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Acta Mathematica sinica,English Series 2023年第7期39卷 1332-1350页

作者： si qi wang Fei GUO School of Mathematics Tianjin UniversityTianjin 300354China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin 300354China

Two results about the multiplicity of nontrivial periodic bouncing solutions for sublinear damped vibration systems-x=g(t)x+f(t,x) are obtained via the Generalized Nonsmooth Saddle Point Theorem and a technique established by Wu Xian and wang *** of them imply the condition "f≥0" required in some previous papers can be weakened,furthermore,one of them also implies the condition about ■F(t,x)/■t required in some previous papers,such as "|■F(t,x)/■t|=σ_(0)F(t,x)" and "|■F(t,x)/■t|≤C(1+F(t,x))", is unnecessary,where F(t,x):=∫_(0)~xf(t,x)ds,and σ_(0),C are positive constants.

关键词： Damped vibration systems generalized Nonsmooth Saddle Point Theorem sublinear conditions periodic bouncing solutions multiplicity

Generalized Lagrangian Duality in Set-valued Vector Optimization via Abstract Subdifferential

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Acta Mathematicae Applicatae sinica 2022年第2期38卷 337-351页

作者： Yan-fei CHAI San-yang LIU si-qi wang Department of Mathematics Xi'an Polytechnic UniversityXi'an 710048China School of Mathematics and Statistics Xidian UniversityXi'an 710071China College of Transportation Engineering Chang'an UniversityXi'an 710064China

In this paper,we investigate dual problems for nonconvex set-valued vector optimization via abstract *** first introduce a generalized augmented Lagrangian function induced by a coupling vector-valued function for set-valued vector optimization problem and construct related set-valued dual map and dual optimization problem on the basic of weak efficiency,which used by the concepts of supremum and infimum of a *** then establish the weak and strong duality results under this augmented Lagrangian and present sufficient conditions for exact penalization via an abstract subdifferential of the object ***,we define the sub-optimal path related to the dual problem and show that every cluster point of this sub-optimal path is a primal optimal solution of the object optimization *** addition,we consider a generalized vector variational inequality as an application of abstract subdifferential.

关键词： Nonconvex set-valued vector optimization abstract subdifferential generalized augmented Lagrangian duality exact penalization sub-optimal path

The role of fibronectin in multiple sclerosis and the effect of drug delivery across the blood-brain barrier

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Neural Regeneration Research 2023年第10期18卷 2147-2155页

作者： Shuang-Shuang Wei Le Chen Feng-Yuan Yang si-qi wang Peng wang Ningxia Key Laboratory of Craniocerebral Diseases School of Clinical MedicineNingxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Ningxia Key Laboratory of Craniocerebral Diseases Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina

Remyelination failure is one of the main characteristics of multiple sclerosis and is potentially correlated with disease *** research has shown that the extracellular matrix is associated with remyelination failure because remodeling of the matrix often fails in both chronic and progressive multiple *** aggregates are assembled and persistently exist in chronic multiple sclerosis,thus inhibiting *** many advances have been made in the mechanisms and treatment of multiple sclerosis,it remains very difficult for drugs to reach pathological brain tissues;this is due to the complexity of brain structure and function,especially the existence of the blood-brain ***,herein,we review the effects of fibronectin aggregates on multiple sclerosis and the efficacy of different forms of drug delivery across the blood-brain barrier in the treatment of this disease.

关键词： blood-brain barrier brain delivery exosomes extracellular matrix fibronectin aggregates fibronectin intestinal flora multiple sclerosis remyelination failure remyelination

Ambiguous roles of innate lymphoid cells in chronic development of liver diseases

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World Journal of Gastroenterology 2018年第18期24卷 1962-1977页

作者： Yue Shen Jing Li si-qi wang Wei Jiang Department of Gastroenterology Zhongshan Hospital Fudan University Department of Gastroenterology Tongji Hospital Tongji University

Innate lymphoid cells(ILCs) are defined as a distinct arm of innate immunity. According to their profile of secreted cytokines and lineage-specific transcriptional factors, ILCs can be categorized into the following three groups: group 1 ILCs(including natural killer(NK) cells and ILC1 s) are dependent on T-bet and can produce interferon-γ; group 2 ILCs(ILC2 s) are dependent on GATA3 and can produce type 2 cytokines, including interleukin(IL)-5 and IL-13; and, group 3 ILCs(including lymphoid tissue-like cells and ILC3 s) are dependent on RORγt and can produce IL-22 and IL-17. Collaborative with adaptive immunity, ILCs are highly reactive innate effectors that promptly orchestrate immunity, inflammation and tissue repair. Dysregulation of ILCs might result in inflammatory disorders. Evidence regarding the function of intrahepatic ILCs is emerging from longitudinal studies of inflammatory liver diseases wherein they exert both physiological and pathological functions, including immune homeostasis, defenses and surveillance. Their overall effect on the liver depends on the balance of their proinflammatory and antiinflammatory populations, specific microenvironment and stages of immune responses. Here, we review the current data about ILCs in chronic liver disease progression, to reveal their roles in different stages as well as to discuss their therapeutic potency as intervention targets.

