinese Medical University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

AIM: To investigate the effect of oridonin on nuclear transcription factors and to study the relationship between biological behavior and inflammatory factors in human pancreatic cancer (BxPC-3) cells.

关键词： Pancreatic cancer Hallmarks Oridonin Inflammatory pathways Nuclear transcription factors

Comments on“Effect of type 2 diabetes mellitus in the prognosis of acute-on-chronic liver failure patients in China”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第14期28卷 1499-1502页

作者： Wei Wang chen-chen Pan Wen-Ying Zhao Jin-Yu Sheng Qi-Qi Wu si-si chen Department of Interventional Oncology Taizhou Municipal HospitalTaizhou 318000Zhejiang ProvinceChina School of Medicine Taizhou University Taizhou 318000Zhejiang ProvinceChina Department of Obstetrics and Gynecology Taizhou Women and Children’s Hospital of Wenzhou Medical UniversityTaizhou 318000Zhejiang ProvinceChina

A study addressing the influence of type 2 diabetes on the prognosis of acute-onchronic liver failure patients was *** statistical deficiencies were found in the reviewed article,and the sample size was too small to s... 详细信息

关键词： Type 2 diabetes mellitus Liver failure Complication Prognosis Age

Short-term Outcomes of Laparoscopic *** Hepatectomy for Primary Hepatocellular Carcinoma:A Prospective Comparative Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2019年第5期39卷 778-783页

作者： Li ZENG Min TIAN si-si chen Yu-ting KE Li GENG Sheng-li YANG Lin YE Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Laparoscopic hepatectomy(LH)is a newly developed technique associated with advantages as open surgery,but the study on outcome of liver function recovery was *** preliminary report was aimed to comparatively assess the short?term outcomes between LH and open hepatectomy(OH)for primary hepatocellular carcinoma(PHC).This study retrospectively analyzed the demographic data and short-term outcomes of 81 patients who underwent LH or OH for the primary treatment of PHC between Oct.2017 and May 2018 at Union Hospital,Tongji Medical College,Huazhong University of Science and Technology(China).A total of 81 PHC patients who received major liver resection were *** were 38(47%)patients in the LH group and 43(53%)patients in the OH *** operative time was significantly longer(373.53±173.38 vs.225.43±55.08,Psignificantly shorter in LH group than in OH *** recovery of liver function was significantly faster in LH group,including higher serum albumin(P=0.002),higher ratio of albumin/globulin(P=0.029)and lower direct bilirubin(P=0.001)than in OH *** is suggested that LH can serve as a fast recovery and cheap surgical procedure in the treatment of PHC,which is safe and feasible.

关键词： laparoscope open hepatectomy primary hepatocellular carcinoma short-term outcomes prospective comparative study

Comment“Asymptomatic small intestinal ulcerative lesions:Obesity and Helicobacter pylori are likely to be risk factors”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第10期28卷 1085-1087页

作者： Wei Wang Zhi-Peng Li Juan Zhang Zi-Jun Lin Mei-Lin Ma si-si chen Department of Interventional Oncology Taizhou Municipal HospitalTaizhou 318000Zhejiang ProvinceChina Medical College Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina Department of Obstetrics and Gynecology Taizhou Women and Children's Hospital of Wenzhou Medical UniversityTaizhou 318000Zhejiang ProvinceChina

There are many causes of *** is unreasonable to simply associate anemia with asymptomatic ulcers in the small intestine.

关键词： Intrinsic factor Iron deficiency anemia Megaloblastic anemia Nonsteroidal anti-inflammatory drugs Statistical bias

Efficacy and safety of decitabine combined with low-dose cytarabine, aclarubicin, and granulocyte colony-stimulating factor compared with standard therapy in acute myeloid leukemia patients with TP53 mutation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第12期134卷 1477-1479页

作者： si-si chen Qian Sun Lan Cao Wen-Zhong Wu Yue Xie Chun Qiao Jian-yong Li si-Xuan Qian Ming Hong Department of Hematology The Affiliated Yixing Hospital of Jiangsu UniversityWuxiJiangsu 214200China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China Pukou CLL Center Pukou division of Jiangsu Province HospitalNanjingJiangsu 211899China

