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Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)

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Chinese Journal of Polymer Science 2015年第4期33卷 587-596页

作者： Zhi-ming Song Bo Shi 丁建勋 Xiu-li Zhuang Xiao-nan Zhang 付长峰 Xue-si chen Department of Sports Medicine First Hospital of Jilin University Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences Department of Spine Surgery First Hospital of Jilin University Changchun sino Biomaterials Co. Ltd.

An electrospun poly（lactide-co-glycolide）（PLGA） membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments, the membrane showed an appropriate degradation rate, and the pH values of degradation media were maintained at around 7.4. simultaneously, the excellent biocompatibility of the membrane in vitro and in vivo was confirmed by live/dead and histopathological analyses. Meanwhile, the membrane can reduce tendon adhesion significantly and promote functional recovery effectively. The encouraging results were further demonstrated by hematoxylin and eosin （H＆E）, and Masson＇s trichrome stainings, and type I collagen immunohistochemical analysis. It was concluded that the model treated with the electrospun PLGA membrane was significantly better with respect to the adhesion prevention and tissue repair than that without treatment. Considering the results of degradation and adhesion prevention efficacy, the electrospun PLGA membrane would be a great candidate for the prevention of postoperative tendon adhesion.

关键词： Anti-adhesion Achilles tendon repair Biodegradability Electrospun membrane Poly(lactide-co-glycolide).

Production induced fracture closure of deep shale gas well under thermo-hydro-mechanical conditions

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Petroleum Science 2024年第3期21卷 1796-1813页

作者： Shi-ming Wei Yang Xia Yan Jin Xu-Yang Guo Jing-Yu Zi Kai-Xuan Qiu si-Yuan chen College of Science China University of Petroleum(Beijing)Beijing102249China CNOOC Research Institute Ltd Beijing100028China The University of Hong Kong Hong Kong999077China

Deep shale gas reservoirs have geological characteristics of high temperature,high pressure,high stress,and inferior ability to pass through *** multi-stage fractured horizontal well is the key to exploiting the deep shale gas ***,during the production process,the effectiveness of the hydraulic fracture network decreases with the closure of fractures,which accelerates the decline of shale gas *** this paper,we addressed the problems of unclear fracture closure mechanisms and low accuracy of shale gas production prediction during deep shale gas *** we established the fluid—solid—heat coupled model coupling the deformation and fluid flow among the fracture surface,proppant and the shale *** the fluid—solid—heat coupled model was applied to the fracture network,it was well solved by our numerical method named discontinuous discrete fracture *** with the conventional discrete fracture method,the discontinuous discrete fracture method can describe the three-dimensional morphology of the fracture while considering the effect of the change of fracture surface permeation coefficient on the coupled fracture—matrix flow and describing the displacement discontinuity across the *** simulations revealed that the degree of fracture closure increases as the production time proceeds,and the degree of closure of the secondary fractures is higher than that of the primary *** creep and proppant embedment both increase the degree of fracture *** reduction in fracture surface permeability due to proppant embedment reduces the rate of fluid transfer between matrix and fracture,which has often been overlooked in the ***,it significantly impacts shale gas production,with calculations showing a 24.7%cumulative three-year yield *** study is helpful to understand the mechanism of hydraulic fracture ***,it provides the theoretical guidance for maintaining the long

关键词： Shalegas Fracture closure Fluid-solid-heat coupling Discontinuous discrete fracture

基于光谱技术的典型互花米草入侵湿地土壤属性预测研究

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光谱学与光谱分析 2025年第1期45卷 197-203页

作者：陈旭曹思珩杨仁敏陈秋宇李建国徐璐 4 江苏师范大学地理测绘与城乡规划学院地理信息科学系江苏徐州221116

为了高效监测互花米草入侵海岸带湿地生态系统的土壤属性变化,选取江苏省盐城湿地珍禽国家级自然保护区的一处典型互花米草入侵湿地作为研究区,利用随机分层采样方法选取15个样点,在3个深度(0~30、30~60、60~100 cm)共采集45个土壤样品... 详细信息