关键词： Innate lymphoid cells Chronic liver disease Hepatitis Liver fibrosis Liver cancer

Expression of BSE-associated proteins in the CNS and lymphoreticular tissues of cattle and buffalo

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Science Bulletin 2016年第17期61卷 1377-1383页

作者： Hui Zhao si-qi wang Li-Li qing Lin-Lin Liu Ya-Ping Zhang State Key Laboratory for Conservation and Utilization of Bioresource Yunnan University Kunming 650091 China School of Life Science Yunnan University Kunming 650091 China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China

Bovine spongiform encephalopathy(BSE),which has been documented in 190,000 cases of BSE-infected cattle,to our knowledge,has not been reported in *** protein(PrP) is critical to susceptibility and development of ***,a new PrP-like protein,Shadoo(Sho),has been shown to have overlapping expression patterns and shared functions with ***,we hypothesize that differences in expression at the transcriptional level and/or the post-transcriptional level of the two genes may be associated with these specific differences between cattle and *** compared the relative mRNA expression of the prion protein gene(PRNP) and the Shadoo gene(SPRN) in 3% RNA samples using real-time *** also analyzed PrP/Sho protein from 96 samples by Western *** results demonstrated significantly lower PrP expression in the cerebellum,obex,mesenteric lymph node,and bronchial lymph node tissues,but higher relative expression of Sho in the cerebrum and spleen in buffalos compared with *** these results support our primary assumption,Sho and PrP expressions did not correlate with corresponding mRNA expression,suggesting that the biological modulations of both PrP and Sho proteins are at post-translational ***,positive correlations between PRNP and SPRN were found in cattle and buffalo cerebrum as well as in buffalo ***,negative correlations between PrP and Sho were detected in buffalo cerebellum and obex *** findings suggest that additional post-transcriptional studies are warranted to elucidate mechanisms behind prion diseases.

关键词： BSE PRNP SPRN Cattle Buffalo

Fate of nitrogen in subsurface infiltration system for treating secondary effluent

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Water Science and Engineering 2017年第3期10卷 217-224页

作者： Ying-hua Li Hai-bo Li Xin-yang Xu si-yao Xiao si-qi wang Shu-cong Xu School of Resources and Civil Engineering Northeastern University School of Material Science and Engineering Shandong University

The concentration of total nitrogen(TN) is reported to vary between 20 and 35 mg/L in domestic wastewater. In raw wastewater, ammonia nitrogen eNHt4-NT is the main nitrogen form, accounting for 70%e82% of the TN concentration. Organic nitrogen, nitrite nitrogen eNOà2-NT,and nitrate nitrogen eNOà3-NT are present as well. For years, due to the lack of regulatory limits on nitrogen concentration in surface waters,nitrogen from secondary effluent has posed a significant threat to the health of aquatic ecosystems. Researchers have made substantial efforts to reduce the nitrogen concentration in secondary effluent. As a kind of advanced wastewater treatment technology, the subsurface infiltration(si)system has been widely used, owing to its advantages, which include low operation cost, easy maintenance, and low energy consumption. This review discusses the fate of various forms of nitrogen in si treatment, including organic nitrogen, NHt4-N, NOà2-N, and NOà3-N. Major biological processes involved in nitrogen removal and the main factors influencing its transformation are suggested. Finally, it is shown that ammonification followed by nitrification-denitrification plays a major role in nitrogen removal. Further research needs to focus on the emission characteristics of gaseous nitrogen(generated from the nitrification, denitrification, and completely autotrophic nitrogen-removal over nitrite(CANON) processes) with respect to their greenhouse effects.

关键词： Wastewater treatment Natural treatment technology Subsurface infiltration Nitrogen Biological process

Global Functional Network Connectivity Disturbances in Parkinson’s Disease with Mild Cognitive Impairment by Resting-State Functional MRI

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Current Medical Science 2020年第6期40卷 1057-1066页

作者： Xin-xin SHUAI Xiang-chuang KONG Yan ZOU si-qi wang Yu-hui wang Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Molecular Imaging Wuhan 430022China

Examining the spontaneous BOLD activity to understand the neural mechanism of Parkinson’s disease(PD)with mild cognitive impairment(MCI)is a focus in resting-state functional MRI(rs-fMRI)*** study aimed to investigate the alteration of brain functional connectivity in PD with MCI in a systematical way at two levels:functional connectivity analysis within resting state networks(RSNs)and functional network connectivity(FNC)*** group independent component analysis(ICA)on rs-fMRI data acquired from 30 participants(14 healthy controls and 16 PD patients with MCI),16 RSNs were identified,and functional connectivity analysis within the RSNs and FNC analysis were carried out between *** to controls,patients with PD showed decreased functional connectivity within putamen network,thalamus network,cerebellar network,attention network,and self-referential network,and increased functional connectivity within execution *** disturbed,mostly increased functional connectivity of FNC was observed in PD group,and insular network and execution network were the dominant network with extensively increased functional connectivity with other *** network showed decreased functional connectivity with caudate network,insular network,and self-referential *** general,decreased functional connectivity within RSNs and globally disturbed,mostly increased functional connectivity of FNC may be characteristics of *** functional connectivity within execution network may be an early marker of *** multi-perspective study based on RSNs may be a valuable means to assess functional changes corresponding to specific RSN,contributing to the understanding of the neural mechanism of PD.