Tumor suppressor gene P53(TP53)is a critical tumor suppressor *** mutant p53 protein enhances the activity,invasion and metastasis of tumor *** myeloid leukemia(AML)patients with TP53 mutations respond poorly to conventional chemotherapy and have poor clinical *** previously conducted a multi-center phase II clinical trial(***-11001700)in elderly AML patients with decitabine,low-dose cytarabine,aclarubicin,and granulocyte colony-stimulating factor(G-CSF)(DCAG regimen),which showed an overall response rate(ORR)of 82.4%and a complete remission(CR)rate of 64.7%.[1]Given this satisfactory effect of DCAG regimen,the present study has been designed to compare the efficacy and safety of DCAG regimen with standard therapy in AML patients with TP53 mutations.

关键词： TP53 patients stimulating

Diagnosis and Management of 60 Children with Congenital Vascular Rings： A 10-year Experience

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第12期128卷 1689-1692页

作者： Guo-Qing Fang Jing Li Feng Xu Yue-Qiang Fu Ying-Fu chen Xiao-Juan Ji He-Lin Zheng si-si chen Department of PICU Children's Hospital of Chongqing Medical University Chongqing 400014 China Department of Pediatrics The Ninth People's Hospital of Chongqing Chongqing 400700 China Department of Cardiology Children's Hospital of Chongqing Medical University Chongqing 400014 China Department of Radiology Children's Hospital of Chongqing Medical University Chongqing 400014 China Department of Respiratory Children's Hospital of Chongqing Medical University Chongqing 400014 China

INTRODUCTION Congenital vascular rings （VRs） are a group of rare cardiovascular anomalies that result from abnormal embryonic development of the paired aortic arches or branching pulmonary arteries. Clinical present... 详细信息

关键词： Airway Constriction Congenital Heart Disease Vascular Rings

同方期刊数据库

High Fe‑Loading single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 187-203页

作者： si chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli si Naijia Xue Yi Liu Ran Zheng Ying chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

McGregor术式修复外伤后眼睑缺损的效果观察

在线全文

学校读者我要写书评

暂无评论

中国现代医学杂志 2022年第22期32卷 80-84页

作者：陈思思赵霖邹同荣吴琛岑瑛四川省人民医院温江医院烧伤整形科四川成都611130 宜宾市第一人民医院烧伤整形科四川宜宾644000 四川大学华西医院整形美容/烧伤外科四川成都610000

目的探讨McGregor术式修复外伤后眼睑缺损效果。方法选取2019年1月—2021年6月四川省人民医院温江医院和宜宾市第一人民医院收治的84例外伤后眼睑缺损患者作为研究对象。将患者分为对照组和研究组,每组42例。两组患者采用外眦颞侧反向... 详细信息

目的探讨McGregor术式修复外伤后眼睑缺损效果。方法选取2019年1月—2021年6月四川省人民医院温江医院和宜宾市第一人民医院收治的84例外伤后眼睑缺损患者作为研究对象。将患者分为对照组和研究组,每组42例。两组患者采用外眦颞侧反向半圆形肌皮瓣进行旋转滑行治疗,对照组患者采取Tenzel术式修复,研究组患者采取McGregor术式修复。术后随访6个月,记录两组手术时间、术中出血量,统计两组患者手术前后的睑裂状况,对比两组眼睑缺损修复美学效果,对比两组患者手术前后的眼表功能状态,统计两组术后并发症发生情况。结果两组患者手术时间、术中出血量比较,差异无统计学意义(P>0.05)。两组患者手术前后睑裂长度、睑裂高度的差值比较,差异无统计学意义(P>0.05)。两组患者总有效率比较,差异无统计学意义(P>0.05)。两组患者手术前后泪膜破裂时间、Schirmer试验差值比较,差异无统计学意义(P>0.05)。研究组术后总并发症发生率低于对照组(P<0.05)。结论McGregor术式、Tenzel术式修复外伤后眼睑中度缺损效果相当,均可有效恢复患者眼睑结构及形态,但McGregor术式在安全性方面具有一定优势。

关键词：眼睑缺损眼睑重建 McGregor术式治疗结果