为了高效监测互花米草入侵海岸带湿地生态系统的土壤属性变化,选取江苏省盐城湿地珍禽国家级自然保护区的一处典型互花米草入侵湿地作为研究区,利用随机分层采样方法选取15个样点,在3个深度(0~30、30~60、60~100 cm)共采集45个土壤样品,测定了土壤可见光-近红外反射光谱和10种土壤理化属性,研究了偏最小二乘和随机森林两种方法的预测能力,分析了不同光谱变换形式对预测精度的影响,探讨了入侵年限和土壤深度作为辅助预测变量的潜力。结果表明:(1)可见光-近红外光谱技术可以较好地预测有机碳、无机碳、全氮、含水量、pH、容重、盐分和黏粒等属性;(2)偏最小二乘回归法比随机森林法更适合监测互花米草入侵湿地的关键土壤理化属性,利用偏最小二乘法对土壤属性建立的预测模型精度(R^(2))在0.341~0.979之间,随机森林方法对土壤属性建立的预测模型精度(R^(2))最高为0.722;(3)基于原始光谱可以获得土壤全氮的最优预测模型(R^(2)为0.769,RMSE为0.091 g·kg^(-1)),而其他土壤属性的最优模型多是基于微分变换或倒数变换建立的模型,微分变换和倒数变换可以有效地提高模型预测精度;(4)模型预测精度在加入入侵年限和土壤深度两个变量后总体上有所提高,其中有机碳、全氮、盐分、pH和容重等属性的预测精度对这两个变量更为敏感,土壤有机碳最优模型的精度(R^(2))从0.794提高到0.806,pH最优模型的精度(R^(2))从0.838提升至0.884,盐分最优模型的精度(R^(2))从0.978提升至0.997。综上所述,可见光-近红外光谱技术在互花米草入侵湿地关键土壤理化属性预测方面具有明显的优越性,通过适当的光谱变换、变量筛选、模型选择等方面可以实现互花米草入侵湿地土壤变化的快速监测。

关键词：互花米草入侵可见光-近红外光谱土壤监测偏最小二乘法随机森林光谱变换

Organolead trihalide perovskite materials for efficient light emitting diodes

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Science China Chemistry 2016年第6期59卷 653-658页

作者： ming Peng Wen Wen si chen Buxin chen Kai Yan Hsienwei Hu Bin Dong Xue Gao Xiao Yu Xiaoming Jiang Dechun Zou Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of Education Center for Soft Matter Science and Engineering College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Wuhan Institute for Food and Cosmetic Control Wuhan 430012 China Beijing Engineering Research Center for Active Matrix Display Peking University Beijing 100871 China

Organolead trihalide perovskite materials have been attracting increasing attention due to their promising role in solid solar cells. Several advantages make them potential candidates for optoelectronics:(1) solution- or/and vapor-processed preparation at low temperature;(2) tunable optical bandgap, wide absorption spectrum but narrow photoluminescence peaks;(3) long car-rier life time, large diffusion length and high charge mobility;(4) various nanostructures via tuning capping agents and sol-vents. In this review, we summarize recent attempts toward efficient LEDs based on organolead trihalide perovskite materials. The strategies of materials science, device design and interface engineering are highlighted. Recent development and future perspectives are summarized for practical perovskite light technologies.

关键词： organolead trihalide perovskite materials interface engineering light emitting diodes

Microstructure evolution and mechanical properties of high-boron steel with different ratios of boron and carbon

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China Foundry 2022年第2期19卷 169-176页

作者： ming-chen Ma Chao-qing Luo si-min chen Hong-qun Tang Shan-shan Hu Yu-mei Zhou Jian-lin Liang Guangxi Key Laboratory of Processing for Nonferrous Metals and Featured Materials Center of Ecological Collaborative Innovation for Aluminium Industry in GuangxiSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China School of Mechanical Engineering Guangxi UniversityNanning 530004China School of Mechatronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China

Boron and carbon contents are the main factors influencing the properties of high-boron *** this study,experimental samples with different boron-to-carbon ratios(%B/%C)were *** microstructures of the different samples were observed,and their hardness,bending strength,and impact toughness were *** show that the main microstructures in the investigated high-boron steel samples are the eutectic Fe_(2)B structure with a fishbone shape and the ternary peritectic Fe_(3)(C,B)structure with a chrysanthemum *** the boron content is 2.5wt.%and the carbon content is 0.43wt.%(i.e.,%B/%C=5.82),the overall mechanical properties of the alloy are the *** alloy's hardness,bending strength and impact toughness reach their maximums,which are 67.3 HRC,1,267.36 MPa and 6.19 J·cm^(-2),*** optimized alloy is compared with conventional materials exhibiting excellent wear resistance(namely,high-manganese steel and high-chromium cast iron)through two-body and three-body abrasion *** wear resistance of this high-boron steelinvestigated in this work is found to be superior to those of the more common materials.