关键词： Parkinson's disease resting-state functional MRI resting-state functional connectivity functional network connectivity

High-rate performance and super long-cycle stability of Na_(3)V_(2)(PO_(4))_(3)cathode material coated by diatomic doped carbon

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Rare Metals 2023年第5期42卷 1570-1582页

作者： Jia Kang Ling Zhu Fei-Yang Teng si-qi wang Yong-Gang Huang Yan-Hong Xiang Zhe Chen Xian-Wen Wu School of Physics and Electromechanical Engineering Jishou UniversityJishou416000China School of Chemistry and Chemical Engineering Jishou UniversityJishou416000China

Na_(3)V_(2)(PO_(4))_(3)is considered as one of the most promising cathodes for sodium ion batteries due to its excellent thermal stability,long cycle life and high energy ***,the inferior intrinsic electronic conductivity which brings about the poor rate capability and cycling performance hinders its commercial ***,the S-N co-doped carbon-coated Na_(3)V_(2)(PO_(4))_(3)(NVP@SNC)has been synthesized to resolve the *** prepared NVP@SNC forms a hierarchical structure assembled with nanosheets,which is in favor of the electrolyte infiltration and shortening the Na^(+)transmission *** lattice defects can be induced in carbon layer by the co-doped elements(S-N),which reduce the Na^(+)diffusion energy barriers and provide adequate Na^(+)migration channels,thus jointly boosting the Na^(+)diffusion ***,the NVP@SNC cathode shows a high reversible capacity with outstanding rate performance and super long-cycle *** discharged at 2.0C,it delivers the capacity near to the theoretical value with a capacity retention of 88.7%after *** if the current is as high as 50.0C,a high capacity of 58.6 mAh·g^(-1)has been released,and41.4 mAh·g^(-1)has been remained after the super long cycling of 4000 *** study is expected to supply a new thought of developing high-performance cathodes by diatomic doping for sodium ion battery.

关键词： Sodium ion battery(siB) Cathode material Na_(3)V_(2)(PO_(4))_(3) Diatomic doping Carbon coating

Analysis of Two Kinds of Stochastic Predator-prey Models with Stage Structure

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Acta Mathematicae Applicatae sinica 2024年

作者： Xin-qi wang Tian-si ZHANG College of Science University of Shanghai for Science and Technology

In this paper, we studied a stochastic predator-prey model of two predators with stage *** constructing a suitable stochastic Lyapunov function, the condition of stationary distribution is verified, and we get the sufficient condition for the model to have ergodic stationary distribution. Then, by using the It?'s formula for the model, the sufficient conditions for the extinction of the predator population are given. Finally,some examples and numerical simulations are illustrated to verify the theoretical results.

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Magnetic resonance imaging apparent diffusion coefficient before and after neoadjuvant chemotherapy in patients with breast cancer and its correlation with tumor load

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Journal of Hainan Medical University 2018年第9期24卷 52-56页

作者： si-qi wang Ping Jiang Radiology Department Zigong Fourth People's Hospital in Sichuan ProvinceZigongSichuan Province643000

Objective:To study the magnetic resonance imaging apparent diffusion coefficient (ADC) before and after neoadjuvant chemotherapy in patients with breast cancer and its correlation with tumor ***: Patients with stage II-III breast cancer who intended to receive radical operation for breast cancer in our hospital between May 2015 and February 2018 were selected and divided into the experimental group who accepted neoadjuvant chemotherapy and the control group who received surgery directly according to the adoption of preoperative neoadjuvant chemotherapy or not in the history data. Experimental group underwent magnetic resonance imaging before and after neoadjuvant chemotherapy to measure the ADC, and control group underwent magnetic resonance imaging before surgery to measure the ADC;the tumor tissues surgically removed from the two groups of patients were collected to measure the expression of oncogenes and invasion ***:ADC value of experimental group after neoadjuvant chemotherapy was higher than that before neoadjuvant chemotherapy, ADC value of experimental group before neoadjuvant chemotherapy was not significantly different from that of control group whereas ADC value after neoadjuvant chemotherapy was significantly higher than that of control group;MCM3, CyclinD1, TC-1,β-catenin, YAP and MMP2 mRNA expression levels in surgically removed tumor tissues of experimental group were significantly lower than those of control group whereas CCN5, ARID1A and PDCD4 mRNA expression levels were significantly higher than those of control group;MCM3, CyclinD1, TC-1,β-catenin, YAP and MMP2 mRNA expression levels in tumor tissues with high ADC value were significantly lower than those in tumor tissues with low ADC value whereas CCN5, ARID1A and PDCD4 mRNA expression levels were significantly higher than those in tumor tissues with low ADC ***:The increase of ADC after breast cancer neoadjuvant chemotherapy is related to the activity of cancer ce

关键词： Breast cancer Neoadjuvant chemotherapy Apparent diffusion coefficient Oncogene Invasion gene