关键词： high-boron steel boron and carbon contents wear resistance microstructure mechanical properties

Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu Deng mingbo Nie Hong chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

Three new coumarins and a new coumarin glycoside from Micromelum integerrimum

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Chinese Journal of Natural Medicines 2021年第8期19卷 621-625页

作者： CAO Nan-Kai chen Yue-Mei ZHU si-si ZENG Ke-Wu ZHAO ming-Bo LI Jun TU Peng-Fei JIANG Yong State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Three new coumarins,integmarins A–C(1–3),and a new coumarin glycoside,integmaside A(4)were isolated from the leaves and stems of Micromelum *** structures were elucidated on the basis of 1 D and 2 D NMR and MS data,and their absolute configurations were assigned according to the ECD data of the in situ formed transition metal complexes and comparison of experimental and calculated ECD *** 1 and 2 are two rare coumarins with butyl and propyl moieties at the C-6 position;compound 3 is a novel coumarin with a highly oxidized prenyl group,and compound 4 is a rare bisdihydrofuranocoumarin glycoside.

关键词： Rutaceae Micromelum integerrimum Coumarins Coumarin glycoside ECD

Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy

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Military Medical Research 2023年第1期10卷 32-44页

作者： Pei-Pei Su Dong-Wei Liu si-Jie Zhou Hang chen Xian-ming Wu Zhang-Suo Liu Department of Nephrology the First Affiliated Hospital of Zhengzhou UniversityResearch Institutes of NephropathyZhengzhou UniversityZhengzhou 450052China Department of Nephrology and Rheumatology the Third People’s Hospital of ZhengzhouZhengzhou 450002China Henan Province Research Center for Kidney Disease Zhengzhou 450052China Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province Zhengzhou 450002China

Background: LncRNA AK044604(regulator of insulin sensitivity and autophagy, Risa) and autophagy-related factors sirt1 and GSK3β play important roles in diabetic nephropathy(DN). In this study, we sought to explore the effect of Risa on sirt1/GSK3β-induced podocyte ***: Diabetic db/db mice received Risa-inhibition adeno-associated virus(AAV) via tail vein injection, and intraperitoneal injection of lithium chloride(LiCl). Blood, urine, and kidney tissue samples were collected and analyzed at different time points. Immortalized mouse podocyte cells(MPCs) were cultured and treated with Risa-inhibition lentivirus(LV), EX-527, and LiCl. MPCs were collected under different stimulations as noted. The effects of Risa on podocyte autophagy were examined by qRT-PCR, Western blotting analysis, transmission electron microscopy,Periodic Acid-Schiff staining, and immunofluorescence ***: Risa and activated GSK3β were overexpressed, but sirt1 was downregulated in DN mice and high glucosetreated MPCs(Psis. Risa overexpression attenuated sirt1-mediated downstream autophagy levels and aggravated podocyte injury by inhibiting the expression of sirt1(Psion enhanced sirt1-induced autophagy and attenuated podocyte injury, which could be abrogated by EX-527(Psion aggravated podocyte injury by decreasing ***: Risa could inhibit autophagy by regulating the sirt1/GSK3β axis, thereby aggravating podocyte injury in DN. Risa may serve as a therapeutic target for the treatment of DN.

关键词： Diabetic nephropathy LncRNA AK044604/sirt1/GSK3β Autophagy

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基于特征增强和样本充分学习的红外飞机检测

电光与控制 2025年第1期32卷 54-60页

作者：徐红鹏刘刚司起峰陈会祥河南科技大学信息工程学院河南洛阳471000

针对深度学习单阶段检测算法对红外飞机目标的特征提取能力不足以及样本学习不充分的问题,提出基于特征增强的全局上下文机制(FEGCM)和样本充分学习的目标检测算法。FEGCM可获取包含目标的全局信息与局部信息的特征图,从而提高特征提取... 详细信息

针对深度学习单阶段检测算法对红外飞机目标的特征提取能力不足以及样本学习不充分的问题,提出基于特征增强的全局上下文机制(FEGCM)和样本充分学习的目标检测算法。FEGCM可获取包含目标的全局信息与局部信息的特征图,从而提高特征提取网络对目标特征的提取能力。通过在Focal Loss中添加调制因子,在关注难负样本学习的基础上,充分利用包含目标特性的部分易负样本,使得样本充分学习,从而帮助检测算法学习到更有意义的目标特征。实验表明,所提算法在自制红外飞机数据集上的mAP_(50)达到96.9%,能够有效实现红外飞机目标检测。

关键词：红外飞机检测全局上下文空间注意力 Focal Loss 易负样本

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